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Protein

Epoxide hydrolase 3

Gene

EPHX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei173NucleophileBy similarity1
Active sitei281Proton donorBy similarity1
Active sitei337Proton acceptorBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105131-MONOMER.

Protein family/group databases

ESTHERihuman-EPHX3. Epoxide_hydrolase.
MEROPSiS33.978.

Chemistry databases

SwissLipidsiSLP:000001116.

Names & Taxonomyi

Protein namesi
Recommended name:
Epoxide hydrolase 3 (EC:3.3.-.-)
Alternative name(s):
Abhydrolase domain-containing protein 9
Gene namesi
Name:EPHX3
Synonyms:ABHD9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:23760. EPHX3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi79852.
OpenTargetsiENSG00000105131.
PharmGKBiPA164719188.

Polymorphism and mutation databases

BioMutaiEPHX3.
DMDMi74718486.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000026423236 – 360Epoxide hydrolase 3Add BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi267N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9H6B9.
MaxQBiQ9H6B9.
PaxDbiQ9H6B9.
PeptideAtlasiQ9H6B9.
PRIDEiQ9H6B9.

PTM databases

iPTMnetiQ9H6B9.
PhosphoSitePlusiQ9H6B9.

Expressioni

Gene expression databases

BgeeiENSG00000105131.
CleanExiHS_ABHD9.
ExpressionAtlasiQ9H6B9. baseline and differential.
GenevisibleiQ9H6B9. HS.

Organism-specific databases

HPAiHPA012842.

Structurei

3D structure databases

ProteinModelPortaliQ9H6B9.
SMRiQ9H6B9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410INN9. Eukaryota.
ENOG410XQGI. LUCA.
GeneTreeiENSGT00530000063213.
HOGENOMiHOG000028073.
HOVERGENiHBG099190.
InParanoidiQ9H6B9.
OMAiCWNLAIQ.
OrthoDBiEOG091G0ASI.
PhylomeDBiQ9H6B9.
TreeFamiTF314403.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
[Graphical view]
PfamiPF12697. Abhydrolase_6. 1 hit.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
PR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H6B9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPELVVTALL APSRLSLKLL RAFMWSLVFS VALVAAAVYG CIALTHVLCR
60 70 80 90 100
PRRGCCGRRR SASPACLSDP SLGEHGFLNL KSSGLRLHYV SAGRGNGPLM
110 120 130 140 150
LFLHGFPENW FSWRYQLREF QSRFHVVAVD LRGYGPSDAP RDVDCYTIDL
160 170 180 190 200
LLVDIKDVIL GLGYSKCILV AHDWGALLAW HFSIYYPSLV ERMVVVSGAP
210 220 230 240 250
MSVYQDYSLH HISQFFRSHY MFLFQLPWLP EKLLSMSDFQ ILKTTLTHRK
260 270 280 290 300
TGIPCLTPSE LEAFLYNFSQ PGGLTGPLNY YRNLFRNFPL EPQELTTPTL
310 320 330 340 350
LLWGEKDTYL ELGLVEAIGS RFVPGRLEAH ILPGIGHWIP QSNPQEMHQY
360
MWAFLQDLLD
Length:360
Mass (Da):40,909
Last modified:March 1, 2001 - v1
Checksum:iC465A4B0E2D56BA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026061 mRNA. Translation: BAB15342.1.
CH471106 Genomic DNA. Translation: EAW84467.1.
BC115002 mRNA. Translation: AAI15003.1.
BC132958 mRNA. Translation: AAI32959.1.
BC132960 mRNA. Translation: AAI32961.1.
CCDSiCCDS12327.1.
RefSeqiNP_001136358.1. NM_001142886.1.
NP_079070.1. NM_024794.2.
UniGeneiHs.156457.

Genome annotation databases

EnsembliENST00000221730; ENSP00000221730; ENSG00000105131.
ENST00000435261; ENSP00000410323; ENSG00000105131.
ENST00000602233; ENSP00000469345; ENSG00000105131.
GeneIDi79852.
KEGGihsa:79852.
UCSCiuc002nap.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026061 mRNA. Translation: BAB15342.1.
CH471106 Genomic DNA. Translation: EAW84467.1.
BC115002 mRNA. Translation: AAI15003.1.
BC132958 mRNA. Translation: AAI32959.1.
BC132960 mRNA. Translation: AAI32961.1.
CCDSiCCDS12327.1.
RefSeqiNP_001136358.1. NM_001142886.1.
NP_079070.1. NM_024794.2.
UniGeneiHs.156457.

3D structure databases

ProteinModelPortaliQ9H6B9.
SMRiQ9H6B9.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

SwissLipidsiSLP:000001116.

Protein family/group databases

ESTHERihuman-EPHX3. Epoxide_hydrolase.
MEROPSiS33.978.

PTM databases

iPTMnetiQ9H6B9.
PhosphoSitePlusiQ9H6B9.

Polymorphism and mutation databases

BioMutaiEPHX3.
DMDMi74718486.

Proteomic databases

EPDiQ9H6B9.
MaxQBiQ9H6B9.
PaxDbiQ9H6B9.
PeptideAtlasiQ9H6B9.
PRIDEiQ9H6B9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221730; ENSP00000221730; ENSG00000105131.
ENST00000435261; ENSP00000410323; ENSG00000105131.
ENST00000602233; ENSP00000469345; ENSG00000105131.
GeneIDi79852.
KEGGihsa:79852.
UCSCiuc002nap.4. human.

Organism-specific databases

CTDi79852.
DisGeNETi79852.
GeneCardsiEPHX3.
HGNCiHGNC:23760. EPHX3.
HPAiHPA012842.
neXtProtiNX_Q9H6B9.
OpenTargetsiENSG00000105131.
PharmGKBiPA164719188.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INN9. Eukaryota.
ENOG410XQGI. LUCA.
GeneTreeiENSGT00530000063213.
HOGENOMiHOG000028073.
HOVERGENiHBG099190.
InParanoidiQ9H6B9.
OMAiCWNLAIQ.
OrthoDBiEOG091G0ASI.
PhylomeDBiQ9H6B9.
TreeFamiTF314403.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105131-MONOMER.

Miscellaneous databases

GenomeRNAii79852.
PROiQ9H6B9.

Gene expression databases

BgeeiENSG00000105131.
CleanExiHS_ABHD9.
ExpressionAtlasiQ9H6B9. baseline and differential.
GenevisibleiQ9H6B9. HS.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
[Graphical view]
PfamiPF12697. Abhydrolase_6. 1 hit.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
PR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEPHX3_HUMAN
AccessioniPrimary (citable) accession number: Q9H6B9
Secondary accession number(s): A3KMR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.