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Q9H6B9

- EPHX3_HUMAN

UniProt

Q9H6B9 - EPHX3_HUMAN

Protein

Epoxide hydrolase 3

Gene

EPHX3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei173 – 1731NucleophileBy similarity
    Active sitei281 – 2811Proton donorBy similarity
    Active sitei337 – 3371Proton acceptorBy similarity

    GO - Molecular functioni

    1. hydrolase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Protein family/group databases

    MEROPSiS33.978.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Epoxide hydrolase 3 (EC:3.3.-.-)
    Alternative name(s):
    Abhydrolase domain-containing protein 9
    Gene namesi
    Name:EPHX3
    Synonyms:ABHD9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:23760. EPHX3.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164719188.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3535Sequence AnalysisAdd
    BLAST
    Chaini36 – 360325Epoxide hydrolase 3PRO_0000264232Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi267 – 2671N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9H6B9.
    PRIDEiQ9H6B9.

    PTM databases

    PhosphoSiteiQ9H6B9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H6B9.
    BgeeiQ9H6B9.
    CleanExiHS_ABHD9.
    GenevestigatoriQ9H6B9.

    Organism-specific databases

    HPAiHPA012842.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H6B9.
    SMRiQ9H6B9. Positions 83-355.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0596.
    HOGENOMiHOG000028073.
    HOVERGENiHBG099190.
    InParanoidiQ9H6B9.
    OMAiLGEHCFL.
    OrthoDBiEOG7VQJDV.
    PhylomeDBiQ9H6B9.
    TreeFamiTF314403.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR000073. AB_hydrolase_1.
    IPR000639. Epox_hydrolase-like.
    [Graphical view]
    PRINTSiPR00111. ABHYDROLASE.
    PR00412. EPOXHYDRLASE.
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9H6B9-1 [UniParc]FASTAAdd to Basket

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    MPELVVTALL APSRLSLKLL RAFMWSLVFS VALVAAAVYG CIALTHVLCR    50
    PRRGCCGRRR SASPACLSDP SLGEHGFLNL KSSGLRLHYV SAGRGNGPLM 100
    LFLHGFPENW FSWRYQLREF QSRFHVVAVD LRGYGPSDAP RDVDCYTIDL 150
    LLVDIKDVIL GLGYSKCILV AHDWGALLAW HFSIYYPSLV ERMVVVSGAP 200
    MSVYQDYSLH HISQFFRSHY MFLFQLPWLP EKLLSMSDFQ ILKTTLTHRK 250
    TGIPCLTPSE LEAFLYNFSQ PGGLTGPLNY YRNLFRNFPL EPQELTTPTL 300
    LLWGEKDTYL ELGLVEAIGS RFVPGRLEAH ILPGIGHWIP QSNPQEMHQY 350
    MWAFLQDLLD 360
    Length:360
    Mass (Da):40,909
    Last modified:March 1, 2001 - v1
    Checksum:iC465A4B0E2D56BA0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK026061 mRNA. Translation: BAB15342.1.
    CH471106 Genomic DNA. Translation: EAW84467.1.
    BC115002 mRNA. Translation: AAI15003.1.
    BC132958 mRNA. Translation: AAI32959.1.
    BC132960 mRNA. Translation: AAI32961.1.
    CCDSiCCDS12327.1.
    RefSeqiNP_001136358.1. NM_001142886.1.
    NP_079070.1. NM_024794.2.
    XP_006722963.1. XM_006722900.1.
    UniGeneiHs.156457.

    Genome annotation databases

    EnsembliENST00000221730; ENSP00000221730; ENSG00000105131.
    ENST00000435261; ENSP00000410323; ENSG00000105131.
    ENST00000602233; ENSP00000469345; ENSG00000105131.
    GeneIDi79852.
    KEGGihsa:79852.
    UCSCiuc002nap.3. human.

    Polymorphism databases

    DMDMi74718486.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK026061 mRNA. Translation: BAB15342.1 .
    CH471106 Genomic DNA. Translation: EAW84467.1 .
    BC115002 mRNA. Translation: AAI15003.1 .
    BC132958 mRNA. Translation: AAI32959.1 .
    BC132960 mRNA. Translation: AAI32961.1 .
    CCDSi CCDS12327.1.
    RefSeqi NP_001136358.1. NM_001142886.1.
    NP_079070.1. NM_024794.2.
    XP_006722963.1. XM_006722900.1.
    UniGenei Hs.156457.

    3D structure databases

    ProteinModelPortali Q9H6B9.
    SMRi Q9H6B9. Positions 83-355.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S33.978.

    PTM databases

    PhosphoSitei Q9H6B9.

    Polymorphism databases

    DMDMi 74718486.

    Proteomic databases

    PaxDbi Q9H6B9.
    PRIDEi Q9H6B9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000221730 ; ENSP00000221730 ; ENSG00000105131 .
    ENST00000435261 ; ENSP00000410323 ; ENSG00000105131 .
    ENST00000602233 ; ENSP00000469345 ; ENSG00000105131 .
    GeneIDi 79852.
    KEGGi hsa:79852.
    UCSCi uc002nap.3. human.

    Organism-specific databases

    CTDi 79852.
    GeneCardsi GC19M015337.
    HGNCi HGNC:23760. EPHX3.
    HPAi HPA012842.
    neXtProti NX_Q9H6B9.
    PharmGKBi PA164719188.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0596.
    HOGENOMi HOG000028073.
    HOVERGENi HBG099190.
    InParanoidi Q9H6B9.
    OMAi LGEHCFL.
    OrthoDBi EOG7VQJDV.
    PhylomeDBi Q9H6B9.
    TreeFami TF314403.

    Miscellaneous databases

    GenomeRNAii 79852.
    NextBioi 69563.
    PROi Q9H6B9.

    Gene expression databases

    ArrayExpressi Q9H6B9.
    Bgeei Q9H6B9.
    CleanExi HS_ABHD9.
    Genevestigatori Q9H6B9.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR000073. AB_hydrolase_1.
    IPR000639. Epox_hydrolase-like.
    [Graphical view ]
    PRINTSi PR00111. ABHYDROLASE.
    PR00412. EPOXHYDRLASE.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Embryonic stem cell.

    Entry informationi

    Entry nameiEPHX3_HUMAN
    AccessioniPrimary (citable) accession number: Q9H6B9
    Secondary accession number(s): A3KMR3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3