Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9H6S0

- YTDC2_HUMAN

UniProt

Q9H6S0 - YTDC2_HUMAN

Protein

Probable ATP-dependent RNA helicase YTHDC2

Gene

YTHDC2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (16 Jun 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi216 – 2238ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. helicase activity Source: UniProtKB-KW
    3. poly(A) RNA binding Source: UniProtKB
    4. protein binding Source: IntAct
    5. RNA-dependent ATPase activity Source: AgBase
    6. RNA polymerase binding Source: AgBase

    GO - Biological processi

    1. ATP catabolic process Source: GOC
    2. positive regulation by host of viral genome replication Source: AgBase
    3. response to interleukin-1 Source: AgBase
    4. response to tumor necrosis factor Source: AgBase

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ATP-dependent RNA helicase YTHDC2 (EC:3.6.4.13)
    Gene namesi
    Name:YTHDC2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:24721. YTHDC2.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: AgBase

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134912676.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14301430Probable ATP-dependent RNA helicase YTHDC2PRO_0000249340Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei23 – 231Phosphoserine1 Publication
    Modified residuei1089 – 10891Phosphoserine1 Publication
    Modified residuei1092 – 10921Phosphoserine1 Publication
    Modified residuei1263 – 12631PhosphoserineBy similarity
    Modified residuei1267 – 12671PhosphoserineBy similarity
    Modified residuei1281 – 12811Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9H6S0.
    PaxDbiQ9H6S0.
    PeptideAtlasiQ9H6S0.
    PRIDEiQ9H6S0.

    PTM databases

    PhosphoSiteiQ9H6S0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H6S0.
    BgeeiQ9H6S0.
    CleanExiHS_YTHDC2.
    GenevestigatoriQ9H6S0.

    Organism-specific databases

    HPAiHPA037364.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Irak1Q99J342EBI-1057466,EBI-6117042From a different organism.
    IRF4Q153062EBI-1057466,EBI-751345

    Protein-protein interaction databases

    BioGridi122321. 11 interactions.
    IntActiQ9H6S0. 10 interactions.
    MINTiMINT-6944358.
    STRINGi9606.ENSP00000161863.

    Structurei

    Secondary structure

    1
    1430
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi1289 – 129810
    Helixi1299 – 13068
    Beta strandi1309 – 13113
    Helixi1317 – 132610
    Beta strandi1330 – 134213
    Beta strandi1344 – 13485
    Beta strandi1352 – 13543
    Beta strandi1368 – 13758
    Helixi1381 – 13844
    Beta strandi1404 – 14063
    Helixi1410 – 14156
    Helixi1416 – 14194

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2YU6NMR-A1288-1421[»]
    ProteinModelPortaliQ9H6S0.
    SMRiQ9H6S0. Positions 190-368, 492-1057, 1288-1421.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9H6S0.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini38 – 10669R3HPROSITE-ProRule annotationAdd
    BLAST
    Domaini203 – 369167Helicase ATP-bindingPROSITE-ProRule annotationAdd
    BLAST
    Repeati506 – 53833ANK 1Add
    BLAST
    Repeati539 – 57133ANK 2Add
    BLAST
    Domaini612 – 784173Helicase C-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini1288 – 1418131YTHPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi316 – 3194DEAH box

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi15 – 3117Gly-richAdd
    BLAST
    Compositional biasi1248 – 128134Ser-richAdd
    BLAST

    Domaini

    The YTH domain mediates RNA-binding.By similarity

    Sequence similaritiesi

    Contains 2 ANK repeats.PROSITE-ProRule annotation
    Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
    Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation
    Contains 1 R3H domain.PROSITE-ProRule annotation
    Contains 1 YTH domain.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG1643.
    HOGENOMiHOG000155703.
    HOVERGENiHBG063891.
    InParanoidiQ9H6S0.
    OMAiPNMPVRY.
    OrthoDBiEOG7Z69BN.
    PhylomeDBiQ9H6S0.
    TreeFamiTF318311.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    3.30.1370.50. 1 hit.
    3.40.50.1820. 1 hit.
    3.40.50.300. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR011709. DUF1605.
    IPR007502. Helicase-assoc_dom.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR001374. R3H_ss-bd.
    IPR007275. YTH_domain.
    [Graphical view]
    PfamiPF12796. Ank_2. 1 hit.
    PF00270. DEAD. 1 hit.
    PF04408. HA2. 1 hit.
    PF00271. Helicase_C. 1 hit.
    PF07717. OB_NTP_bind. 1 hit.
    PF01424. R3H. 1 hit.
    PF04146. YTH. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 2 hits.
    SM00487. DEXDc. 1 hit.
    SM00847. HA2. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    SSF52540. SSF52540. 2 hits.
    SSF82708. SSF82708. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS51061. R3H. 1 hit.
    PS50882. YTH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9H6S0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRPSSVSPR QPAPGGGGGG GPSPCGPGGG GRAKGLKDIR IDEEVKIAVN     50
    IALERFRYGD QREMEFPSSL TSTERAFIHR LSQSLGLVSK SKGKGANRYL 100
    TVKKKDGSET AHAMMTCNLT HNTKHAVRSL IQRFPVTNKE RTELLPKTER 150
    GNVFAVEAEN REMSKTSGRL NNGIPQIPVK RGESEFDSFR QSLPVFEKQE 200
    EIVKIIKENK VVLIVGETGS GKTTQIPQFL LDDCFKNGIP CRIFCTQPRR 250
    LAAIAVAERV AAERRERIGQ TIGYQIRLES RVSPKTLLTF CTNGVLLRTL 300
    MAGDSTLSTV THVIVDEVHE RDRFSDFLLT KLRDLLQKHP TLKLILSSAA 350
    LDVNLFIRYF GSCPVIYIQG RPFEVKEMFL EDILRTTGYT NKEMLKYKKE 400
    KQQEEKQQTT LTEWYSAQEN SFKPESQRQR TVLNVTDEYD LLDDGGDAVF 450
    SQLTEKDVNC LEPWLIKEMD ACLSDIWLHK DIDAFAQVFH LILTENVSVD 500
    YRHSETSATA LMVAAGRGFA SQVEQLISMG ANVHSKASNG WMALDWAKHF 550
    GQTEIVDLLE SYSATLEFGN LDESSLVQTN GSDLSAEDRE LLKAYHHSFD 600
    DEKVDLDLIM HLLYNICHSC DAGAVLIFLP GYDEIVGLRD RILFDDKRFA 650
    DSTHRYQVFM LHSNMQTSDQ KKVLKNPPAG VRKIILSTNI AETSITVNDV 700
    VFVIDSGKVK EKSFDALNFV TMLKMVWISK ASAIQRKGRA GRCRPGICFR 750
    LFSRLRFQNM LEFQTPELLR MPLQELCLHT KLLAPVNCPI ADFLMKAPEP 800
    PPALIVRNAV QMLKTIDAMD TWEDLTELGY HLADLPVEPH LGKMVLCAVV 850
    LKCLDPILTI ACTLAYRDPF VLPTQASQKR AAMLCRKRFT AGAFSDHMAL 900
    LRAFQAWQKA RSDGWERAFC EKNFLSQATM EIIIGMRTQL LGQLRASGFV 950
    RARGGGDIRD VNTNSENWAV VKAALVAGMY PNLVHVDREN LVLTGPKEKK 1000
    VRFHPASVLS QPQYKKIPPA NGQAAAIKAL PTDWLIYDEM TRAHRIANIR 1050
    CCSAVTPVTI LVFCGPARLA SNALQEPSSF RVDGIPNDSS DSEMEDKTTA 1100
    NLAALKLDEW LHFTLEPEAA SLLLQLRQKW HSLFLRRMRA PSKPWSQVDE 1150
    ATIRAIIAVL STEEQSAGLQ QPSGIGQRPR PMSSEELPLA SSWRSNNSRK 1200
    SSADTEFSDE CTTAERVLMK SPSPALHPPQ KYKDRGILHP KRGTEDRSDQ 1250
    SSLKSTDSSS YPSPCASPSP PSSGKGSKSP SPRPNMPVRY FIMKSSNLRN 1300
    LEISQQKGIW STTPSNERKL NRAFWESSIV YLVFSVQGSG HFQGFSRMSS 1350
    EIGREKSQDW GSAGLGGVFK VEWIRKESLP FQFAHHLLNP WNDNKKVQIS 1400
    RDGQELEPLV GEQLLQLWER LPLGEKNTTD 1430
    Length:1,430
    Mass (Da):160,248
    Last modified:June 16, 2009 - v2
    Checksum:iA0C3B45771A3DE16
    GO

    Sequence cautioni

    The sequence BAB15183.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti860 – 8601I → V in BAB15183. (PubMed:14702039)Curated
    Sequence conflicti993 – 9931L → S in BAB15183. (PubMed:14702039)Curated
    Sequence conflicti1230 – 12301Q → R in BAB15183. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti652 – 6521S → N.
    Corresponds to variant rs10071816 [ dbSNP | Ensembl ].
    VAR_058002
    Natural varianti1409 – 14091L → Q.1 Publication
    Corresponds to variant rs1132528 [ dbSNP | Ensembl ].
    VAR_058003

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC093208 Genomic DNA. No translation available.
    AC010389 Genomic DNA. No translation available.
    BC137285 mRNA. Translation: AAI37286.1.
    AK025593 mRNA. Translation: BAB15183.1. Different initiation.
    CCDSiCCDS4113.1.
    RefSeqiNP_073739.3. NM_022828.3.
    UniGeneiHs.231942.

    Genome annotation databases

    EnsembliENST00000161863; ENSP00000161863; ENSG00000047188.
    GeneIDi64848.
    KEGGihsa:64848.
    UCSCiuc003kqn.3. human.

    Polymorphism databases

    DMDMi239938805.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC093208 Genomic DNA. No translation available.
    AC010389 Genomic DNA. No translation available.
    BC137285 mRNA. Translation: AAI37286.1 .
    AK025593 mRNA. Translation: BAB15183.1 . Different initiation.
    CCDSi CCDS4113.1.
    RefSeqi NP_073739.3. NM_022828.3.
    UniGenei Hs.231942.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2YU6 NMR - A 1288-1421 [» ]
    ProteinModelPortali Q9H6S0.
    SMRi Q9H6S0. Positions 190-368, 492-1057, 1288-1421.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122321. 11 interactions.
    IntActi Q9H6S0. 10 interactions.
    MINTi MINT-6944358.
    STRINGi 9606.ENSP00000161863.

    PTM databases

    PhosphoSitei Q9H6S0.

    Polymorphism databases

    DMDMi 239938805.

    Proteomic databases

    MaxQBi Q9H6S0.
    PaxDbi Q9H6S0.
    PeptideAtlasi Q9H6S0.
    PRIDEi Q9H6S0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000161863 ; ENSP00000161863 ; ENSG00000047188 .
    GeneIDi 64848.
    KEGGi hsa:64848.
    UCSCi uc003kqn.3. human.

    Organism-specific databases

    CTDi 64848.
    GeneCardsi GC05P112877.
    HGNCi HGNC:24721. YTHDC2.
    HPAi HPA037364.
    neXtProti NX_Q9H6S0.
    PharmGKBi PA134912676.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1643.
    HOGENOMi HOG000155703.
    HOVERGENi HBG063891.
    InParanoidi Q9H6S0.
    OMAi PNMPVRY.
    OrthoDBi EOG7Z69BN.
    PhylomeDBi Q9H6S0.
    TreeFami TF318311.

    Miscellaneous databases

    EvolutionaryTracei Q9H6S0.
    GenomeRNAii 64848.
    NextBioi 66962.
    PROi Q9H6S0.

    Gene expression databases

    ArrayExpressi Q9H6S0.
    Bgeei Q9H6S0.
    CleanExi HS_YTHDC2.
    Genevestigatori Q9H6S0.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    3.30.1370.50. 1 hit.
    3.40.50.1820. 1 hit.
    3.40.50.300. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR011709. DUF1605.
    IPR007502. Helicase-assoc_dom.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR001374. R3H_ss-bd.
    IPR007275. YTH_domain.
    [Graphical view ]
    Pfami PF12796. Ank_2. 1 hit.
    PF00270. DEAD. 1 hit.
    PF04408. HA2. 1 hit.
    PF00271. Helicase_C. 1 hit.
    PF07717. OB_NTP_bind. 1 hit.
    PF01424. R3H. 1 hit.
    PF04146. YTH. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 2 hits.
    SM00487. DEXDc. 1 hit.
    SM00847. HA2. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    SSF52540. SSF52540. 2 hits.
    SSF82708. SSF82708. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS51061. R3H. 1 hit.
    PS50882. YTH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 730-1430, VARIANT GLN-1409.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1092 AND SER-1281, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1089, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Solution structure of the YTH domain in YTH domain-containing protein 2."
      RIKEN structural genomics initiative (RSGI)
      Submitted (OCT-2007) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 1288-1421.

    Entry informationi

    Entry nameiYTDC2_HUMAN
    AccessioniPrimary (citable) accession number: Q9H6S0
    Secondary accession number(s): B2RP66
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3