UniProtKB - Q9H6S1 (AZI2_HUMAN)
(max 400 entries)x
Your basket is currently empty. i
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Protein
5-azacytidine-induced protein 2
Gene
AZI2
Organism
Homo sapiens (Human)
Status
Functioni
Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1.3 Publications
Caution
GO - Biological processi
- dendritic cell differentiation Source: Ensembl
- dendritic cell proliferation Source: Ensembl
- I-kappaB kinase/NF-kappaB signaling Source: Ensembl
- interferon-alpha production Source: Ensembl
- interferon-gamma production Source: Ensembl
- interleukin-6 production Source: Ensembl
- mitotic cell cycle Source: Ensembl
- T cell activation Source: Ensembl
- tumor necrosis factor production Source: Ensembl
- viral process Source: UniProtKB-KW
Keywordsi
Biological process | Host-virus interaction |
Enzyme and pathway databases
SignaLinki | Q9H6S1 |
Names & Taxonomyi
Protein namesi | Recommended name: 5-azacytidine-induced protein 2Alternative name(s): NF-kappa-B-activating kinase-associated protein 1 Short name: Nak-associated protein 1 TILP |
Gene namesi | Name:AZI2 Synonyms:NAP1, TBKBP2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000163512.13 |
HGNCi | HGNC:24002 AZI2 |
MIMi | 609916 gene |
neXtProti | NX_Q9H6S1 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 64343 |
OpenTargetsi | ENSG00000163512 |
PharmGKBi | PA134950985 |
Polymorphism and mutation databases
BioMutai | AZI2 |
DMDMi | 74718550 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000280602 | 1 – 392 | 5-azacytidine-induced protein 2Add BLAST | 392 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 318 | PhosphoserineBy similarity | 1 | |
Modified residuei | 353 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9H6S1 |
MaxQBi | Q9H6S1 |
PaxDbi | Q9H6S1 |
PeptideAtlasi | Q9H6S1 |
PRIDEi | Q9H6S1 |
PTM databases
iPTMneti | Q9H6S1 |
PhosphoSitePlusi | Q9H6S1 |
Expressioni
Tissue specificityi
Widely expressed. Abundant expression seen in the pancreas and testis.1 Publication
Gene expression databases
Bgeei | ENSG00000163512 |
CleanExi | HS_AZI2 |
ExpressionAtlasi | Q9H6S1 baseline and differential |
Genevisiblei | Q9H6S1 HS |
Organism-specific databases
HPAi | HPA035258 |
Interactioni
Subunit structurei
Homodimer. Interacts with IKBKE, TBK1 and TICAM1.4 Publications
(Microbial infection) Interacts with vaccinia virus protein C6 (PubMed:21931555).1 Publication
Binary interactionsi
Protein-protein interaction databases
BioGridi | 12214218 interactors. |
CORUMi | Q9H6S1 |
DIPi | DIP-27605N |
IntActi | Q9H6S1 12 interactors. |
MINTi | Q9H6S1 |
STRINGi | 9606.ENSP00000419371 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Helixi | 216 – 246 | Combined sources | 31 | |
Beta strandi | 247 – 249 | Combined sources | 3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5EP6 | X-ray | 1.45 | A/C | 215-255 | [»] | |
ProteinModelPortali | Q9H6S1 | |||||
SMRi | Q9H6S1 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 197 | HomodimerizationBy similarityAdd BLAST | 197 | |
Regioni | 216 – 257 | Interaction with TBK1 and IKBKEAdd BLAST | 42 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 40 – 76 | Sequence analysisAdd BLAST | 37 | |
Coiled coili | 102 – 196 | Sequence analysisAdd BLAST | 95 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG410IG4Z Eukaryota ENOG4111IT0 LUCA |
GeneTreei | ENSGT00390000001279 |
HOGENOMi | HOG000013059 |
HOVERGENi | HBG067551 |
InParanoidi | Q9H6S1 |
KOi | K12651 |
OMAi | KDSTKLH |
OrthoDBi | EOG091G09UX |
PhylomeDBi | Q9H6S1 |
TreeFami | TF331289 |
Family and domain databases
InterProi | View protein in InterPro IPR024581 TBD |
Pfami | View protein in Pfam PF12845 TBD, 1 hit |
s (4)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9H6S1-1) [UniParc]FASTAAdd to basket
Also known as: Long
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MDALVEDDIC ILNHEKAHKR DTVTPVSIYS GDESVASHFA LVTAYEDIKK
60 70 80 90 100
RLKDSEKENS LLKKRIRFLE EKLIARFEEE TSSVGREQVN KAYHAYREVC
110 120 130 140 150
IDRDNLKSKL DKMNKDNSES LKVLNEQLQS KEVELLQLRT EVETQQVMRN
160 170 180 190 200
LNPPSSNWEV EKLSCDLKIH GLEQELELMR KECSDLKIEL QKAKQTDPYQ
210 220 230 240 250
EDNLKSRDLQ KLSISSDNMQ HAYWELKREM SNLHLVTQVQ AELLRKLKTS
260 270 280 290 300
TAIKKACAPV GCSEDLGRDS TKLHLMNFTA TYTRHPPLLP NGKALCHTTS
310 320 330 340 350
SPLPGDVKVL SEKAILQSWT DNERSIPNDG TCFQEHSSYG RNSLEDNSWV
360 370 380 390
FPSPPKSSET AFGETKTKTL PLPNLPPLHY LDQHNQNCLY KN
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047087 | 216 – 243 | SDNMQ…VQAEL → RQSICSTAWSAVAQSWDSMN FEDCSLFA in isoform 3. CuratedAdd BLAST | 28 | |
Alternative sequenceiVSP_047088 | 216 – 232 | SDNMQ…REMSN → RVSVAQPGVQWRNHGIA in isoform 4. CuratedAdd BLAST | 17 | |
Alternative sequenceiVSP_023817 | 216 – 228 | SDNMQ…WELKR → TQPGVQWRNHGIA in isoform 2. CuratedAdd BLAST | 13 | |
Alternative sequenceiVSP_023818 | 229 – 392 | Missing in isoform 2. CuratedAdd BLAST | 164 | |
Alternative sequenceiVSP_047089 | 233 – 392 | Missing in isoform 4. CuratedAdd BLAST | 160 | |
Alternative sequenceiVSP_047090 | 244 – 392 | Missing in isoform 3. CuratedAdd BLAST | 149 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY151386 mRNA Translation: AAO05967.1 AF044917 Genomic DNA Translation: AAF22368.1 AF044918 Genomic DNA Translation: AAF22369.1 AK025592 mRNA Translation: BAB15182.1 AK290637 mRNA Translation: BAF83326.1 AC092503 Genomic DNA No translation available. AC098616 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW64395.1 |
CCDSi | CCDS2647.1 [Q9H6S1-1] CCDS46782.1 [Q9H6S1-4] CCDS46783.1 [Q9H6S1-5] |
RefSeqi | NP_001127904.1, NM_001134432.1 [Q9H6S1-4] NP_001127905.1, NM_001134433.1 [Q9H6S1-5] NP_071906.1, NM_022461.4 [Q9H6S1-1] XP_005265449.1, XM_005265392.2 [Q9H6S1-1] |
UniGenei | Hs.706676 |
Genome annotation databases
Ensembli | ENST00000334100; ENSP00000335609; ENSG00000163512 [Q9H6S1-5] ENST00000420543; ENSP00000391696; ENSG00000163512 [Q9H6S1-4] ENST00000457172; ENSP00000389577; ENSG00000163512 [Q9H6S1-4] ENST00000479665; ENSP00000419371; ENSG00000163512 [Q9H6S1-1] |
GeneIDi | 64343 |
KEGGi | hsa:64343 |
UCSCi | uc003ceb.5 human [Q9H6S1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | AZI2_HUMAN | |
Accessioni | Q9H6S1Primary (citable) accession number: Q9H6S1 Secondary accession number(s): A8K3M2 Q9BQF1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 2007 |
Last sequence update: | March 1, 2001 | |
Last modified: | April 25, 2018 | |
This is version 116 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |