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Protein

Trimeric intracellular cation channel type A

Gene

TMEM38A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei122Phosphatidylinositol 4,5-bisphosphate (PIP2)By similarity1
Binding sitei126Phosphatidylinositol 4,5-bisphosphate (PIP2)By similarity1

GO - Molecular functioni

  • calcium-activated potassium channel activity Source: GO_Central
  • potassium channel activity Source: BHF-UCL

Keywordsi

Molecular functionIon channel, Potassium channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Names & Taxonomyi

Protein namesi
Recommended name:
Trimeric intracellular cation channel type A
Short name:
TRIC-A
Short name:
TRICA
Alternative name(s):
Transmembrane protein 38A
Gene namesi
Name:TMEM38A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28462. TMEM38A.

Subcellular locationi

  • Sarcoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
  • Nucleus membrane By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 18LumenalCuratedAdd BLAST18
Transmembranei19 – 39Helical;Name=1Sequence analysisAdd BLAST21
Topological domaini40 – 51CytoplasmicCuratedAdd BLAST12
Transmembranei52 – 72Helical;Name=2Sequence analysisAdd BLAST21
Topological domaini73 – 85LumenalCuratedAdd BLAST13
Transmembranei86 – 106Helical;Name=3Sequence analysisAdd BLAST21
Topological domaini107 – 144CytoplasmicCuratedAdd BLAST38
Transmembranei145 – 165Helical;Name=4Sequence analysisAdd BLAST21
Topological domaini166 – 178LumenalCuratedAdd BLAST13
Transmembranei179 – 199Helical;Name=5Sequence analysisAdd BLAST21
Topological domaini200 – 209CytoplasmicCurated10
Transmembranei210 – 230Helical;Name=6Sequence analysisAdd BLAST21
Topological domaini231 – 234LumenalCurated4
Transmembranei235 – 255Helical;Name=7Sequence analysisAdd BLAST21
Topological domaini256 – 299CytoplasmicCuratedAdd BLAST44

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • nuclear membrane Source: BHF-UCL
  • sarcoplasmic reticulum Source: UniProtKB-KW
  • sarcoplasmic reticulum membrane Source: BHF-UCL

Keywords - Cellular componenti

Membrane, Nucleus, Sarcoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

DisGeNETi79041.
OpenTargetsiENSG00000072954.
PharmGKBiPA134891982.

Polymorphism and mutation databases

BioMutaiTMEM38A.
DMDMi74733603.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002710681 – 299Trimeric intracellular cation channel type AAdd BLAST299

Proteomic databases

EPDiQ9H6F2.
PaxDbiQ9H6F2.
PeptideAtlasiQ9H6F2.
PRIDEiQ9H6F2.

PTM databases

iPTMnetiQ9H6F2.
PhosphoSitePlusiQ9H6F2.

Expressioni

Gene expression databases

BgeeiENSG00000072954.
CleanExiHS_TMEM38A.
ExpressionAtlasiQ9H6F2. baseline and differential.
GenevisibleiQ9H6F2. HS.

Organism-specific databases

HPAiHPA048100.
HPA050463.

Interactioni

Subunit structurei

Homotrimer; trimerization probably requires binding to phosphatidylinositol 4,5-bisphosphate (PIP2).By similarity

Protein-protein interaction databases

BioGridi122504. 7 interactors.
STRINGi9606.ENSP00000187762.

Structurei

3D structure databases

ProteinModelPortaliQ9H6F2.
SMRiQ9H6F2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi135 – 143His-rich9

Sequence similaritiesi

Belongs to the TMEM38 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3944. Eukaryota.
ENOG410XQ0P. LUCA.
GeneTreeiENSGT00390000018845.
HOGENOMiHOG000037929.
HOVERGENiHBG059853.
InParanoidiQ9H6F2.
OMAiKYEPGAV.
OrthoDBiEOG091G0GQP.
PhylomeDBiQ9H6F2.
TreeFamiTF313483.

Family and domain databases

InterProiView protein in InterPro
IPR007866. TRIC_channel.
PANTHERiPTHR12454. PTHR12454. 1 hit.
PfamiView protein in Pfam
PF05197. TRIC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9H6F2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLSALSLG ELALSFSRVP LFPVFDLSYF IVSILYLKYE PGAVELSRRH
60 70 80 90 100
PIASWLCAML HCFGSYILAD LLLGEPLIDY FSNNSSILLA SAVWYLIFFC
110 120 130 140 150
PLDLFYKCVC FLPVKLIFVA MKEVVRVRKI AVGIHHAHHH YHHGWFVMIA
160 170 180 190 200
TGWVKGSGVA LMSNFEQLLR GVWKPETNEI LHMSFPTKAS LYGAILFTLQ
210 220 230 240 250
QTRWLPVSKA SLIFIFTLFM VSCKVFLTAT HSHSSPFDAL EGYICPVLFG
260 270 280 290
SACGGDHHHD NHGGSHSGGG PGAQHSAMPA KSKEELSEGS RKKKAKKAD
Length:299
Mass (Da):33,260
Last modified:March 1, 2001 - v1
Checksum:i40E9D5917F5E3907
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025981 mRNA. Translation: BAB15307.1.
AK292764 mRNA. Translation: BAF85453.1.
CH471106 Genomic DNA. Translation: EAW84559.1.
BC001195 mRNA. Translation: AAH01195.1.
CCDSiCCDS12349.1.
RefSeqiNP_076979.1. NM_024074.2.
UniGeneiHs.436068.

Genome annotation databases

EnsembliENST00000187762; ENSP00000187762; ENSG00000072954.
GeneIDi79041.
KEGGihsa:79041.
UCSCiuc002nes.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025981 mRNA. Translation: BAB15307.1.
AK292764 mRNA. Translation: BAF85453.1.
CH471106 Genomic DNA. Translation: EAW84559.1.
BC001195 mRNA. Translation: AAH01195.1.
CCDSiCCDS12349.1.
RefSeqiNP_076979.1. NM_024074.2.
UniGeneiHs.436068.

3D structure databases

ProteinModelPortaliQ9H6F2.
SMRiQ9H6F2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122504. 7 interactors.
STRINGi9606.ENSP00000187762.

PTM databases

iPTMnetiQ9H6F2.
PhosphoSitePlusiQ9H6F2.

Polymorphism and mutation databases

BioMutaiTMEM38A.
DMDMi74733603.

Proteomic databases

EPDiQ9H6F2.
PaxDbiQ9H6F2.
PeptideAtlasiQ9H6F2.
PRIDEiQ9H6F2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000187762; ENSP00000187762; ENSG00000072954.
GeneIDi79041.
KEGGihsa:79041.
UCSCiuc002nes.4. human.

Organism-specific databases

CTDi79041.
DisGeNETi79041.
GeneCardsiTMEM38A.
HGNCiHGNC:28462. TMEM38A.
HPAiHPA048100.
HPA050463.
MIMi611235. gene.
neXtProtiNX_Q9H6F2.
OpenTargetsiENSG00000072954.
PharmGKBiPA134891982.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3944. Eukaryota.
ENOG410XQ0P. LUCA.
GeneTreeiENSGT00390000018845.
HOGENOMiHOG000037929.
HOVERGENiHBG059853.
InParanoidiQ9H6F2.
OMAiKYEPGAV.
OrthoDBiEOG091G0GQP.
PhylomeDBiQ9H6F2.
TreeFamiTF313483.

Miscellaneous databases

ChiTaRSiTMEM38A. human.
GenomeRNAii79041.
PROiPR:Q9H6F2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000072954.
CleanExiHS_TMEM38A.
ExpressionAtlasiQ9H6F2. baseline and differential.
GenevisibleiQ9H6F2. HS.

Family and domain databases

InterProiView protein in InterPro
IPR007866. TRIC_channel.
PANTHERiPTHR12454. PTHR12454. 1 hit.
PfamiView protein in Pfam
PF05197. TRIC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTM38A_HUMAN
AccessioniPrimary (citable) accession number: Q9H6F2
Secondary accession number(s): A8K9P9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2001
Last modified: June 7, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.