ID WDCP_HUMAN Reviewed; 721 AA. AC Q9H6R7; D6W532; Q8IYK0; Q9HBP5; DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2001, sequence version 1. DT 27-MAR-2024, entry version 155. DE RecName: Full=WD repeat and coiled-coil-containing protein {ECO:0000305}; GN Name=WDCP {ECO:0000312|HGNC:HGNC:26157}; Synonyms=C2orf44; GN ORFNames=PP384; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH HCK, AND MUTAGENESIS OF RP PRO-540 AND PRO-543. RX PubMed=25469238; DOI=10.3892/br.2014.374; RA Yokoyama N., Miller W.T.; RT "Molecular characterization of WDCP, a novel fusion partner for the RT anaplastic lymphoma tyrosine kinase ALK."; RL Biomed. Rep. 3:9-13(2015). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). RX PubMed=15498874; DOI=10.1073/pnas.0404089101; RA Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., RA Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X., RA Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.; RT "Large-scale cDNA transfection screening for genes related to cancer RT development and progression."; RL Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Hepatoma; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., RA Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 and RT 4."; RL Nature 434:724-731(2005). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Eye; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [8] RP INTERACTION WITH HCK, AND IDENTIFICATION BY MASS SPECTROMETRY. RX PubMed=12029088; DOI=10.1074/jbc.m202783200; RA Scott M.P., Zappacosta F., Kim E.Y., Annan R.S., Miller W.T.; RT "Identification of novel SH3 domain ligands for the Src family kinase Hck. RT Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), RT and ELMO1."; RL J. Biol. Chem. 277:28238-28246(2002). RN [9] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-299; SER-501 AND SER-523, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007; RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., RA Greff Z., Keri G., Stemmann O., Mann M.; RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the RT kinome across the cell cycle."; RL Mol. Cell 31:438-448(2008). RN [10] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-690, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [11] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-690, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Leukemic T-cell; RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:RA46-RA46(2009). RN [12] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21406692; DOI=10.1126/scisignal.2001570; RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.; RT "System-wide temporal characterization of the proteome and phosphoproteome RT of human embryonic stem cell differentiation."; RL Sci. Signal. 4:RS3-RS3(2011). RN [13] RP CHROMOSOMAL TRANSLOCATION WITH ALK. RX PubMed=22327622; DOI=10.1038/nm.2673; RA Lipson D., Capelletti M., Yelensky R., Otto G., Parker A., Jarosz M., RA Curran J.A., Balasubramanian S., Bloom T., Brennan K.W., Donahue A., RA Downing S.R., Frampton G.M., Garcia L., Juhn F., Mitchell K.C., White E., RA White J., Zwirko Z., Peretz T., Nechushtan H., Soussan-Gutman L., Kim J., RA Sasaki H., Kim H.R., Park S.I., Ercan D., Sheehan C.E., Ross J.S., RA Cronin M.T., Jaenne P.A., Stephens P.J.; RT "Identification of new ALK and RET gene fusions from colorectal and lung RT cancer biopsies."; RL Nat. Med. 18:382-384(2012). RN [14] RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=22814378; DOI=10.1073/pnas.1210303109; RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.; RT "N-terminal acetylome analyses and functional insights of the N-terminal RT acetyltransferase NatB."; RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012). RN [15] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-299; SER-468; THR-530; RP SER-686 AND SER-690, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE RP ANALYSIS]. RC TISSUE=Cervix carcinoma, and Erythroleukemia; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [16] RP VARIANT [LARGE SCALE ANALYSIS] SER-454. RX PubMed=16959974; DOI=10.1126/science.1133427; RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., RA Velculescu V.E.; RT "The consensus coding sequences of human breast and colorectal cancers."; RL Science 314:268-274(2006). CC -!- SUBUNIT: Oligomer. Interacts with HCK (via SH3 domain). CC {ECO:0000269|PubMed:12029088, ECO:0000269|PubMed:25469238}. CC -!- INTERACTION: CC Q9H6R7-2; P23560-2: BDNF; NbExp=3; IntAct=EBI-25833271, EBI-12275524; CC Q9H6R7-2; P07900: HSP90AA1; NbExp=3; IntAct=EBI-25833271, EBI-296047; CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q9H6R7-1; Sequence=Displayed; CC Name=2; CC IsoId=Q9H6R7-2; Sequence=VSP_027713, VSP_027714; CC Name=3; CC IsoId=Q9H6R7-3; Sequence=VSP_027712, VSP_027715; CC -!- PTM: Phosphorylated on Tyr when associated with HCK. CC {ECO:0000269|PubMed:25469238}. CC -!- DISEASE: Note=A chromosomal aberration involving WDCP is found in one CC subject with colorectal cancer. Translocation t(2;2)(p23.3;p23.1). A 5 CC million base pair tandem duplication generates an in-frame WDCP-ALK CC gene fusion. {ECO:0000269|PubMed:22327622}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF218013; AAG17255.1; -; mRNA. DR EMBL; AK025598; BAB15186.1; -; mRNA. DR EMBL; AC104665; AAY24115.1; -; Genomic_DNA. DR EMBL; CH471053; EAX00771.1; -; Genomic_DNA. DR EMBL; CH471053; EAX00772.1; -; Genomic_DNA. DR EMBL; BC035698; AAH35698.1; -; mRNA. DR CCDS; CCDS1705.1; -. [Q9H6R7-1] DR CCDS; CCDS46229.1; -. [Q9H6R7-2] DR RefSeq; NP_001135791.1; NM_001142319.1. [Q9H6R7-2] DR RefSeq; NP_079479.1; NM_025203.2. [Q9H6R7-1] DR AlphaFoldDB; Q9H6R7; -. DR BioGRID; 123217; 102. DR IntAct; Q9H6R7; 58. DR MINT; Q9H6R7; -. DR STRING; 9606.ENSP00000295148; -. DR GlyGen; Q9H6R7; 2 sites, 1 O-linked glycan (2 sites). DR iPTMnet; Q9H6R7; -. DR PhosphoSitePlus; Q9H6R7; -. DR BioMuta; WDCP; -. DR DMDM; 74752699; -. DR EPD; Q9H6R7; -. DR jPOST; Q9H6R7; -. DR MassIVE; Q9H6R7; -. DR MaxQB; Q9H6R7; -. DR PaxDb; 9606-ENSP00000295148; -. DR PeptideAtlas; Q9H6R7; -. DR ProteomicsDB; 81022; -. [Q9H6R7-1] DR ProteomicsDB; 81023; -. [Q9H6R7-2] DR ProteomicsDB; 81024; -. [Q9H6R7-3] DR Pumba; Q9H6R7; -. DR Antibodypedia; 51026; 92 antibodies from 14 providers. DR DNASU; 80304; -. DR Ensembl; ENST00000295148.9; ENSP00000295148.4; ENSG00000163026.12. [Q9H6R7-1] DR Ensembl; ENST00000406895.3; ENSP00000385816.3; ENSG00000163026.12. [Q9H6R7-2] DR GeneID; 80304; -. DR KEGG; hsa:80304; -. DR MANE-Select; ENST00000295148.9; ENSP00000295148.4; NM_025203.3; NP_079479.1. DR UCSC; uc002rep.3; human. [Q9H6R7-1] DR AGR; HGNC:26157; -. DR CTD; 80304; -. DR DisGeNET; 80304; -. DR GeneCards; WDCP; -. DR HGNC; HGNC:26157; WDCP. DR HPA; ENSG00000163026; Low tissue specificity. DR MIM; 616234; gene. DR neXtProt; NX_Q9H6R7; -. DR OpenTargets; ENSG00000163026; -. DR PharmGKB; PA147358716; -. DR VEuPathDB; HostDB:ENSG00000163026; -. DR eggNOG; ENOG502QUUX; Eukaryota. DR GeneTree; ENSGT00390000001660; -. DR HOGENOM; CLU_025195_0_0_1; -. DR InParanoid; Q9H6R7; -. DR OMA; DISEPYP; -. DR OrthoDB; 3084099at2759; -. DR PhylomeDB; Q9H6R7; -. DR TreeFam; TF333528; -. DR PathwayCommons; Q9H6R7; -. DR Reactome; R-HSA-9725370; Signaling by ALK fusions and activated point mutants. DR SignaLink; Q9H6R7; -. DR SIGNOR; Q9H6R7; -. DR BioGRID-ORCS; 80304; 20 hits in 1132 CRISPR screens. DR GenomeRNAi; 80304; -. DR Pharos; Q9H6R7; Tdark. DR PRO; PR:Q9H6R7; -. DR Proteomes; UP000005640; Chromosome 2. DR RNAct; Q9H6R7; Protein. DR Bgee; ENSG00000163026; Expressed in secondary oocyte and 113 other cell types or tissues. DR ExpressionAtlas; Q9H6R7; baseline and differential. DR GO; GO:0019900; F:kinase binding; IPI:UniProtKB. DR GO; GO:0051259; P:protein complex oligomerization; IDA:UniProtKB. DR InterPro; IPR028041; WDCP. DR PANTHER; PTHR14897; WD REPEAT AND COILED-COIL-CONTAINING PROTEIN; 1. DR PANTHER; PTHR14897:SF5; WD REPEAT AND COILED-COIL-CONTAINING PROTEIN; 1. DR Pfam; PF15390; WDCP; 1. DR SUPFAM; SSF69322; Tricorn protease domain 2; 1. DR Genevisible; Q9H6R7; HS. PE 1: Evidence at protein level; KW Acetylation; Alternative splicing; Chromosomal rearrangement; Coiled coil; KW Phosphoprotein; Reference proteome; Repeat; WD repeat. FT CHAIN 1..721 FT /note="WD repeat and coiled-coil-containing protein" FT /id="PRO_0000299501" FT REPEAT 55..98 FT /note="WD 1" FT REPEAT 154..194 FT /note="WD 2" FT REGION 520..553 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 539..545 FT /note="Interaction with HCK" FT /evidence="ECO:0000269|PubMed:25469238" FT COILED 556..584 FT /evidence="ECO:0000255" FT COMPBIAS 522..543 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 1 FT /note="N-acetylmethionine" FT /evidence="ECO:0007744|PubMed:22814378" FT MOD_RES 299 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:18691976, FT ECO:0007744|PubMed:23186163" FT MOD_RES 468 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:23186163" FT MOD_RES 501 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:18691976" FT MOD_RES 523 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:18691976" FT MOD_RES 530 FT /note="Phosphothreonine" FT /evidence="ECO:0007744|PubMed:23186163" FT MOD_RES 686 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:23186163" FT MOD_RES 690 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:18669648, FT ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163" FT VAR_SEQ 1..487 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:15498874" FT /id="VSP_027712" FT VAR_SEQ 488 FT /note="N -> M (in isoform 3)" FT /evidence="ECO:0000303|PubMed:15498874" FT /id="VSP_027715" FT VAR_SEQ 607..622 FT /note="KPYYLGPVVEKRAVLL -> IPTGFFSLLTVRALSR (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_027713" FT VAR_SEQ 623..721 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_027714" FT VARIANT 102 FT /note="T -> M (in dbSNP:rs3731620)" FT /id="VAR_034834" FT VARIANT 454 FT /note="P -> S (in a breast cancer sample; somatic FT mutation)" FT /evidence="ECO:0000269|PubMed:16959974" FT /id="VAR_035876" FT MUTAGEN 540 FT /note="P->A: Loss of interaction with HCK; when associated FT with P-543." FT /evidence="ECO:0000269|PubMed:25469238" FT MUTAGEN 543 FT /note="P->A: Loss of interaction with HCK; when associated FT with P-543." FT /evidence="ECO:0000269|PubMed:25469238" SQ SEQUENCE 721 AA; 79136 MW; 4A4164C81A693DAE CRC64; MELGKGKLLR TGLNALHQAV HPIHGLAWTD GNQVVLTDLR LHSGEVKFGD SKVIGQFECV CGLSWAPPVA DDTPVLLAVQ HEKHVTVWQL CPSPMESSKW LTSQTCEIRG SLPILPQGCV WHPKCAILTV LTAQDVSIFP NVHSDDSQVK ADINTQGRIH CACWTQDGLR LVVAVGSSLH SYIWDSAQKT LHRCSSCLVF DVDSHVCSIT ATVDSQVAIA TELPLDKICG LNASETFNIP PNSKDMTPYA LPVIGEVRSM DKEATDSETN SEVSVSSSYL EPLDLTHIHF NQHKSEGNSL ICLRKKDYLT GTGQDSSHLV LVTFKKAVTM TRKVTIPGIL VPDLIAFNLK AHVVAVASNT CNIILIYSVI PSSVPNIQQI RLENTERPKG ICFLTDQLLL ILVGKQKLTD TTFLPSSKSD QYAISLIVRE IMLEEEPSIT SGESQTTYST FSAPLNKANR KKLIESLSPD FCHQNKGLLL TVNTSSQNGR PGRTLIKEIQ SPLSSICDGS IALDAEPVTQ PASLPRHSST PDHTSTLEPP RLPQRKNLQS EKETYQLSKE VEILSRNLVE MQRCLSELTN RLHNGKKSSS VYPLSQDLPY VHIIYQKPYY LGPVVEKRAV LLCDGKLRLS TVQQTFGLSL IEMLHDSHWI LLSADSEGFI PLTFTATQEI IIRDGSLSRS DVFRDSFSHS PGAVSSLKVF TGLAAPSLDT TGCCNHVDGM A //