Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Armadillo repeat-containing protein 7

Gene

ARMC7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Enzyme and pathway databases

SignaLinkiQ9H6L4.

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo repeat-containing protein 7
Gene namesi
Name:ARMC7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:26168. ARMC7.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000125449.
PharmGKBiPA134901380.

Polymorphism and mutation databases

BioMutaiARMC7.
DMDMi74733612.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002426661 – 198Armadillo repeat-containing protein 7Add BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei169PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H6L4.
MaxQBiQ9H6L4.
PaxDbiQ9H6L4.
PeptideAtlasiQ9H6L4.
PRIDEiQ9H6L4.
TopDownProteomicsiQ9H6L4-1. [Q9H6L4-1]

PTM databases

iPTMnetiQ9H6L4.
PhosphoSitePlusiQ9H6L4.

Expressioni

Gene expression databases

BgeeiENSG00000125449.
CleanExiHS_ARMC7.
ExpressionAtlasiQ9H6L4. baseline and differential.
GenevisibleiQ9H6L4. HS.

Organism-specific databases

HPAiHPA024229.
HPA053076.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122766. 29 interactors.
IntActiQ9H6L4. 44 interactors.
MINTiMINT-1447895.
STRINGi9606.ENSP00000245543.

Structurei

3D structure databases

ProteinModelPortaliQ9H6L4.
SMRiQ9H6L4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati57 – 99ARM 1Add BLAST43
Repeati100 – 140ARM 2Add BLAST41

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4646. Eukaryota.
ENOG4111JC6. LUCA.
GeneTreeiENSGT00510000048298.
HOGENOMiHOG000231171.
HOVERGENiHBG061557.
InParanoidiQ9H6L4.
OMAiQCMLRFS.
OrthoDBiEOG091G0DGX.
PhylomeDBiQ9H6L4.
TreeFamiTF354322.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
PfamiView protein in Pfam
PF00514. Arm. 1 hit.
SMARTiView protein in SMART
SM00185. ARM. 2 hits.
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H6L4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQKPKVDPH VGRLGYLQAL VTEFQETQSQ DAKEQVLANL ANFAYDPSNY
60 70 80 90 100
EYLRQLQVLD LFLDSLSEEN ETLVEFAIGG LCNLCPDRAN KEHILHAGGV
110 120 130 140 150
PLIINCLSSP NEETVLSAIT TLMHLSPPGR SFLPELTATP VVQCMLRFSL
160 170 180 190
SASARLRNLA QIFLEDFCSP RQVAEARSRQ AHSALGIPLP RSVAPRQR
Length:198
Mass (Da):21,924
Last modified:March 1, 2001 - v1
Checksum:iB637A76677FE645E
GO
Isoform 2 (identifier: Q9H6L4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-103: VLDLFLDSLS...ILHAGGVPLI → EACATCAQTG...CCLPSPRSCT
     104-198: Missing.

Note: No experimental confirmation available.
Show »
Length:103
Mass (Da):11,417
Checksum:iF9E32FBBE427497F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05693658 – 103VLDLF…GVPLI → EACATCAQTGPTRSTSCTQE VSHSSSTAYPAPMRRRCCLP SPRSCT in isoform 2. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_056937104 – 198Missing in isoform 2. 1 PublicationAdd BLAST95

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025813 mRNA. Translation: BAB15242.1.
AK300997 mRNA. Translation: BAG62616.1.
AC022211 Genomic DNA. No translation available.
AC111186 Genomic DNA. No translation available.
BC011728 mRNA. Translation: AAH11728.1.
CCDSiCCDS11714.1. [Q9H6L4-1]
CCDS77107.1. [Q9H6L4-2]
RefSeqiNP_001291200.1. NM_001304271.1. [Q9H6L4-2]
NP_001291201.1. NM_001304272.1.
NP_001291202.1. NM_001304273.1.
NP_078861.1. NM_024585.3. [Q9H6L4-1]
UniGeneiHs.413047.

Genome annotation databases

EnsembliENST00000245543; ENSP00000245543; ENSG00000125449. [Q9H6L4-1]
ENST00000581078; ENSP00000462962; ENSG00000125449. [Q9H6L4-2]
GeneIDi79637.
KEGGihsa:79637.
UCSCiuc002jmw.1. human. [Q9H6L4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025813 mRNA. Translation: BAB15242.1.
AK300997 mRNA. Translation: BAG62616.1.
AC022211 Genomic DNA. No translation available.
AC111186 Genomic DNA. No translation available.
BC011728 mRNA. Translation: AAH11728.1.
CCDSiCCDS11714.1. [Q9H6L4-1]
CCDS77107.1. [Q9H6L4-2]
RefSeqiNP_001291200.1. NM_001304271.1. [Q9H6L4-2]
NP_001291201.1. NM_001304272.1.
NP_001291202.1. NM_001304273.1.
NP_078861.1. NM_024585.3. [Q9H6L4-1]
UniGeneiHs.413047.

3D structure databases

ProteinModelPortaliQ9H6L4.
SMRiQ9H6L4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122766. 29 interactors.
IntActiQ9H6L4. 44 interactors.
MINTiMINT-1447895.
STRINGi9606.ENSP00000245543.

PTM databases

iPTMnetiQ9H6L4.
PhosphoSitePlusiQ9H6L4.

Polymorphism and mutation databases

BioMutaiARMC7.
DMDMi74733612.

Proteomic databases

EPDiQ9H6L4.
MaxQBiQ9H6L4.
PaxDbiQ9H6L4.
PeptideAtlasiQ9H6L4.
PRIDEiQ9H6L4.
TopDownProteomicsiQ9H6L4-1. [Q9H6L4-1]

Protocols and materials databases

DNASUi79637.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000245543; ENSP00000245543; ENSG00000125449. [Q9H6L4-1]
ENST00000581078; ENSP00000462962; ENSG00000125449. [Q9H6L4-2]
GeneIDi79637.
KEGGihsa:79637.
UCSCiuc002jmw.1. human. [Q9H6L4-1]

Organism-specific databases

CTDi79637.
GeneCardsiARMC7.
HGNCiHGNC:26168. ARMC7.
HPAiHPA024229.
HPA053076.
neXtProtiNX_Q9H6L4.
OpenTargetsiENSG00000125449.
PharmGKBiPA134901380.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4646. Eukaryota.
ENOG4111JC6. LUCA.
GeneTreeiENSGT00510000048298.
HOGENOMiHOG000231171.
HOVERGENiHBG061557.
InParanoidiQ9H6L4.
OMAiQCMLRFS.
OrthoDBiEOG091G0DGX.
PhylomeDBiQ9H6L4.
TreeFamiTF354322.

Enzyme and pathway databases

SignaLinkiQ9H6L4.

Miscellaneous databases

ChiTaRSiARMC7. human.
GenomeRNAii79637.
PROiQ9H6L4.

Gene expression databases

BgeeiENSG00000125449.
CleanExiHS_ARMC7.
ExpressionAtlasiQ9H6L4. baseline and differential.
GenevisibleiQ9H6L4. HS.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
PfamiView protein in Pfam
PF00514. Arm. 1 hit.
SMARTiView protein in SMART
SM00185. ARM. 2 hits.
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARMC7_HUMAN
AccessioniPrimary (citable) accession number: Q9H6L4
Secondary accession number(s): B4DVA4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2001
Last modified: March 15, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.