ID ARMC7_HUMAN Reviewed; 198 AA. AC Q9H6L4; B4DVA4; DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2001, sequence version 1. DT 24-JAN-2024, entry version 153. DE RecName: Full=Armadillo repeat-containing protein 7; GN Name=ARMC7; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). RC TISSUE=Small intestine; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16625196; DOI=10.1038/nature04689; RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.; RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the RT human lineage."; RL Nature 440:1045-1049(2006). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Skin; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-169, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=20068231; DOI=10.1126/scisignal.2000475; RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.; RT "Quantitative phosphoproteomics reveals widespread full phosphorylation RT site occupancy during mitosis."; RL Sci. Signal. 3:RA3-RA3(2010). RN [5] {ECO:0007744|PDB:7DVQ} RP STRUCTURE BY ELECTRON MICROSCOPY (2.89 ANGSTROMS), FUNCTION, AND SUBUNIT. RX PubMed=33509932; DOI=10.1126/science.abg0879; RA Bai R., Wan R., Wang L., Xu K., Zhang Q., Lei J., Shi Y.; RT "Structure of the activated human minor spliceosome."; RL Science 371:0-0(2021). CC -!- FUNCTION: As a component of the minor spliceosome, involved in the CC splicing of U12-type introns in pre-mRNAs. CC {ECO:0000305|PubMed:33509932}. CC -!- SUBUNIT: Component of the minor spliceosome. Within this complex, CC interacts with RBM48. {ECO:0000269|PubMed:33509932}. CC -!- INTERACTION: CC Q9H6L4; Q9NYB9: ABI2; NbExp=4; IntAct=EBI-742909, EBI-743598; CC Q9H6L4; Q9P2A4: ABI3; NbExp=3; IntAct=EBI-742909, EBI-742038; CC Q9H6L4; Q8NA61: CBY2; NbExp=3; IntAct=EBI-742909, EBI-741724; CC Q9H6L4; Q9BUN5-3: CCDC28B; NbExp=3; IntAct=EBI-742909, EBI-12920646; CC Q9H6L4; Q00587-2: CDC42EP1; NbExp=3; IntAct=EBI-742909, EBI-11027409; CC Q9H6L4; Q9H5F2: CFAP68; NbExp=3; IntAct=EBI-742909, EBI-718615; CC Q9H6L4; Q9NX63: CHCHD3; NbExp=3; IntAct=EBI-742909, EBI-743375; CC Q9H6L4; Q16630: CPSF6; NbExp=4; IntAct=EBI-742909, EBI-358410; CC Q9H6L4; Q16630-2: CPSF6; NbExp=3; IntAct=EBI-742909, EBI-11088043; CC Q9H6L4; Q8N684: CPSF7; NbExp=3; IntAct=EBI-742909, EBI-746909; CC Q9H6L4; Q8N684-3: CPSF7; NbExp=3; IntAct=EBI-742909, EBI-11523759; CC Q9H6L4; Q9NRI5-2: DISC1; NbExp=3; IntAct=EBI-742909, EBI-11988027; CC Q9H6L4; A0A0U1RQF7: DPEP2NB; NbExp=3; IntAct=EBI-742909, EBI-18398199; CC Q9H6L4; Q86UW9: DTX2; NbExp=3; IntAct=EBI-742909, EBI-740376; CC Q9H6L4; Q5JST6: EFHC2; NbExp=3; IntAct=EBI-742909, EBI-2349927; CC Q9H6L4; Q96DF8: ESS2; NbExp=3; IntAct=EBI-742909, EBI-3928124; CC Q9H6L4; P15976-2: GATA1; NbExp=3; IntAct=EBI-742909, EBI-9090198; CC Q9H6L4; O75420: GIGYF1; NbExp=3; IntAct=EBI-742909, EBI-947774; CC Q9H6L4; O14964: HGS; NbExp=3; IntAct=EBI-742909, EBI-740220; CC Q9H6L4; P49639: HOXA1; NbExp=3; IntAct=EBI-742909, EBI-740785; CC Q9H6L4; Q13422: IKZF1; NbExp=3; IntAct=EBI-742909, EBI-745305; CC Q9H6L4; Q9UKT9: IKZF3; NbExp=9; IntAct=EBI-742909, EBI-747204; CC Q9H6L4; Q0VD86: INCA1; NbExp=3; IntAct=EBI-742909, EBI-6509505; CC Q9H6L4; Q8WZ19: KCTD13; NbExp=4; IntAct=EBI-742909, EBI-742916; CC Q9H6L4; Q15323: KRT31; NbExp=6; IntAct=EBI-742909, EBI-948001; CC Q9H6L4; O76011: KRT34; NbExp=3; IntAct=EBI-742909, EBI-1047093; CC Q9H6L4; Q6A163: KRT39; NbExp=3; IntAct=EBI-742909, EBI-11958242; CC Q9H6L4; Q6A162: KRT40; NbExp=6; IntAct=EBI-742909, EBI-10171697; CC Q9H6L4; O95678: KRT75; NbExp=3; IntAct=EBI-742909, EBI-2949715; CC Q9H6L4; Q3SYF9: KRTAP19-7; NbExp=3; IntAct=EBI-742909, EBI-10241353; CC Q9H6L4; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-742909, EBI-741037; CC Q9H6L4; Q99750: MDFI; NbExp=3; IntAct=EBI-742909, EBI-724076; CC Q9H6L4; O00746: NME4; NbExp=3; IntAct=EBI-742909, EBI-744871; CC Q9H6L4; Q9P286: PAK5; NbExp=3; IntAct=EBI-742909, EBI-741896; CC Q9H6L4; Q9BSJ6: PIMREG; NbExp=3; IntAct=EBI-742909, EBI-2568609; CC Q9H6L4; Q58EX7: PLEKHG4; NbExp=3; IntAct=EBI-742909, EBI-949255; CC Q9H6L4; P0CW24: PNMA6A; NbExp=3; IntAct=EBI-742909, EBI-721270; CC Q9H6L4; Q5RL73: RBM48; NbExp=5; IntAct=EBI-742909, EBI-473821; CC Q9H6L4; Q04864-2: REL; NbExp=3; IntAct=EBI-742909, EBI-10829018; CC Q9H6L4; Q9Y3A4: RRP7A; NbExp=3; IntAct=EBI-742909, EBI-7223720; CC Q9H6L4; Q59EK9: RUNDC3A; NbExp=3; IntAct=EBI-742909, EBI-747225; CC Q9H6L4; Q59EK9-3: RUNDC3A; NbExp=3; IntAct=EBI-742909, EBI-11957366; CC Q9H6L4; Q8IYX7: SAXO1; NbExp=3; IntAct=EBI-742909, EBI-3957636; CC Q9H6L4; Q8NA69: SAXO5; NbExp=3; IntAct=EBI-742909, EBI-12021638; CC Q9H6L4; Q6ZU15: SEPTIN14; NbExp=3; IntAct=EBI-742909, EBI-2009297; CC Q9H6L4; Q6ZSJ9: SHISA6; NbExp=3; IntAct=EBI-742909, EBI-12037847; CC Q9H6L4; Q8ND83: SLAIN1; NbExp=3; IntAct=EBI-742909, EBI-10269374; CC Q9H6L4; Q9H0A9: SPATC1L; NbExp=3; IntAct=EBI-742909, EBI-372911; CC Q9H6L4; Q9H0A9-2: SPATC1L; NbExp=3; IntAct=EBI-742909, EBI-11995806; CC Q9H6L4; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-742909, EBI-742688; CC Q9H6L4; O95926: SYF2; NbExp=3; IntAct=EBI-742909, EBI-2557644; CC Q9H6L4; Q5VWN6: TASOR2; NbExp=3; IntAct=EBI-742909, EBI-745958; CC Q9H6L4; P15884: TCF4; NbExp=3; IntAct=EBI-742909, EBI-533224; CC Q9H6L4; Q13829: TNFAIP1; NbExp=6; IntAct=EBI-742909, EBI-2505861; CC Q9H6L4; P19237: TNNI1; NbExp=3; IntAct=EBI-742909, EBI-746692; CC Q9H6L4; Q96RU7: TRIB3; NbExp=3; IntAct=EBI-742909, EBI-492476; CC Q9H6L4; P14373: TRIM27; NbExp=6; IntAct=EBI-742909, EBI-719493; CC Q9H6L4; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-742909, EBI-5235829; CC Q9H6L4; Q9BYV2: TRIM54; NbExp=3; IntAct=EBI-742909, EBI-2130429; CC Q9H6L4; Q70EL1-9: USP54; NbExp=3; IntAct=EBI-742909, EBI-11975223; CC Q9H6L4; P08670: VIM; NbExp=3; IntAct=EBI-742909, EBI-353844; CC Q9H6L4; Q86XT2: VPS37D; NbExp=3; IntAct=EBI-742909, EBI-7604353; CC Q9H6L4; Q96BR9: ZBTB8A; NbExp=3; IntAct=EBI-742909, EBI-742740; CC Q9H6L4; Q53FD0-2: ZC2HC1C; NbExp=3; IntAct=EBI-742909, EBI-14104088; CC Q9H6L4; Q9UDW3: ZMAT5; NbExp=3; IntAct=EBI-742909, EBI-7850213; CC Q9H6L4; P52738: ZNF140; NbExp=3; IntAct=EBI-742909, EBI-12069140; CC Q9H6L4; Q9BUY5: ZNF426; NbExp=3; IntAct=EBI-742909, EBI-743265; CC Q9H6L4; Q96BR6: ZNF669; NbExp=3; IntAct=EBI-742909, EBI-12006574; CC Q9H6L4; Q96H86: ZNF764; NbExp=3; IntAct=EBI-742909, EBI-745775; CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q9H6L4-1; Sequence=Displayed; CC Name=2; CC IsoId=Q9H6L4-2; Sequence=VSP_056936, VSP_056937; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK025813; BAB15242.1; -; mRNA. DR EMBL; AK300997; BAG62616.1; -; mRNA. DR EMBL; AC022211; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC111186; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC011728; AAH11728.1; -; mRNA. DR CCDS; CCDS11714.1; -. [Q9H6L4-1] DR CCDS; CCDS77107.1; -. [Q9H6L4-2] DR RefSeq; NP_001291200.1; NM_001304271.1. [Q9H6L4-2] DR RefSeq; NP_001291201.1; NM_001304272.1. DR RefSeq; NP_001291202.1; NM_001304273.1. DR RefSeq; NP_078861.1; NM_024585.3. [Q9H6L4-1] DR PDB; 7DVQ; EM; 2.89 A; K=1-198. DR PDBsum; 7DVQ; -. DR AlphaFoldDB; Q9H6L4; -. DR EMDB; EMD-30875; -. DR SMR; Q9H6L4; -. DR BioGRID; 122766; 85. DR IntAct; Q9H6L4; 104. DR STRING; 9606.ENSP00000245543; -. DR iPTMnet; Q9H6L4; -. DR PhosphoSitePlus; Q9H6L4; -. DR BioMuta; ARMC7; -. DR DMDM; 74733612; -. DR EPD; Q9H6L4; -. DR jPOST; Q9H6L4; -. DR MassIVE; Q9H6L4; -. DR MaxQB; Q9H6L4; -. DR PaxDb; 9606-ENSP00000245543; -. DR PeptideAtlas; Q9H6L4; -. DR ProteomicsDB; 81001; -. [Q9H6L4-1] DR Pumba; Q9H6L4; -. DR TopDownProteomics; Q9H6L4-1; -. [Q9H6L4-1] DR Antibodypedia; 19498; 80 antibodies from 20 providers. DR DNASU; 79637; -. DR Ensembl; ENST00000245543.6; ENSP00000245543.1; ENSG00000125449.7. [Q9H6L4-1] DR Ensembl; ENST00000581078.1; ENSP00000462962.1; ENSG00000125449.7. [Q9H6L4-2] DR GeneID; 79637; -. DR KEGG; hsa:79637; -. DR MANE-Select; ENST00000245543.6; ENSP00000245543.1; NM_024585.4; NP_078861.1. DR UCSC; uc002jmw.1; human. [Q9H6L4-1] DR AGR; HGNC:26168; -. DR CTD; 79637; -. DR GeneCards; ARMC7; -. DR HGNC; HGNC:26168; ARMC7. DR HPA; ENSG00000125449; Tissue enhanced (kidney). DR neXtProt; NX_Q9H6L4; -. DR OpenTargets; ENSG00000125449; -. DR PharmGKB; PA134901380; -. DR VEuPathDB; HostDB:ENSG00000125449; -. DR eggNOG; KOG4646; Eukaryota. DR GeneTree; ENSGT00940000162633; -. DR HOGENOM; CLU_2262837_0_0_1; -. DR InParanoid; Q9H6L4; -. DR OMA; ILQCMLR; -. DR OrthoDB; 103037at2759; -. DR PhylomeDB; Q9H6L4; -. DR TreeFam; TF354322; -. DR PathwayCommons; Q9H6L4; -. DR SignaLink; Q9H6L4; -. DR BioGRID-ORCS; 79637; 760 hits in 1167 CRISPR screens. DR ChiTaRS; ARMC7; human. DR GenomeRNAi; 79637; -. DR Pharos; Q9H6L4; Tdark. DR PRO; PR:Q9H6L4; -. DR Proteomes; UP000005640; Chromosome 17. DR RNAct; Q9H6L4; Protein. DR Bgee; ENSG00000125449; Expressed in triceps brachii and 203 other cell types or tissues. DR ExpressionAtlas; Q9H6L4; baseline and differential. DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW. DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW. DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1. DR InterPro; IPR011989; ARM-like. DR InterPro; IPR016024; ARM-type_fold. DR InterPro; IPR000225; Armadillo. DR InterPro; IPR042462; ARMC7. DR PANTHER; PTHR46263; ARMADILLO REPEAT-CONTAINING PROTEIN 7; 1. DR PANTHER; PTHR46263:SF1; ARMADILLO REPEAT-CONTAINING PROTEIN 7; 1. DR Pfam; PF00514; Arm; 1. DR SMART; SM00185; ARM; 2. DR SUPFAM; SSF48371; ARM repeat; 1. DR Genevisible; Q9H6L4; HS. PE 1: Evidence at protein level; KW 3D-structure; Alternative splicing; mRNA processing; mRNA splicing; KW Phosphoprotein; Reference proteome; Repeat; Spliceosome. FT CHAIN 1..198 FT /note="Armadillo repeat-containing protein 7" FT /id="PRO_0000242666" FT REPEAT 57..99 FT /note="ARM 1" FT REPEAT 100..140 FT /note="ARM 2" FT MOD_RES 169 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:20068231" FT VAR_SEQ 58..103 FT /note="VLDLFLDSLSEENETLVEFAIGGLCNLCPDRANKEHILHAGGVPLI -> EA FT CATCAQTGPTRSTSCTQEVSHSSSTAYPAPMRRRCCLPSPRSCT (in isoform FT 2)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_056936" FT VAR_SEQ 104..198 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_056937" FT HELIX 13..26 FT /evidence="ECO:0007829|PDB:7DVQ" FT HELIX 30..43 FT /evidence="ECO:0007829|PDB:7DVQ" FT HELIX 49..54 FT /evidence="ECO:0007829|PDB:7DVQ" FT TURN 55..57 FT /evidence="ECO:0007829|PDB:7DVQ" FT HELIX 58..67 FT /evidence="ECO:0007829|PDB:7DVQ" FT HELIX 71..84 FT /evidence="ECO:0007829|PDB:7DVQ" FT HELIX 88..97 FT /evidence="ECO:0007829|PDB:7DVQ" FT HELIX 100..104 FT /evidence="ECO:0007829|PDB:7DVQ" FT HELIX 105..108 FT /evidence="ECO:0007829|PDB:7DVQ" FT HELIX 112..124 FT /evidence="ECO:0007829|PDB:7DVQ" FT TURN 128..131 FT /evidence="ECO:0007829|PDB:7DVQ" FT HELIX 133..138 FT /evidence="ECO:0007829|PDB:7DVQ" FT HELIX 141..149 FT /evidence="ECO:0007829|PDB:7DVQ" FT HELIX 154..167 FT /evidence="ECO:0007829|PDB:7DVQ" FT HELIX 170..185 FT /evidence="ECO:0007829|PDB:7DVQ" SQ SEQUENCE 198 AA; 21924 MW; B637A76677FE645E CRC64; MAQKPKVDPH VGRLGYLQAL VTEFQETQSQ DAKEQVLANL ANFAYDPSNY EYLRQLQVLD LFLDSLSEEN ETLVEFAIGG LCNLCPDRAN KEHILHAGGV PLIINCLSSP NEETVLSAIT TLMHLSPPGR SFLPELTATP VVQCMLRFSL SASARLRNLA QIFLEDFCSP RQVAEARSRQ AHSALGIPLP RSVAPRQR //