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Protein

Coiled-coil domain-containing protein 134

Gene

CCDC134

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In extracellular secreted form, promotes proliferation and activation of CD8+ T cells, suggesting a cytokine-like function (PubMed:25125657). Enhances cytotoxic anti-tumor activity of CD8+ T cells (PubMed:25125657). May inhibit ERK and JNK signaling activity (PubMed:18087676, PubMed:23070808). May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling (PubMed:23070808).3 Publications
In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated H3K14 and H4K8 HAT activity. May inhibit TADA2A-mediated TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 134
Gene namesi
Name:CCDC134
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100147.13
HGNCiHGNC:26185 CCDC134
neXtProtiNX_Q9H6E4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Nucleus, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi79879
OpenTargetsiENSG00000100147
PharmGKBiPA162381361

Polymorphism and mutation databases

BioMutaiCCDC134
DMDMi74752694

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000025410923 – 229Coiled-coil domain-containing protein 134Add BLAST207

Post-translational modificationi

O-glycosylated, with additional sialic acid modifications.1 Publication

Proteomic databases

EPDiQ9H6E4
MaxQBiQ9H6E4
PaxDbiQ9H6E4
PeptideAtlasiQ9H6E4
PRIDEiQ9H6E4

PTM databases

iPTMnetiQ9H6E4
PhosphoSitePlusiQ9H6E4

Expressioni

Tissue specificityi

Expressed in cervical gland, cervical squamous epithelium, endometrium, stomach, kidney distal convoluted tubule, spermatogenic cells in testis, mammary gland, liver and striated muscle (at protein level) (PubMed:18087676, PubMed:23070808). Also detected in placenta (PubMed:18087676). Highest expression in testis relative to other tissues (PubMed:18087676). Detected in T cells and dendritic cells; highly expressed in activated CD8+ T cells, and also expressed at lower levels in CD4+ T cells (PubMed:25125657).3 Publications

Gene expression databases

BgeeiENSG00000100147
CleanExiHS_CCDC134
ExpressionAtlasiQ9H6E4 baseline and differential
GenevisibleiQ9H6E4 HS

Organism-specific databases

HPAiHPA003936

Interactioni

Subunit structurei

Interacts with TADA2A. Associates with the PCAF complex via TADA2A binding.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TADA2AO754786EBI-953766,EBI-742268

Protein-protein interaction databases

BioGridi122966, 6 interactors
IntActiQ9H6E4, 4 interactors
STRINGi9606.ENSP00000255784

Structurei

3D structure databases

ProteinModelPortaliQ9H6E4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili196 – 218Sequence analysisAdd BLAST23

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi206 – 213Nuclear localization signalPROSITE-ProRule annotation1 Publication8

Sequence similaritiesi

Belongs to the CCDC134 family.Curated

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiENOG410IEFZ Eukaryota
ENOG4111VZ0 LUCA
GeneTreeiENSGT00390000020164
HOGENOMiHOG000111386
HOVERGENiHBG081032
InParanoidiQ9H6E4
OMAiPSTDPFQ
OrthoDBiEOG091G0Q5S
PhylomeDBiQ9H6E4
TreeFamiTF323839

Family and domain databases

InterProiView protein in InterPro
IPR026321 Coiled-coil_dom_con_pro_134
PANTHERiPTHR14735 PTHR14735, 1 hit
PfamiView protein in Pfam
PF15002 ERK-JNK_inhib, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H6E4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLLQFLAFL FVLLLSGMGA TGTLRTSLDP SLEIYKKMFE VKRREQLLAL
60 70 80 90 100
KNLAQLNDIH QQYKILDVML KGLFKVLEDS RTVLTAADVL PDGPFPQDEK
110 120 130 140 150
LKDAFSHVVE NTAFFGDVVL RFPRIVHYYF DHNSNWNLLI RWGISFCNQT
160 170 180 190 200
GVFNQGPHSP ILSLMAQELG ISEKDSNFQN PFKIDRTEFI PSTDPFQKAL
210 220
REEEKRRKKE EKRKEIRKGP RISRSQSEL
Length:229
Mass (Da):26,561
Last modified:March 1, 2001 - v1
Checksum:iF14C6797854B0598
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456484 mRNA Translation: CAG30370.1
AK026002 mRNA Translation: BAB15315.1
AL021453 Genomic DNA No translation available.
BC017693 mRNA Translation: AAH17693.1
CCDSiCCDS33654.1
RefSeqiNP_079097.1, NM_024821.3
XP_005261805.1, XM_005261748.3
UniGeneiHs.474991

Genome annotation databases

EnsembliENST00000255784; ENSP00000255784; ENSG00000100147
GeneIDi79879
KEGGihsa:79879
UCSCiuc003bbh.2 human

Similar proteinsi

Entry informationi

Entry nameiCC134_HUMAN
AccessioniPrimary (citable) accession number: Q9H6E4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health