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Protein

Armadillo repeat-containing protein 7

Gene

ARMC7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ9H6L4.

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo repeat-containing protein 7
Gene namesi
Name:ARMC7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:26168. ARMC7.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. nucleus Source: GO_Central
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134901380.

Polymorphism and mutation databases

BioMutaiARMC7.
DMDMi74733612.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198Armadillo repeat-containing protein 7PRO_0000242666Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei169 – 1691Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9H6L4.
PaxDbiQ9H6L4.
PRIDEiQ9H6L4.

PTM databases

PhosphoSiteiQ9H6L4.

Expressioni

Gene expression databases

BgeeiQ9H6L4.
CleanExiHS_ARMC7.
ExpressionAtlasiQ9H6L4. baseline and differential.
GenevestigatoriQ9H6L4.

Organism-specific databases

HPAiHPA024229.
HPA053076.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ABI2Q9NYB93EBI-742909,EBI-743598
ABI3Q9P2A43EBI-742909,EBI-742038
CPSF6Q166304EBI-742909,EBI-358410
CPSF7Q8N6843EBI-742909,EBI-746909
EFHC2Q5JST63EBI-742909,EBI-2349927
IKZF1Q134223EBI-742909,EBI-745305
IKZF3Q9UKT93EBI-742909,EBI-747204
INCA1Q0VD863EBI-742909,EBI-6509505
KRT31Q153233EBI-742909,EBI-948001
KRT40Q6A1623EBI-742909,EBI-10171697
LZTS2Q9BRK43EBI-742909,EBI-741037
PAK7Q8TB933EBI-742909,EBI-741896
RUNDC3AQ59EK93EBI-742909,EBI-747225
SPATC1LQ9H0A93EBI-742909,EBI-372911
SPERTQ8NA613EBI-742909,EBI-741724
TCF4P158843EBI-742909,EBI-533224
TNFAIP1Q138293EBI-742909,EBI-2505861
TRIM27P143733EBI-742909,EBI-719493
TRIM42A1L4B63EBI-742909,EBI-10172216

Protein-protein interaction databases

BioGridi122766. 23 interactions.
IntActiQ9H6L4. 21 interactions.
MINTiMINT-1447895.
STRINGi9606.ENSP00000245543.

Structurei

3D structure databases

ProteinModelPortaliQ9H6L4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati57 – 9943ARM 1Add
BLAST
Repeati100 – 14041ARM 2Add
BLAST

Sequence similaritiesi

Contains 2 ARM repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG312529.
GeneTreeiENSGT00510000048298.
HOGENOMiHOG000231171.
HOVERGENiHBG061557.
InParanoidiQ9H6L4.
OMAiQCMLRFS.
PhylomeDBiQ9H6L4.
TreeFamiTF354322.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
PfamiPF00514. Arm. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H6L4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQKPKVDPH VGRLGYLQAL VTEFQETQSQ DAKEQVLANL ANFAYDPSNY
60 70 80 90 100
EYLRQLQVLD LFLDSLSEEN ETLVEFAIGG LCNLCPDRAN KEHILHAGGV
110 120 130 140 150
PLIINCLSSP NEETVLSAIT TLMHLSPPGR SFLPELTATP VVQCMLRFSL
160 170 180 190
SASARLRNLA QIFLEDFCSP RQVAEARSRQ AHSALGIPLP RSVAPRQR
Length:198
Mass (Da):21,924
Last modified:March 1, 2001 - v1
Checksum:iB637A76677FE645E
GO
Isoform 2 (identifier: Q9H6L4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-103: VLDLFLDSLS...ILHAGGVPLI → EACATCAQTG...CCLPSPRSCT
     104-198: Missing.

Note: No experimental confirmation available.

Show »
Length:103
Mass (Da):11,417
Checksum:iF9E32FBBE427497F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei58 – 10346VLDLF…GVPLI → EACATCAQTGPTRSTSCTQE VSHSSSTAYPAPMRRRCCLP SPRSCT in isoform 2. 1 PublicationVSP_056936Add
BLAST
Alternative sequencei104 – 19895Missing in isoform 2. 1 PublicationVSP_056937Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025813 mRNA. Translation: BAB15242.1.
AK300997 mRNA. Translation: BAG62616.1.
AC022211 Genomic DNA. No translation available.
AC111186 Genomic DNA. No translation available.
BC011728 mRNA. Translation: AAH11728.1.
CCDSiCCDS11714.1. [Q9H6L4-1]
RefSeqiNP_078861.1. NM_024585.3. [Q9H6L4-1]
UniGeneiHs.413047.

Genome annotation databases

EnsembliENST00000245543; ENSP00000245543; ENSG00000125449. [Q9H6L4-1]
ENST00000581078; ENSP00000462962; ENSG00000125449. [Q9H6L4-2]
GeneIDi79637.
KEGGihsa:79637.
UCSCiuc002jmw.1. human. [Q9H6L4-1]
uc010wru.1. human.

Polymorphism and mutation databases

BioMutaiARMC7.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025813 mRNA. Translation: BAB15242.1.
AK300997 mRNA. Translation: BAG62616.1.
AC022211 Genomic DNA. No translation available.
AC111186 Genomic DNA. No translation available.
BC011728 mRNA. Translation: AAH11728.1.
CCDSiCCDS11714.1. [Q9H6L4-1]
RefSeqiNP_078861.1. NM_024585.3. [Q9H6L4-1]
UniGeneiHs.413047.

3D structure databases

ProteinModelPortaliQ9H6L4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122766. 23 interactions.
IntActiQ9H6L4. 21 interactions.
MINTiMINT-1447895.
STRINGi9606.ENSP00000245543.

PTM databases

PhosphoSiteiQ9H6L4.

Polymorphism and mutation databases

BioMutaiARMC7.
DMDMi74733612.

Proteomic databases

MaxQBiQ9H6L4.
PaxDbiQ9H6L4.
PRIDEiQ9H6L4.

Protocols and materials databases

DNASUi79637.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000245543; ENSP00000245543; ENSG00000125449. [Q9H6L4-1]
ENST00000581078; ENSP00000462962; ENSG00000125449. [Q9H6L4-2]
GeneIDi79637.
KEGGihsa:79637.
UCSCiuc002jmw.1. human. [Q9H6L4-1]
uc010wru.1. human.

Organism-specific databases

CTDi79637.
GeneCardsiGC17P073106.
HGNCiHGNC:26168. ARMC7.
HPAiHPA024229.
HPA053076.
neXtProtiNX_Q9H6L4.
PharmGKBiPA134901380.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG312529.
GeneTreeiENSGT00510000048298.
HOGENOMiHOG000231171.
HOVERGENiHBG061557.
InParanoidiQ9H6L4.
OMAiQCMLRFS.
PhylomeDBiQ9H6L4.
TreeFamiTF354322.

Enzyme and pathway databases

SignaLinkiQ9H6L4.

Miscellaneous databases

ChiTaRSiARMC7. human.
GenomeRNAii79637.
NextBioi35475403.
PROiQ9H6L4.

Gene expression databases

BgeeiQ9H6L4.
CleanExiHS_ARMC7.
ExpressionAtlasiQ9H6L4. baseline and differential.
GenevestigatoriQ9H6L4.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
PfamiPF00514. Arm. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Small intestine.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skin.
  4. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-169, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiARMC7_HUMAN
AccessioniPrimary (citable) accession number: Q9H6L4
Secondary accession number(s): B4DVA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2001
Last modified: April 29, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.