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Protein

Fibronectin type III domain-containing protein 4

Gene

FNDC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro-inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Fibronectin type III domain-containing protein 4
Alternative name(s):
Fibronectin type III repeat-containing protein 1
Gene namesi
Name:FNDC4
Synonyms:FRCP1
ORF Names:UNQ6389/PRO21134
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115226.9.
HGNCiHGNC:20239. FNDC4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini45 – 167ExtracellularSequence analysisAdd BLAST123
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189 – 234CytoplasmicSequence analysisAdd BLAST46

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi64838.
OpenTargetsiENSG00000115226.
PharmGKBiPA134883376.

Polymorphism and mutation databases

BioMutaiFNDC4.
DMDMi74762739.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 44Sequence analysisAdd BLAST44
ChainiPRO_000027137945 – 234Fibronectin type III domain-containing protein 4Add BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi147N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9H6D8.
PaxDbiQ9H6D8.
PeptideAtlasiQ9H6D8.
PRIDEiQ9H6D8.

PTM databases

iPTMnetiQ9H6D8.
PhosphoSitePlusiQ9H6D8.

Expressioni

Tissue specificityi

Up-regulated in colon cells of patients with inflammatory bowel disease (IBD).1 Publication

Inductioni

Induced by TGFB1.1 Publication

Gene expression databases

BgeeiENSG00000115226.
CleanExiHS_FNDC4.
GenevisibleiQ9H6D8. HS.

Organism-specific databases

HPAiHPA051804.
HPA063581.

Interactioni

Protein-protein interaction databases

BioGridi122314. 21 interactors.
IntActiQ9H6D8. 1 interactor.
STRINGi9606.ENSP00000264703.

Structurei

3D structure databases

ProteinModelPortaliQ9H6D8.
SMRiQ9H6D8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 140Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST94

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEB6. Eukaryota.
ENOG4110D1D. LUCA.
GeneTreeiENSGT00390000004923.
HOGENOMiHOG000082536.
HOVERGENiHBG067308.
InParanoidiQ9H6D8.
OMAiQASKKVH.
OrthoDBiEOG091G0HLN.
PhylomeDBiQ9H6D8.
TreeFamiTF325415.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR003961. FN3_dom.
IPR036116. FN3_sf.
IPR013783. Ig-like_fold.
PfamiView protein in Pfam
PF00041. fn3. 1 hit.
SMARTiView protein in SMART
SM00060. FN3. 1 hit.
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiView protein in PROSITE
PS50853. FN3. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H6D8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSGCHSSPP SGLRGDMASL VPLSPYLSPT VLLLVSCDLG FVRADRPPSP
60 70 80 90 100
VNVTVTHLRA NSATVSWDVP EGNIVIGYSI SQQRQNGPGQ RVIREVNTTT
110 120 130 140 150
RACALWGLAE DSDYTVQVRS IGLRGESPPG PRVHFRTLKG SDRLPSNSSS
160 170 180 190 200
PGDITVEGLD GERPLQTGEV VIIVVVLLMW AAVIGLFCRQ YDIIKDNDSN
210 220 230
NNPKEKGKGP EQSPQGRPVG TRQKKSPSIN TIDV
Length:234
Mass (Da):25,159
Last modified:March 1, 2001 - v1
Checksum:i5BCD23C12F583727
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026015 mRNA. Translation: BAB15321.1.
AY358136 mRNA. Translation: AAQ88503.1.
AC074117 Genomic DNA. Translation: AAY14849.1.
CH471053 Genomic DNA. Translation: EAX00569.1.
CH471053 Genomic DNA. Translation: EAX00570.1.
BC032725 mRNA. Translation: AAH32725.1.
CCDSiCCDS1756.1.
RefSeqiNP_073734.1. NM_022823.2.
UniGeneiHs.27836.
Hs.732184.

Genome annotation databases

EnsembliENST00000264703; ENSP00000264703; ENSG00000115226.
GeneIDi64838.
KEGGihsa:64838.
UCSCiuc002rkx.4. human.

Similar proteinsi

Entry informationi

Entry nameiFNDC4_HUMAN
AccessioniPrimary (citable) accession number: Q9H6D8
Secondary accession number(s): D6W560
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2001
Last modified: October 25, 2017
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot