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Q9H6F2

- TM38A_HUMAN

UniProt

Q9H6F2 - TM38A_HUMAN

Protein

Trimeric intracellular cation channel type A

Gene

TMEM38A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores By similarity.By similarity

    GO - Molecular functioni

    1. potassium channel activity Source: BHF-UCL

    Keywords - Molecular functioni

    Ion channel, Potassium channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trimeric intracellular cation channel type A
    Short name:
    TRIC-A
    Short name:
    TRICA
    Alternative name(s):
    Transmembrane protein 38A
    Gene namesi
    Name:TMEM38A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:28462. TMEM38A.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB-KW
    3. nuclear membrane Source: BHF-UCL
    4. sarcoplasmic reticulum membrane Source: BHF-UCL

    Keywords - Cellular componenti

    Membrane, Nucleus, Sarcoplasmic reticulum

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134891982.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299Trimeric intracellular cation channel type APRO_0000271068Add
    BLAST

    Proteomic databases

    PaxDbiQ9H6F2.
    PRIDEiQ9H6F2.

    PTM databases

    PhosphoSiteiQ9H6F2.

    Expressioni

    Gene expression databases

    BgeeiQ9H6F2.
    CleanExiHS_TMEM38A.
    GenevestigatoriQ9H6F2.

    Organism-specific databases

    HPAiHPA048100.
    HPA050463.

    Interactioni

    Subunit structurei

    Homotrimer.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000187762.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H6F2.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5151LumenalSequence AnalysisAdd
    BLAST
    Topological domaini73 – 8513CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini107 – 14438CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini166 – 20944LumenalSequence AnalysisAdd
    BLAST
    Topological domaini231 – 29969CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei52 – 7221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei86 – 10621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei145 – 16521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei210 – 23021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi135 – 1439His-rich

    Domaini

    The second transmembrane domain has been proposed to cross only half of the lipid bilayer and to loop back into the cytosol, so that the domains on each side of this domain are both found on the cytosolic face of the membrane. The cytosolic loop may form an ion-conducting pore.

    Sequence similaritiesi

    Belongs to the TMEM38 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG310260.
    HOGENOMiHOG000037929.
    HOVERGENiHBG059853.
    InParanoidiQ9H6F2.
    OMAiNLFYKCV.
    PhylomeDBiQ9H6F2.
    TreeFamiTF313483.

    Family and domain databases

    InterProiIPR007866. TRIC_channel.
    [Graphical view]
    PANTHERiPTHR12454. PTHR12454. 1 hit.
    PfamiPF05197. TRIC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9H6F2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELLSALSLG ELALSFSRVP LFPVFDLSYF IVSILYLKYE PGAVELSRRH    50
    PIASWLCAML HCFGSYILAD LLLGEPLIDY FSNNSSILLA SAVWYLIFFC 100
    PLDLFYKCVC FLPVKLIFVA MKEVVRVRKI AVGIHHAHHH YHHGWFVMIA 150
    TGWVKGSGVA LMSNFEQLLR GVWKPETNEI LHMSFPTKAS LYGAILFTLQ 200
    QTRWLPVSKA SLIFIFTLFM VSCKVFLTAT HSHSSPFDAL EGYICPVLFG 250
    SACGGDHHHD NHGGSHSGGG PGAQHSAMPA KSKEELSEGS RKKKAKKAD 299
    Length:299
    Mass (Da):33,260
    Last modified:March 1, 2001 - v1
    Checksum:i40E9D5917F5E3907
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK025981 mRNA. Translation: BAB15307.1.
    AK292764 mRNA. Translation: BAF85453.1.
    CH471106 Genomic DNA. Translation: EAW84559.1.
    BC001195 mRNA. Translation: AAH01195.1.
    CCDSiCCDS12349.1.
    RefSeqiNP_076979.1. NM_024074.1.
    UniGeneiHs.436068.

    Genome annotation databases

    EnsembliENST00000187762; ENSP00000187762; ENSG00000072954.
    GeneIDi79041.
    KEGGihsa:79041.
    UCSCiuc002nes.3. human.

    Polymorphism databases

    DMDMi74733603.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK025981 mRNA. Translation: BAB15307.1 .
    AK292764 mRNA. Translation: BAF85453.1 .
    CH471106 Genomic DNA. Translation: EAW84559.1 .
    BC001195 mRNA. Translation: AAH01195.1 .
    CCDSi CCDS12349.1.
    RefSeqi NP_076979.1. NM_024074.1.
    UniGenei Hs.436068.

    3D structure databases

    ProteinModelPortali Q9H6F2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000187762.

    PTM databases

    PhosphoSitei Q9H6F2.

    Polymorphism databases

    DMDMi 74733603.

    Proteomic databases

    PaxDbi Q9H6F2.
    PRIDEi Q9H6F2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000187762 ; ENSP00000187762 ; ENSG00000072954 .
    GeneIDi 79041.
    KEGGi hsa:79041.
    UCSCi uc002nes.3. human.

    Organism-specific databases

    CTDi 79041.
    GeneCardsi GC19P016771.
    HGNCi HGNC:28462. TMEM38A.
    HPAi HPA048100.
    HPA050463.
    MIMi 611235. gene.
    neXtProti NX_Q9H6F2.
    PharmGKBi PA134891982.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG310260.
    HOGENOMi HOG000037929.
    HOVERGENi HBG059853.
    InParanoidi Q9H6F2.
    OMAi NLFYKCV.
    PhylomeDBi Q9H6F2.
    TreeFami TF313483.

    Miscellaneous databases

    ChiTaRSi TMEM38A. human.
    GenomeRNAii 79041.
    NextBioi 67777.
    PROi Q9H6F2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9H6F2.
    CleanExi HS_TMEM38A.
    Genevestigatori Q9H6F2.

    Family and domain databases

    InterProi IPR007866. TRIC_channel.
    [Graphical view ]
    PANTHERi PTHR12454. PTHR12454. 1 hit.
    Pfami PF05197. TRIC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    4. Cited for: TOPOLOGY.

    Entry informationi

    Entry nameiTM38A_HUMAN
    AccessioniPrimary (citable) accession number: Q9H6F2
    Secondary accession number(s): A8K9P9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3