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Q9H6L4

- ARMC7_HUMAN

UniProt

Q9H6L4 - ARMC7_HUMAN

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Protein

Armadillo repeat-containing protein 7

Gene

ARMC7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ9H6L4.

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo repeat-containing protein 7
Gene namesi
Name:ARMC7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:26168. ARMC7.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134901380.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198Armadillo repeat-containing protein 7PRO_0000242666Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei169 – 1691Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9H6L4.
PaxDbiQ9H6L4.
PRIDEiQ9H6L4.

PTM databases

PhosphoSiteiQ9H6L4.

Expressioni

Gene expression databases

BgeeiQ9H6L4.
CleanExiHS_ARMC7.
ExpressionAtlasiQ9H6L4. baseline and differential.
GenevestigatoriQ9H6L4.

Organism-specific databases

HPAiHPA024229.
HPA053076.

Interactioni

Protein-protein interaction databases

BioGridi122766. 5 interactions.
IntActiQ9H6L4. 3 interactions.
MINTiMINT-1447895.
STRINGi9606.ENSP00000245543.

Structurei

3D structure databases

ProteinModelPortaliQ9H6L4.
SMRiQ9H6L4. Positions 11-167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati57 – 9943ARM 1Add
BLAST
Repeati100 – 14041ARM 2Add
BLAST

Sequence similaritiesi

Contains 2 ARM repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG312529.
GeneTreeiENSGT00510000048298.
HOGENOMiHOG000231171.
HOVERGENiHBG061557.
InParanoidiQ9H6L4.
OMAiQCMLRFS.
PhylomeDBiQ9H6L4.
TreeFamiTF354322.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
PfamiPF00514. Arm. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H6L4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQKPKVDPH VGRLGYLQAL VTEFQETQSQ DAKEQVLANL ANFAYDPSNY
60 70 80 90 100
EYLRQLQVLD LFLDSLSEEN ETLVEFAIGG LCNLCPDRAN KEHILHAGGV
110 120 130 140 150
PLIINCLSSP NEETVLSAIT TLMHLSPPGR SFLPELTATP VVQCMLRFSL
160 170 180 190
SASARLRNLA QIFLEDFCSP RQVAEARSRQ AHSALGIPLP RSVAPRQR
Length:198
Mass (Da):21,924
Last modified:March 1, 2001 - v1
Checksum:iB637A76677FE645E
GO
Isoform 2 (identifier: Q9H6L4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-103: VLDLFLDSLS...ILHAGGVPLI → EACATCAQTG...CCLPSPRSCT
     104-198: Missing.

Note: No experimental confirmation available

Show »
Length:103
Mass (Da):11,417
Checksum:iF9E32FBBE427497F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei58 – 10346VLDLF…GVPLI → EACATCAQTGPTRSTSCTQE VSHSSSTAYPAPMRRRCCLP SPRSCT in isoform 2. 1 PublicationVSP_056936Add
BLAST
Alternative sequencei104 – 19895Missing in isoform 2. 1 PublicationVSP_056937Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025813 mRNA. Translation: BAB15242.1.
AK300997 mRNA. Translation: BAG62616.1.
AC022211 Genomic DNA. No translation available.
AC111186 Genomic DNA. No translation available.
BC011728 mRNA. Translation: AAH11728.1.
CCDSiCCDS11714.1.
RefSeqiNP_078861.1. NM_024585.2.
UniGeneiHs.413047.

Genome annotation databases

EnsembliENST00000245543; ENSP00000245543; ENSG00000125449. [Q9H6L4-1]
ENST00000581078; ENSP00000462962; ENSG00000125449. [Q9H6L4-2]
GeneIDi79637.
KEGGihsa:79637.
UCSCiuc002jmw.1. human. [Q9H6L4-1]

Polymorphism databases

DMDMi74733612.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025813 mRNA. Translation: BAB15242.1 .
AK300997 mRNA. Translation: BAG62616.1 .
AC022211 Genomic DNA. No translation available.
AC111186 Genomic DNA. No translation available.
BC011728 mRNA. Translation: AAH11728.1 .
CCDSi CCDS11714.1.
RefSeqi NP_078861.1. NM_024585.2.
UniGenei Hs.413047.

3D structure databases

ProteinModelPortali Q9H6L4.
SMRi Q9H6L4. Positions 11-167.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122766. 5 interactions.
IntActi Q9H6L4. 3 interactions.
MINTi MINT-1447895.
STRINGi 9606.ENSP00000245543.

PTM databases

PhosphoSitei Q9H6L4.

Polymorphism databases

DMDMi 74733612.

Proteomic databases

MaxQBi Q9H6L4.
PaxDbi Q9H6L4.
PRIDEi Q9H6L4.

Protocols and materials databases

DNASUi 79637.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000245543 ; ENSP00000245543 ; ENSG00000125449 . [Q9H6L4-1 ]
ENST00000581078 ; ENSP00000462962 ; ENSG00000125449 . [Q9H6L4-2 ]
GeneIDi 79637.
KEGGi hsa:79637.
UCSCi uc002jmw.1. human. [Q9H6L4-1 ]

Organism-specific databases

CTDi 79637.
GeneCardsi GC17P073106.
HGNCi HGNC:26168. ARMC7.
HPAi HPA024229.
HPA053076.
neXtProti NX_Q9H6L4.
PharmGKBi PA134901380.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG312529.
GeneTreei ENSGT00510000048298.
HOGENOMi HOG000231171.
HOVERGENi HBG061557.
InParanoidi Q9H6L4.
OMAi QCMLRFS.
PhylomeDBi Q9H6L4.
TreeFami TF354322.

Enzyme and pathway databases

SignaLinki Q9H6L4.

Miscellaneous databases

ChiTaRSi ARMC7. human.
GenomeRNAii 79637.
NextBioi 68753.
PROi Q9H6L4.

Gene expression databases

Bgeei Q9H6L4.
CleanExi HS_ARMC7.
ExpressionAtlasi Q9H6L4. baseline and differential.
Genevestigatori Q9H6L4.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view ]
Pfami PF00514. Arm. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Small intestine.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skin.
  4. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-169, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiARMC7_HUMAN
AccessioniPrimary (citable) accession number: Q9H6L4
Secondary accession number(s): B4DVA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2001
Last modified: November 26, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3