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Q9H6B9 (EPHX3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Epoxide hydrolase 3

EC=3.3.-.-
Alternative name(s):
Abhydrolase domain-containing protein 9
Gene names
Name:EPHX3
Synonyms:ABHD9
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionhydrolase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3535 Potential
Chain36 – 360325Epoxide hydrolase 3
PRO_0000264232

Sites

Active site1731Nucleophile By similarity
Active site2811Proton donor By similarity
Active site3371Proton acceptor By similarity

Amino acid modifications

Glycosylation2671N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9H6B9 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: C465A4B0E2D56BA0

FASTA36040,909
        10         20         30         40         50         60 
MPELVVTALL APSRLSLKLL RAFMWSLVFS VALVAAAVYG CIALTHVLCR PRRGCCGRRR 

        70         80         90        100        110        120 
SASPACLSDP SLGEHGFLNL KSSGLRLHYV SAGRGNGPLM LFLHGFPENW FSWRYQLREF 

       130        140        150        160        170        180 
QSRFHVVAVD LRGYGPSDAP RDVDCYTIDL LLVDIKDVIL GLGYSKCILV AHDWGALLAW 

       190        200        210        220        230        240 
HFSIYYPSLV ERMVVVSGAP MSVYQDYSLH HISQFFRSHY MFLFQLPWLP EKLLSMSDFQ 

       250        260        270        280        290        300 
ILKTTLTHRK TGIPCLTPSE LEAFLYNFSQ PGGLTGPLNY YRNLFRNFPL EPQELTTPTL 

       310        320        330        340        350        360 
LLWGEKDTYL ELGLVEAIGS RFVPGRLEAH ILPGIGHWIP QSNPQEMHQY MWAFLQDLLD 

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Embryonic stem cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK026061 mRNA. Translation: BAB15342.1.
CH471106 Genomic DNA. Translation: EAW84467.1.
BC115002 mRNA. Translation: AAI15003.1.
BC132958 mRNA. Translation: AAI32959.1.
BC132960 mRNA. Translation: AAI32961.1.
CCDSCCDS12327.1.
RefSeqNP_001136358.1. NM_001142886.1.
NP_079070.1. NM_024794.2.
XP_006722963.1. XM_006722900.1.
UniGeneHs.156457.

3D structure databases

ProteinModelPortalQ9H6B9.
SMRQ9H6B9. Positions 83-355.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS33.978.

PTM databases

PhosphoSiteQ9H6B9.

Polymorphism databases

DMDM74718486.

Proteomic databases

PaxDbQ9H6B9.
PRIDEQ9H6B9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000221730; ENSP00000221730; ENSG00000105131.
ENST00000435261; ENSP00000410323; ENSG00000105131.
ENST00000602233; ENSP00000469345; ENSG00000105131.
GeneID79852.
KEGGhsa:79852.
UCSCuc002nap.3. human.

Organism-specific databases

CTD79852.
GeneCardsGC19M015337.
HGNCHGNC:23760. EPHX3.
HPAHPA012842.
neXtProtNX_Q9H6B9.
PharmGKBPA164719188.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0596.
HOGENOMHOG000028073.
HOVERGENHBG099190.
InParanoidQ9H6B9.
OMALGEHCFL.
OrthoDBEOG7VQJDV.
PhylomeDBQ9H6B9.
TreeFamTF314403.

Gene expression databases

ArrayExpressQ9H6B9.
BgeeQ9H6B9.
CleanExHS_ABHD9.
GenevestigatorQ9H6B9.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
[Graphical view]
PRINTSPR00111. ABHYDROLASE.
PR00412. EPOXHYDRLASE.
SUPFAMSSF53474. SSF53474. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi79852.
NextBio69563.
PROQ9H6B9.

Entry information

Entry nameEPHX3_HUMAN
AccessionPrimary (citable) accession number: Q9H6B9
Secondary accession number(s): A3KMR3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM