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Q9H6D3

- XKR8_HUMAN

UniProt

Q9H6D3 - XKR8_HUMAN

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Protein

XK-related protein 8

Gene

XKR8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Promotes phosphatidylserine exposure on apoptotic cell surface, possibly by mediating phospholipid scrambling. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. Has no effect on calcium-induced exposure of phosphatidylserine. Activated upon caspase cleavage, suggesting that it does not act prior the onset of apoptosis.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei355 – 3562Cleavage; by caspase-3Sequence Analysis

GO - Biological processi

  1. engulfment of apoptotic cell Source: UniProtKB
  2. phosphatidylserine exposure on apoptotic cell surface Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
XK-related protein 8
Short name:
hXkr8
Cleaved into the following chain:
Gene namesi
Name:XKR8
Synonyms:XRG8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:25508. XKR8.

Subcellular locationi

Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei13 – 3321HelicalSequence AnalysisAdd
BLAST
Topological domaini34 – 4714ExtracellularSequence AnalysisAdd
BLAST
Transmembranei48 – 6821HelicalSequence AnalysisAdd
BLAST
Topological domaini69 – 15890CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei159 – 17921HelicalSequence AnalysisAdd
BLAST
Topological domaini180 – 20021ExtracellularSequence AnalysisAdd
BLAST
Transmembranei201 – 22121HelicalSequence AnalysisAdd
BLAST
Topological domaini222 – 2232CytoplasmicSequence Analysis
Transmembranei224 – 24421HelicalSequence AnalysisAdd
BLAST
Topological domaini245 – 25915ExtracellularSequence AnalysisAdd
BLAST
Transmembranei260 – 27718HelicalSequence AnalysisAdd
BLAST
Topological domaini278 – 2847CytoplasmicSequence Analysis
Transmembranei285 – 30521HelicalSequence AnalysisAdd
BLAST
Topological domaini306 – 3127ExtracellularSequence Analysis
Transmembranei313 – 33321HelicalSequence AnalysisAdd
BLAST
Topological domaini334 – 39562CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi352 – 3554DQVD → AQVA: Abolishes cleavage by CASP3 and ability to promote phosphatidylserine exposure. 1 Publication

Organism-specific databases

PharmGKBiPA142670566.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 395395XK-related protein 8PRO_0000190792Add
BLAST
Chaini1 – 355355XK-related protein 8, processed formSequence AnalysisPRO_0000423984Add
BLAST

Post-translational modificationi

Undergoes proteolytic processing by caspase-3 (CASP3), leading to its activation.1 Publication

Proteomic databases

PaxDbiQ9H6D3.
PRIDEiQ9H6D3.

Expressioni

Gene expression databases

BgeeiQ9H6D3.
CleanExiHS_XKR8.
ExpressionAtlasiQ9H6D3. baseline and differential.
GenevestigatoriQ9H6D3.

Organism-specific databases

HPAiHPA049984.

Interactioni

Protein-protein interaction databases

MINTiMINT-4723120.
STRINGi9606.ENSP00000362991.

Structurei

3D structure databases

ProteinModelPortaliQ9H6D3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the XK family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG258849.
GeneTreeiENSGT00530000062854.
HOGENOMiHOG000082540.
HOVERGENiHBG055840.
InParanoidiQ9H6D3.
OMAiFPHYVAL.
OrthoDBiEOG7T4MKZ.
PhylomeDBiQ9H6D3.
TreeFamiTF316454.

Family and domain databases

InterProiIPR018629. Transport_prot_XK.
[Graphical view]
PfamiPF09815. XK-related. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H6D3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPWSSRGALL RDLVLGVLGT AAFLLDLGTD LWAAVQYALG GRYLWAALVL
60 70 80 90 100
ALLGLASVAL QLFSWLWLRA DPAGLHGSQP PRRCLALLHL LQLGYLYRCV
110 120 130 140 150
QELRQGLLVW QQEEPSEFDL AYADFLALDI SMLRLFETFL ETAPQLTLVL
160 170 180 190 200
AIMLQSGRAE YYQWVGICTS FLGISWALLD YHRALRTCLP SKPLLGLGSS
210 220 230 240 250
VIYFLWNLLL LWPRVLAVAL FSALFPSYVA LHFLGLWLVL LLWVWLQGTD
260 270 280 290 300
FMPDPSSEWL YRVTVATILY FSWFNVAEGR TRGRAIIHFA FLLSDSILLV
310 320 330 340 350
ATWVTHSSWL PSGIPLQLWL PVGCGCFFLG LALRLVYYHW LHPSCCWKPD
360 370 380 390
PDQVDGARSL LSPEGYQLPQ NRRMTHLAQK FFPKAKDEAA SPVKG
Length:395
Mass (Da):44,655
Last modified:March 1, 2001 - v1
Checksum:i23199BAEEA6964C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY534246 mRNA. Translation: AAT07095.1.
AK026024 mRNA. Translation: BAB15326.1.
AL512288 Genomic DNA. Translation: CAI14292.1.
BC013379 mRNA. Translation: AAH13379.1.
BC028564 mRNA. Translation: AAH28564.1.
CCDSiCCDS315.1.
RefSeqiNP_060523.2. NM_018053.2.
UniGeneiHs.55024.

Genome annotation databases

EnsembliENST00000373884; ENSP00000362991; ENSG00000158156.
GeneIDi55113.
KEGGihsa:55113.
UCSCiuc001bph.1. human.

Polymorphism databases

DMDMi74752693.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY534246 mRNA. Translation: AAT07095.1 .
AK026024 mRNA. Translation: BAB15326.1 .
AL512288 Genomic DNA. Translation: CAI14292.1 .
BC013379 mRNA. Translation: AAH13379.1 .
BC028564 mRNA. Translation: AAH28564.1 .
CCDSi CCDS315.1.
RefSeqi NP_060523.2. NM_018053.2.
UniGenei Hs.55024.

3D structure databases

ProteinModelPortali Q9H6D3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4723120.
STRINGi 9606.ENSP00000362991.

Polymorphism databases

DMDMi 74752693.

Proteomic databases

PaxDbi Q9H6D3.
PRIDEi Q9H6D3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373884 ; ENSP00000362991 ; ENSG00000158156 .
GeneIDi 55113.
KEGGi hsa:55113.
UCSCi uc001bph.1. human.

Organism-specific databases

CTDi 55113.
GeneCardsi GC01P028285.
HGNCi HGNC:25508. XKR8.
HPAi HPA049984.
neXtProti NX_Q9H6D3.
PharmGKBi PA142670566.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG258849.
GeneTreei ENSGT00530000062854.
HOGENOMi HOG000082540.
HOVERGENi HBG055840.
InParanoidi Q9H6D3.
OMAi FPHYVAL.
OrthoDBi EOG7T4MKZ.
PhylomeDBi Q9H6D3.
TreeFami TF316454.

Miscellaneous databases

GenomeRNAii 55113.
NextBioi 58740.
PROi Q9H6D3.

Gene expression databases

Bgeei Q9H6D3.
CleanExi HS_XKR8.
ExpressionAtlasi Q9H6D3. baseline and differential.
Genevestigatori Q9H6D3.

Family and domain databases

InterProi IPR018629. Transport_prot_XK.
[Graphical view ]
Pfami PF09815. XK-related. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A superfamily of XK-related genes (XRG) widely expressed in vertebrates and invertebrates."
    Huang C.-H., Chen Y.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  6. "Xk-Related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells."
    Suzuki J., Denning D.P., Imanishi E., Horvitz H.R., Nagata S.
    Science 341:403-406(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, PROTEOLYTIC PROCESSING BY CASP3, MUTAGENESIS OF 352-ASP--ASP-355.

Entry informationi

Entry nameiXKR8_HUMAN
AccessioniPrimary (citable) accession number: Q9H6D3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Expression is repressed in PLB-985 leukemia and Raji lymphoma cells due to CpG methylation near the transcription start site of XKR8 gene, possibly explaining the inability of PLB-985 leukemia and Raji lymphoma cells to expose phosphatidylserine during apoptosis.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3