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Q9H6R3

- ACSS3_HUMAN

UniProt

Q9H6R3 - ACSS3_HUMAN

Protein

Acyl-CoA synthetase short-chain family member 3, mitochondrial

Gene

ACSS3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Activates acetate so that it can be used for lipid synthesis or for energy generation.By similarity

    Catalytic activityi

    ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei539 – 5391ATPBy similarity
    Binding sitei554 – 5541ATPBy similarity
    Binding sitei565 – 5651ATPBy similarity
    Binding sitei624 – 6241Coenzyme ABy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi425 – 4273ATPBy similarity
    Nucleotide bindingi446 – 4516ATPBy similarity

    GO - Molecular functioni

    1. acetate-CoA ligase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ligase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acyl-CoA synthetase short-chain family member 3, mitochondrial (EC:6.2.1.1)
    Alternative name(s):
    Acyl-CoA synthetase short-chain family member 3
    Gene namesi
    Name:ACSS3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:24723. ACSS3.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162375534.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2929MitochondrionSequence AnalysisAdd
    BLAST
    Chaini30 – 686657Acyl-CoA synthetase short-chain family member 3, mitochondrialPRO_0000320624Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei518 – 5181N6-succinyllysineBy similarity
    Modified residuei524 – 5241N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9H6R3.
    PaxDbiQ9H6R3.
    PRIDEiQ9H6R3.

    PTM databases

    PhosphoSiteiQ9H6R3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H6R3.
    BgeeiQ9H6R3.
    CleanExiHS_ACSS3.
    GenevestigatoriQ9H6R3.

    Organism-specific databases

    HPAiHPA039353.

    Interactioni

    Protein-protein interaction databases

    BioGridi122745. 1 interaction.
    IntActiQ9H6R3. 1 interaction.
    STRINGi9606.ENSP00000261206.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H6R3.
    SMRiQ9H6R3. Positions 61-659.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni227 – 2304Coenzyme A bindingBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0365.
    HOGENOMiHOG000229981.
    HOVERGENiHBG014401.
    InParanoidiQ9H6R3.
    KOiK01908.
    OMAiRTIEYLP.
    OrthoDBiEOG7XDBFC.
    PhylomeDBiQ9H6R3.
    TreeFamiTF354241.

    Family and domain databases

    InterProiIPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view]
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H6R3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKPSWLQCRK VTSAGGLGGP LPGSSPARGA GAALRALVVP GPRGGLGGRG    50
    CRALSSGSGS EYKTHFAASV TDPERFWGKA AEQISWYKPW TKTLENKHSP 100
    STRWFVEGML NICYNAVDRH IENGKGDKIA IIYDSPVTNT KATFTYKEVL 150
    EQVSKLAGVL VKHGIKKGDT VVIYMPMIPQ AMYTMLACAR IGAIHSLIFG 200
    GFASKELSSR IDHVKPKVVV TASFGIEPGR RVEYVPLVEE ALKIGQHKPD 250
    KILIYNRPNM EAVPLAPGRD LDWDEEMAKA QSHDCVPVLS EHPLYILYTS 300
    GTTGLPKGVI RPTGGYAVML HWSMSSIYGL QPGEVWWAAS DLGWVVGHSY 350
    ICYGPLLHGN TTVLYEGKPV GTPDAGAYFR VLAEHGVAAL FTAPTAIRAI 400
    RQQDPGAALG KQYSLTRFKT LFVAGERCDV ETLEWSKNVF RVPVLDHWWQ 450
    TETGSPITAS CVGLGNSKTP PPGQAGKSVP GYNVMILDDN MQKLKARCLG 500
    NIVVKLPLPP GAFSGLWKNQ EAFKHLYFEK FPGYYDTMDA GYMDEEGYLY 550
    VMSRVDDVIN VAGHRISAGA IEESILSHGT VADCAVVGKE DPLKGHVPLA 600
    LCVLRKDINA TEEQVLEEIV KHVRQNIGPV AAFRNAVFVK QLPKTRSGKI 650
    PRSALSAIVN GKPYKITSTI EDPSIFGHVE EMLKQA 686
    Length:686
    Mass (Da):74,778
    Last modified:March 1, 2001 - v1
    Checksum:i3386338C6FFFD7E8
    GO
    Isoform 2 (identifier: Q9H6R3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-318: Missing.

    Show »
    Length:368
    Mass (Da):40,326
    Checksum:i8DAB2F64E31A36A3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti428 – 4281C → S in BAC11304. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 318318Missing in isoform 2. 1 PublicationVSP_031692Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK025616 mRNA. Translation: BAB15190.1.
    AK074938 mRNA. Translation: BAC11304.1.
    CH471054 Genomic DNA. Translation: EAW97372.1.
    BC009317 mRNA. Translation: AAH09317.1.
    BC015769 mRNA. Translation: AAH15769.1.
    CCDSiCCDS9022.1. [Q9H6R3-1]
    RefSeqiNP_078836.1. NM_024560.2. [Q9H6R3-1]
    UniGeneiHs.259559.

    Genome annotation databases

    EnsembliENST00000548058; ENSP00000449535; ENSG00000111058. [Q9H6R3-1]
    GeneIDi79611.
    KEGGihsa:79611.
    UCSCiuc001szl.1. human. [Q9H6R3-1]

    Polymorphism databases

    DMDMi74752698.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK025616 mRNA. Translation: BAB15190.1 .
    AK074938 mRNA. Translation: BAC11304.1 .
    CH471054 Genomic DNA. Translation: EAW97372.1 .
    BC009317 mRNA. Translation: AAH09317.1 .
    BC015769 mRNA. Translation: AAH15769.1 .
    CCDSi CCDS9022.1. [Q9H6R3-1 ]
    RefSeqi NP_078836.1. NM_024560.2. [Q9H6R3-1 ]
    UniGenei Hs.259559.

    3D structure databases

    ProteinModelPortali Q9H6R3.
    SMRi Q9H6R3. Positions 61-659.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122745. 1 interaction.
    IntActi Q9H6R3. 1 interaction.
    STRINGi 9606.ENSP00000261206.

    PTM databases

    PhosphoSitei Q9H6R3.

    Polymorphism databases

    DMDMi 74752698.

    Proteomic databases

    MaxQBi Q9H6R3.
    PaxDbi Q9H6R3.
    PRIDEi Q9H6R3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000548058 ; ENSP00000449535 ; ENSG00000111058 . [Q9H6R3-1 ]
    GeneIDi 79611.
    KEGGi hsa:79611.
    UCSCi uc001szl.1. human. [Q9H6R3-1 ]

    Organism-specific databases

    CTDi 79611.
    GeneCardsi GC12P081331.
    HGNCi HGNC:24723. ACSS3.
    HPAi HPA039353.
    MIMi 614356. gene.
    neXtProti NX_Q9H6R3.
    PharmGKBi PA162375534.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0365.
    HOGENOMi HOG000229981.
    HOVERGENi HBG014401.
    InParanoidi Q9H6R3.
    KOi K01908.
    OMAi RTIEYLP.
    OrthoDBi EOG7XDBFC.
    PhylomeDBi Q9H6R3.
    TreeFami TF354241.

    Miscellaneous databases

    ChiTaRSi ACSS3. human.
    GenomeRNAii 79611.
    NextBioi 68660.
    PROi Q9H6R3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H6R3.
    Bgeei Q9H6R3.
    CleanExi HS_ACSS3.
    Genevestigatori Q9H6R3.

    Family and domain databases

    InterProi IPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view ]
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Hepatoma and Teratocarcinoma.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Muscle.
    4. "Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome."
      Watkins P.A., Maiguel D., Jia Z., Pevsner J.
      J. Lipid Res. 48:2736-2750(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, NOMENCLATURE.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiACSS3_HUMAN
    AccessioniPrimary (citable) accession number: Q9H6R3
    Secondary accession number(s): Q8NC66
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3