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Protein

Acyl-CoA synthetase short-chain family member 3, mitochondrial

Gene

ACSS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Activates acetate so that it can be used for lipid synthesis or for energy generation.By similarity

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei539ATPBy similarity1
Binding sitei554ATPBy similarity1
Binding sitei565ATPBy similarity1
Binding sitei624Coenzyme ABy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi425 – 427ATPBy similarity3
Nucleotide bindingi446 – 451ATPBy similarity6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS03366-MONOMER.
ReactomeiR-HSA-77111. Synthesis of Ketone Bodies.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA synthetase short-chain family member 3, mitochondrial (EC:6.2.1.1)
Alternative name(s):
Acyl-CoA synthetase short-chain family member 3
Gene namesi
Name:ACSS3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:24723. ACSS3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi79611.
OpenTargetsiENSG00000111058.
PharmGKBiPA162375534.

Polymorphism and mutation databases

BioMutaiACSS3.
DMDMi74752698.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionSequence analysisAdd BLAST29
ChainiPRO_000032062430 – 686Acyl-CoA synthetase short-chain family member 3, mitochondrialAdd BLAST657

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei518N6-succinyllysineBy similarity1
Modified residuei524N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9H6R3.
MaxQBiQ9H6R3.
PaxDbiQ9H6R3.
PeptideAtlasiQ9H6R3.
PRIDEiQ9H6R3.
TopDownProteomicsiQ9H6R3-1. [Q9H6R3-1]

PTM databases

iPTMnetiQ9H6R3.
PhosphoSitePlusiQ9H6R3.

Expressioni

Gene expression databases

BgeeiENSG00000111058.
CleanExiHS_ACSS3.
ExpressionAtlasiQ9H6R3. baseline and differential.
GenevisibleiQ9H6R3. HS.

Organism-specific databases

HPAiHPA039353.
HPA047956.
HPA061517.

Interactioni

Protein-protein interaction databases

BioGridi122745. 1 interactor.
IntActiQ9H6R3. 1 interactor.
STRINGi9606.ENSP00000449535.

Structurei

3D structure databases

ProteinModelPortaliQ9H6R3.
SMRiQ9H6R3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni227 – 230Coenzyme A bindingBy similarity4

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1175. Eukaryota.
COG0365. LUCA.
GeneTreeiENSGT00760000119178.
HOGENOMiHOG000229981.
HOVERGENiHBG014401.
InParanoidiQ9H6R3.
KOiK01908.
OMAiLPVKHGS.
OrthoDBiEOG091G03IL.
PhylomeDBiQ9H6R3.
TreeFamiTF354241.

Family and domain databases

InterProiIPR032387. ACAS_N.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF16177. ACAS_N. 1 hit.
PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H6R3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKPSWLQCRK VTSAGGLGGP LPGSSPARGA GAALRALVVP GPRGGLGGRG
60 70 80 90 100
CRALSSGSGS EYKTHFAASV TDPERFWGKA AEQISWYKPW TKTLENKHSP
110 120 130 140 150
STRWFVEGML NICYNAVDRH IENGKGDKIA IIYDSPVTNT KATFTYKEVL
160 170 180 190 200
EQVSKLAGVL VKHGIKKGDT VVIYMPMIPQ AMYTMLACAR IGAIHSLIFG
210 220 230 240 250
GFASKELSSR IDHVKPKVVV TASFGIEPGR RVEYVPLVEE ALKIGQHKPD
260 270 280 290 300
KILIYNRPNM EAVPLAPGRD LDWDEEMAKA QSHDCVPVLS EHPLYILYTS
310 320 330 340 350
GTTGLPKGVI RPTGGYAVML HWSMSSIYGL QPGEVWWAAS DLGWVVGHSY
360 370 380 390 400
ICYGPLLHGN TTVLYEGKPV GTPDAGAYFR VLAEHGVAAL FTAPTAIRAI
410 420 430 440 450
RQQDPGAALG KQYSLTRFKT LFVAGERCDV ETLEWSKNVF RVPVLDHWWQ
460 470 480 490 500
TETGSPITAS CVGLGNSKTP PPGQAGKSVP GYNVMILDDN MQKLKARCLG
510 520 530 540 550
NIVVKLPLPP GAFSGLWKNQ EAFKHLYFEK FPGYYDTMDA GYMDEEGYLY
560 570 580 590 600
VMSRVDDVIN VAGHRISAGA IEESILSHGT VADCAVVGKE DPLKGHVPLA
610 620 630 640 650
LCVLRKDINA TEEQVLEEIV KHVRQNIGPV AAFRNAVFVK QLPKTRSGKI
660 670 680
PRSALSAIVN GKPYKITSTI EDPSIFGHVE EMLKQA
Length:686
Mass (Da):74,778
Last modified:March 1, 2001 - v1
Checksum:i3386338C6FFFD7E8
GO
Isoform 2 (identifier: Q9H6R3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-318: Missing.

Show »
Length:368
Mass (Da):40,326
Checksum:i8DAB2F64E31A36A3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti428C → S in BAC11304 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0316921 – 318Missing in isoform 2. 1 PublicationAdd BLAST318

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025616 mRNA. Translation: BAB15190.1.
AK074938 mRNA. Translation: BAC11304.1.
CH471054 Genomic DNA. Translation: EAW97372.1.
BC009317 mRNA. Translation: AAH09317.1.
BC015769 mRNA. Translation: AAH15769.1.
CCDSiCCDS9022.1. [Q9H6R3-1]
RefSeqiNP_001317171.1. NM_001330242.1.
NP_001317172.1. NM_001330243.1.
NP_078836.1. NM_024560.3. [Q9H6R3-1]
UniGeneiHs.259559.

Genome annotation databases

EnsembliENST00000548058; ENSP00000449535; ENSG00000111058. [Q9H6R3-1]
GeneIDi79611.
KEGGihsa:79611.
UCSCiuc001szl.2. human. [Q9H6R3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025616 mRNA. Translation: BAB15190.1.
AK074938 mRNA. Translation: BAC11304.1.
CH471054 Genomic DNA. Translation: EAW97372.1.
BC009317 mRNA. Translation: AAH09317.1.
BC015769 mRNA. Translation: AAH15769.1.
CCDSiCCDS9022.1. [Q9H6R3-1]
RefSeqiNP_001317171.1. NM_001330242.1.
NP_001317172.1. NM_001330243.1.
NP_078836.1. NM_024560.3. [Q9H6R3-1]
UniGeneiHs.259559.

3D structure databases

ProteinModelPortaliQ9H6R3.
SMRiQ9H6R3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122745. 1 interactor.
IntActiQ9H6R3. 1 interactor.
STRINGi9606.ENSP00000449535.

PTM databases

iPTMnetiQ9H6R3.
PhosphoSitePlusiQ9H6R3.

Polymorphism and mutation databases

BioMutaiACSS3.
DMDMi74752698.

Proteomic databases

EPDiQ9H6R3.
MaxQBiQ9H6R3.
PaxDbiQ9H6R3.
PeptideAtlasiQ9H6R3.
PRIDEiQ9H6R3.
TopDownProteomicsiQ9H6R3-1. [Q9H6R3-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000548058; ENSP00000449535; ENSG00000111058. [Q9H6R3-1]
GeneIDi79611.
KEGGihsa:79611.
UCSCiuc001szl.2. human. [Q9H6R3-1]

Organism-specific databases

CTDi79611.
DisGeNETi79611.
GeneCardsiACSS3.
HGNCiHGNC:24723. ACSS3.
HPAiHPA039353.
HPA047956.
HPA061517.
MIMi614356. gene.
neXtProtiNX_Q9H6R3.
OpenTargetsiENSG00000111058.
PharmGKBiPA162375534.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1175. Eukaryota.
COG0365. LUCA.
GeneTreeiENSGT00760000119178.
HOGENOMiHOG000229981.
HOVERGENiHBG014401.
InParanoidiQ9H6R3.
KOiK01908.
OMAiLPVKHGS.
OrthoDBiEOG091G03IL.
PhylomeDBiQ9H6R3.
TreeFamiTF354241.

Enzyme and pathway databases

BioCyciZFISH:HS03366-MONOMER.
ReactomeiR-HSA-77111. Synthesis of Ketone Bodies.

Miscellaneous databases

ChiTaRSiACSS3. human.
GenomeRNAii79611.
PROiQ9H6R3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111058.
CleanExiHS_ACSS3.
ExpressionAtlasiQ9H6R3. baseline and differential.
GenevisibleiQ9H6R3. HS.

Family and domain databases

InterProiIPR032387. ACAS_N.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF16177. ACAS_N. 1 hit.
PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACSS3_HUMAN
AccessioniPrimary (citable) accession number: Q9H6R3
Secondary accession number(s): Q8NC66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.