Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9H6S3

- ES8L2_HUMAN

UniProt

Q9H6S3 - ES8L2_HUMAN

Protein

Epidermal growth factor receptor kinase substrate 8-like protein 2

Gene

EPS8L2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (30 May 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton.1 Publication

    GO - Molecular functioni

    1. actin binding Source: UniProt

    GO - Biological processi

    1. positive regulation of Rac GTPase activity Source: GOC
    2. positive regulation of Rho GTPase activity Source: GOC
    3. positive regulation of ruffle assembly Source: UniProt
    4. regulation of Rho protein signal transduction Source: UniProt
    5. Rho protein signal transduction Source: UniProt

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Epidermal growth factor receptor kinase substrate 8-like protein 2
    Short name:
    EPS8-like protein 2
    Alternative name(s):
    Epidermal growth factor receptor pathway substrate 8-related protein 2
    Short name:
    EPS8-related protein 2
    Gene namesi
    Name:EPS8L2
    Synonyms:EPS8R2
    ORF Names:PP13181
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:21296. EPS8L2.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. extracellular vesicular exosome Source: UniProt
    3. plasma membrane Source: HPA
    4. protein complex Source: UniProt
    5. ruffle membrane Source: UniProt
    6. vesicle Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134981048.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 715715Epidermal growth factor receptor kinase substrate 8-like protein 2PRO_0000239084Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei303 – 3031PhosphothreonineBy similarity
    Modified residuei449 – 4491Phosphoserine1 Publication
    Modified residuei469 – 4691Phosphothreonine1 Publication
    Modified residuei570 – 5701Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9H6S3.
    PaxDbiQ9H6S3.
    PRIDEiQ9H6S3.

    PTM databases

    PhosphoSiteiQ9H6S3.

    Expressioni

    Tissue specificityi

    Detected in fibroblasts and placenta.1 Publication

    Gene expression databases

    ArrayExpressiQ9H6S3.
    BgeeiQ9H6S3.
    CleanExiHS_EPS8L2.
    GenevestigatoriQ9H6S3.

    Organism-specific databases

    HPAiHPA041143.

    Interactioni

    Subunit structurei

    Interacts with ABI1. Part of a complex that contains SOS1, ABI1 and EPS8L2. Associates with F-actin.1 Publication

    Protein-protein interaction databases

    BioGridi122297. 6 interactions.
    IntActiQ9H6S3. 6 interactions.
    MINTiMINT-5002000.
    STRINGi9606.ENSP00000320828.

    Structurei

    Secondary structure

    1
    715
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi506 – 5105
    Beta strandi518 – 5236
    Beta strandi525 – 5328
    Beta strandi538 – 5425
    Turni543 – 5453
    Helixi630 – 64011
    Helixi646 – 6494
    Helixi655 – 6595
    Helixi663 – 6708
    Turni671 – 6733
    Helixi674 – 68916

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1WWUNMR-A612-697[»]
    1WXBNMR-A495-549[»]
    ProteinModelPortaliQ9H6S3.
    SMRiQ9H6S3. Positions 46-175, 494-555, 612-697.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9H6S3.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 202157PIDPROSITE-ProRule annotationAdd
    BLAST
    Domaini492 – 55160SH3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the EPS8 family.Curated
    Contains 1 PID domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3 domain

    Phylogenomic databases

    eggNOGiNOG263108.
    HOVERGENiHBG003090.
    InParanoidiQ9H6S3.
    KOiK17277.
    OMAiVLQEAPW.
    OrthoDBiEOG7TMZR9.
    PhylomeDBiQ9H6S3.
    TreeFamiTF313069.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR011993. PH_like_dom.
    IPR013625. PTB.
    IPR006020. PTB/PI_dom.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF08416. PTB. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    SMARTiSM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    PROSITEiPS01179. PID. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H6S3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSQSGAVSCC PGATNGSLGR SDGVAKMSPK DLFEQRKKYS NSNVIMHETS    50
    QYHVQHLATF IMDKSEAITS VDDAIRKLVQ LSSKEKIWTQ EMLLQVNDQS 100
    LRLLDIESQE ELEDFPLPTV QRSQTVLNQL RYPSVLLLVC QDSEQSKPDV 150
    HFFHCDEVEA ELVHEDIESA LADCRLGKKM RPQTLKGHQE KIRQRQSILP 200
    PPQGPAPIPF QHRGGDSPEA KNRVGPQVPL SEPGFRRRES QEEPRAVLAQ 250
    KIEKETQILN CALDDIEWFV ARLQKAAEAF KQLNQRKKGK KKGKKAPAEG 300
    VLTLRARPPS EGEFIDCFQK IKLAINLLAK LQKHIQNPSA AELVHFLFGP 350
    LDLIVNTCSG PDIARSVSCP LLSRDAVDFL RGHLVPKEMS LWESLGESWM 400
    RPRSEWPREP QVPLYVPKFH SGWEPPVDVL QEAPWEVEGL ASAPIEEVSP 450
    VSRQSIRNSQ KHSPTSEPTP PGDALPPVSS PHTHRGYQPT PAMAKYVKIL 500
    YDFTARNANE LSVLKDEVLE VLEDGRQWWK LRSRSGQAGY VPCNILGEAR 550
    PEDAGAPFEQ AGQKYWGPAS PTHKLPPSFP GNKDELMQHM DEVNDELIRK 600
    ISNIRAQPQR HFRVERSQPV SQPLTYESGP DEVRAWLEAK AFSPRIVENL 650
    GILTGPQLFS LNKEELKKVC GEEGVRVYSQ LTMQKAFLEK QQSGSELEEL 700
    MNKFHSMNQR RGEDS 715
    Length:715
    Mass (Da):80,621
    Last modified:May 30, 2006 - v2
    Checksum:iDAB07744B04CFEE2
    GO
    Isoform 2 (identifier: Q9H6S3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-388: Missing.

    Show »
    Length:327
    Mass (Da):37,113
    Checksum:i9D933D44E34CC320
    GO
    Isoform 3 (identifier: Q9H6S3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         108-108: S → SQSAQTPGASRVRAMYP

    Note: No experimental confirmation available.

    Show »
    Length:731
    Mass (Da):82,323
    Checksum:i9D355BAFCF33601B
    GO

    Sequence cautioni

    The sequence AAL55838.1 differs from that shown. Reason: Frameshift at position 593.
    The sequence BAB15180.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti146 – 1461S → N in BAD96623. 1 PublicationCurated
    Sequence conflicti198 – 1981I → F in BAB15180. (PubMed:14702039)Curated
    Sequence conflicti589 – 5891H → R in BAB15180. (PubMed:14702039)Curated
    Sequence conflicti620 – 6201V → A in BAB15180. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 388388Missing in isoform 2. 2 PublicationsVSP_019092Add
    BLAST
    Alternative sequencei108 – 1081S → SQSAQTPGASRVRAMYP in isoform 3. 1 PublicationVSP_054144

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY074929 mRNA. Translation: AAL76118.1.
    AF318331 mRNA. Translation: AAL55838.1. Frameshift.
    AK025588 mRNA. Translation: BAB15180.1. Different initiation.
    AK025824 mRNA. Translation: BAB15248.1.
    AK027765 mRNA. Translation: BAB55354.1.
    AK094539 mRNA. Translation: BAG52883.1.
    AK222903 mRNA. Translation: BAD96623.1.
    BC080636 mRNA. Translation: AAH80636.1.
    BC093878 mRNA. Translation: AAH93878.1.
    BC101481 mRNA. Translation: AAI01482.1.
    BC143242 mRNA. Translation: AAI43243.1.
    AC131934 Genomic DNA. No translation available.
    AP006621 Genomic DNA. No translation available.
    CCDSiCCDS31328.1. [Q9H6S3-1]
    RefSeqiNP_073609.2. NM_022772.3. [Q9H6S3-1]
    XP_006718336.1. XM_006718273.1. [Q9H6S3-1]
    XP_006718337.1. XM_006718274.1. [Q9H6S3-1]
    XP_006718338.1. XM_006718275.1. [Q9H6S3-1]
    UniGeneiHs.55016.

    Genome annotation databases

    EnsembliENST00000318562; ENSP00000320828; ENSG00000177106. [Q9H6S3-1]
    ENST00000526198; ENSP00000436230; ENSG00000177106. [Q9H6S3-3]
    ENST00000530636; ENSP00000436035; ENSG00000177106. [Q9H6S3-1]
    ENST00000533256; ENSP00000435585; ENSG00000177106. [Q9H6S3-1]
    GeneIDi64787.
    KEGGihsa:64787.
    UCSCiuc001lqt.3. human. [Q9H6S3-1]
    uc001lqw.3. human. [Q9H6S3-2]

    Polymorphism databases

    DMDMi108864726.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY074929 mRNA. Translation: AAL76118.1 .
    AF318331 mRNA. Translation: AAL55838.1 . Frameshift.
    AK025588 mRNA. Translation: BAB15180.1 . Different initiation.
    AK025824 mRNA. Translation: BAB15248.1 .
    AK027765 mRNA. Translation: BAB55354.1 .
    AK094539 mRNA. Translation: BAG52883.1 .
    AK222903 mRNA. Translation: BAD96623.1 .
    BC080636 mRNA. Translation: AAH80636.1 .
    BC093878 mRNA. Translation: AAH93878.1 .
    BC101481 mRNA. Translation: AAI01482.1 .
    BC143242 mRNA. Translation: AAI43243.1 .
    AC131934 Genomic DNA. No translation available.
    AP006621 Genomic DNA. No translation available.
    CCDSi CCDS31328.1. [Q9H6S3-1 ]
    RefSeqi NP_073609.2. NM_022772.3. [Q9H6S3-1 ]
    XP_006718336.1. XM_006718273.1. [Q9H6S3-1 ]
    XP_006718337.1. XM_006718274.1. [Q9H6S3-1 ]
    XP_006718338.1. XM_006718275.1. [Q9H6S3-1 ]
    UniGenei Hs.55016.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1WWU NMR - A 612-697 [» ]
    1WXB NMR - A 495-549 [» ]
    ProteinModelPortali Q9H6S3.
    SMRi Q9H6S3. Positions 46-175, 494-555, 612-697.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122297. 6 interactions.
    IntActi Q9H6S3. 6 interactions.
    MINTi MINT-5002000.
    STRINGi 9606.ENSP00000320828.

    PTM databases

    PhosphoSitei Q9H6S3.

    Polymorphism databases

    DMDMi 108864726.

    Proteomic databases

    MaxQBi Q9H6S3.
    PaxDbi Q9H6S3.
    PRIDEi Q9H6S3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000318562 ; ENSP00000320828 ; ENSG00000177106 . [Q9H6S3-1 ]
    ENST00000526198 ; ENSP00000436230 ; ENSG00000177106 . [Q9H6S3-3 ]
    ENST00000530636 ; ENSP00000436035 ; ENSG00000177106 . [Q9H6S3-1 ]
    ENST00000533256 ; ENSP00000435585 ; ENSG00000177106 . [Q9H6S3-1 ]
    GeneIDi 64787.
    KEGGi hsa:64787.
    UCSCi uc001lqt.3. human. [Q9H6S3-1 ]
    uc001lqw.3. human. [Q9H6S3-2 ]

    Organism-specific databases

    CTDi 64787.
    GeneCardsi GC11P000696.
    HGNCi HGNC:21296. EPS8L2.
    HPAi HPA041143.
    MIMi 614988. gene.
    neXtProti NX_Q9H6S3.
    PharmGKBi PA134981048.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG263108.
    HOVERGENi HBG003090.
    InParanoidi Q9H6S3.
    KOi K17277.
    OMAi VLQEAPW.
    OrthoDBi EOG7TMZR9.
    PhylomeDBi Q9H6S3.
    TreeFami TF313069.

    Miscellaneous databases

    ChiTaRSi EPS8L2. human.
    EvolutionaryTracei Q9H6S3.
    GeneWikii EPS8L2.
    GenomeRNAii 64787.
    NextBioi 35481152.
    PROi Q9H6S3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H6S3.
    Bgeei Q9H6S3.
    CleanExi HS_EPS8L2.
    Genevestigatori Q9H6S3.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR011993. PH_like_dom.
    IPR013625. PTB.
    IPR006020. PTB/PI_dom.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF08416. PTB. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    SMARTi SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    PROSITEi PS01179. PID. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure."
      Tocchetti A., Confalonieri S., Scita G., Di Fiore P.P., Betsholtz C.
      Genomics 81:234-244(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain cortex and Placenta.
    4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Kidney.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Brain and Prostate.
    7. "The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway."
      Offenhaeuser N., Borgonovo A., Disanza A., Romano P., Ponzanelli I., Iannolo G., Di Fiore P.P., Scita G.
      Mol. Biol. Cell 15:91-98(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN A COMPLEX WITH ABI1 AND SOS1, INTERACTION WITH ABI1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-449, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-469 AND SER-570, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "solution structure of the SH3 domain from human epidermal growth factor receptor pathway substrate 8-like protein."
      RIKEN structural genomics initiative (RSGI)
      Submitted (JUL-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 495-549.

    Entry informationi

    Entry nameiES8L2_HUMAN
    AccessioniPrimary (citable) accession number: Q9H6S3
    Secondary accession number(s): B3KSX1
    , B7ZKL3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: May 30, 2006
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3