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Protein

Putative uncharacterized protein MYH16

Gene

MYH16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Has most probably lost the function in masticatory muscles contraction suspected for its homologs in dog (AC F1PT61) and apes.1 Publication

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Putative uncharacterized protein MYH16Curated
Alternative name(s):
Myosin heavy chain 16 pseudogeneImported
myosin heavy polypeptide 5Imported
Gene namesi
Name:MYH16Imported
Synonyms:MYH5Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:31038. MYH16.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10971097Putative uncharacterized protein MYH16PRO_0000433095Add
BLAST

Proteomic databases

MaxQBiQ9H6N6.
PRIDEiQ9H6N6.

Expressioni

Tissue specificityi

Specifically expressed in muscles of the head including temporalis and tensor veli palatini.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9H6N6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili31 – 10871057Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOVERGENiHBG004704.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR027401. Myosin-like_IQ_dom.
IPR002928. Myosin_tail.
[Graphical view]
PfamiPF01576. Myosin_tail_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H6N6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLKVIQQNV HKFLQLRFWG WWKLYNKVKP LLNVARQEEE MKAKEEELRK
60 70 80 90 100
AMAQTQELVN KVKELEEKTA TLSQEKNDLT IQLQAEQENL MDAEERLTWM
110 120 130 140 150
MKTKMDLESQ ISDMRERLEE EEGMAASLSA AKRKLEGELS DLKRDLEGLE
160 170 180 190 200
TTLAKTEKEK QALDHKVRTL TGDLSLREDS ITKLQKEKRA LEELHQKTLD
210 220 230 240 250
DLQAEEDKVN HLTKNNSKLS TQIHELEDNW EQEKKIRAEV EKARRKAESD
260 270 280 290 300
LKMTIDNLNE MERSKLDLEE VVKKRDLEIN SVNSKYEDEQ SLNSTLQRKL
310 320 330 340 350
KEHQDRIEEL EEELEAERAM RAKIEQNRKR EAELLKLRRE LEEAALQSEA
360 370 380 390 400
TASTLRKKHV DSMAELTEHV ESLQRVKSKL EKDKQVMKAE IDDLNASMET
410 420 430 440 450
IQKSKMNAEA HVRKLEDSLS EANAKVAELE RNQAEINAIR TRLQAENSEL
460 470 480 490 500
SREYEESQSR LNQILRIKTS LTSQVDDYKR QLDEESKSRS TAVVSLANTK
510 520 530 540 550
HDLDLVKEQL EEEQGGKSEL QRLVSKLNTE VTTWRTKYET DAIQRTEELE
560 570 580 590 600
ETKRKLAARL QEAEEAAETA QARAASLEKN KQRLQAEVED LTIDLEKANA
610 620 630 640 650
AAAALDKKQR LFDKMLAEWQ QKCEELQVEV DSSQKECRMY MTESFKIKTA
660 670 680 690 700
YEESLEHLES VKKENKTLQE EIKDLIDQLG EGGRSVHELQ KLKKKLEMEK
710 720 730 740 750
EELQVALEEA ESSLEVEESK VIRIQLELAQ VKADIDRRIH EKEEEFEATR
760 770 780 790 800
KNHQRAIESL QASLEAEAKG RAEALRLKKK METDLNEMEI QLDHANKNNS
810 820 830 840 850
ELVKTLKRLQ QQIKDLQVQM DEDARQHEEL RKQYNLQERR LSLLQTELEE
860 870 880 890 900
VRSALEGSER SRKLLEQEVV EITEWHNEIN IQNQSLLVVK RKLESDVQRI
910 920 930 940 950
SNEHEELISE FRLTEERAKK AMMDAARMAE ELRQEQDHCM HLEKIKKNYE
960 970 980 990 1000
VTIKDLQAKM EEAEQLALKG GKRTIMKLEA RIKELETELD GEQKQHVETV
1010 1020 1030 1040 1050
KTLCKNERRL KELVFQTEED HKTNQRMQAL VEKLQNKLKV YKRQIEEAED
1060 1070 1080 1090
QANQTLARYR KTVHELDDAE DRAGMAETAL NKLRTRHRVA GKGITSV
Length:1,097
Mass (Da):128,290
Last modified:May 27, 2015 - v2
Checksum:iDC459CD5FA5D0BC4
GO

Sequence cautioni

The sequence BAB15219.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 111H → R in BAB15219 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004834 Genomic DNA. No translation available.
AK025690 mRNA. Translation: BAB15219.1. Sequence problems.
UniGeneiHs.621401.

Genome annotation databases

UCSCiuc003upw.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004834 Genomic DNA. No translation available.
AK025690 mRNA. Translation: BAB15219.1. Sequence problems.
UniGeneiHs.621401.

3D structure databases

ProteinModelPortaliQ9H6N6.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiQ9H6N6.
PRIDEiQ9H6N6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc003upw.3. human.

Organism-specific databases

HGNCiHGNC:31038. MYH16.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG004704.

Miscellaneous databases

NextBioi35541791.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR027401. Myosin-like_IQ_dom.
IPR002928. Myosin_tail.
[Graphical view]
PfamiPF01576. Myosin_tail_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-740.
  3. Cited for: FUNCTION, TISSUE SPECIFICITY, CAUTION.
  4. "Of muscle-bound crania and human brain evolution: the story behind the MYH16 headlines."
    McCollum M.A., Sherwood C.C., Vinyard C.J., Lovejoy C.O., Schachat F.
    J. Hum. Evol. 50:232-236(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: CAUTION.
  5. "HiRIEF LC-MS enables deep proteome coverage and unbiased proteogenomics."
    Branca R.M., Orre L.M., Johansson H.J., Granholm V., Huss M., Perez-Bercoff A., Forshed J., Kaell L., Lehtioe J.
    Nat. Methods 11:59-62(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, CAUTION.

Entry informationi

Entry nameiMYH16_HUMAN
AccessioniPrimary (citable) accession number: Q9H6N6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2015
Last sequence update: May 27, 2015
Last modified: May 27, 2015
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

An inactivating mutation in MYH16 probably appeared 2.4 million years ago in a hominid ancestor (PubMed:15042088). The inactivation and its correlation with evolution of the skull and cranial capacity in hominids is not clear (PubMed:15042088, PubMed:16376411). However, the gene is transcribed and the N-terminally truncated protein shown here was detected in a human cell line (PubMed:24240322). Its biological significance remains unclear since it lacks most of the domains important for the function of myosins (PubMed:15042088).3 Publications

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.