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Q9H6F2

- TM38A_HUMAN

UniProt

Q9H6F2 - TM38A_HUMAN

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Protein

Trimeric intracellular cation channel type A

Gene
TMEM38A
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores By similarity.

GO - Molecular functioni

  1. potassium channel activity Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Trimeric intracellular cation channel type A
Short name:
TRIC-A
Short name:
TRICA
Alternative name(s):
Transmembrane protein 38A
Gene namesi
Name:TMEM38A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:28462. TMEM38A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5151Lumenal Reviewed predictionAdd
BLAST
Transmembranei52 – 7221Helical; Reviewed predictionAdd
BLAST
Topological domaini73 – 8513Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei86 – 10621Helical; Reviewed predictionAdd
BLAST
Topological domaini107 – 14438Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei145 – 16521Helical; Reviewed predictionAdd
BLAST
Topological domaini166 – 20944Lumenal Reviewed predictionAdd
BLAST
Transmembranei210 – 23021Helical; Reviewed predictionAdd
BLAST
Topological domaini231 – 29969Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of membrane Source: UniProtKB-KW
  3. nuclear membrane Source: BHF-UCL
  4. sarcoplasmic reticulum membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus, Sarcoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134891982.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Trimeric intracellular cation channel type APRO_0000271068Add
BLAST

Proteomic databases

PaxDbiQ9H6F2.
PRIDEiQ9H6F2.

PTM databases

PhosphoSiteiQ9H6F2.

Expressioni

Gene expression databases

BgeeiQ9H6F2.
CleanExiHS_TMEM38A.
GenevestigatoriQ9H6F2.

Organism-specific databases

HPAiHPA048100.
HPA050463.

Interactioni

Subunit structurei

Homotrimer By similarity.

Protein-protein interaction databases

STRINGi9606.ENSP00000187762.

Structurei

3D structure databases

ProteinModelPortaliQ9H6F2.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi135 – 1439His-rich

Domaini

The second transmembrane domain has been proposed to cross only half of the lipid bilayer and to loop back into the cytosol, so that the domains on each side of this domain are both found on the cytosolic face of the membrane. The cytosolic loop may form an ion-conducting pore.

Sequence similaritiesi

Belongs to the TMEM38 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG310260.
HOGENOMiHOG000037929.
HOVERGENiHBG059853.
InParanoidiQ9H6F2.
OMAiNLFYKCV.
PhylomeDBiQ9H6F2.
TreeFamiTF313483.

Family and domain databases

InterProiIPR007866. TRIC_channel.
[Graphical view]
PANTHERiPTHR12454. PTHR12454. 1 hit.
PfamiPF05197. TRIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H6F2-1 [UniParc]FASTAAdd to Basket

« Hide

MELLSALSLG ELALSFSRVP LFPVFDLSYF IVSILYLKYE PGAVELSRRH    50
PIASWLCAML HCFGSYILAD LLLGEPLIDY FSNNSSILLA SAVWYLIFFC 100
PLDLFYKCVC FLPVKLIFVA MKEVVRVRKI AVGIHHAHHH YHHGWFVMIA 150
TGWVKGSGVA LMSNFEQLLR GVWKPETNEI LHMSFPTKAS LYGAILFTLQ 200
QTRWLPVSKA SLIFIFTLFM VSCKVFLTAT HSHSSPFDAL EGYICPVLFG 250
SACGGDHHHD NHGGSHSGGG PGAQHSAMPA KSKEELSEGS RKKKAKKAD 299
Length:299
Mass (Da):33,260
Last modified:March 1, 2001 - v1
Checksum:i40E9D5917F5E3907
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK025981 mRNA. Translation: BAB15307.1.
AK292764 mRNA. Translation: BAF85453.1.
CH471106 Genomic DNA. Translation: EAW84559.1.
BC001195 mRNA. Translation: AAH01195.1.
CCDSiCCDS12349.1.
RefSeqiNP_076979.1. NM_024074.1.
UniGeneiHs.436068.

Genome annotation databases

EnsembliENST00000187762; ENSP00000187762; ENSG00000072954.
GeneIDi79041.
KEGGihsa:79041.
UCSCiuc002nes.3. human.

Polymorphism databases

DMDMi74733603.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK025981 mRNA. Translation: BAB15307.1 .
AK292764 mRNA. Translation: BAF85453.1 .
CH471106 Genomic DNA. Translation: EAW84559.1 .
BC001195 mRNA. Translation: AAH01195.1 .
CCDSi CCDS12349.1.
RefSeqi NP_076979.1. NM_024074.1.
UniGenei Hs.436068.

3D structure databases

ProteinModelPortali Q9H6F2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000187762.

PTM databases

PhosphoSitei Q9H6F2.

Polymorphism databases

DMDMi 74733603.

Proteomic databases

PaxDbi Q9H6F2.
PRIDEi Q9H6F2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000187762 ; ENSP00000187762 ; ENSG00000072954 .
GeneIDi 79041.
KEGGi hsa:79041.
UCSCi uc002nes.3. human.

Organism-specific databases

CTDi 79041.
GeneCardsi GC19P016771.
HGNCi HGNC:28462. TMEM38A.
HPAi HPA048100.
HPA050463.
MIMi 611235. gene.
neXtProti NX_Q9H6F2.
PharmGKBi PA134891982.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG310260.
HOGENOMi HOG000037929.
HOVERGENi HBG059853.
InParanoidi Q9H6F2.
OMAi NLFYKCV.
PhylomeDBi Q9H6F2.
TreeFami TF313483.

Miscellaneous databases

ChiTaRSi TMEM38A. human.
GenomeRNAii 79041.
NextBioi 67777.
PROi Q9H6F2.
SOURCEi Search...

Gene expression databases

Bgeei Q9H6F2.
CleanExi HS_TMEM38A.
Genevestigatori Q9H6F2.

Family and domain databases

InterProi IPR007866. TRIC_channel.
[Graphical view ]
PANTHERi PTHR12454. PTHR12454. 1 hit.
Pfami PF05197. TRIC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  4. Cited for: TOPOLOGY.

Entry informationi

Entry nameiTM38A_HUMAN
AccessioniPrimary (citable) accession number: Q9H6F2
Secondary accession number(s): A8K9P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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