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Protein

Trimeric intracellular cation channel type A

Gene

TMEM38A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores (By similarity).By similarity

GO - Molecular functioni

  • calcium-activated potassium channel activity Source: GO_Central
  • potassium channel activity Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000072954-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Trimeric intracellular cation channel type A
Short name:
TRIC-A
Short name:
TRICA
Alternative name(s):
Transmembrane protein 38A
Gene namesi
Name:TMEM38A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28462. TMEM38A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 51LumenalSequence analysisAdd BLAST51
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Topological domaini73 – 85CytoplasmicSequence analysisAdd BLAST13
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Topological domaini107 – 144CytoplasmicSequence analysisAdd BLAST38
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Topological domaini166 – 209LumenalSequence analysisAdd BLAST44
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Topological domaini231 – 299CytoplasmicSequence analysisAdd BLAST69

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • nuclear membrane Source: BHF-UCL
  • sarcoplasmic reticulum membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus, Sarcoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

DisGeNETi79041.
OpenTargetsiENSG00000072954.
PharmGKBiPA134891982.

Polymorphism and mutation databases

BioMutaiTMEM38A.
DMDMi74733603.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002710681 – 299Trimeric intracellular cation channel type AAdd BLAST299

Proteomic databases

PaxDbiQ9H6F2.
PeptideAtlasiQ9H6F2.
PRIDEiQ9H6F2.

PTM databases

iPTMnetiQ9H6F2.
PhosphoSitePlusiQ9H6F2.

Expressioni

Gene expression databases

BgeeiENSG00000072954.
CleanExiHS_TMEM38A.
ExpressionAtlasiQ9H6F2. baseline and differential.
GenevisibleiQ9H6F2. HS.

Organism-specific databases

HPAiHPA048100.
HPA050463.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

BioGridi122504. 7 interactors.
STRINGi9606.ENSP00000187762.

Structurei

3D structure databases

ProteinModelPortaliQ9H6F2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi135 – 143His-rich9

Domaini

The second transmembrane domain has been proposed to cross only half of the lipid bilayer and to loop back into the cytosol, so that the domains on each side of this domain are both found on the cytosolic face of the membrane. The cytosolic loop may form an ion-conducting pore.

Sequence similaritiesi

Belongs to the TMEM38 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3944. Eukaryota.
ENOG410XQ0P. LUCA.
GeneTreeiENSGT00390000018845.
HOGENOMiHOG000037929.
HOVERGENiHBG059853.
InParanoidiQ9H6F2.
OMAiYKCVSFL.
OrthoDBiEOG091G0GQP.
PhylomeDBiQ9H6F2.
TreeFamiTF313483.

Family and domain databases

InterProiIPR007866. TRIC_channel.
[Graphical view]
PfamiPF05197. TRIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H6F2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLSALSLG ELALSFSRVP LFPVFDLSYF IVSILYLKYE PGAVELSRRH
60 70 80 90 100
PIASWLCAML HCFGSYILAD LLLGEPLIDY FSNNSSILLA SAVWYLIFFC
110 120 130 140 150
PLDLFYKCVC FLPVKLIFVA MKEVVRVRKI AVGIHHAHHH YHHGWFVMIA
160 170 180 190 200
TGWVKGSGVA LMSNFEQLLR GVWKPETNEI LHMSFPTKAS LYGAILFTLQ
210 220 230 240 250
QTRWLPVSKA SLIFIFTLFM VSCKVFLTAT HSHSSPFDAL EGYICPVLFG
260 270 280 290
SACGGDHHHD NHGGSHSGGG PGAQHSAMPA KSKEELSEGS RKKKAKKAD
Length:299
Mass (Da):33,260
Last modified:March 1, 2001 - v1
Checksum:i40E9D5917F5E3907
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025981 mRNA. Translation: BAB15307.1.
AK292764 mRNA. Translation: BAF85453.1.
CH471106 Genomic DNA. Translation: EAW84559.1.
BC001195 mRNA. Translation: AAH01195.1.
CCDSiCCDS12349.1.
RefSeqiNP_076979.1. NM_024074.2.
UniGeneiHs.436068.

Genome annotation databases

EnsembliENST00000187762; ENSP00000187762; ENSG00000072954.
GeneIDi79041.
KEGGihsa:79041.
UCSCiuc002nes.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025981 mRNA. Translation: BAB15307.1.
AK292764 mRNA. Translation: BAF85453.1.
CH471106 Genomic DNA. Translation: EAW84559.1.
BC001195 mRNA. Translation: AAH01195.1.
CCDSiCCDS12349.1.
RefSeqiNP_076979.1. NM_024074.2.
UniGeneiHs.436068.

3D structure databases

ProteinModelPortaliQ9H6F2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122504. 7 interactors.
STRINGi9606.ENSP00000187762.

PTM databases

iPTMnetiQ9H6F2.
PhosphoSitePlusiQ9H6F2.

Polymorphism and mutation databases

BioMutaiTMEM38A.
DMDMi74733603.

Proteomic databases

PaxDbiQ9H6F2.
PeptideAtlasiQ9H6F2.
PRIDEiQ9H6F2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000187762; ENSP00000187762; ENSG00000072954.
GeneIDi79041.
KEGGihsa:79041.
UCSCiuc002nes.4. human.

Organism-specific databases

CTDi79041.
DisGeNETi79041.
GeneCardsiTMEM38A.
HGNCiHGNC:28462. TMEM38A.
HPAiHPA048100.
HPA050463.
MIMi611235. gene.
neXtProtiNX_Q9H6F2.
OpenTargetsiENSG00000072954.
PharmGKBiPA134891982.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3944. Eukaryota.
ENOG410XQ0P. LUCA.
GeneTreeiENSGT00390000018845.
HOGENOMiHOG000037929.
HOVERGENiHBG059853.
InParanoidiQ9H6F2.
OMAiYKCVSFL.
OrthoDBiEOG091G0GQP.
PhylomeDBiQ9H6F2.
TreeFamiTF313483.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000072954-MONOMER.

Miscellaneous databases

ChiTaRSiTMEM38A. human.
GenomeRNAii79041.
PROiQ9H6F2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000072954.
CleanExiHS_TMEM38A.
ExpressionAtlasiQ9H6F2. baseline and differential.
GenevisibleiQ9H6F2. HS.

Family and domain databases

InterProiIPR007866. TRIC_channel.
[Graphical view]
PfamiPF05197. TRIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM38A_HUMAN
AccessioniPrimary (citable) accession number: Q9H6F2
Secondary accession number(s): A8K9P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.