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Q9H6F2 (TM38A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Trimeric intracellular cation channel type A

Short name=TRIC-A
Short name=TRICA
Alternative name(s):
Transmembrane protein 38A
Gene names
Name:TMEM38A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length299 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores By similarity.

Subunit structure

Homotrimer By similarity.

Subcellular location

Sarcoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane By similarity.

Domain

The second transmembrane domain has been proposed to cross only half of the lipid bilayer and to loop back into the cytosol, so that the domains on each side of this domain are both found on the cytosolic face of the membrane. The cytosolic loop may form an ion-conducting pore.

Sequence similarities

Belongs to the TMEM38 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 299299Trimeric intracellular cation channel type A
PRO_0000271068

Regions

Topological domain1 – 5151Lumenal Potential
Transmembrane52 – 7221Helical; Potential
Topological domain73 – 8513Cytoplasmic Potential
Transmembrane86 – 10621Helical; Potential
Topological domain107 – 14438Cytoplasmic Potential
Transmembrane145 – 16521Helical; Potential
Topological domain166 – 20944Lumenal Potential
Transmembrane210 – 23021Helical; Potential
Topological domain231 – 29969Cytoplasmic Potential
Compositional bias135 – 1439His-rich

Sequences

Sequence LengthMass (Da)Tools
Q9H6F2 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 40E9D5917F5E3907

FASTA29933,260
        10         20         30         40         50         60 
MELLSALSLG ELALSFSRVP LFPVFDLSYF IVSILYLKYE PGAVELSRRH PIASWLCAML 

        70         80         90        100        110        120 
HCFGSYILAD LLLGEPLIDY FSNNSSILLA SAVWYLIFFC PLDLFYKCVC FLPVKLIFVA 

       130        140        150        160        170        180 
MKEVVRVRKI AVGIHHAHHH YHHGWFVMIA TGWVKGSGVA LMSNFEQLLR GVWKPETNEI 

       190        200        210        220        230        240 
LHMSFPTKAS LYGAILFTLQ QTRWLPVSKA SLIFIFTLFM VSCKVFLTAT HSHSSPFDAL 

       250        260        270        280        290 
EGYICPVLFG SACGGDHHHD NHGGSHSGGG PGAQHSAMPA KSKEELSEGS RKKKAKKAD 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
[4]"TRIC channels are essential for Ca2+ handling in intracellular stores."
Yazawa M., Ferrante C., Feng J., Mio K., Ogura T., Zhang M., Lin P.-H., Pan Z., Komazaki S., Kato K., Nishi M., Zhao X., Weisleder N., Sato C., Ma J., Takeshima H.
Nature 448:78-82(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK025981 mRNA. Translation: BAB15307.1.
AK292764 mRNA. Translation: BAF85453.1.
CH471106 Genomic DNA. Translation: EAW84559.1.
BC001195 mRNA. Translation: AAH01195.1.
CCDSCCDS12349.1.
RefSeqNP_076979.1. NM_024074.1.
UniGeneHs.436068.

3D structure databases

ProteinModelPortalQ9H6F2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000187762.

PTM databases

PhosphoSiteQ9H6F2.

Polymorphism databases

DMDM74733603.

Proteomic databases

PaxDbQ9H6F2.
PRIDEQ9H6F2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000187762; ENSP00000187762; ENSG00000072954.
GeneID79041.
KEGGhsa:79041.
UCSCuc002nes.3. human.

Organism-specific databases

CTD79041.
GeneCardsGC19P016771.
HGNCHGNC:28462. TMEM38A.
HPAHPA048100.
HPA050463.
MIM611235. gene.
neXtProtNX_Q9H6F2.
PharmGKBPA134891982.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG310260.
HOGENOMHOG000037929.
HOVERGENHBG059853.
InParanoidQ9H6F2.
OMANLFYKCV.
PhylomeDBQ9H6F2.
TreeFamTF313483.

Gene expression databases

BgeeQ9H6F2.
CleanExHS_TMEM38A.
GenevestigatorQ9H6F2.

Family and domain databases

InterProIPR007866. TRIC_channel.
[Graphical view]
PANTHERPTHR12454. PTHR12454. 1 hit.
PfamPF05197. TRIC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTMEM38A. human.
GenomeRNAi79041.
NextBio67777.
PROQ9H6F2.
SOURCESearch...

Entry information

Entry nameTM38A_HUMAN
AccessionPrimary (citable) accession number: Q9H6F2
Secondary accession number(s): A8K9P9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM