Reviewed,
UniProtKB/Swiss-Prot Q9H6R3 (ACSS3_HUMAN)
Last modified
November 24, 2009.
Version 65.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Acyl-CoA synthetase short-chain family member 3, mitochondrial EC=6.2.1.1 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 686 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Activates acetate so that it can be used for lipid synthesis or for energy generation By similarity. |
| Catalytic activity | ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. |
| Subcellular location | Mitochondrion Potential. |
| Sequence similarities | Belongs to the ATP-dependent AMP-binding enzyme family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Mitochondrion |
| Coding sequence diversity | Alternative splicing |
| Domain | Transit peptide |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | metabolic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q9H6R3-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q9H6R3-2) The sequence of this isoform differs from the canonical sequence as follows: 1-318: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 29 | 29 | Mitochondrion Potential | ||||||
| Chain | 30 – 686 | 657 | Acyl-CoA synthetase short-chain family member 3, mitochondrial | PRO_0000320624 | |||||
Natural variations | |||||||||
| Alternative sequence | 1 – 318 | 318 | Missing in isoform 2. | VSP_031692 | |||||
Experimental info | |||||||||
| Sequence conflict | 428 | 1 | C → S in BAC11304. Ref.1 | ||||||
Sequences
| ||||||||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Hepatoma and Teratocarcinoma. |
| [2] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Muscle. |
| [4] | "Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome." Watkins P.A., Maiguel D., Jia Z., Pevsner J. J. Lipid Res. 48:2736-2750(2007) [PubMed: 17762044] [Abstract] Cited for: IDENTIFICATION, NOMENCLATURE. |
Cross-references
Sequence databases | |
|---|---|
| AK025616 mRNA. Translation: BAB15190.1. AK074938 mRNA. Translation: BAC11304.1. CH471054 Genomic DNA. Translation: EAW97372.1. BC009317 mRNA. Translation: AAH09317.1. BC015769 mRNA. Translation: AAH15769.1. | |
| IPI | IPI00002245. IPI00795694. |
| RefSeq | NP_078836.1. |
| UniGene | Hs.259559 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1RY2 based on UniProtKB Q01574. |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q9H6R3. |
Genome annotation databases | |
| Ensembl | ENST00000261206; ENSP00000261206; ENSG00000111058; Homo sapiens. [Genome view] |
| GeneID | 79611. |
| KEGG | hsa:79611. |
| UCSC | uc001szl.1. human. uc001szm.1. human. |
Organism-specific databases | |
| CTD | 79611. |
| GeneCards | GC12P079995. |
| HGNC | HGNC:24723. ACSS3. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q9H6R3. |
| HOVERGEN | Q9H6R3. |
| OMA | GKPYKIT |
| OrthoDB | EOG934ZRF |
Enzyme and pathway databases | |
| BRENDA | 6.2.1.1. 247. |
Gene expression databases | |
| ArrayExpress | Q9H6R3. |
| Bgee | Q9H6R3. |
| CleanEx | HS_ACSS3. |
| Genevestigator | Q9H6R3. |
Family and domain databases | |
| InterPro | IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view] |
| Pfam | PF00501. AMP-binding. 1 hit. [Graphical view] |
| PROSITE | PS00455. AMP_BINDING. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 68660. |
Entry information
| Entry name | ACSS3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9H6R3 Secondary accession number(s): Q8NC66 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 12 Human chromosome 12: entries, gene names and cross-references to MIM |
| SIMILARITY comments Index of protein domains and families |

Clusters with


