Q9H6H8 (Q9H6H8_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: cDNA: FLJ22263 fis, clone HRC03036 EMBL BAB15281.1
Organism	Homo sapiens (Human) EMBL BAB15281.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	699 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
Sequence similarities	Contains 1 SET domain. RuleBase RU004538 SAAS SAAS001214 Contains 1 post-SET domain. RuleBase RU004541 SAAS SAAS001214

Ontologies

Keywords
Cellular component	Nucleus SAAS SAAS003616
Domain	Zinc-finger SAAS SAAS001965
Ligand	Metal-binding Zinc
Molecular function	Methyltransferase SAAS SAAS001214 RuleBase RU004541 Transferase
Gene Ontology (GO)
Biological_process	gastrulation with mouth forming second Inferred from electronic annotation. Source: Compara
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	chromatin binding Inferred from electronic annotation. Source: Compara histone methyltransferase activity Inferred from electronic annotation. Source: Compara transcription cofactor activity Inferred from electronic annotation. Source: Compara zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9H6H8 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 83F9AEACE70FADAF	FASTA	699	75,116
	10 20 30 40 50 60 MLTLDKDRII DAGPKGNYAR FMNHCCQPNC ETQKWSVNGD TRVGLFALSD IKAGTELTFN 70 80 90 100 110 120 YNLECLGNGK TVCKCGAPNC SGFLGVRPKN QPIATEEKSK KFKKKQQGKR RTQGEITKER 130 140 150 160 170 180 EDECFSCGDA GQLVSCKKPG CPKVYHADCL NLTKRPAGKW ECPWHQCDIC GKEAASFCEM 190 200 210 220 230 240 CPSSFCKQHR EGMLFISKLD GRLSCTEHDP CGPNPLEPGE IREYVPPPVP LPPGPSTHLA 250 260 270 280 290 300 EQSTGMAAQA PKMSDKPPAD TNQMLSLSKK ALAGTCQRPL LPERPLERTD SRPQPLDKVR 310 320 330 340 350 360 DLAGSGTKSQ SLVSSQRPLD RPPAVAGPRP QLSDKPSPVT SPSSSPSVRS QPLERPLGTA 370 380 390 400 410 420 DPRLDKSIGA ASPRPQSLEK TSVPTGLRLP PPDRLLITSS PKPQTSDRPT DKPHASLSQR 430 440 450 460 470 480 LPPPEKVLSA VVQTLVAKEK ALRPVDQNTQ SKNRAALVMD LIDLTPRQKE RAASPHQVTP 490 500 510 520 530 540 QADEKMPVLE SSSWPASKGL GHMPRAVEKG CVSDPLQTSG KAAAPSEDPW QAVKSLTQAR 550 560 570 580 590 600 LLSQPPAKAF LYEPTTQASG RASAGAEQTP GPLSQSPGLV KQAKQMVGGQ QLPALAAKSG 610 620 630 640 650 660 QSFRSLGKAP ASLPTEEKKL VTTEQSPWAL GKASSRAGLW PIVAGQTLAQ SCWSAGSTQT 670 680 690 LAQTCWSLGR GQDPKPEQNT LPALNQAPSS HKCAESEQK

References

[1]	"NEDO human cDNA sequencing project." Watanabe K., Kumagai A., Itakura S., Yamazaki M., Tashiro H., Ota T., Suzuki Y., Obayashi M., Nishi T., Shibahara T., Tanaka T., Nakamura Y., Isogai T., Sugano S. Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK025916 mRNA. Translation: BAB15281.1.
IPI	IPI00173901.
UniGene	Hs.106861.
3D structure databases
HSSP	HSSP built from PDB template 1PEG based on UniProtKB Q8X225.
ProteinModelPortal	Q9H6H8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9H6H8.
Proteomic databases
PRIDE	Q9H6H8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc021yip.1. human.
Phylogenomic databases
HOVERGEN	HBG060312.
Gene expression databases
ArrayExpress	Q9H6H8.
Bgee	Q9H6H8.
Family and domain databases
Gene3D	3.30.40.10. 1 hit.
InterPro	IPR003616. Post-SET_dom. IPR001214. SET_dom. IPR011011. Znf_FYVE_PHD. IPR001965. Znf_PHD. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
Pfam	PF00856. SET. 1 hit. [Graphical view]
SMART	SM00249. PHD. 1 hit. SM00508. PostSET. 1 hit. SM00317. SET. 1 hit. [Graphical view]
SUPFAM	SSF57903. FYVE_PHD_ZnF. 1 hit.
PROSITE	PS50868. POST_SET. 1 hit. PS50280. SET. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9H6H8_HUMAN

Accession

Primary (citable) accession number: Q9H6H8

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2001
Last sequence update:	March 1, 2001
Last modified:	April 3, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.