Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

XK-related protein 8

Gene

XKR8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes phosphatidylserine exposure on apoptotic cell surface, possibly by mediating phospholipid scrambling. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. Has no effect on calcium-induced exposure of phosphatidylserine. Activated upon caspase cleavage, suggesting that it does not act prior the onset of apoptosis.1 Publication

Miscellaneous

Expression is repressed in PLB-985 leukemia and Raji lymphoma cells due to CpG methylation near the transcription start site of XKR8 gene, possibly explaining the inability of PLB-985 leukemia and Raji lymphoma cells to expose phosphatidylserine during apoptosis.1 Publication

GO - Biological processi

  • engulfment of apoptotic cell Source: UniProtKB
  • phosphatidylserine exposure on apoptotic cell surface Source: UniProtKB

Keywordsi

Biological processApoptosis

Protein family/group databases

TCDBi2.A.112.1.13 the kx blood-group antigen (kxa) family

Names & Taxonomyi

Protein namesi
Recommended name:
XK-related protein 8
Short name:
hXkr8
Cleaved into the following chain:
Gene namesi
Name:XKR8
Synonyms:XRG8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000158156.7
HGNCiHGNC:25508 XKR8
neXtProtiNX_Q9H6D3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Topological domaini34 – 47ExtracellularSequence analysisAdd BLAST14
Transmembranei48 – 68HelicalSequence analysisAdd BLAST21
Topological domaini69 – 158CytoplasmicSequence analysisAdd BLAST90
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Topological domaini180 – 200ExtracellularSequence analysisAdd BLAST21
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Topological domaini222 – 223CytoplasmicSequence analysis2
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Topological domaini245 – 259ExtracellularSequence analysisAdd BLAST15
Transmembranei260 – 277HelicalSequence analysisAdd BLAST18
Topological domaini278 – 284CytoplasmicSequence analysis7
Transmembranei285 – 305HelicalSequence analysisAdd BLAST21
Topological domaini306 – 312ExtracellularSequence analysis7
Transmembranei313 – 333HelicalSequence analysisAdd BLAST21
Topological domaini334 – 395CytoplasmicSequence analysisAdd BLAST62

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi352 – 355DQVD → AQVA: Abolishes cleavage by CASP3 and ability to promote phosphatidylserine exposure. 1 Publication4

Organism-specific databases

OpenTargetsiENSG00000158156
PharmGKBiPA142670566

Polymorphism and mutation databases

BioMutaiXKR8
DMDMi74752693

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001907921 – 395XK-related protein 8Add BLAST395
ChainiPRO_00004239841 – 355XK-related protein 8, processed formSequence analysisAdd BLAST355

Post-translational modificationi

Undergoes proteolytic processing by caspase-3 (CASP3), leading to its activation.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei355 – 356Cleavage; by caspase-3Sequence analysis2

Proteomic databases

EPDiQ9H6D3
PaxDbiQ9H6D3
PeptideAtlasiQ9H6D3
PRIDEiQ9H6D3

PTM databases

iPTMnetiQ9H6D3

Expressioni

Gene expression databases

BgeeiENSG00000158156
CleanExiHS_XKR8
GenevisibleiQ9H6D3 HS

Organism-specific databases

HPAiHPA049984
HPA053529

Interactioni

Protein-protein interaction databases

BioGridi120423, 4 interactors
STRINGi9606.ENSP00000362991

Structurei

3D structure databases

ProteinModelPortaliQ9H6D3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the XK family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4790 Eukaryota
ENOG410YRUD LUCA
GeneTreeiENSGT00530000062854
HOGENOMiHOG000082540
HOVERGENiHBG055840
InParanoidiQ9H6D3
OMAiRWLHPSC
OrthoDBiEOG091G048S
PhylomeDBiQ9H6D3
TreeFamiTF316454

Family and domain databases

InterProiView protein in InterPro
IPR018629 XK-rel
PfamiView protein in Pfam
PF09815 XK-related, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H6D3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPWSSRGALL RDLVLGVLGT AAFLLDLGTD LWAAVQYALG GRYLWAALVL
60 70 80 90 100
ALLGLASVAL QLFSWLWLRA DPAGLHGSQP PRRCLALLHL LQLGYLYRCV
110 120 130 140 150
QELRQGLLVW QQEEPSEFDL AYADFLALDI SMLRLFETFL ETAPQLTLVL
160 170 180 190 200
AIMLQSGRAE YYQWVGICTS FLGISWALLD YHRALRTCLP SKPLLGLGSS
210 220 230 240 250
VIYFLWNLLL LWPRVLAVAL FSALFPSYVA LHFLGLWLVL LLWVWLQGTD
260 270 280 290 300
FMPDPSSEWL YRVTVATILY FSWFNVAEGR TRGRAIIHFA FLLSDSILLV
310 320 330 340 350
ATWVTHSSWL PSGIPLQLWL PVGCGCFFLG LALRLVYYHW LHPSCCWKPD
360 370 380 390
PDQVDGARSL LSPEGYQLPQ NRRMTHLAQK FFPKAKDEAA SPVKG
Length:395
Mass (Da):44,655
Last modified:March 1, 2001 - v1
Checksum:i23199BAEEA6964C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY534246 mRNA Translation: AAT07095.1
AK026024 mRNA Translation: BAB15326.1
AL512288 Genomic DNA No translation available.
BC013379 mRNA Translation: AAH13379.1
BC028564 mRNA Translation: AAH28564.1
CCDSiCCDS315.1
RefSeqiNP_060523.2, NM_018053.3
UniGeneiHs.55024

Genome annotation databases

EnsembliENST00000373884; ENSP00000362991; ENSG00000158156
GeneIDi55113
KEGGihsa:55113
UCSCiuc001bph.2 human

Similar proteinsi

Entry informationi

Entry nameiXKR8_HUMAN
AccessioniPrimary (citable) accession number: Q9H6D3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: March 1, 2001
Last modified: February 28, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health