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Protein

HAUS augmin-like complex subunit 4

Gene

HAUS4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.2 Publications

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • centrosome organization Source: UniProtKB
  • G2/M transition of mitotic cell cycle Source: Reactome
  • mitotic nuclear division Source: UniProtKB-KW
  • spindle assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-HSA-380259. Loss of Nlp from mitotic centrosomes.
R-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-5620912. Anchoring of the basal body to the plasma membrane.
R-HSA-8854518. AURKA Activation by TPX2.

Names & Taxonomyi

Protein namesi
Recommended name:
HAUS augmin-like complex subunit 4
Gene namesi
Name:HAUS4
Synonyms:C14orf94
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20163. HAUS4.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • cytosol Source: Reactome
  • HAUS complex Source: UniProtKB
  • microtubule Source: UniProtKB-KW
  • spindle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165478984.

Polymorphism and mutation databases

BioMutaiHAUS4.
DMDMi33301114.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363HAUS augmin-like complex subunit 4PRO_0000089901Add
BLAST

Proteomic databases

EPDiQ9H6D7.
MaxQBiQ9H6D7.
PaxDbiQ9H6D7.
PRIDEiQ9H6D7.

PTM databases

iPTMnetiQ9H6D7.
PhosphoSiteiQ9H6D7.

Expressioni

Gene expression databases

BgeeiQ9H6D7.
CleanExiHS_C14orf94.
ExpressionAtlasiQ9H6D7. baseline and differential.
GenevisibleiQ9H6D7. HS.

Organism-specific databases

HPAiHPA029803.

Interactioni

Subunit structurei

Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly.2 Publications

Protein-protein interaction databases

BioGridi120270. 46 interactions.
DIPiDIP-48837N.
IntActiQ9H6D7. 31 interactions.
STRINGi9606.ENSP00000206474.

Structurei

3D structure databases

ProteinModelPortaliQ9H6D7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HAUS4 family.Curated

Phylogenomic databases

eggNOGiENOG410IFF7. Eukaryota.
ENOG4111KUB. LUCA.
GeneTreeiENSGT00390000014634.
InParanoidiQ9H6D7.
KOiK16587.
OMAiWENESEG.
OrthoDBiEOG78M029.
PhylomeDBiQ9H6D7.
TreeFamiTF330353.

Family and domain databases

InterProiIPR029327. HAUS4.
IPR026214. HAUS4_met.
[Graphical view]
PfamiPF14735. HAUS4. 1 hit.
[Graphical view]
PRINTSiPR02090. HAUSAUGMINL4.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H6D7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASGDFCSPG EGMEILQQVC SKQLPPCNLS KEDLLQNPYF SKLLLNLSQH
60 70 80 90 100
VDESGLSLTL AKEQAQAWKE VRLHKTTWLR SEILHRVIQE LLVDYYVKIQ
110 120 130 140 150
DTNVTSEDKK FHETLEQRLL VTELMRLLGP SQEREIPPLL GLEKADLLEL
160 170 180 190 200
MPLSEDFVWM RARLQQEVEE QLKKKCFTLL CYYDPNSDAD SETVKAAKVW
210 220 230 240 250
KLAEVLVGEQ QQCQDAKSQQ KEQMLLLEKK SAAYSQVLLR CLTLLQRLLQ
260 270 280 290 300
EHRLKTQSEL DRINAQYLEV KCGAMILKLR MEELKILSDT YTVEKVEVHR
310 320 330 340 350
LIRDRLEGAI HLQEQDMENS RQVLNSYEVL GEEFDRLVKE YTVLKQATEN
360
KRWALQEFSK VYR
Length:363
Mass (Da):42,400
Last modified:March 1, 2001 - v1
Checksum:iAAAFA1FFC25189C0
GO
Isoform 2 (identifier: Q9H6D7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-236: Missing.

Note: No experimental confirmation available.
Show »
Length:237
Mass (Da):27,791
Checksum:i7C6F4FB2CC6AD3B3
GO
Isoform 3 (identifier: Q9H6D7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-124: Missing.

Note: No experimental confirmation available.
Show »
Length:239
Mass (Da):28,119
Checksum:iC59E25891211506E
GO
Isoform 4 (identifier: Q9H6D7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-155: Missing.

Note: No experimental confirmation available.
Show »
Length:318
Mass (Da):37,219
Checksum:iAC421A12072D246A
GO

Sequence cautioni

The sequence CAD62584.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti154 – 1541S → T in BAA91161 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 124124Missing in isoform 3. 1 PublicationVSP_007851Add
BLAST
Alternative sequencei111 – 236126Missing in isoform 2. 1 PublicationVSP_007853Add
BLAST
Alternative sequencei111 – 15545Missing in isoform 4. 1 PublicationVSP_007852Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026016 mRNA. Translation: BAB15322.1.
AK000431 mRNA. Translation: BAA91161.1.
BX247981 mRNA. Translation: CAD62315.1.
BX247995 mRNA. Translation: CAD62328.1.
BX248256 mRNA. Translation: CAD62584.1. Different initiation.
AL132780 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW66207.1.
CH471078 Genomic DNA. Translation: EAW66206.1.
CH471078 Genomic DNA. Translation: EAW66209.1.
CH471078 Genomic DNA. Translation: EAW66210.1.
CH471078 Genomic DNA. Translation: EAW66213.1.
BC001916 mRNA. Translation: AAH01916.1.
BC002554 mRNA. Translation: AAH02554.1.
CCDSiCCDS53886.1. [Q9H6D7-4]
CCDS9580.1. [Q9H6D7-1]
RefSeqiNP_001159741.1. NM_001166269.1. [Q9H6D7-1]
NP_001159742.1. NM_001166270.1. [Q9H6D7-4]
NP_060285.2. NM_017815.2. [Q9H6D7-1]
UniGeneiHs.442782.
Hs.727321.

Genome annotation databases

EnsembliENST00000206474; ENSP00000206474; ENSG00000092036. [Q9H6D7-1]
ENST00000342454; ENSP00000342776; ENSG00000092036. [Q9H6D7-4]
ENST00000347758; ENSP00000343473; ENSG00000092036. [Q9H6D7-2]
ENST00000490506; ENSP00000452260; ENSG00000092036. [Q9H6D7-3]
ENST00000541587; ENSP00000441026; ENSG00000092036. [Q9H6D7-1]
ENST00000555367; ENSP00000452239; ENSG00000092036. [Q9H6D7-4]
ENST00000555986; ENSP00000451018; ENSG00000092036. [Q9H6D7-4]
GeneIDi54930.
KEGGihsa:54930.
UCSCiuc001whq.4. human. [Q9H6D7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026016 mRNA. Translation: BAB15322.1.
AK000431 mRNA. Translation: BAA91161.1.
BX247981 mRNA. Translation: CAD62315.1.
BX247995 mRNA. Translation: CAD62328.1.
BX248256 mRNA. Translation: CAD62584.1. Different initiation.
AL132780 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW66207.1.
CH471078 Genomic DNA. Translation: EAW66206.1.
CH471078 Genomic DNA. Translation: EAW66209.1.
CH471078 Genomic DNA. Translation: EAW66210.1.
CH471078 Genomic DNA. Translation: EAW66213.1.
BC001916 mRNA. Translation: AAH01916.1.
BC002554 mRNA. Translation: AAH02554.1.
CCDSiCCDS53886.1. [Q9H6D7-4]
CCDS9580.1. [Q9H6D7-1]
RefSeqiNP_001159741.1. NM_001166269.1. [Q9H6D7-1]
NP_001159742.1. NM_001166270.1. [Q9H6D7-4]
NP_060285.2. NM_017815.2. [Q9H6D7-1]
UniGeneiHs.442782.
Hs.727321.

3D structure databases

ProteinModelPortaliQ9H6D7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120270. 46 interactions.
DIPiDIP-48837N.
IntActiQ9H6D7. 31 interactions.
STRINGi9606.ENSP00000206474.

PTM databases

iPTMnetiQ9H6D7.
PhosphoSiteiQ9H6D7.

Polymorphism and mutation databases

BioMutaiHAUS4.
DMDMi33301114.

Proteomic databases

EPDiQ9H6D7.
MaxQBiQ9H6D7.
PaxDbiQ9H6D7.
PRIDEiQ9H6D7.

Protocols and materials databases

DNASUi54930.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000206474; ENSP00000206474; ENSG00000092036. [Q9H6D7-1]
ENST00000342454; ENSP00000342776; ENSG00000092036. [Q9H6D7-4]
ENST00000347758; ENSP00000343473; ENSG00000092036. [Q9H6D7-2]
ENST00000490506; ENSP00000452260; ENSG00000092036. [Q9H6D7-3]
ENST00000541587; ENSP00000441026; ENSG00000092036. [Q9H6D7-1]
ENST00000555367; ENSP00000452239; ENSG00000092036. [Q9H6D7-4]
ENST00000555986; ENSP00000451018; ENSG00000092036. [Q9H6D7-4]
GeneIDi54930.
KEGGihsa:54930.
UCSCiuc001whq.4. human. [Q9H6D7-1]

Organism-specific databases

CTDi54930.
GeneCardsiHAUS4.
H-InvDBHIX0011526.
HIX0115333.
HGNCiHGNC:20163. HAUS4.
HPAiHPA029803.
MIMi613431. gene.
neXtProtiNX_Q9H6D7.
PharmGKBiPA165478984.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFF7. Eukaryota.
ENOG4111KUB. LUCA.
GeneTreeiENSGT00390000014634.
InParanoidiQ9H6D7.
KOiK16587.
OMAiWENESEG.
OrthoDBiEOG78M029.
PhylomeDBiQ9H6D7.
TreeFamiTF330353.

Enzyme and pathway databases

ReactomeiR-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-HSA-380259. Loss of Nlp from mitotic centrosomes.
R-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-5620912. Anchoring of the basal body to the plasma membrane.
R-HSA-8854518. AURKA Activation by TPX2.

Miscellaneous databases

ChiTaRSiHAUS4. human.
GenomeRNAii54930.
PROiQ9H6D7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H6D7.
CleanExiHS_C14orf94.
ExpressionAtlasiQ9H6D7. baseline and differential.
GenevisibleiQ9H6D7. HS.

Family and domain databases

InterProiIPR029327. HAUS4.
IPR026214. HAUS4_met.
[Graphical view]
PfamiPF14735. HAUS4. 1 hit.
[Graphical view]
PRINTSiPR02090. HAUSAUGMINL4.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney epithelium and Signet-ring cell carcinoma.
  2. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
    Tissue: Fetal brain and T-cell.
  3. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Choriocarcinoma and Melanoma.
  6. Cited for: IDENTIFICATION IN THE HAUS AUGMIN-LIKE COMPLEX, FUNCTION, SUBCELLULAR LOCATION.
  7. "The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells."
    Uehara R., Nozawa R.-S., Tomioka A., Petry S., Vale R.D., Obuse C., Goshima G.
    Proc. Natl. Acad. Sci. U.S.A. 106:6998-7003(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE HAUS AUGMIN-LIKE COMPLEX, FUNCTION, SUBCELLULAR LOCATION.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHAUS4_HUMAN
AccessioniPrimary (citable) accession number: Q9H6D7
Secondary accession number(s): B7WP17
, D3DS34, Q86T15, Q86T16, Q86U43, Q9NX59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.