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Protein

Nucleolar protein 6

Gene

NOL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-6790901. rRNA modification in the nucleus.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar protein 6
Alternative name(s):
Nucleolar RNA-associated protein
Short name:
Nrap
Gene namesi
Name:NOL6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:19910. NOL6.

Subcellular locationi

GO - Cellular componenti

  • condensed nuclear chromosome Source: UniProtKB
  • CURI complex Source: GO_Central
  • mitochondrion Source: HPA
  • nucleolus Source: UniProtKB
  • nucleoplasm Source: Reactome
  • nucleus Source: HPA
  • small-subunit processome Source: GO_Central
  • UTP-C complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134979388.

Polymorphism and mutation databases

BioMutaiNOL6.
DMDMi62900709.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11461146Nucleolar protein 6PRO_0000215647Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei56 – 561PhosphoserineCombined sources
Modified residuei283 – 2831PhosphoserineCombined sources
Modified residuei289 – 2891PhosphoserineCombined sources
Modified residuei811 – 8111PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H6R4.
MaxQBiQ9H6R4.
PaxDbiQ9H6R4.
PeptideAtlasiQ9H6R4.
PRIDEiQ9H6R4.

2D gel databases

SWISS-2DPAGEQ9H6R4.

PTM databases

iPTMnetiQ9H6R4.
PhosphoSiteiQ9H6R4.
SwissPalmiQ9H6R4.

Expressioni

Gene expression databases

BgeeiENSG00000165271.
ExpressionAtlasiQ9H6R4. baseline and differential.
GenevisibleiQ9H6R4. HS.

Organism-specific databases

HPAiHPA055891.
HPA061002.

Interactioni

Subunit structurei

Probably associated with rRNA.

Binary interactionsi

WithEntry#Exp.IntActNotes
SIAH1Q8IUQ43EBI-10307896,EBI-747107

Protein-protein interaction databases

BioGridi122391. 47 interactions.
IntActiQ9H6R4. 13 interactions.
MINTiMINT-3046044.
STRINGi9606.ENSP00000297990.

Structurei

3D structure databases

ProteinModelPortaliQ9H6R4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili83 – 11432Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the NRAP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2054. Eukaryota.
ENOG410XPP9. LUCA.
GeneTreeiENSGT00390000018619.
HOVERGENiHBG052644.
InParanoidiQ9H6R4.
KOiK14544.
OMAiHQAFSVV.
OrthoDBiEOG091G01Z2.
PhylomeDBiQ9H6R4.

Family and domain databases

InterProiIPR005554. Nrap.
[Graphical view]
PANTHERiPTHR17972. PTHR17972. 1 hit.
PfamiPF03813. Nrap. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H6R4-1) [UniParc]FASTAAdd to basket
Also known as: Alpha, Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPAPAGEQL RGATGEPEVM EPALEGTGKE GKKASSRKRT LAEPPAKGLL
60 70 80 90 100
QPVKLSRAEL YKEPTNEELN RLRETEILFH SSLLRLQVEE LLKEVRLSEK
110 120 130 140 150
KKDRIDAFLR EVNQRVVRVP SVPETELTDQ AWLPAGVRVP LHQVPYAVKG
160 170 180 190 200
CFRFLPPAQV TVVGSYLLGT CIRPDINVDV ALTMPREILQ DKDGLNQRYF
210 220 230 240 250
RKRALYLAHL AHHLAQDPLF GSVCFSYTNG CHLKPSLLLR PRGKDERLVT
260 270 280 290 300
VRLHPCPPPD FFRPCRLLPT KNNVRSAWYR GQSPAGDGSP EPPTPRYNTW
310 320 330 340 350
VLQDTVLESH LQLLSTILSS AQGLKDGVAL LKVWLRQREL DKGQGGFTGF
360 370 380 390 400
LVSMLVVFLV STRKIHTTMS GYQVLRSVLQ FLATTDLTVN GISLCLSSDP
410 420 430 440 450
SLPALADFHQ AFSVVFLDSS GHLNLCADVT ASTYHQVQHE ARLSMMLLDS
460 470 480 490 500
RADDGFHLLL MTPKPMIRAF DHVLHLRPLS RLQAACHRLK LWPELQDNGG
510 520 530 540 550
DYVSAALGPL TTLLEQGLGA RLNLLAHSRP PVPEWDISQD PPKHKDSGTL
560 570 580 590 600
TLGLLLRPEG LTSVLELGPE ADQPEAAKFR QFWGSRSELR RFQDGAIREA
610 620 630 640 650
VVWEAASMSQ KRLIPHQVVT HLLALHADIP ETCVHYVGGP LDALIQGLKE
660 670 680 690 700
TSSTGEEALV AAVRCYDDLS RLLWGLEGLP LTVSAVQGAH PVLRYTEVFP
710 720 730 740 750
PTPVRPAFSF YETLRERSSL LPRLDKPCPA YVEPMTVVCH LEGSGQWPQD
760 770 780 790 800
AEAVQRVRAA FQLRLAELLT QQHGLQCRAT ATHTDVLKDG FVFRIRVAYQ
810 820 830 840 850
REPQILKEVQ SPEGMISLRD TAASLRLERD TRQLPLLTSA LHGLQQQHPA
860 870 880 890 900
FSGVARLAKR WVRAQLLGEG FADESLDLVA AALFLHPEPF TPPSSPQVGF
910 920 930 940 950
LRFLFLVSTF DWKNNPLFVN LNNELTVEEQ VEIRSGFLAA RAQLPVMVIV
960 970 980 990 1000
TPQDRKNSVW TQDGPSAQIL QQLVVLAAEA LPMLEKQLMD PRGPGDIRTV
1010 1020 1030 1040 1050
FRPPLDIYDV LIRLSPRHIP RHRQAVDSPA ASFCRGLLSQ PGPSSLMPVL
1060 1070 1080 1090 1100
GYDPPQLYLT QLREAFGDLA LFFYDQHGGE VIGVLWKPTS FQPQPFKASS
1110 1120 1130 1140
TKGRMVMSRG GELVMVPNVE AILEDFAVLG EGLVQTVEAR SERWTV
Length:1,146
Mass (Da):127,593
Last modified:April 26, 2005 - v2
Checksum:i2E73D31BC3D4AF6B
GO
Isoform 2 (identifier: Q9H6R4-2) [UniParc]FASTAAdd to basket
Also known as: Beta, Mid

The sequence of this isoform differs from the canonical sequence as follows:
     999-1146: TVFRPPLDIY...VEARSERWTV → WDPAKMWPF

Show »
Length:1,007
Mass (Da):112,304
Checksum:i01D3B9CCAA02BCDA
GO
Isoform 3 (identifier: Q9H6R4-3) [UniParc]FASTAAdd to basket
Also known as: Gamma, Short

The sequence of this isoform differs from the canonical sequence as follows:
     651-1097: Missing.

Show »
Length:699
Mass (Da):77,638
Checksum:i75A45AF2E1FA4999
GO
Isoform 4 (identifier: Q9H6R4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     383-385: Missing.

Note: No experimental confirmation available.
Show »
Length:1,143
Mass (Da):127,320
Checksum:i9645DBFD0F457291
GO

Sequence cautioni

The sequence AAH08298 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB15189 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB15389 differs from that shown.Intron retention.Curated
The sequence CAI13312 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI13313 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1098 – 10981A → T in AAL74405 (PubMed:11895476).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti52 – 521P → S.
Corresponds to variant rs10971523 [ dbSNP | Ensembl ].
VAR_053541
Natural varianti723 – 7231R → W.
Corresponds to variant rs35135082 [ dbSNP | Ensembl ].
VAR_053542

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei383 – 3853Missing in isoform 4. 1 PublicationVSP_013530
Alternative sequencei651 – 1097447Missing in isoform 3. 1 PublicationVSP_013531Add
BLAST
Alternative sequencei999 – 1146148TVFRP…ERWTV → WDPAKMWPF in isoform 2. 1 PublicationVSP_013532Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361079 mRNA. Translation: AAL74403.1.
AF361080 mRNA. Translation: AAL74404.1.
AF361081 mRNA. Translation: AAL74405.1.
AL356218 Genomic DNA. Translation: CAI13312.1. Sequence problems.
AL356218 Genomic DNA. Translation: CAI13313.1. Sequence problems.
AL356218 Genomic DNA. Translation: CAI13314.1.
AL356218 Genomic DNA. Translation: CAI13315.1.
BC008298 mRNA. Translation: AAH08298.1. Different initiation.
BC008852 mRNA. Translation: AAH08852.2.
BC030139 mRNA. Translation: AAH30139.1.
AK025612 mRNA. Translation: BAB15189.1. Different initiation.
AK026193 mRNA. Translation: BAB15389.1. Sequence problems.
CCDSiCCDS6543.1. [Q9H6R4-1]
CCDS6544.1. [Q9H6R4-3]
RefSeqiNP_075068.2. NM_022917.4. [Q9H6R4-1]
NP_631981.2. NM_139235.3. [Q9H6R4-3]
UniGeneiHs.493709.

Genome annotation databases

EnsembliENST00000297990; ENSP00000297990; ENSG00000165271. [Q9H6R4-1]
ENST00000353159; ENSP00000313978; ENSG00000165271. [Q9H6R4-3]
GeneIDi65083.
KEGGihsa:65083.
UCSCiuc003zsy.4. human. [Q9H6R4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361079 mRNA. Translation: AAL74403.1.
AF361080 mRNA. Translation: AAL74404.1.
AF361081 mRNA. Translation: AAL74405.1.
AL356218 Genomic DNA. Translation: CAI13312.1. Sequence problems.
AL356218 Genomic DNA. Translation: CAI13313.1. Sequence problems.
AL356218 Genomic DNA. Translation: CAI13314.1.
AL356218 Genomic DNA. Translation: CAI13315.1.
BC008298 mRNA. Translation: AAH08298.1. Different initiation.
BC008852 mRNA. Translation: AAH08852.2.
BC030139 mRNA. Translation: AAH30139.1.
AK025612 mRNA. Translation: BAB15189.1. Different initiation.
AK026193 mRNA. Translation: BAB15389.1. Sequence problems.
CCDSiCCDS6543.1. [Q9H6R4-1]
CCDS6544.1. [Q9H6R4-3]
RefSeqiNP_075068.2. NM_022917.4. [Q9H6R4-1]
NP_631981.2. NM_139235.3. [Q9H6R4-3]
UniGeneiHs.493709.

3D structure databases

ProteinModelPortaliQ9H6R4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122391. 47 interactions.
IntActiQ9H6R4. 13 interactions.
MINTiMINT-3046044.
STRINGi9606.ENSP00000297990.

PTM databases

iPTMnetiQ9H6R4.
PhosphoSiteiQ9H6R4.
SwissPalmiQ9H6R4.

Polymorphism and mutation databases

BioMutaiNOL6.
DMDMi62900709.

2D gel databases

SWISS-2DPAGEQ9H6R4.

Proteomic databases

EPDiQ9H6R4.
MaxQBiQ9H6R4.
PaxDbiQ9H6R4.
PeptideAtlasiQ9H6R4.
PRIDEiQ9H6R4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297990; ENSP00000297990; ENSG00000165271. [Q9H6R4-1]
ENST00000353159; ENSP00000313978; ENSG00000165271. [Q9H6R4-3]
GeneIDi65083.
KEGGihsa:65083.
UCSCiuc003zsy.4. human. [Q9H6R4-1]

Organism-specific databases

CTDi65083.
GeneCardsiNOL6.
HGNCiHGNC:19910. NOL6.
HPAiHPA055891.
HPA061002.
MIMi611532. gene.
neXtProtiNX_Q9H6R4.
PharmGKBiPA134979388.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2054. Eukaryota.
ENOG410XPP9. LUCA.
GeneTreeiENSGT00390000018619.
HOVERGENiHBG052644.
InParanoidiQ9H6R4.
KOiK14544.
OMAiHQAFSVV.
OrthoDBiEOG091G01Z2.
PhylomeDBiQ9H6R4.

Enzyme and pathway databases

ReactomeiR-HSA-6790901. rRNA modification in the nucleus.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.

Miscellaneous databases

ChiTaRSiNOL6. human.
GeneWikiiNOL6.
GenomeRNAii65083.
PROiQ9H6R4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165271.
ExpressionAtlasiQ9H6R4. baseline and differential.
GenevisibleiQ9H6R4. HS.

Family and domain databases

InterProiIPR005554. Nrap.
[Graphical view]
PANTHERiPTHR17972. PTHR17972. 1 hit.
PfamiPF03813. Nrap. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNOL6_HUMAN
AccessioniPrimary (citable) accession number: Q9H6R4
Secondary accession number(s): Q5T5M3
, Q5T5M4, Q7L4G6, Q8N6I0, Q8TEY9, Q8TEZ0, Q8TEZ1, Q9H675
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: September 7, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.