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Protein

UPF0705 protein C11orf49

Gene

C11orf49

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0705 protein C11orf49
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149179.13
HGNCiHGNC:28720 C11orf49
neXtProtiNX_Q9H6J7

Pathology & Biotechi

Organism-specific databases

DisGeNETi79096
OpenTargetsiENSG00000149179
PharmGKBiPA143485345

Polymorphism and mutation databases

DMDMi134035405

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002814251 – 331UPF0705 protein C11orf49Add BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei319PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9H6J7
PaxDbiQ9H6J7
PeptideAtlasiQ9H6J7
PRIDEiQ9H6J7

PTM databases

iPTMnetiQ9H6J7
PhosphoSitePlusiQ9H6J7

Expressioni

Gene expression databases

BgeeiENSG00000149179
CleanExiHS_C11orf49
ExpressionAtlasiQ9H6J7 baseline and differential
GenevisibleiQ9H6J7 HS

Organism-specific databases

HPAiHPA040051
HPA040280

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi122543, 21 interactors
IntActiQ9H6J7, 17 interactors
MINTiQ9H6J7
STRINGi9606.ENSP00000367878

Structurei

3D structure databases

ProteinModelPortaliQ9H6J7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0705 family.Curated

Phylogenomic databases

eggNOGiENOG410IIYX Eukaryota
ENOG4110Y2Q LUCA
GeneTreeiENSGT00390000012935
HOGENOMiHOG000231517
HOVERGENiHBG056002
InParanoidiQ9H6J7
OMAiHVLFREF
OrthoDBiEOG091G0AWI
PhylomeDBiQ9H6J7
TreeFamiTF329168

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H6J7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSPERLALP DYEYLAQRHV LTYMEDAVCQ LLENREDISQ YGIARFFTEY
60 70 80 90 100
FNSVCQGTHI LFREFSFVQA TPHNRVSFLR AFWRCFRTVG KNGDLLTMKE
110 120 130 140 150
YHCLLQLLCP DFPLELTQKA ARIVLMDDAM DCLMSFSDFL FAFQIQFYYS
160 170 180 190 200
EFLDSVAAIY EDLLSGKNPN TVIVPTSSSG QHRQRPALGG AGTLEGVEAS
210 220 230 240 250
LFYQCLENLC DRHKYSCPPP ALVKEALSNV QRLTFYGFLM ALSKHRGINQ
260 270 280 290 300
ALGALPDKGD LMHDPAMDEE LERLLAQVPG LVNSVTASPE ASCLPSRTPP
310 320 330
RVGSPWRPLH HSRKVDGESD GSTEETDESE T
Length:331
Mass (Da):37,353
Last modified:March 20, 2007 - v2
Checksum:i7D1973A9984EE429
GO
Isoform 2 (identifier: Q9H6J7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     274-274: L → LLLPFFR

Show »
Length:337
Mass (Da):38,127
Checksum:iD6B8F9BB3561D0FF
GO
Isoform 3 (identifier: Q9H6J7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     275-331: Missing.

Show »
Length:274
Mass (Da):31,316
Checksum:i3010B30DE8CCDD09
GO
Isoform 4 (identifier: Q9H6J7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     275-331: LAQVPGLVNS...STEETDESET → VVRSKLHRTS...PYHYRWEPRE

Note: No experimental confirmation available.
Show »
Length:326
Mass (Da):37,531
Checksum:i4D492B1AD1B67954
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88T → A in BAB15262 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024000274L → LLLPFFR in isoform 2. 2 Publications1
Alternative sequenceiVSP_024001275 – 331Missing in isoform 3. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_044902275 – 331LAQVP…DESET → VVRSKLHRTSRQHRAKEPGA FGFQRREKQEALERVSSASV PTPYHYRWEPRE in isoform 4. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025863 mRNA Translation: BAB15262.1
CR457351 mRNA Translation: CAG33632.1
AL136575 mRNA Translation: CAB66510.2
AC021573 Genomic DNA No translation available.
AC090470 Genomic DNA No translation available.
AC090589 Genomic DNA No translation available.
AC103792 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW67970.1
CH471064 Genomic DNA Translation: EAW67972.1
BC001860 mRNA Translation: AAH01860.1
BC009455 mRNA Translation: AAH09455.1
BC013988 mRNA Translation: AAH13988.1
BC052291 mRNA Translation: AAH52291.1
BU728094 mRNA No translation available.
CCDSiCCDS31479.1 [Q9H6J7-4]
CCDS31480.1 [Q9H6J7-2]
CCDS41641.1 [Q9H6J7-3]
CCDS7925.1 [Q9H6J7-1]
RefSeqiNP_001003676.1, NM_001003676.2 [Q9H6J7-3]
NP_001003677.1, NM_001003677.2 [Q9H6J7-2]
NP_001003678.1, NM_001003678.2 [Q9H6J7-4]
NP_077018.1, NM_024113.4 [Q9H6J7-1]
UniGeneiHs.368296

Genome annotation databases

EnsembliENST00000278460; ENSP00000278460; ENSG00000149179 [Q9H6J7-1]
ENST00000378615; ENSP00000367878; ENSG00000149179 [Q9H6J7-2]
ENST00000378618; ENSP00000367881; ENSG00000149179 [Q9H6J7-4]
ENST00000395460; ENSP00000378844; ENSG00000149179 [Q9H6J7-3]
GeneIDi79096
KEGGihsa:79096
UCSCiuc001ndp.5 human [Q9H6J7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCK049_HUMAN
AccessioniPrimary (citable) accession number: Q9H6J7
Secondary accession number(s): D3DQQ8
, E9PAX7, Q7L077, Q96CS8, Q9BQH4, Q9BUW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: March 28, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health