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Protein

Epoxide hydrolase 3

Gene

EPHX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei173 – 1731NucleophileBy similarity
Active sitei281 – 2811Proton donorBy similarity
Active sitei337 – 3371Proton acceptorBy similarity

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Protein family/group databases

MEROPSiS33.978.

Names & Taxonomyi

Protein namesi
Recommended name:
Epoxide hydrolase 3 (EC:3.3.-.-)
Alternative name(s):
Abhydrolase domain-containing protein 9
Gene namesi
Name:EPHX3
Synonyms:ABHD9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:23760. EPHX3.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164719188.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535Sequence AnalysisAdd
BLAST
Chaini36 – 360325Epoxide hydrolase 3PRO_0000264232Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi267 – 2671N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9H6B9.
PRIDEiQ9H6B9.

PTM databases

PhosphoSiteiQ9H6B9.

Expressioni

Gene expression databases

BgeeiQ9H6B9.
CleanExiHS_ABHD9.
ExpressionAtlasiQ9H6B9. baseline and differential.
GenevestigatoriQ9H6B9.

Organism-specific databases

HPAiHPA012842.

Structurei

3D structure databases

ProteinModelPortaliQ9H6B9.
SMRiQ9H6B9. Positions 83-355.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0596.
GeneTreeiENSGT00530000063213.
HOGENOMiHOG000028073.
HOVERGENiHBG099190.
InParanoidiQ9H6B9.
OMAiTHHKRGI.
OrthoDBiEOG7VQJDV.
PhylomeDBiQ9H6B9.
TreeFamiTF314403.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
[Graphical view]
PfamiPF12697. Abhydrolase_6. 1 hit.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
PR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H6B9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPELVVTALL APSRLSLKLL RAFMWSLVFS VALVAAAVYG CIALTHVLCR
60 70 80 90 100
PRRGCCGRRR SASPACLSDP SLGEHGFLNL KSSGLRLHYV SAGRGNGPLM
110 120 130 140 150
LFLHGFPENW FSWRYQLREF QSRFHVVAVD LRGYGPSDAP RDVDCYTIDL
160 170 180 190 200
LLVDIKDVIL GLGYSKCILV AHDWGALLAW HFSIYYPSLV ERMVVVSGAP
210 220 230 240 250
MSVYQDYSLH HISQFFRSHY MFLFQLPWLP EKLLSMSDFQ ILKTTLTHRK
260 270 280 290 300
TGIPCLTPSE LEAFLYNFSQ PGGLTGPLNY YRNLFRNFPL EPQELTTPTL
310 320 330 340 350
LLWGEKDTYL ELGLVEAIGS RFVPGRLEAH ILPGIGHWIP QSNPQEMHQY
360
MWAFLQDLLD
Length:360
Mass (Da):40,909
Last modified:March 1, 2001 - v1
Checksum:iC465A4B0E2D56BA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026061 mRNA. Translation: BAB15342.1.
CH471106 Genomic DNA. Translation: EAW84467.1.
BC115002 mRNA. Translation: AAI15003.1.
BC132958 mRNA. Translation: AAI32959.1.
BC132960 mRNA. Translation: AAI32961.1.
CCDSiCCDS12327.1.
RefSeqiNP_001136358.1. NM_001142886.1.
NP_079070.1. NM_024794.2.
XP_006722963.1. XM_006722900.1.
UniGeneiHs.156457.

Genome annotation databases

EnsembliENST00000221730; ENSP00000221730; ENSG00000105131.
ENST00000435261; ENSP00000410323; ENSG00000105131.
ENST00000602233; ENSP00000469345; ENSG00000105131.
GeneIDi79852.
KEGGihsa:79852.
UCSCiuc002nap.3. human.

Polymorphism databases

DMDMi74718486.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026061 mRNA. Translation: BAB15342.1.
CH471106 Genomic DNA. Translation: EAW84467.1.
BC115002 mRNA. Translation: AAI15003.1.
BC132958 mRNA. Translation: AAI32959.1.
BC132960 mRNA. Translation: AAI32961.1.
CCDSiCCDS12327.1.
RefSeqiNP_001136358.1. NM_001142886.1.
NP_079070.1. NM_024794.2.
XP_006722963.1. XM_006722900.1.
UniGeneiHs.156457.

3D structure databases

ProteinModelPortaliQ9H6B9.
SMRiQ9H6B9. Positions 83-355.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS33.978.

PTM databases

PhosphoSiteiQ9H6B9.

Polymorphism databases

DMDMi74718486.

Proteomic databases

PaxDbiQ9H6B9.
PRIDEiQ9H6B9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221730; ENSP00000221730; ENSG00000105131.
ENST00000435261; ENSP00000410323; ENSG00000105131.
ENST00000602233; ENSP00000469345; ENSG00000105131.
GeneIDi79852.
KEGGihsa:79852.
UCSCiuc002nap.3. human.

Organism-specific databases

CTDi79852.
GeneCardsiGC19M015337.
HGNCiHGNC:23760. EPHX3.
HPAiHPA012842.
neXtProtiNX_Q9H6B9.
PharmGKBiPA164719188.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0596.
GeneTreeiENSGT00530000063213.
HOGENOMiHOG000028073.
HOVERGENiHBG099190.
InParanoidiQ9H6B9.
OMAiTHHKRGI.
OrthoDBiEOG7VQJDV.
PhylomeDBiQ9H6B9.
TreeFamiTF314403.

Miscellaneous databases

GenomeRNAii79852.
NextBioi69563.
PROiQ9H6B9.

Gene expression databases

BgeeiQ9H6B9.
CleanExiHS_ABHD9.
ExpressionAtlasiQ9H6B9. baseline and differential.
GenevestigatoriQ9H6B9.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
[Graphical view]
PfamiPF12697. Abhydrolase_6. 1 hit.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
PR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Embryonic stem cell.

Entry informationi

Entry nameiEPHX3_HUMAN
AccessioniPrimary (citable) accession number: Q9H6B9
Secondary accession number(s): A3KMR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 1, 2001
Last modified: April 1, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.