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Protein

WD repeat and coiled-coil-containing protein

Gene

WDCP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • kinase binding Source: UniProtKB

GO - Biological processi

  • protein oligomerization Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163026-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat and coiled-coil-containing proteinCurated
Gene namesi
Name:WDCPImported
Synonyms:C2orf44
ORF Names:PP384
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:26157. WDCP.

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving WDCP is found in one subject with colorectal cancer. Translocation t(2;2)(p23.3;p23.1). A 5 million base pair tandem duplication generates an in-frame WDCP-ALK gene fusion.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi540P → A: Loss of interaction with HCK; when associated with P-543. 1 Publication1
Mutagenesisi543P → A: Loss of interaction with HCK; when associated with P-543. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000163026.
PharmGKBiPA147358716.

Polymorphism and mutation databases

BioMutaiC2orf44.
DMDMi74752699.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002995011 – 721WD repeat and coiled-coil-containing proteinAdd BLAST721

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei299PhosphoserineCombined sources1
Modified residuei468PhosphoserineCombined sources1
Modified residuei501PhosphoserineCombined sources1
Modified residuei523PhosphoserineCombined sources1
Modified residuei530PhosphothreonineCombined sources1
Modified residuei686PhosphoserineCombined sources1
Modified residuei690PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on Tyr when associated with HCK.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9H6R7.
MaxQBiQ9H6R7.
PaxDbiQ9H6R7.
PeptideAtlasiQ9H6R7.
PRIDEiQ9H6R7.

PTM databases

iPTMnetiQ9H6R7.
PhosphoSitePlusiQ9H6R7.

Expressioni

Gene expression databases

BgeeiENSG00000163026.
CleanExiHS_C2orf44.
ExpressionAtlasiQ9H6R7. baseline and differential.
GenevisibleiQ9H6R7. HS.

Organism-specific databases

HPAiHPA041054.

Interactioni

Subunit structurei

Oligomer. Interacts with HCK (via SH3 domain).2 Publications

GO - Molecular functioni

  • kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi123217. 48 interactors.
IntActiQ9H6R7. 33 interactors.
MINTiMINT-1370597.
STRINGi9606.ENSP00000295148.

Structurei

3D structure databases

ProteinModelPortaliQ9H6R7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati55 – 98WD 1Add BLAST44
Repeati154 – 194WD 2Add BLAST41

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni539 – 545Interaction with HCK1 Publication7

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili556 – 584Sequence analysisAdd BLAST29

Sequence similaritiesi

Contains 2 WD repeats.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IJSA. Eukaryota.
ENOG410YM0Q. LUCA.
GeneTreeiENSGT00390000001660.
HOGENOMiHOG000111320.
HOVERGENiHBG055062.
InParanoidiQ9H6R7.
OMAiVWQLCPS.
OrthoDBiEOG091G0Q4H.
PhylomeDBiQ9H6R7.
TreeFamiTF333528.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR028041. WDCP.
[Graphical view]
PfamiPF15390. DUF4613. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H6R7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELGKGKLLR TGLNALHQAV HPIHGLAWTD GNQVVLTDLR LHSGEVKFGD
60 70 80 90 100
SKVIGQFECV CGLSWAPPVA DDTPVLLAVQ HEKHVTVWQL CPSPMESSKW
110 120 130 140 150
LTSQTCEIRG SLPILPQGCV WHPKCAILTV LTAQDVSIFP NVHSDDSQVK
160 170 180 190 200
ADINTQGRIH CACWTQDGLR LVVAVGSSLH SYIWDSAQKT LHRCSSCLVF
210 220 230 240 250
DVDSHVCSIT ATVDSQVAIA TELPLDKICG LNASETFNIP PNSKDMTPYA
260 270 280 290 300
LPVIGEVRSM DKEATDSETN SEVSVSSSYL EPLDLTHIHF NQHKSEGNSL
310 320 330 340 350
ICLRKKDYLT GTGQDSSHLV LVTFKKAVTM TRKVTIPGIL VPDLIAFNLK
360 370 380 390 400
AHVVAVASNT CNIILIYSVI PSSVPNIQQI RLENTERPKG ICFLTDQLLL
410 420 430 440 450
ILVGKQKLTD TTFLPSSKSD QYAISLIVRE IMLEEEPSIT SGESQTTYST
460 470 480 490 500
FSAPLNKANR KKLIESLSPD FCHQNKGLLL TVNTSSQNGR PGRTLIKEIQ
510 520 530 540 550
SPLSSICDGS IALDAEPVTQ PASLPRHSST PDHTSTLEPP RLPQRKNLQS
560 570 580 590 600
EKETYQLSKE VEILSRNLVE MQRCLSELTN RLHNGKKSSS VYPLSQDLPY
610 620 630 640 650
VHIIYQKPYY LGPVVEKRAV LLCDGKLRLS TVQQTFGLSL IEMLHDSHWI
660 670 680 690 700
LLSADSEGFI PLTFTATQEI IIRDGSLSRS DVFRDSFSHS PGAVSSLKVF
710 720
TGLAAPSLDT TGCCNHVDGM A
Length:721
Mass (Da):79,136
Last modified:March 1, 2001 - v1
Checksum:i4A4164C81A693DAE
GO
Isoform 2 (identifier: Q9H6R7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     607-622: KPYYLGPVVEKRAVLL → IPTGFFSLLTVRALSR
     623-721: Missing.

Note: No experimental confirmation available.
Show »
Length:622
Mass (Da):68,456
Checksum:i04657B17D5096FD0
GO
Isoform 3 (identifier: Q9H6R7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-487: Missing.
     488-488: N → M

Note: No experimental confirmation available.
Show »
Length:234
Mass (Da):25,845
Checksum:iD06EAF3E6B5A9073
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034834102T → M.Corresponds to variant rs3731620dbSNPEnsembl.1
Natural variantiVAR_035876454P → S in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0277121 – 487Missing in isoform 3. 1 PublicationAdd BLAST487
Alternative sequenceiVSP_027715488N → M in isoform 3. 1 Publication1
Alternative sequenceiVSP_027713607 – 622KPYYL…RAVLL → IPTGFFSLLTVRALSR in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_027714623 – 721Missing in isoform 2. 1 PublicationAdd BLAST99

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218013 mRNA. Translation: AAG17255.1.
AK025598 mRNA. Translation: BAB15186.1.
AC104665 Genomic DNA. Translation: AAY24115.1.
CH471053 Genomic DNA. Translation: EAX00771.1.
CH471053 Genomic DNA. Translation: EAX00772.1.
BC035698 mRNA. Translation: AAH35698.1.
CCDSiCCDS1705.1. [Q9H6R7-1]
CCDS46229.1. [Q9H6R7-2]
RefSeqiNP_001135791.1. NM_001142319.1. [Q9H6R7-2]
NP_079479.1. NM_025203.2. [Q9H6R7-1]
UniGeneiHs.24624.

Genome annotation databases

EnsembliENST00000295148; ENSP00000295148; ENSG00000163026. [Q9H6R7-1]
ENST00000406895; ENSP00000385816; ENSG00000163026. [Q9H6R7-2]
GeneIDi80304.
KEGGihsa:80304.
UCSCiuc002rep.3. human. [Q9H6R7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218013 mRNA. Translation: AAG17255.1.
AK025598 mRNA. Translation: BAB15186.1.
AC104665 Genomic DNA. Translation: AAY24115.1.
CH471053 Genomic DNA. Translation: EAX00771.1.
CH471053 Genomic DNA. Translation: EAX00772.1.
BC035698 mRNA. Translation: AAH35698.1.
CCDSiCCDS1705.1. [Q9H6R7-1]
CCDS46229.1. [Q9H6R7-2]
RefSeqiNP_001135791.1. NM_001142319.1. [Q9H6R7-2]
NP_079479.1. NM_025203.2. [Q9H6R7-1]
UniGeneiHs.24624.

3D structure databases

ProteinModelPortaliQ9H6R7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123217. 48 interactors.
IntActiQ9H6R7. 33 interactors.
MINTiMINT-1370597.
STRINGi9606.ENSP00000295148.

PTM databases

iPTMnetiQ9H6R7.
PhosphoSitePlusiQ9H6R7.

Polymorphism and mutation databases

BioMutaiC2orf44.
DMDMi74752699.

Proteomic databases

EPDiQ9H6R7.
MaxQBiQ9H6R7.
PaxDbiQ9H6R7.
PeptideAtlasiQ9H6R7.
PRIDEiQ9H6R7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295148; ENSP00000295148; ENSG00000163026. [Q9H6R7-1]
ENST00000406895; ENSP00000385816; ENSG00000163026. [Q9H6R7-2]
GeneIDi80304.
KEGGihsa:80304.
UCSCiuc002rep.3. human. [Q9H6R7-1]

Organism-specific databases

CTDi80304.
GeneCardsiC2orf44.
H-InvDBHIX0001870.
HGNCiHGNC:26157. WDCP.
HPAiHPA041054.
MIMi616234. gene.
neXtProtiNX_Q9H6R7.
OpenTargetsiENSG00000163026.
PharmGKBiPA147358716.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJSA. Eukaryota.
ENOG410YM0Q. LUCA.
GeneTreeiENSGT00390000001660.
HOGENOMiHOG000111320.
HOVERGENiHBG055062.
InParanoidiQ9H6R7.
OMAiVWQLCPS.
OrthoDBiEOG091G0Q4H.
PhylomeDBiQ9H6R7.
TreeFamiTF333528.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163026-MONOMER.

Miscellaneous databases

GenomeRNAii80304.
PROiQ9H6R7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163026.
CleanExiHS_C2orf44.
ExpressionAtlasiQ9H6R7. baseline and differential.
GenevisibleiQ9H6R7. HS.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR028041. WDCP.
[Graphical view]
PfamiPF15390. DUF4613. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWDCP_HUMAN
AccessioniPrimary (citable) accession number: Q9H6R7
Secondary accession number(s): D6W532, Q8IYK0, Q9HBP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.