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Protein

UPF0705 protein C11orf49

Gene

C11orf49

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0705 protein C11orf49
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:28720. C11orf49.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485345.

Polymorphism and mutation databases

DMDMi134035405.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331UPF0705 protein C11orf49PRO_0000281425Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei319 – 3191PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H6J7.
MaxQBiQ9H6J7.
PaxDbiQ9H6J7.
PeptideAtlasiQ9H6J7.
PRIDEiQ9H6J7.

PTM databases

iPTMnetiQ9H6J7.

Expressioni

Gene expression databases

BgeeiQ9H6J7.
CleanExiHS_C11orf49.
ExpressionAtlasiQ9H6J7. baseline and differential.
GenevisibleiQ9H6J7. HS.

Organism-specific databases

HPAiHPA040051.
HPA040280.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PNMA5Q96PV43EBI-721300,EBI-10171633
RAB17Q9H0T73EBI-721300,EBI-721615
RAB7L1Q6FGU73EBI-721300,EBI-10249635

Protein-protein interaction databases

BioGridi122543. 21 interactions.
IntActiQ9H6J7. 14 interactions.
MINTiMINT-2876192.
STRINGi9606.ENSP00000367878.

Structurei

3D structure databases

ProteinModelPortaliQ9H6J7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0705 family.Curated

Phylogenomic databases

eggNOGiENOG410IIYX. Eukaryota.
ENOG4110Y2Q. LUCA.
GeneTreeiENSGT00390000012935.
HOGENOMiHOG000231517.
HOVERGENiHBG056002.
InParanoidiQ9H6J7.
OMAiXCPPPAL.
PhylomeDBiQ9H6J7.
TreeFamiTF329168.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H6J7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSPERLALP DYEYLAQRHV LTYMEDAVCQ LLENREDISQ YGIARFFTEY
60 70 80 90 100
FNSVCQGTHI LFREFSFVQA TPHNRVSFLR AFWRCFRTVG KNGDLLTMKE
110 120 130 140 150
YHCLLQLLCP DFPLELTQKA ARIVLMDDAM DCLMSFSDFL FAFQIQFYYS
160 170 180 190 200
EFLDSVAAIY EDLLSGKNPN TVIVPTSSSG QHRQRPALGG AGTLEGVEAS
210 220 230 240 250
LFYQCLENLC DRHKYSCPPP ALVKEALSNV QRLTFYGFLM ALSKHRGINQ
260 270 280 290 300
ALGALPDKGD LMHDPAMDEE LERLLAQVPG LVNSVTASPE ASCLPSRTPP
310 320 330
RVGSPWRPLH HSRKVDGESD GSTEETDESE T
Length:331
Mass (Da):37,353
Last modified:March 20, 2007 - v2
Checksum:i7D1973A9984EE429
GO
Isoform 2 (identifier: Q9H6J7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     274-274: L → LLLPFFR

Show »
Length:337
Mass (Da):38,127
Checksum:iD6B8F9BB3561D0FF
GO
Isoform 3 (identifier: Q9H6J7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     275-331: Missing.

Show »
Length:274
Mass (Da):31,316
Checksum:i3010B30DE8CCDD09
GO
Isoform 4 (identifier: Q9H6J7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     275-331: LAQVPGLVNS...STEETDESET → VVRSKLHRTS...PYHYRWEPRE

Note: No experimental confirmation available.
Show »
Length:326
Mass (Da):37,531
Checksum:i4D492B1AD1B67954
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti88 – 881T → A in BAB15262 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei274 – 2741L → LLLPFFR in isoform 2. 2 PublicationsVSP_024000
Alternative sequencei275 – 33157Missing in isoform 3. 1 PublicationVSP_024001Add
BLAST
Alternative sequencei275 – 33157LAQVP…DESET → VVRSKLHRTSRQHRAKEPGA FGFQRREKQEALERVSSASV PTPYHYRWEPRE in isoform 4. 1 PublicationVSP_044902Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025863 mRNA. Translation: BAB15262.1.
CR457351 mRNA. Translation: CAG33632.1.
AL136575 mRNA. Translation: CAB66510.2.
AC021573 Genomic DNA. No translation available.
AC090470 Genomic DNA. No translation available.
AC090589 Genomic DNA. No translation available.
AC103792 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW67970.1.
CH471064 Genomic DNA. Translation: EAW67972.1.
BC001860 mRNA. Translation: AAH01860.1.
BC009455 mRNA. Translation: AAH09455.1.
BC013988 mRNA. Translation: AAH13988.1.
BC052291 mRNA. Translation: AAH52291.1.
BU728094 mRNA. No translation available.
CCDSiCCDS31479.1. [Q9H6J7-4]
CCDS31480.1. [Q9H6J7-2]
CCDS41641.1. [Q9H6J7-3]
CCDS7925.1. [Q9H6J7-1]
RefSeqiNP_001003676.1. NM_001003676.2. [Q9H6J7-3]
NP_001003677.1. NM_001003677.2. [Q9H6J7-2]
NP_001003678.1. NM_001003678.2. [Q9H6J7-4]
NP_077018.1. NM_024113.4. [Q9H6J7-1]
UniGeneiHs.368296.

Genome annotation databases

EnsembliENST00000278460; ENSP00000278460; ENSG00000149179. [Q9H6J7-1]
ENST00000378615; ENSP00000367878; ENSG00000149179. [Q9H6J7-2]
ENST00000378618; ENSP00000367881; ENSG00000149179. [Q9H6J7-4]
ENST00000395460; ENSP00000378844; ENSG00000149179. [Q9H6J7-3]
GeneIDi79096.
KEGGihsa:79096.
UCSCiuc001ndp.5. human. [Q9H6J7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025863 mRNA. Translation: BAB15262.1.
CR457351 mRNA. Translation: CAG33632.1.
AL136575 mRNA. Translation: CAB66510.2.
AC021573 Genomic DNA. No translation available.
AC090470 Genomic DNA. No translation available.
AC090589 Genomic DNA. No translation available.
AC103792 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW67970.1.
CH471064 Genomic DNA. Translation: EAW67972.1.
BC001860 mRNA. Translation: AAH01860.1.
BC009455 mRNA. Translation: AAH09455.1.
BC013988 mRNA. Translation: AAH13988.1.
BC052291 mRNA. Translation: AAH52291.1.
BU728094 mRNA. No translation available.
CCDSiCCDS31479.1. [Q9H6J7-4]
CCDS31480.1. [Q9H6J7-2]
CCDS41641.1. [Q9H6J7-3]
CCDS7925.1. [Q9H6J7-1]
RefSeqiNP_001003676.1. NM_001003676.2. [Q9H6J7-3]
NP_001003677.1. NM_001003677.2. [Q9H6J7-2]
NP_001003678.1. NM_001003678.2. [Q9H6J7-4]
NP_077018.1. NM_024113.4. [Q9H6J7-1]
UniGeneiHs.368296.

3D structure databases

ProteinModelPortaliQ9H6J7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122543. 21 interactions.
IntActiQ9H6J7. 14 interactions.
MINTiMINT-2876192.
STRINGi9606.ENSP00000367878.

PTM databases

iPTMnetiQ9H6J7.

Polymorphism and mutation databases

DMDMi134035405.

Proteomic databases

EPDiQ9H6J7.
MaxQBiQ9H6J7.
PaxDbiQ9H6J7.
PeptideAtlasiQ9H6J7.
PRIDEiQ9H6J7.

Protocols and materials databases

DNASUi79096.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278460; ENSP00000278460; ENSG00000149179. [Q9H6J7-1]
ENST00000378615; ENSP00000367878; ENSG00000149179. [Q9H6J7-2]
ENST00000378618; ENSP00000367881; ENSG00000149179. [Q9H6J7-4]
ENST00000395460; ENSP00000378844; ENSG00000149179. [Q9H6J7-3]
GeneIDi79096.
KEGGihsa:79096.
UCSCiuc001ndp.5. human. [Q9H6J7-1]

Organism-specific databases

CTDi79096.
GeneCardsiC11orf49.
HGNCiHGNC:28720. C11orf49.
HPAiHPA040051.
HPA040280.
neXtProtiNX_Q9H6J7.
PharmGKBiPA143485345.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIYX. Eukaryota.
ENOG4110Y2Q. LUCA.
GeneTreeiENSGT00390000012935.
HOGENOMiHOG000231517.
HOVERGENiHBG056002.
InParanoidiQ9H6J7.
OMAiXCPPPAL.
PhylomeDBiQ9H6J7.
TreeFamiTF329168.

Miscellaneous databases

ChiTaRSiC11orf49. human.
GeneWikiiC11orf49.
GenomeRNAii79096.
PROiQ9H6J7.

Gene expression databases

BgeeiQ9H6J7.
CleanExiHS_C11orf49.
ExpressionAtlasiQ9H6J7. baseline and differential.
GenevisibleiQ9H6J7. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Amygdala.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Blood, Colon and Lung.
  7. "Normalization and subtraction: two approaches to facilitate gene discovery."
    Bonaldo M.F., Lennon G., Soares M.B.
    Genome Res. 6:791-806(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 242-326 (ISOFORM 4).
    Tissue: Optic nerve.

Entry informationi

Entry nameiCK049_HUMAN
AccessioniPrimary (citable) accession number: Q9H6J7
Secondary accession number(s): D3DQQ8
, E9PAX7, Q7L077, Q96CS8, Q9BQH4, Q9BUW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: July 6, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.