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Protein

Proline-rich protein 36

Gene

PRR36

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-rich protein 36Imported
Gene namesi
Name:PRR36Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:26172. PRR36.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13461346Proline-rich protein 36PRO_0000329437Add
BLAST

Proteomic databases

MaxQBiQ9H6K5.
PaxDbiQ9H6K5.
PRIDEiQ9H6K5.

PTM databases

PhosphoSiteiQ9H6K5.

Expressioni

Gene expression databases

GenevestigatoriQ9H6K5.

Organism-specific databases

HPAiHPA062741.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi17 – 12191203Pro-richPROSITE-ProRule annotationAdd
BLAST
Compositional biasi1272 – 129221Gly-richPROSITE-ProRule annotationAdd
BLAST

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000170825.

Family and domain databases

InterProiIPR027907. DUF4596.
[Graphical view]
PfamiPF15363. DUF4596. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H6K5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDNKRDKAKA GAAARTPAAR APGLLTPRPP GSPRPPPPVT PAALRVLGAA
60 70 80 90 100
GAVGRKPLAE RAGGIGGATI PESAPRAGPT RSAGTSSRNP ASRPPASGRG
110 120 130 140 150
ERAPPAKNTS PGPVSSPGRA SGTTRPGPLG QKGLRISAEE TVARGKATEA
160 170 180 190 200
PKRSALSAGA RRDTSGPTPG TPSPAMARRS RAAGTEVGLP RPAPSARPRP
210 220 230 240 250
PTEGPRKSVS SASEHSTTEP SPAARRRPSA GGGLQRPASR SLSSSATPLS
260 270 280 290 300
SPARSGPSAR GTPRAPAHPS QPKPKGLQAL RPPQVTPPRK DAAPALGPLS
310 320 330 340 350
SSPLATPSPS GTKARPVPPP DNAATPLPAT LPPSPPVTPP PPAALQSQAP
360 370 380 390 400
PTLPATPHSS SLTCQLATPL PLAPPSPSAP PSLQTLPSPP ATPPSQVPPT
410 420 430 440 450
QLIMSFPEAG VSSLATAAFV ASVSPSVSSP LQSMPPTQAN PALPSLPTLL
460 470 480 490 500
SPLATPPLSA MSPLQGPVSP ATSLGNSAFP LAALPQPGLS ALTTPPPQAS
510 520 530 540 550
PSPSPPSLQA TPHTLATLPL QDSPLLATLP LQASPSPLTT VSLQDPPLVS
560 570 580 590 600
PSLLASPPLQ APPHPQAPPS MTTPPMQAPP SLQTIPPIQV PHSLTSPSLQ
610 620 630 640 650
APPSPLALSS LQATTSLGSP TLQATHSFLT MSPRQTQASL ISPSRPASTP
660 670 680 690 700
PDSPPLQAPL SLPASPPLQT SLSPAVSPLS SPLTIHPLQA LSSLASHSPQ
710 720 730 740 750
APLSSLIMPP LETQSSLAPP SLQTPPASLT TPPLENLPSL APPPLQTASA
760 770 780 790 800
PLTTPPLENL PSLAPPPLQT ASAPLTTPHL ETPPCPAPCP LQAPPSPLTT
810 820 830 840 850
PPPETPSSIA TPPPQAPPAL ASPPLQGLPS PPLSPLATPP PQAPPALALP
860 870 880 890 900
PLQAPPSPPA SPPLSPLATP SPQAPNALAV HLLQAPFSPP PSPPVQAPFS
910 920 930 940 950
PPASPPVSPS ATPPSQAPPS LAAPPLQVPP SPPASPPMSP SATPPPQAPP
960 970 980 990 1000
PLAAPPLQVP PSPPASPPMS PSATPPPRVP PLLAAPPLQV PPSPPASLPM
1010 1020 1030 1040 1050
SPLAKPPPQA PPALATPPLQ ALPSPPASFP GQAPFSPSAS LPMSPLATPP
1060 1070 1080 1090 1100
PQAPPVLAAP LLQVPPSPPA SPTLQAPRRP PTPGPDTSVS GPRLTLALAP
1110 1120 1130 1140 1150
GPPPPPSRSP SSTLSGPDLA GHSSSATSTP EELRGYDSGP EGGAAASPPP
1160 1170 1180 1190 1200
DAELAACHPA AWSRGPAPPL AFRGAPGAPL PWPPATGPGS ADGLCTIYET
1210 1220 1230 1240 1250
EGPESATPAP GALDPGPSPG TSGGKAAAGA GAGASSRSPK QARLGELPLG
1260 1270 1280 1290 1300
ALQASVVQHL LSRTLLLAAA EGAAGGSGGG PGGAEGGGVT GGARAALSDA
1310 1320 1330 1340
ELGRWAELLS PLDESRASIT SVTSFSPDDV ASPQGDWTVV EVETFH
Length:1,346
Mass (Da):132,748
Last modified:February 4, 2015 - v2
Checksum:i3021FAACA0F80262
GO
Isoform 2 (identifier: Q9H6K5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     729-751: Missing.

Show »
Length:1,323
Mass (Da):130,440
Checksum:i6D7C429B04F87701
GO

Sequence cautioni

The sequence BAB15254.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1170 – 11701L → P in BAB15254. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei729 – 75123Missing in isoform 2. CuratedVSP_057467Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010336 Genomic DNA. No translation available.
KF459711 Genomic DNA. No translation available.
AK025837 mRNA. Translation: BAB15254.1. Different initiation.
AL442075 mRNA. Translation: CAC09441.1.
UniGeneiHs.288540.

Genome annotation databases

EnsembliENST00000618550; ENSP00000482374; ENSG00000183248.

Polymorphism databases

DMDMi74718524.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010336 Genomic DNA. No translation available.
KF459711 Genomic DNA. No translation available.
AK025837 mRNA. Translation: BAB15254.1. Different initiation.
AL442075 mRNA. Translation: CAC09441.1.
UniGeneiHs.288540.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9H6K5.

Polymorphism databases

DMDMi74718524.

Proteomic databases

MaxQBiQ9H6K5.
PaxDbiQ9H6K5.
PRIDEiQ9H6K5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000618550; ENSP00000482374; ENSG00000183248.

Organism-specific databases

HGNCiHGNC:26172. PRR36.
HPAiHPA062741.
neXtProtiNX_Q9H6K5.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000170825.

Gene expression databases

GenevestigatoriQ9H6K5.

Family and domain databases

InterProiIPR027907. DUF4596.
[Graphical view]
PfamiPF15363. DUF4596. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 679-1346 (ISOFORM 2).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1109-1346 (ISOFORMS 1/2).
    Tissue: Amygdala.

Entry informationi

Entry nameiPRR36_HUMAN
AccessioniPrimary (citable) accession number: Q9H6K5
Secondary accession number(s): A0A087WZ52, Q9H3X1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: February 4, 2015
Last modified: February 4, 2015
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.