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Protein

Coiled-coil domain-containing protein 134

Gene

CCDC134

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 134
Gene namesi
Name:CCDC134
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:26185. CCDC134.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162381361.

Polymorphism and mutation databases

BioMutaiCCDC134.
DMDMi74752694.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 229207Coiled-coil domain-containing protein 134PRO_0000254109Add
BLAST

Proteomic databases

EPDiQ9H6E4.
MaxQBiQ9H6E4.
PaxDbiQ9H6E4.
PRIDEiQ9H6E4.

PTM databases

iPTMnetiQ9H6E4.
PhosphoSiteiQ9H6E4.

Expressioni

Gene expression databases

BgeeiQ9H6E4.
CleanExiHS_CCDC134.
ExpressionAtlasiQ9H6E4. baseline and differential.
GenevisibleiQ9H6E4. HS.

Organism-specific databases

HPAiHPA003936.

Interactioni

Protein-protein interaction databases

BioGridi122966. 5 interactions.
IntActiQ9H6E4. 2 interactions.
MINTiMINT-2876517.
STRINGi9606.ENSP00000255784.

Structurei

3D structure databases

ProteinModelPortaliQ9H6E4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili196 – 21823Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi201 – 21818Arg/Glu/Lys-rich (mixed charge)Add
BLAST

Sequence similaritiesi

Belongs to the UPF0388 family.Curated

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiENOG410IEFZ. Eukaryota.
ENOG4111VZ0. LUCA.
GeneTreeiENSGT00390000020164.
HOGENOMiHOG000111386.
HOVERGENiHBG081032.
InParanoidiQ9H6E4.
OMAiDAYSHVV.
PhylomeDBiQ9H6E4.
TreeFamiTF323839.

Family and domain databases

InterProiIPR026321. Coiled-coil_dom_con_pro_134.
[Graphical view]
PANTHERiPTHR14735. PTHR14735. 1 hit.
PfamiPF15002. ERK-JNK_inhib. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H6E4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLLQFLAFL FVLLLSGMGA TGTLRTSLDP SLEIYKKMFE VKRREQLLAL
60 70 80 90 100
KNLAQLNDIH QQYKILDVML KGLFKVLEDS RTVLTAADVL PDGPFPQDEK
110 120 130 140 150
LKDAFSHVVE NTAFFGDVVL RFPRIVHYYF DHNSNWNLLI RWGISFCNQT
160 170 180 190 200
GVFNQGPHSP ILSLMAQELG ISEKDSNFQN PFKIDRTEFI PSTDPFQKAL
210 220
REEEKRRKKE EKRKEIRKGP RISRSQSEL
Length:229
Mass (Da):26,561
Last modified:March 1, 2001 - v1
Checksum:iF14C6797854B0598
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456484 mRNA. Translation: CAG30370.1.
AK026002 mRNA. Translation: BAB15315.1.
AL021453 Genomic DNA. Translation: CAI22916.1.
BC017693 mRNA. Translation: AAH17693.1.
CCDSiCCDS33654.1.
RefSeqiNP_079097.1. NM_024821.3.
XP_005261805.1. XM_005261748.2.
UniGeneiHs.474991.

Genome annotation databases

EnsembliENST00000255784; ENSP00000255784; ENSG00000100147.
GeneIDi79879.
KEGGihsa:79879.
UCSCiuc003bbh.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456484 mRNA. Translation: CAG30370.1.
AK026002 mRNA. Translation: BAB15315.1.
AL021453 Genomic DNA. Translation: CAI22916.1.
BC017693 mRNA. Translation: AAH17693.1.
CCDSiCCDS33654.1.
RefSeqiNP_079097.1. NM_024821.3.
XP_005261805.1. XM_005261748.2.
UniGeneiHs.474991.

3D structure databases

ProteinModelPortaliQ9H6E4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122966. 5 interactions.
IntActiQ9H6E4. 2 interactions.
MINTiMINT-2876517.
STRINGi9606.ENSP00000255784.

PTM databases

iPTMnetiQ9H6E4.
PhosphoSiteiQ9H6E4.

Polymorphism and mutation databases

BioMutaiCCDC134.
DMDMi74752694.

Proteomic databases

EPDiQ9H6E4.
MaxQBiQ9H6E4.
PaxDbiQ9H6E4.
PRIDEiQ9H6E4.

Protocols and materials databases

DNASUi79879.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255784; ENSP00000255784; ENSG00000100147.
GeneIDi79879.
KEGGihsa:79879.
UCSCiuc003bbh.2. human.

Organism-specific databases

CTDi79879.
GeneCardsiCCDC134.
HGNCiHGNC:26185. CCDC134.
HPAiHPA003936.
neXtProtiNX_Q9H6E4.
PharmGKBiPA162381361.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEFZ. Eukaryota.
ENOG4111VZ0. LUCA.
GeneTreeiENSGT00390000020164.
HOGENOMiHOG000111386.
HOVERGENiHBG081032.
InParanoidiQ9H6E4.
OMAiDAYSHVV.
PhylomeDBiQ9H6E4.
TreeFamiTF323839.

Miscellaneous databases

GenomeRNAii79879.
PROiQ9H6E4.

Gene expression databases

BgeeiQ9H6E4.
CleanExiHS_CCDC134.
ExpressionAtlasiQ9H6E4. baseline and differential.
GenevisibleiQ9H6E4. HS.

Family and domain databases

InterProiIPR026321. Coiled-coil_dom_con_pro_134.
[Graphical view]
PANTHERiPTHR14735. PTHR14735. 1 hit.
PfamiPF15002. ERK-JNK_inhib. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney epithelium.
  3. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary carcinoma.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCC134_HUMAN
AccessioniPrimary (citable) accession number: Q9H6E4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.