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Protein

Palmitoyltransferase ZDHHC6

Gene

ZDHHC6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins.1 Publication

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri99 – 14951DHHC-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • protein palmitoylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC6 (EC:2.3.1.225)
Alternative name(s):
Transmembrane protein H4
Zinc finger DHHC domain-containing protein 6
Short name:
DHHC-6
Zinc finger protein 376
Gene namesi
Name:ZDHHC6
Synonyms:ZNF376
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:19160. ZDHHC6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4521HelicalSequence analysisAdd
BLAST
Transmembranei58 – 7821HelicalSequence analysisAdd
BLAST
Transmembranei144 – 16421HelicalSequence analysisAdd
BLAST
Transmembranei206 – 22621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38803.

Polymorphism and mutation databases

BioMutaiZDHHC6.
DMDMi28202106.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 413413Palmitoyltransferase ZDHHC6PRO_0000212871Add
BLAST

Proteomic databases

EPDiQ9H6R6.
MaxQBiQ9H6R6.
PaxDbiQ9H6R6.
PRIDEiQ9H6R6.

PTM databases

iPTMnetiQ9H6R6.
PhosphoSiteiQ9H6R6.
SwissPalmiQ9H6R6.

Expressioni

Gene expression databases

BgeeiQ9H6R6.
CleanExiHS_ZDHHC6.
ExpressionAtlasiQ9H6R6. baseline and differential.
GenevisibleiQ9H6R6. HS.

Organism-specific databases

HPAiHPA014357.

Interactioni

Protein-protein interaction databases

BioGridi122177. 16 interactions.
IntActiQ9H6R6. 1 interaction.
MINTiMINT-1415568.
STRINGi9606.ENSP00000358413.

Structurei

3D structure databases

ProteinModelPortaliQ9H6R6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated
Contains 1 DHHC-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri99 – 14951DHHC-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG1314. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00840000129737.
HOGENOMiHOG000017896.
HOVERGENiHBG054221.
InParanoidiQ9H6R6.
KOiK20031.
OMAiWFPRRCV.
OrthoDBiEOG7J17ZW.
PhylomeDBiQ9H6R6.
TreeFamiTF320809.

Family and domain databases

InterProiIPR011511. SH3_2.
IPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF07653. SH3_2. 1 hit.
PF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. ZF_DHHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H6R6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGTFCSVIKF ENLQELKRLC HWGPIIALGV IAICSTMAMI DSVLWYWPLH
60 70 80 90 100
TTGGSVNFIM LINWTVMILY NYFNAMFVGP GFVPLGWKPE ISQDTMYLQY
110 120 130 140 150
CKVCQAYKAP RSHHCRKCNR CVMKMDHHCP WINNCCGYQN HASFTLFLLL
160 170 180 190 200
APLGCIHAAF IFVMTMYTQL YHRLSFGWNT VKIDMSAARR DPLPIVPFGL
210 220 230 240 250
AAFATTLFAL GLALGTTIAV GMLFFIQMKI ILRNKTSIES WIEEKAKDRI
260 270 280 290 300
QYYQLDEVFV FPYDMGSRWR NFKQVFTWSG VPEGDGLEWP VREGCHQYSL
310 320 330 340 350
TIEQLKQKAD KRVRSVRYKV IEDYSGACCP LNKGIKTFFT SPCTEEPRIQ
360 370 380 390 400
LQKGEFILAT RGLRYWLYGD KILDDSFIEG VSRIRGWFPR KCVEKCPCDA
410
ETDQAPEGEK KNR
Length:413
Mass (Da):47,663
Last modified:March 1, 2001 - v1
Checksum:iE4C6CD875FA03713
GO
Isoform 2 (identifier: Q9H6R6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     90-93: Missing.

Note: No experimental confirmation available.
Show »
Length:409
Mass (Da):47,205
Checksum:iAC56FA6C4DBDE189
GO

Sequence cautioni

The sequence BAB15462.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 571N → S in BAD96806 (Ref. 3) Curated
Sequence conflicti66 – 661V → I in BAD96806 (Ref. 3) Curated
Sequence conflicti78 – 781V → A in BAD96806 (Ref. 3) Curated
Sequence conflicti342 – 3421P → L in BAB15462 (PubMed:14702039).Curated
Sequence conflicti370 – 3701D → G in BAB15462 (PubMed:14702039).Curated
Sequence conflicti376 – 3761S → P in BAD96806 (Ref. 3) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti41 – 411D → N.
Corresponds to variant rs34350728 [ dbSNP | Ensembl ].
VAR_052974

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei90 – 934Missing in isoform 2. 1 PublicationVSP_006938

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF267740 mRNA. Translation: AAL56663.1.
AK025605 mRNA. Translation: BAB15187.1.
AK026369 mRNA. Translation: BAB15462.1. Different initiation.
AK223086 mRNA. Translation: BAD96806.1.
CH471066 Genomic DNA. Translation: EAW49526.1.
CH471066 Genomic DNA. Translation: EAW49528.1.
BC007213 mRNA. Translation: AAH07213.1.
BC017434 mRNA. Translation: AAH17434.1.
CCDSiCCDS7574.1. [Q9H6R6-1]
CCDS76335.1. [Q9H6R6-2]
RefSeqiNP_001290063.1. NM_001303134.1. [Q9H6R6-2]
NP_071939.1. NM_022494.2. [Q9H6R6-1]
XP_005270108.1. XM_005270051.3. [Q9H6R6-1]
XP_006718011.1. XM_006717948.2. [Q9H6R6-1]
UniGeneiHs.196990.

Genome annotation databases

EnsembliENST00000369404; ENSP00000358412; ENSG00000023041. [Q9H6R6-2]
ENST00000369405; ENSP00000358413; ENSG00000023041. [Q9H6R6-1]
GeneIDi64429.
KEGGihsa:64429.
UCSCiuc001kzv.3. human. [Q9H6R6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF267740 mRNA. Translation: AAL56663.1.
AK025605 mRNA. Translation: BAB15187.1.
AK026369 mRNA. Translation: BAB15462.1. Different initiation.
AK223086 mRNA. Translation: BAD96806.1.
CH471066 Genomic DNA. Translation: EAW49526.1.
CH471066 Genomic DNA. Translation: EAW49528.1.
BC007213 mRNA. Translation: AAH07213.1.
BC017434 mRNA. Translation: AAH17434.1.
CCDSiCCDS7574.1. [Q9H6R6-1]
CCDS76335.1. [Q9H6R6-2]
RefSeqiNP_001290063.1. NM_001303134.1. [Q9H6R6-2]
NP_071939.1. NM_022494.2. [Q9H6R6-1]
XP_005270108.1. XM_005270051.3. [Q9H6R6-1]
XP_006718011.1. XM_006717948.2. [Q9H6R6-1]
UniGeneiHs.196990.

3D structure databases

ProteinModelPortaliQ9H6R6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122177. 16 interactions.
IntActiQ9H6R6. 1 interaction.
MINTiMINT-1415568.
STRINGi9606.ENSP00000358413.

PTM databases

iPTMnetiQ9H6R6.
PhosphoSiteiQ9H6R6.
SwissPalmiQ9H6R6.

Polymorphism and mutation databases

BioMutaiZDHHC6.
DMDMi28202106.

Proteomic databases

EPDiQ9H6R6.
MaxQBiQ9H6R6.
PaxDbiQ9H6R6.
PRIDEiQ9H6R6.

Protocols and materials databases

DNASUi64429.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369404; ENSP00000358412; ENSG00000023041. [Q9H6R6-2]
ENST00000369405; ENSP00000358413; ENSG00000023041. [Q9H6R6-1]
GeneIDi64429.
KEGGihsa:64429.
UCSCiuc001kzv.3. human. [Q9H6R6-1]

Organism-specific databases

CTDi64429.
GeneCardsiZDHHC6.
HGNCiHGNC:19160. ZDHHC6.
HPAiHPA014357.
neXtProtiNX_Q9H6R6.
PharmGKBiPA38803.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1314. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00840000129737.
HOGENOMiHOG000017896.
HOVERGENiHBG054221.
InParanoidiQ9H6R6.
KOiK20031.
OMAiWFPRRCV.
OrthoDBiEOG7J17ZW.
PhylomeDBiQ9H6R6.
TreeFamiTF320809.

Miscellaneous databases

GenomeRNAii64429.
PROiQ9H6R6.

Gene expression databases

BgeeiQ9H6R6.
CleanExiHS_ZDHHC6.
ExpressionAtlasiQ9H6R6. baseline and differential.
GenevisibleiQ9H6R6. HS.

Family and domain databases

InterProiIPR011511. SH3_2.
IPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF07653. SH3_2. 1 hit.
PF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. ZF_DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "H4, a novel protein containing 4 transmembrane domains."
    Yang Y.C., Chen S.Y., Chang M.S.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Muscle.
  6. "Palmitoylated calnexin is a key component of the ribosome-translocon complex."
    Lakkaraju A.K., Abrami L., Lemmin T., Blaskovic S., Kunz B., Kihara A., Dal Peraro M., van der Goot F.G.
    EMBO J. 31:1823-1835(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: CATALYTIC ACTIVITY, FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiZDHC6_HUMAN
AccessioniPrimary (citable) accession number: Q9H6R6
Secondary accession number(s): D3DRB6
, Q53G45, Q96IV7, Q9H605
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.