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Q9H6K1

- CF106_HUMAN

UniProt

Q9H6K1 - CF106_HUMAN

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Protein

Uncharacterized protein C6orf106

Gene

C6orf106

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C6orf106
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:21215. C6orf106.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134935866.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298Uncharacterized protein C6orf106PRO_0000089519Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei215 – 2151Phosphoserine3 Publications
Modified residuei272 – 2721Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9H6K1.
PaxDbiQ9H6K1.
PRIDEiQ9H6K1.

PTM databases

PhosphoSiteiQ9H6K1.

Expressioni

Gene expression databases

BgeeiQ9H6K1.
CleanExiHS_C6orf106.
ExpressionAtlasiQ9H6K1. baseline and differential.
GenevestigatoriQ9H6K1.

Organism-specific databases

HPAiHPA034489.
HPA034490.

Interactioni

Protein-protein interaction databases

BioGridi122282. 5 interactions.
IntActiQ9H6K1. 1 interaction.
STRINGi9606.ENSP00000363135.

Structurei

3D structure databases

ProteinModelPortaliQ9H6K1.
SMRiQ9H6K1. Positions 74-180.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG304920.
GeneTreeiENSGT00490000043415.
HOGENOMiHOG000236314.
HOVERGENiHBG055075.
InParanoidiQ9H6K1.
OMAiNVPSMSF.
OrthoDBiEOG72VH6V.
PhylomeDBiQ9H6K1.
TreeFamiTF105872.

Family and domain databases

InterProiIPR009060. UBA-like.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H6K1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGMDVDLDP ELMQKFSCLG TTDKDVLISE FQRLLGFQLN PAGCAFFLDM
60 70 80 90 100
TNWNLQAAIG AYYDFESPNI SVPSMSFVED VTIGEGESIP PDTQFVKTWR
110 120 130 140 150
IQNSGAEAWP PGVCLKYVGG DQFGHVNMVM VRSLEPQEIA DVSVQMCSPS
160 170 180 190 200
RAGMYQGQWR MCTATGLYYG DVIWVILSVE VGGLLGVTQQ LSSFETEFNT
210 220 230 240 250
QPHRKVEGNF NPFASPQKNR QSDENNLKDP GGSEFDSISK NTWAPAPDTW
260 270 280 290
APAPDQTEQD QNRLSQNSVN LSPSSHANNL SVVTYSKGLH GPYPFGQS
Length:298
Mass (Da):32,872
Last modified:February 21, 2006 - v2
Checksum:i3BA3E7F7B4D26D76
GO
Isoform 2 (identifier: Q9H6K1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     105-170: Missing.

Show »
Length:232
Mass (Da):25,673
Checksum:iC1380288B8EB3AF7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 541N → S in BAB71327. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei105 – 17066Missing in isoform 2. 1 PublicationVSP_017259Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK025848 mRNA. Translation: BAB15258.1. Sequence problems.
AK056964 mRNA. Translation: BAB71327.1.
AK313410 mRNA. Translation: BAG36204.1.
AL031577, AL451165 Genomic DNA. Translation: CAI20393.1.
AL031577, AL451165 Genomic DNA. Translation: CAI20394.1.
AL451165, AL031577 Genomic DNA. Translation: CAH70507.1.
AL451165, AL031577 Genomic DNA. Translation: CAH70508.1.
CH471081 Genomic DNA. Translation: EAX03790.1.
BC002328 mRNA. Translation: AAH02328.1.
BC010184 mRNA. Translation: AAH10184.1.
BC075810 mRNA. Translation: AAH75810.1.
CCDSiCCDS4795.1. [Q9H6K1-2]
CCDS4796.1. [Q9H6K1-1]
RefSeqiNP_073595.2. NM_022758.5. [Q9H6K1-2]
NP_077270.1. NM_024294.3. [Q9H6K1-1]
UniGeneiHs.643498.
Hs.716193.

Genome annotation databases

EnsembliENST00000374023; ENSP00000363135; ENSG00000196821. [Q9H6K1-1]
ENST00000374026; ENSP00000363138; ENSG00000196821. [Q9H6K1-2]
GeneIDi64771.
KEGGihsa:64771.
UCSCiuc003ojr.2. human. [Q9H6K1-1]
uc003ojs.2. human. [Q9H6K1-2]

Polymorphism databases

DMDMi88984085.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK025848 mRNA. Translation: BAB15258.1 . Sequence problems.
AK056964 mRNA. Translation: BAB71327.1 .
AK313410 mRNA. Translation: BAG36204.1 .
AL031577 , AL451165 Genomic DNA. Translation: CAI20393.1 .
AL031577 , AL451165 Genomic DNA. Translation: CAI20394.1 .
AL451165 , AL031577 Genomic DNA. Translation: CAH70507.1 .
AL451165 , AL031577 Genomic DNA. Translation: CAH70508.1 .
CH471081 Genomic DNA. Translation: EAX03790.1 .
BC002328 mRNA. Translation: AAH02328.1 .
BC010184 mRNA. Translation: AAH10184.1 .
BC075810 mRNA. Translation: AAH75810.1 .
CCDSi CCDS4795.1. [Q9H6K1-2 ]
CCDS4796.1. [Q9H6K1-1 ]
RefSeqi NP_073595.2. NM_022758.5. [Q9H6K1-2 ]
NP_077270.1. NM_024294.3. [Q9H6K1-1 ]
UniGenei Hs.643498.
Hs.716193.

3D structure databases

ProteinModelPortali Q9H6K1.
SMRi Q9H6K1. Positions 74-180.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122282. 5 interactions.
IntActi Q9H6K1. 1 interaction.
STRINGi 9606.ENSP00000363135.

PTM databases

PhosphoSitei Q9H6K1.

Polymorphism databases

DMDMi 88984085.

Proteomic databases

MaxQBi Q9H6K1.
PaxDbi Q9H6K1.
PRIDEi Q9H6K1.

Protocols and materials databases

DNASUi 64771.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374023 ; ENSP00000363135 ; ENSG00000196821 . [Q9H6K1-1 ]
ENST00000374026 ; ENSP00000363138 ; ENSG00000196821 . [Q9H6K1-2 ]
GeneIDi 64771.
KEGGi hsa:64771.
UCSCi uc003ojr.2. human. [Q9H6K1-1 ]
uc003ojs.2. human. [Q9H6K1-2 ]

Organism-specific databases

CTDi 64771.
GeneCardsi GC06M035732.
H-InvDB HIX0005794.
HGNCi HGNC:21215. C6orf106.
HPAi HPA034489.
HPA034490.
MIMi 612217. gene.
neXtProti NX_Q9H6K1.
PharmGKBi PA134935866.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG304920.
GeneTreei ENSGT00490000043415.
HOGENOMi HOG000236314.
HOVERGENi HBG055075.
InParanoidi Q9H6K1.
OMAi NVPSMSF.
OrthoDBi EOG72VH6V.
PhylomeDBi Q9H6K1.
TreeFami TF105872.

Miscellaneous databases

ChiTaRSi C6orf106. human.
GenomeRNAii 64771.
NextBioi 66777.
SOURCEi Search...

Gene expression databases

Bgeei Q9H6K1.
CleanExi HS_C6orf106.
ExpressionAtlasi Q9H6K1. baseline and differential.
Genevestigatori Q9H6K1.

Family and domain databases

InterProi IPR009060. UBA-like.
[Graphical view ]
SUPFAMi SSF46934. SSF46934. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Skeletal muscle and Uterus.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta and Uterus.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-215, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-215 AND SER-272, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-215, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCF106_HUMAN
AccessioniPrimary (citable) accession number: Q9H6K1
Secondary accession number(s): B2R8K7
, Q5VV77, Q96MG5, Q9BUR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: February 21, 2006
Last modified: October 29, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3