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Q9H6D3

- XKR8_HUMAN

UniProt

Q9H6D3 - XKR8_HUMAN

Protein

XK-related protein 8

Gene

XKR8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Promotes phosphatidylserine exposure on apoptotic cell surface, possibly by mediating phospholipid scrambling. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. Has no effect on calcium-induced exposure of phosphatidylserine. Activated upon caspase cleavage, suggesting that it does not act prior the onset of apoptosis.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei355 – 3562Cleavage; by caspase-3Sequence Analysis

    GO - Biological processi

    1. engulfment of apoptotic cell Source: UniProtKB
    2. phosphatidylserine exposure on apoptotic cell surface Source: UniProtKB

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    XK-related protein 8
    Short name:
    hXkr8
    Cleaved into the following chain:
    Gene namesi
    Name:XKR8
    Synonyms:XRG8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:25508. XKR8.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi352 – 3554DQVD → AQVA: Abolishes cleavage by CASP3 and ability to promote phosphatidylserine exposure. 1 Publication

    Organism-specific databases

    PharmGKBiPA142670566.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 395395XK-related protein 8PRO_0000190792Add
    BLAST
    Chaini1 – 355355XK-related protein 8, processed formSequence AnalysisPRO_0000423984Add
    BLAST

    Post-translational modificationi

    Undergoes proteolytic processing by caspase-3 (CASP3), leading to its activation.1 Publication

    Proteomic databases

    PaxDbiQ9H6D3.
    PRIDEiQ9H6D3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H6D3.
    BgeeiQ9H6D3.
    CleanExiHS_XKR8.
    GenevestigatoriQ9H6D3.

    Organism-specific databases

    HPAiHPA049984.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4723120.
    STRINGi9606.ENSP00000362991.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H6D3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1212CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini34 – 4714ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini69 – 15890CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini180 – 20021ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini222 – 2232CytoplasmicSequence Analysis
    Topological domaini245 – 25915ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini278 – 2847CytoplasmicSequence Analysis
    Topological domaini306 – 3127ExtracellularSequence Analysis
    Topological domaini334 – 39562CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei48 – 6821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei201 – 22121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei224 – 24421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei260 – 27718HelicalSequence AnalysisAdd
    BLAST
    Transmembranei285 – 30521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei313 – 33321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the XK family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG258849.
    HOGENOMiHOG000082540.
    HOVERGENiHBG055840.
    InParanoidiQ9H6D3.
    OMAiFPHYVAL.
    OrthoDBiEOG7T4MKZ.
    PhylomeDBiQ9H6D3.
    TreeFamiTF316454.

    Family and domain databases

    InterProiIPR018629. Transport_prot_XK.
    [Graphical view]
    PfamiPF09815. XK-related. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9H6D3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPWSSRGALL RDLVLGVLGT AAFLLDLGTD LWAAVQYALG GRYLWAALVL    50
    ALLGLASVAL QLFSWLWLRA DPAGLHGSQP PRRCLALLHL LQLGYLYRCV 100
    QELRQGLLVW QQEEPSEFDL AYADFLALDI SMLRLFETFL ETAPQLTLVL 150
    AIMLQSGRAE YYQWVGICTS FLGISWALLD YHRALRTCLP SKPLLGLGSS 200
    VIYFLWNLLL LWPRVLAVAL FSALFPSYVA LHFLGLWLVL LLWVWLQGTD 250
    FMPDPSSEWL YRVTVATILY FSWFNVAEGR TRGRAIIHFA FLLSDSILLV 300
    ATWVTHSSWL PSGIPLQLWL PVGCGCFFLG LALRLVYYHW LHPSCCWKPD 350
    PDQVDGARSL LSPEGYQLPQ NRRMTHLAQK FFPKAKDEAA SPVKG 395
    Length:395
    Mass (Da):44,655
    Last modified:March 1, 2001 - v1
    Checksum:i23199BAEEA6964C6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY534246 mRNA. Translation: AAT07095.1.
    AK026024 mRNA. Translation: BAB15326.1.
    AL512288 Genomic DNA. Translation: CAI14292.1.
    BC013379 mRNA. Translation: AAH13379.1.
    BC028564 mRNA. Translation: AAH28564.1.
    CCDSiCCDS315.1.
    RefSeqiNP_060523.2. NM_018053.2.
    UniGeneiHs.55024.

    Genome annotation databases

    EnsembliENST00000373884; ENSP00000362991; ENSG00000158156.
    GeneIDi55113.
    KEGGihsa:55113.
    UCSCiuc001bph.1. human.

    Polymorphism databases

    DMDMi74752693.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY534246 mRNA. Translation: AAT07095.1 .
    AK026024 mRNA. Translation: BAB15326.1 .
    AL512288 Genomic DNA. Translation: CAI14292.1 .
    BC013379 mRNA. Translation: AAH13379.1 .
    BC028564 mRNA. Translation: AAH28564.1 .
    CCDSi CCDS315.1.
    RefSeqi NP_060523.2. NM_018053.2.
    UniGenei Hs.55024.

    3D structure databases

    ProteinModelPortali Q9H6D3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4723120.
    STRINGi 9606.ENSP00000362991.

    Polymorphism databases

    DMDMi 74752693.

    Proteomic databases

    PaxDbi Q9H6D3.
    PRIDEi Q9H6D3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373884 ; ENSP00000362991 ; ENSG00000158156 .
    GeneIDi 55113.
    KEGGi hsa:55113.
    UCSCi uc001bph.1. human.

    Organism-specific databases

    CTDi 55113.
    GeneCardsi GC01P028285.
    HGNCi HGNC:25508. XKR8.
    HPAi HPA049984.
    neXtProti NX_Q9H6D3.
    PharmGKBi PA142670566.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG258849.
    HOGENOMi HOG000082540.
    HOVERGENi HBG055840.
    InParanoidi Q9H6D3.
    OMAi FPHYVAL.
    OrthoDBi EOG7T4MKZ.
    PhylomeDBi Q9H6D3.
    TreeFami TF316454.

    Miscellaneous databases

    GenomeRNAii 55113.
    NextBioi 58740.
    PROi Q9H6D3.

    Gene expression databases

    ArrayExpressi Q9H6D3.
    Bgeei Q9H6D3.
    CleanExi HS_XKR8.
    Genevestigatori Q9H6D3.

    Family and domain databases

    InterProi IPR018629. Transport_prot_XK.
    [Graphical view ]
    Pfami PF09815. XK-related. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A superfamily of XK-related genes (XRG) widely expressed in vertebrates and invertebrates."
      Huang C.-H., Chen Y.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.
    5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    6. "Xk-Related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells."
      Suzuki J., Denning D.P., Imanishi E., Horvitz H.R., Nagata S.
      Science 341:403-406(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, PROTEOLYTIC PROCESSING BY CASP3, MUTAGENESIS OF 352-ASP--ASP-355.

    Entry informationi

    Entry nameiXKR8_HUMAN
    AccessioniPrimary (citable) accession number: Q9H6D3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2005
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Expression is repressed in PLB-985 leukemia and Raji lymphoma cells due to CpG methylation near the transcription start site of XKR8 gene, possibly explaining the inability of PLB-985 leukemia and Raji lymphoma cells to expose phosphatidylserine during apoptosis.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3