Q9H6F2 (TM38A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Trimeric intracellular cation channel type A
Short name=TRIC-A
Short name=TRICA

Alternative name(s):
Transmembrane protein 38A

Gene names

Name:

TMEM38A

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores By similarity.
Subunit structure	Homotrimer By similarity.
Subcellular location	Sarcoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane By similarity.
Domain	The second transmembrane domain has been proposed to cross only half of the lipid bilayer and to loop back into the cytosol, so that the domains on each side of this domain are both found on the cytosolic face of the membrane. The cytosolic loop may form an ion-conducting pore.
Sequence similarities	Belongs to the TMEM38 family.

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Membrane Nucleus Sarcoplasmic reticulum
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ion channel Potassium channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nuclear membrane Non-traceable author statement PubMed 19095005. Source: BHF-UCL sarcoplasmic reticulum membrane Non-traceable author statement PubMed 19095005. Source: BHF-UCL
Molecular_function	potassium channel activity Traceable author statement PubMed 19095005. Source: BHF-UCL
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 299	299	Trimeric intracellular cation channel type A		PRO_0000271068
Regions
	Topological domain	1 – 51	51	Lumenal Potential
	Transmembrane	52 – 72	21	Helical; Potential
	Topological domain	73 – 85	13	Cytoplasmic Potential
	Transmembrane	86 – 106	21	Helical; Potential
	Topological domain	107 – 144	38	Cytoplasmic Potential
	Transmembrane	145 – 165	21	Helical; Potential
	Topological domain	166 – 209	44	Lumenal Potential
	Transmembrane	210 – 230	21	Helical; Potential
	Topological domain	231 – 299	69	Cytoplasmic Potential
	Compositional bias	135 – 143	9	His-rich

Sequences

	Sequence		Length	Mass (Da)
	Q9H6F2 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 40E9D5917F5E3907	FASTA	299	33,260
	10 20 30 40 50 60 MELLSALSLG ELALSFSRVP LFPVFDLSYF IVSILYLKYE PGAVELSRRH PIASWLCAML 70 80 90 100 110 120 HCFGSYILAD LLLGEPLIDY FSNNSSILLA SAVWYLIFFC PLDLFYKCVC FLPVKLIFVA 130 140 150 160 170 180 MKEVVRVRKI AVGIHHAHHH YHHGWFVMIA TGWVKGSGVA LMSNFEQLLR GVWKPETNEI 190 200 210 220 230 240 LHMSFPTKAS LYGAILFTLQ QTRWLPVSKA SLIFIFTLFM VSCKVFLTAT HSHSSPFDAL 250 260 270 280 290 EGYICPVLFG SACGGDHHHD NHGGSHSGGG PGAQHSAMPA KSKEELSEGS RKKKAKKAD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
[4]	"TRIC channels are essential for Ca2+ handling in intracellular stores." Yazawa M., Ferrante C., Feng J., Mio K., Ogura T., Zhang M., Lin P.-H., Pan Z., Komazaki S., Kato K., Nishi M., Zhao X., Weisleder N., Sato C., Ma J., Takeshima H. Nature 448:78-82(2007) [PubMed] [Europe PMC] [Abstract] Cited for: TOPOLOGY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK025981 mRNA. Translation: BAB15307.1. AK292764 mRNA. Translation: BAF85453.1. CH471106 Genomic DNA. Translation: EAW84559.1. BC001195 mRNA. Translation: AAH01195.1.
IPI	IPI00031641.
RefSeq	NP_076979.1. NM_024074.1.
UniGene	Hs.436068.
3D structure databases
ProteinModelPortal	Q9H6F2.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000187762.
PTM databases
PhosphoSite	Q9H6F2.
Polymorphism databases
DMDM	74733603.
Proteomic databases
PaxDb	Q9H6F2.
PRIDE	Q9H6F2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000187762; ENSP00000187762; ENSG00000072954.
GeneID	79041.
KEGG	hsa:79041.
UCSC	uc002nes.3. human.
Organism-specific databases
CTD	79041.
GeneCards	GC19P016771.
HGNC	HGNC:28462. TMEM38A.
HPA	HPA048100. HPA050463.
MIM	611235. gene.
neXtProt	NX_Q9H6F2.
PharmGKB	PA134891982.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG310260.
HOGENOM	HOG000037929.
HOVERGEN	HBG059853.
InParanoid	Q9H6F2.
OMA	NLFYKCV.
OrthoDB	EOG43TZW6.
PhylomeDB	Q9H6F2.
Gene expression databases
Bgee	Q9H6F2.
CleanEx	HS_TMEM38A.
Genevestigator	Q9H6F2.
Family and domain databases
InterPro	IPR007866. TRIC_channel. [Graphical view]
PANTHER	PTHR12454. PTHR12454. 1 hit.
Pfam	PF05197. TRIC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TMEM38A. human.
GenomeRNAi	79041.
NextBio	67777.
SOURCE	Search...

Entry information

Entry name

TM38A_HUMAN

Accession

Primary (citable) accession number: Q9H6F2
Secondary accession number(s): A8K9P9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	March 1, 2001
Last modified:	April 3, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.