ID   PRR36_HUMAN             Reviewed;        1346 AA.
AC   Q9H6K5; A0A087WZ52; Q9H3X1;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-FEB-2015, sequence version 2.
DT   27-MAR-2024, entry version 118.
DE   RecName: Full=Proline-rich protein 36 {ECO:0000312|HGNC:HGNC:26172};
GN   Name=PRR36 {ECO:0000312|HGNC:HGNC:26172};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 679-1346 (ISOFORM 2).
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1109-1346 (ISOFORMS 1/2).
RC   TISSUE=Amygdala;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1310, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Leukemic T-cell;
RX   PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA   Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA   Rodionov V., Han D.K.;
RT   "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT   reveals system-wide modulation of protein-protein interactions.";
RL   Sci. Signal. 2:RA46-RA46(2009).
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1310, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA   Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA   Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT   "System-wide temporal characterization of the proteome and phosphoproteome
RT   of human embryonic stem cell differentiation.";
RL   Sci. Signal. 4:RS3-RS3(2011).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9H6K5-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9H6K5-2; Sequence=VSP_057467;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB15254.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AC010336; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF459711; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK025837; BAB15254.1; ALT_INIT; mRNA.
DR   EMBL; AL442075; CAC09441.1; -; mRNA.
DR   CCDS; CCDS74276.1; -. [Q9H6K5-1]
DR   RefSeq; NP_001177396.1; NM_001190467.1. [Q9H6K5-1]
DR   AlphaFoldDB; Q9H6K5; -.
DR   IntAct; Q9H6K5; 6.
DR   MINT; Q9H6K5; -.
DR   STRING; 9606.ENSP00000482374; -.
DR   GlyGen; Q9H6K5; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q9H6K5; -.
DR   PhosphoSitePlus; Q9H6K5; -.
DR   BioMuta; PRR36; -.
DR   DMDM; 74718524; -.
DR   EPD; Q9H6K5; -.
DR   jPOST; Q9H6K5; -.
DR   MassIVE; Q9H6K5; -.
DR   MaxQB; Q9H6K5; -.
DR   PaxDb; 9606-ENSP00000482374; -.
DR   PeptideAtlas; Q9H6K5; -.
DR   Pumba; Q9H6K5; -.
DR   Antibodypedia; 70670; 3 antibodies from 3 providers.
DR   Ensembl; ENST00000618550.5; ENSP00000482374.1; ENSG00000183248.12. [Q9H6K5-1]
DR   GeneID; 80164; -.
DR   KEGG; hsa:80164; -.
DR   MANE-Select; ENST00000618550.5; ENSP00000482374.1; NM_001190467.2; NP_001177396.1.
DR   UCSC; uc032hlq.2; human.
DR   AGR; HGNC:26172; -.
DR   CTD; 80164; -.
DR   GeneCards; PRR36; -.
DR   HGNC; HGNC:26172; PRR36.
DR   HPA; ENSG00000183248; Group enriched (brain, pituitary gland).
DR   neXtProt; NX_Q9H6K5; -.
DR   OpenTargets; ENSG00000183248; -.
DR   VEuPathDB; HostDB:ENSG00000183248; -.
DR   eggNOG; ENOG502S4AG; Eukaryota.
DR   GeneTree; ENSGT00940000154382; -.
DR   HOGENOM; CLU_286361_0_0_1; -.
DR   InParanoid; Q9H6K5; -.
DR   OMA; TSPXTSP; -.
DR   OrthoDB; 4330736at2759; -.
DR   PathwayCommons; Q9H6K5; -.
DR   SignaLink; Q9H6K5; -.
DR   BioGRID-ORCS; 80164; 2 hits in 162 CRISPR screens.
DR   ChiTaRS; PRR36; human.
DR   GenomeRNAi; 80164; -.
DR   Pharos; Q9H6K5; Tdark.
DR   PRO; PR:Q9H6K5; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q9H6K5; Protein.
DR   Bgee; ENSG00000183248; Expressed in cortical plate and 93 other cell types or tissues.
DR   ExpressionAtlas; Q9H6K5; baseline and differential.
DR   InterPro; IPR027907; BTBD8_C.
DR   PANTHER; PTHR22427:SF8; PROLINE-RICH PROTEIN 36; 1.
DR   PANTHER; PTHR22427; UNCHARACTERIZED; 1.
DR   Pfam; PF15363; BTBD8_C; 1.
DR   Genevisible; Q9H6K5; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Phosphoprotein; Reference proteome.
FT   CHAIN           1..1346
FT                   /note="Proline-rich protein 36"
FT                   /id="PRO_0000329437"
FT   REGION          1..403
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          426..512
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          537..606
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          633..679
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          711..1155
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1168..1240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        23..42
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        79..93
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        206..223
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        236..257
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        312..348
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        349..367
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        370..397
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        426..445
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        490..508
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        551..586
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        587..606
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        647..662
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        663..679
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        711..735
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        736..750
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        758..772
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        779..870
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        886..1032
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1043..1087
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1097..1111
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1112..1132
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1172..1186
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1310
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:19690332,
FT                   ECO:0007744|PubMed:21406692"
FT   VAR_SEQ         729..751
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_057467"
FT   CONFLICT        1170
FT                   /note="L -> P (in Ref. 2; BAB15254)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1346 AA;  132748 MW;  3021FAACA0F80262 CRC64;
     MDNKRDKAKA GAAARTPAAR APGLLTPRPP GSPRPPPPVT PAALRVLGAA GAVGRKPLAE
     RAGGIGGATI PESAPRAGPT RSAGTSSRNP ASRPPASGRG ERAPPAKNTS PGPVSSPGRA
     SGTTRPGPLG QKGLRISAEE TVARGKATEA PKRSALSAGA RRDTSGPTPG TPSPAMARRS
     RAAGTEVGLP RPAPSARPRP PTEGPRKSVS SASEHSTTEP SPAARRRPSA GGGLQRPASR
     SLSSSATPLS SPARSGPSAR GTPRAPAHPS QPKPKGLQAL RPPQVTPPRK DAAPALGPLS
     SSPLATPSPS GTKARPVPPP DNAATPLPAT LPPSPPVTPP PPAALQSQAP PTLPATPHSS
     SLTCQLATPL PLAPPSPSAP PSLQTLPSPP ATPPSQVPPT QLIMSFPEAG VSSLATAAFV
     ASVSPSVSSP LQSMPPTQAN PALPSLPTLL SPLATPPLSA MSPLQGPVSP ATSLGNSAFP
     LAALPQPGLS ALTTPPPQAS PSPSPPSLQA TPHTLATLPL QDSPLLATLP LQASPSPLTT
     VSLQDPPLVS PSLLASPPLQ APPHPQAPPS MTTPPMQAPP SLQTIPPIQV PHSLTSPSLQ
     APPSPLALSS LQATTSLGSP TLQATHSFLT MSPRQTQASL ISPSRPASTP PDSPPLQAPL
     SLPASPPLQT SLSPAVSPLS SPLTIHPLQA LSSLASHSPQ APLSSLIMPP LETQSSLAPP
     SLQTPPASLT TPPLENLPSL APPPLQTASA PLTTPPLENL PSLAPPPLQT ASAPLTTPHL
     ETPPCPAPCP LQAPPSPLTT PPPETPSSIA TPPPQAPPAL ASPPLQGLPS PPLSPLATPP
     PQAPPALALP PLQAPPSPPA SPPLSPLATP SPQAPNALAV HLLQAPFSPP PSPPVQAPFS
     PPASPPVSPS ATPPSQAPPS LAAPPLQVPP SPPASPPMSP SATPPPQAPP PLAAPPLQVP
     PSPPASPPMS PSATPPPRVP PLLAAPPLQV PPSPPASLPM SPLAKPPPQA PPALATPPLQ
     ALPSPPASFP GQAPFSPSAS LPMSPLATPP PQAPPVLAAP LLQVPPSPPA SPTLQAPRRP
     PTPGPDTSVS GPRLTLALAP GPPPPPSRSP SSTLSGPDLA GHSSSATSTP EELRGYDSGP
     EGGAAASPPP DAELAACHPA AWSRGPAPPL AFRGAPGAPL PWPPATGPGS ADGLCTIYET
     EGPESATPAP GALDPGPSPG TSGGKAAAGA GAGASSRSPK QARLGELPLG ALQASVVQHL
     LSRTLLLAAA EGAAGGSGGG PGGAEGGGVT GGARAALSDA ELGRWAELLS PLDESRASIT
     SVTSFSPDDV ASPQGDWTVV EVETFH
//