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Protein

Fibronectin type III domain-containing protein 4

Gene

FNDC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115226-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibronectin type III domain-containing protein 4
Alternative name(s):
Fibronectin type III repeat-containing protein 1
Gene namesi
Name:FNDC4
Synonyms:FRCP1
ORF Names:UNQ6389/PRO21134
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:20239. FNDC4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini45 – 167ExtracellularSequence analysisAdd BLAST123
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189 – 234CytoplasmicSequence analysisAdd BLAST46

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi64838.
OpenTargetsiENSG00000115226.
PharmGKBiPA134883376.

Polymorphism and mutation databases

BioMutaiFNDC4.
DMDMi74762739.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 44Sequence analysisAdd BLAST44
ChainiPRO_000027137945 – 234Fibronectin type III domain-containing protein 4Add BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi52N-linked (GlcNAc...)Sequence analysis1
Glycosylationi97N-linked (GlcNAc...)Sequence analysis1
Glycosylationi147N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9H6D8.
PeptideAtlasiQ9H6D8.
PRIDEiQ9H6D8.

PTM databases

iPTMnetiQ9H6D8.
PhosphoSitePlusiQ9H6D8.

Expressioni

Gene expression databases

BgeeiENSG00000115226.
CleanExiHS_FNDC4.
GenevisibleiQ9H6D8. HS.

Organism-specific databases

HPAiHPA051804.
HPA063581.

Interactioni

Protein-protein interaction databases

BioGridi122314. 19 interactors.
IntActiQ9H6D8. 1 interactor.
STRINGi9606.ENSP00000264703.

Structurei

3D structure databases

ProteinModelPortaliQ9H6D8.
SMRiQ9H6D8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 140Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST94

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEB6. Eukaryota.
ENOG4110D1D. LUCA.
GeneTreeiENSGT00390000004923.
HOGENOMiHOG000082536.
HOVERGENiHBG067308.
InParanoidiQ9H6D8.
OMAiSKRVHFR.
OrthoDBiEOG091G0HLN.
PhylomeDBiQ9H6D8.
TreeFamiTF325415.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H6D8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSGCHSSPP SGLRGDMASL VPLSPYLSPT VLLLVSCDLG FVRADRPPSP
60 70 80 90 100
VNVTVTHLRA NSATVSWDVP EGNIVIGYSI SQQRQNGPGQ RVIREVNTTT
110 120 130 140 150
RACALWGLAE DSDYTVQVRS IGLRGESPPG PRVHFRTLKG SDRLPSNSSS
160 170 180 190 200
PGDITVEGLD GERPLQTGEV VIIVVVLLMW AAVIGLFCRQ YDIIKDNDSN
210 220 230
NNPKEKGKGP EQSPQGRPVG TRQKKSPSIN TIDV
Length:234
Mass (Da):25,159
Last modified:March 1, 2001 - v1
Checksum:i5BCD23C12F583727
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026015 mRNA. Translation: BAB15321.1.
AY358136 mRNA. Translation: AAQ88503.1.
AC074117 Genomic DNA. Translation: AAY14849.1.
CH471053 Genomic DNA. Translation: EAX00569.1.
CH471053 Genomic DNA. Translation: EAX00570.1.
BC032725 mRNA. Translation: AAH32725.1.
CCDSiCCDS1756.1.
RefSeqiNP_073734.1. NM_022823.2.
UniGeneiHs.27836.
Hs.732184.

Genome annotation databases

EnsembliENST00000264703; ENSP00000264703; ENSG00000115226.
GeneIDi64838.
KEGGihsa:64838.
UCSCiuc002rkx.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026015 mRNA. Translation: BAB15321.1.
AY358136 mRNA. Translation: AAQ88503.1.
AC074117 Genomic DNA. Translation: AAY14849.1.
CH471053 Genomic DNA. Translation: EAX00569.1.
CH471053 Genomic DNA. Translation: EAX00570.1.
BC032725 mRNA. Translation: AAH32725.1.
CCDSiCCDS1756.1.
RefSeqiNP_073734.1. NM_022823.2.
UniGeneiHs.27836.
Hs.732184.

3D structure databases

ProteinModelPortaliQ9H6D8.
SMRiQ9H6D8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122314. 19 interactors.
IntActiQ9H6D8. 1 interactor.
STRINGi9606.ENSP00000264703.

PTM databases

iPTMnetiQ9H6D8.
PhosphoSitePlusiQ9H6D8.

Polymorphism and mutation databases

BioMutaiFNDC4.
DMDMi74762739.

Proteomic databases

PaxDbiQ9H6D8.
PeptideAtlasiQ9H6D8.
PRIDEiQ9H6D8.

Protocols and materials databases

DNASUi64838.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264703; ENSP00000264703; ENSG00000115226.
GeneIDi64838.
KEGGihsa:64838.
UCSCiuc002rkx.4. human.

Organism-specific databases

CTDi64838.
DisGeNETi64838.
GeneCardsiFNDC4.
HGNCiHGNC:20239. FNDC4.
HPAiHPA051804.
HPA063581.
MIMi611905. gene.
neXtProtiNX_Q9H6D8.
OpenTargetsiENSG00000115226.
PharmGKBiPA134883376.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEB6. Eukaryota.
ENOG4110D1D. LUCA.
GeneTreeiENSGT00390000004923.
HOGENOMiHOG000082536.
HOVERGENiHBG067308.
InParanoidiQ9H6D8.
OMAiSKRVHFR.
OrthoDBiEOG091G0HLN.
PhylomeDBiQ9H6D8.
TreeFamiTF325415.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115226-MONOMER.

Miscellaneous databases

GenomeRNAii64838.
PROiQ9H6D8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115226.
CleanExiHS_FNDC4.
GenevisibleiQ9H6D8. HS.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFNDC4_HUMAN
AccessioniPrimary (citable) accession number: Q9H6D8
Secondary accession number(s): D6W560
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.