Q9H6R3 (ACSS3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acyl-CoA synthetase short-chain family member 3, mitochondrial
EC=6.2.1.1

Alternative name(s):
Acyl-CoA synthetase short-chain family member 3

Gene names

Name:

ACSS3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	686 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Activates acetate so that it can be used for lipid synthesis or for energy generation By similarity.
Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
Subcellular location	Mitochondrion Potential.
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
Cellular component	Mitochondrion
Coding sequence diversity	Alternative splicing
Domain	Transit peptide
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H6R3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9H6R3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-318: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 29	29	Mitochondrion Potential
	Chain	30 – 686	657	Acyl-CoA synthetase short-chain family member 3, mitochondrial		PRO_0000320624
Natural variations
	Alternative sequence	1 – 318	318	Missing in isoform 2.		VSP_031692
Experimental info
	Sequence conflict	428	1	C → S in BAC11304. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 3386338C6FFFD7E8	FASTA	686	74,778
	10 20 30 40 50 60 MKPSWLQCRK VTSAGGLGGP LPGSSPARGA GAALRALVVP GPRGGLGGRG CRALSSGSGS 70 80 90 100 110 120 EYKTHFAASV TDPERFWGKA AEQISWYKPW TKTLENKHSP STRWFVEGML NICYNAVDRH 130 140 150 160 170 180 IENGKGDKIA IIYDSPVTNT KATFTYKEVL EQVSKLAGVL VKHGIKKGDT VVIYMPMIPQ 190 200 210 220 230 240 AMYTMLACAR IGAIHSLIFG GFASKELSSR IDHVKPKVVV TASFGIEPGR RVEYVPLVEE 250 260 270 280 290 300 ALKIGQHKPD KILIYNRPNM EAVPLAPGRD LDWDEEMAKA QSHDCVPVLS EHPLYILYTS 310 320 330 340 350 360 GTTGLPKGVI RPTGGYAVML HWSMSSIYGL QPGEVWWAAS DLGWVVGHSY ICYGPLLHGN 370 380 390 400 410 420 TTVLYEGKPV GTPDAGAYFR VLAEHGVAAL FTAPTAIRAI RQQDPGAALG KQYSLTRFKT 430 440 450 460 470 480 LFVAGERCDV ETLEWSKNVF RVPVLDHWWQ TETGSPITAS CVGLGNSKTP PPGQAGKSVP 490 500 510 520 530 540 GYNVMILDDN MQKLKARCLG NIVVKLPLPP GAFSGLWKNQ EAFKHLYFEK FPGYYDTMDA 550 560 570 580 590 600 GYMDEEGYLY VMSRVDDVIN VAGHRISAGA IEESILSHGT VADCAVVGKE DPLKGHVPLA 610 620 630 640 650 660 LCVLRKDINA TEEQVLEEIV KHVRQNIGPV AAFRNAVFVK QLPKTRSGKI PRSALSAIVN 670 680 GKPYKITSTI EDPSIFGHVE EMLKQA
	Isoform 2 [UniParc]. Checksum: 8DAB2F64E31A36A3	FASTA	368	40,326
	10 20 30 40 50 60 MLHWSMSSIY GLQPGEVWWA ASDLGWVVGH SYICYGPLLH GNTTVLYEGK PVGTPDAGAY 70 80 90 100 110 120 FRVLAEHGVA ALFTAPTAIR AIRQQDPGAA LGKQYSLTRF KTLFVAGERC DVETLEWSKN 130 140 150 160 170 180 VFRVPVLDHW WQTETGSPIT ASCVGLGNSK TPPPGQAGKS VPGYNVMILD DNMQKLKARC 190 200 210 220 230 240 LGNIVVKLPL PPGAFSGLWK NQEAFKHLYF EKFPGYYDTM DAGYMDEEGY LYVMSRVDDV 250 260 270 280 290 300 INVAGHRISA GAIEESILSH GTVADCAVVG KEDPLKGHVP LALCVLRKDI NATEEQVLEE 310 320 330 340 350 360 IVKHVRQNIG PVAAFRNAVF VKQLPKTRSG KIPRSALSAI VNGKPYKITS TIEDPSIFGH VEEMLKQA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Hepatoma and Teratocarcinoma.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Muscle.
[4]	"Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome." Watkins P.A., Maiguel D., Jia Z., Pevsner J. J. Lipid Res. 48:2736-2750(2007) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, NOMENCLATURE.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK025616 mRNA. Translation: BAB15190.1. AK074938 mRNA. Translation: BAC11304.1. CH471054 Genomic DNA. Translation: EAW97372.1. BC009317 mRNA. Translation: AAH09317.1. BC015769 mRNA. Translation: AAH15769.1.
IPI	IPI00002245. IPI00795694.
RefSeq	NP_078836.1. NM_024560.2.
UniGene	Hs.259559.
3D structure databases
HSSP	HSSP built from PDB template 1RY2 based on UniProtKB Q01574.
ProteinModelPortal	Q9H6R3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H6R3. 1 interaction.
STRING	9606.ENSP00000261206.
PTM databases
PhosphoSite	Q9H6R3.
Polymorphism databases
DMDM	74752698.
Proteomic databases
PaxDb	Q9H6R3.
PRIDE	Q9H6R3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000548058; ENSP00000449535; ENSG00000111058. ENST00000548324; ENSP00000448965; ENSG00000111058.
GeneID	79611.
KEGG	hsa:79611.
UCSC	uc001szl.1. human.
Organism-specific databases
CTD	79611.
GeneCards	GC12P081331.
HGNC	HGNC:24723. ACSS3.
HPA	HPA039353.
MIM	614356. gene.
neXtProt	NX_Q9H6R3.
PharmGKB	PA162375534.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0365.
HOGENOM	HOG000229981.
HOVERGEN	HBG014401.
InParanoid	Q9H6R3.
KO	K01908.
OMA	WAIAANC.
OrthoDB	EOG48D0V3.
PhylomeDB	Q9H6R3.
Gene expression databases
ArrayExpress	Q9H6R3.
Bgee	Q9H6R3.
CleanEx	HS_ACSS3.
Genevestigator	Q9H6R3.
Family and domain databases
InterPro	IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. IPR025110. DUF4009. [Graphical view]
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. PF13193. DUF4009. 1 hit. [Graphical view]
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ACSS3. human.
GenomeRNAi	79611.
NextBio	68660.
SOURCE	Search...

Entry information

Entry name

ACSS3_HUMAN

Accession

Primary (citable) accession number: Q9H6R3
Secondary accession number(s): Q8NC66

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.