Reviewed, UniProtKB/Swiss-Prot Q9H6L5 (F134B_HUMAN)

Names and origin

Protein names

Recommended name:
    Protein FAM134B

Gene names

Name:

FAM134B

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	497 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the FAM134 family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane
PTM	Phosphoprotein
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H6L5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9H6L5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-141: Missing.
     142-152: RGAQLWRSLSE → MPEGEDFGPGK

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 497	497	Protein FAM134B		PRO_0000288466
Regions
	Transmembrane	96 – 116	21	Potential
	Transmembrane	119 – 139	21	Potential
	Transmembrane	209 – 229	21	Potential
Amino acid modifications
	Modified residue	276	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 141	141	Missing in isoform 2.		VSP_025685
	Alternative sequence	142 – 152	11	RGAQLWRSLSE → MPEGEDFGPGK in isoform 2.		VSP_025686
	Natural variant	379	1	Q → E: dbSNP rs34432513.		VAR_032422
Experimental info
	Sequence conflict	382	1	S → G in BAB15252. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 4EEB84B941DBFCE5	FASTA	497	54,681
	10 20 30 40 50 60 MASPAPPEHA EEGCPAPAAE EQAPPSPPPP QASPAERQQQ EEEAQEAGAA EGAGLQVEEA 70 80 90 100 110 120 AGRAAAAVTW LLGEPVLWLG CRADELLSWK RPLRSLLGFV AANLLFWFLA LTPWRVYHLI 130 140 150 160 170 180 SVMILGRVIM QIIKDMVLSR TRGAQLWRSL SESWEVINSK PDERPRLSHC IAESWMNFSI 190 200 210 220 230 240 FLQEMSLFKQ QSPGKFCLLV CSVCTFFTIL GSYIPGVILS YLLLLCAFLC PLFKCNDIGQ 250 260 270 280 290 300 KIYSKIKSVL LKLDFGIGEY INQKKRERSE ADKEKSHKDD SELDFSALCP KISLTVAAKE 310 320 330 340 350 360 LSVSDTDVSE VSWTDNGTFN LSEGYTPQTD TSDDLDRPSE EVFSRDLSDF PSLENGMGTN 370 380 390 400 410 420 DEDELSLGLP TELKRKKEQL DSGHRPSKET QSAAGLTLPL NSDQTFHLMS NLAGDVITAA 430 440 450 460 470 480 VTAAIKDQLE GVQQALSQAA PIPEEDTDTE EGDDFELLDQ SELDQIESEL GLTQDQEAEA 490 QQNKKSSGFL SNLLGGH
	Isoform 2. Checksum: 2133E985B91539AC	FASTA	356	39,317
	10 20 30 40 50 60 MPEGEDFGPG KSWEVINSKP DERPRLSHCI AESWMNFSIF LQEMSLFKQQ SPGKFCLLVC 70 80 90 100 110 120 SVCTFFTILG SYIPGVILSY LLLLCAFLCP LFKCNDIGQK IYSKIKSVLL KLDFGIGEYI 130 140 150 160 170 180 NQKKRERSEA DKEKSHKDDS ELDFSALCPK ISLTVAAKEL SVSDTDVSEV SWTDNGTFNL 190 200 210 220 230 240 SEGYTPQTDT SDDLDRPSEE VFSRDLSDFP SLENGMGTND EDELSLGLPT ELKRKKEQLD 250 260 270 280 290 300 SGHRPSKETQ SAAGLTLPLN SDQTFHLMSN LAGDVITAAV TAAIKDQLEG VQQALSQAAP 310 320 330 340 350 IPEEDTDTEE GDDFELLDQS ELDQIESELG LTQDQEAEAQ QNKKSSGFLS NLLGGH

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Colon.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Colon and Lung.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 80-497. Tissue: Melanoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK000159 mRNA. Translation: BAA90982.1. Different initiation. AK024920 mRNA. Translation: BAB15034.1. AK025808 mRNA. Translation: BAB15241.1. AK025832 mRNA. Translation: BAB15252.1. Different initiation. BC030517 mRNA. Translation: AAH30517.1. Different initiation. BC053326 mRNA. Translation: AAH53326.1. BC073132 mRNA. Translation: AAH73132.1. AL832438 mRNA. Translation: CAH10610.1.
IPI	IPI00465357. IPI00549844.
RefSeq	NP_001030022.1. NP_061873.2.
UniGene	Hs.481704
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q9H6L5.
Proteomic databases
PRIDE	Q9H6L5.
Genome annotation databases
Ensembl	ENSG00000154153. Homo sapiens. [Contig view]
GeneID	54463.
KEGG	hsa:54463.
Organism-specific databases
GeneCards	GC05M016527.
HGNC	HGNC:25964. FAM134B.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9H6L5.
HOVERGEN	Q9H6L5.
OMA	Q9H6L5. IFLQEMS.
Gene expression databases
ArrayExpress	Q9H6L5.
Bgee	Q9H6L5.
CleanEx	HS_FAM134B.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	56725.

Entry information

Entry name

F134B_HUMAN

Accession

Primary (citable) accession number: Q9H6L5
Secondary accession number(s): Q69YN8 , Q9H6K6, Q9H764, Q9NXM8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	March 1, 2001
Last modified:	June 16, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)