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Protein

HAUS augmin-like complex subunit 4

Gene

HAUS4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.2 Publications

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • centrosome cycle Source: UniProtKB
  • ciliary basal body-plasma membrane docking Source: Reactome
  • G2/M transition of mitotic cell cycle Source: Reactome
  • regulation of G2/M transition of mitotic cell cycle Source: Reactome
  • spindle assembly Source: UniProtKB

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-HSA-380259. Loss of Nlp from mitotic centrosomes.
R-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-380284. Loss of proteins required for interphase microtubule organization from the centrosome.
R-HSA-380320. Recruitment of NuMA to mitotic centrosomes.
R-HSA-5620912. Anchoring of the basal body to the plasma membrane.
R-HSA-8854518. AURKA Activation by TPX2.

Names & Taxonomyi

Protein namesi
Recommended name:
HAUS augmin-like complex subunit 4
Gene namesi
Name:HAUS4
Synonyms:C14orf94
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000092036.16.
HGNCiHGNC:20163. HAUS4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000092036.
PharmGKBiPA165478984.

Polymorphism and mutation databases

BioMutaiHAUS4.
DMDMi33301114.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000899011 – 363HAUS augmin-like complex subunit 4Add BLAST363

Proteomic databases

EPDiQ9H6D7.
MaxQBiQ9H6D7.
PaxDbiQ9H6D7.
PeptideAtlasiQ9H6D7.
PRIDEiQ9H6D7.

PTM databases

iPTMnetiQ9H6D7.
PhosphoSitePlusiQ9H6D7.

Expressioni

Gene expression databases

BgeeiENSG00000092036.
CleanExiHS_C14orf94.
ExpressionAtlasiQ9H6D7. baseline and differential.
GenevisibleiQ9H6D7. HS.

Organism-specific databases

HPAiHPA029803.
HPA071195.

Interactioni

Subunit structurei

Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HAUS1Q96CS23EBI-2558168,EBI-2514791

Protein-protein interaction databases

BioGridi120270. 52 interactors.
DIPiDIP-48837N.
IntActiQ9H6D7. 34 interactors.
STRINGi9606.ENSP00000206474.

Structurei

3D structure databases

ProteinModelPortaliQ9H6D7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HAUS4 family.Curated

Phylogenomic databases

eggNOGiENOG410IFF7. Eukaryota.
ENOG4111KUB. LUCA.
GeneTreeiENSGT00390000014634.
InParanoidiQ9H6D7.
KOiK16587.
OMAiVKAAKVW.
OrthoDBiEOG091G0GFJ.
PhylomeDBiQ9H6D7.
TreeFamiTF330353.

Family and domain databases

InterProiView protein in InterPro
IPR029327. HAUS4.
IPR026214. HAUS4_met.
PfamiView protein in Pfam
PF14735. HAUS4. 1 hit.
PRINTSiPR02090. HAUSAUGMINL4.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H6D7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASGDFCSPG EGMEILQQVC SKQLPPCNLS KEDLLQNPYF SKLLLNLSQH
60 70 80 90 100
VDESGLSLTL AKEQAQAWKE VRLHKTTWLR SEILHRVIQE LLVDYYVKIQ
110 120 130 140 150
DTNVTSEDKK FHETLEQRLL VTELMRLLGP SQEREIPPLL GLEKADLLEL
160 170 180 190 200
MPLSEDFVWM RARLQQEVEE QLKKKCFTLL CYYDPNSDAD SETVKAAKVW
210 220 230 240 250
KLAEVLVGEQ QQCQDAKSQQ KEQMLLLEKK SAAYSQVLLR CLTLLQRLLQ
260 270 280 290 300
EHRLKTQSEL DRINAQYLEV KCGAMILKLR MEELKILSDT YTVEKVEVHR
310 320 330 340 350
LIRDRLEGAI HLQEQDMENS RQVLNSYEVL GEEFDRLVKE YTVLKQATEN
360
KRWALQEFSK VYR
Length:363
Mass (Da):42,400
Last modified:March 1, 2001 - v1
Checksum:iAAAFA1FFC25189C0
GO
Isoform 2 (identifier: Q9H6D7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-236: Missing.

Note: No experimental confirmation available.
Show »
Length:237
Mass (Da):27,791
Checksum:i7C6F4FB2CC6AD3B3
GO
Isoform 3 (identifier: Q9H6D7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-124: Missing.

Note: No experimental confirmation available.
Show »
Length:239
Mass (Da):28,119
Checksum:iC59E25891211506E
GO
Isoform 4 (identifier: Q9H6D7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-155: Missing.

Note: No experimental confirmation available.
Show »
Length:318
Mass (Da):37,219
Checksum:iAC421A12072D246A
GO

Sequence cautioni

The sequence CAD62584 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti154S → T in BAA91161 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0078511 – 124Missing in isoform 3. 1 PublicationAdd BLAST124
Alternative sequenceiVSP_007853111 – 236Missing in isoform 2. 1 PublicationAdd BLAST126
Alternative sequenceiVSP_007852111 – 155Missing in isoform 4. 1 PublicationAdd BLAST45

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026016 mRNA. Translation: BAB15322.1.
AK000431 mRNA. Translation: BAA91161.1.
BX247981 mRNA. Translation: CAD62315.1.
BX247995 mRNA. Translation: CAD62328.1.
BX248256 mRNA. Translation: CAD62584.1. Different initiation.
AL132780 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW66207.1.
CH471078 Genomic DNA. Translation: EAW66206.1.
CH471078 Genomic DNA. Translation: EAW66209.1.
CH471078 Genomic DNA. Translation: EAW66210.1.
CH471078 Genomic DNA. Translation: EAW66213.1.
BC001916 mRNA. Translation: AAH01916.1.
BC002554 mRNA. Translation: AAH02554.1.
CCDSiCCDS53886.1. [Q9H6D7-4]
CCDS9580.1. [Q9H6D7-1]
RefSeqiNP_001159741.1. NM_001166269.1. [Q9H6D7-1]
NP_001159742.1. NM_001166270.1. [Q9H6D7-4]
NP_060285.2. NM_017815.2. [Q9H6D7-1]
UniGeneiHs.442782.
Hs.727321.

Genome annotation databases

EnsembliENST00000206474; ENSP00000206474; ENSG00000092036. [Q9H6D7-1]
ENST00000342454; ENSP00000342776; ENSG00000092036. [Q9H6D7-4]
ENST00000347758; ENSP00000343473; ENSG00000092036. [Q9H6D7-2]
ENST00000490506; ENSP00000452260; ENSG00000092036. [Q9H6D7-3]
ENST00000541587; ENSP00000441026; ENSG00000092036. [Q9H6D7-1]
ENST00000555367; ENSP00000452239; ENSG00000092036. [Q9H6D7-4]
ENST00000555986; ENSP00000451018; ENSG00000092036. [Q9H6D7-4]
GeneIDi54930.
KEGGihsa:54930.
UCSCiuc001whq.4. human. [Q9H6D7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiHAUS4_HUMAN
AccessioniPrimary (citable) accession number: Q9H6D7
Secondary accession number(s): B7WP17
, D3DS34, Q86T15, Q86T16, Q86U43, Q9NX59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: March 1, 2001
Last modified: September 27, 2017
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families