Q9H6B4 (CLMP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CXADR-like membrane protein

Alternative name(s):
Adipocyte adhesion molecule
Coxsackie- and adenovirus receptor-like membrane protein
Short name=CAR-like membrane protein

Gene names

Name:	CLMP
Synonyms:	ACAM, ASAM
ORF Names:	UNQ318/PRO363

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	373 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Ref.1 Ref.5
Subcellular location	Cell junction › tight junction. Cell membrane; Single-pass type I membrane protein Potential Ref.5.
Tissue specificity	Predominantly expressed in epithelial cells within different tissues and in the white adipose tissue. Expressed at high levels in small intestine and placenta, at intermediate levels in the heart, skeletal muscle, colon, spleen, kidney and lung and at low levels in the liver and peripheral blood leukocytes. Ref.1 Ref.5
Induction	Up-regulated in mature adipocytes and adipocyte tissue of obese individuals. Ref.1
Sequence similarities	Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Membrane Tight junction
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW tight junction Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 373	355	CXADR-like membrane protein		PRO_0000293026
Regions
	Topological domain	19 – 235	217	Extracellular Potential
	Transmembrane	236 – 256	21	Helical; Potential
	Topological domain	257 – 373	117	Cytoplasmic Potential
	Domain	19 – 127	109	Ig-like C2-type 1
	Domain	135 – 224	90	Ig-like C2-type 2
	Compositional bias	265 – 268	4	Poly-Glu
	Compositional bias	288 – 314	27	Ser-rich
Amino acid modifications
	Glycosylation	74	1	N-linked (GlcNAc...) Potential
	Glycosylation	197	1	N-linked (GlcNAc...) Potential
	Disulfide bond	35 ↔ 111		By similarity
	Disulfide bond	153 ↔ 208		By similarity
Natural variations
	Natural variant	69	1	R → H. Corresponds to variant rs2276348 [ dbSNP | Ensembl ].		VAR_049824

Sequences

	Sequence		Length	Mass (Da)
	Q9H6B4 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: FDA215EB3B3C4335	FASTA	373	41,281
	10 20 30 40 50 60 MSLLLLLLLV SYYVGTLGTH TEIKRVAEEK VTLPCHHQLG LPEKDTLDIE WLLTDNEGNQ 70 80 90 100 110 120 KVVITYSSRH VYNNLTEEQK GRVAFASNFL AGDASLQIEP LKPSDEGRYT CKVKNSGRYV 130 140 150 160 170 180 WSHVILKVLV RPSKPKCELE GELTEGSDLT LQCESSSGTE PIVYYWQRIR EKEGEDERLP 190 200 210 220 230 240 PKSRIDYNHP GRVLLQNLTM SYSGLYQCTA GNEAGKESCV VRVTVQYVQS IGMVAGAVTG 250 260 270 280 290 300 IVAGALLIFL LVWLLIRRKD KERYEEEERP NEIREDAEAP KARLVKPSSS SSGSRSSRSG 310 320 330 340 350 360 SSSTRSTANS ASRSQRTLST DAAPQPGLAT QAYSLVGPEV RGSEPKKVHH ANLTKAETTP 370 SMIPSQSRAF QTV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of adipocyte adhesion molecule (ACAM), a novel CTX gene family, implicated in adipocyte maturation and development of obesity." Eguchi J., Wada J., Hida K., Zhang H., Matsuoka T., Baba M., Hashimoto I., Shikata K., Ogawa N., Makino H. Biochem. J. 387:343-353(2005) [PubMed: 15563274] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION, TISSUE SPECIFICITY.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle.
[5]	"CLMP, a novel member of the CTX family and a new component of epithelial tight junctions." Raschperger E., Engstrom U., Pettersson R.F., Fuxe J. J. Biol. Chem. 279:796-804(2004) [PubMed: 14573622] [Abstract] Cited for: IDENTIFICATION, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY326422 mRNA. Translation: AAP88386.1. AY358340 mRNA. Translation: AAQ88706.1. AK026068 mRNA. Translation: BAB15347.1. BC009371 mRNA. Translation: AAH09371.1. BK001245 mRNA. Translation: DAA01139.1.
IPI	IPI00024929.
RefSeq	NP_079045.1. NM_024769.2.
UniGene	Hs.591949.
3D structure databases
HSSP	HSSP built from PDB template 1F5W based on UniProtKB P78310.
ProteinModelPortal	Q9H6B4.
SMR	Q9H6B4. Positions 20-228.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H6B4. 1 interaction.
STRING	Q9H6B4.
PTM databases
PhosphoSite	Q9H6B4.
Polymorphism databases
DMDM	74761472.
Proteomic databases
PeptideAtlas	Q9H6B4.
PRIDE	Q9H6B4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000299322; ENSP00000299322; ENSG00000166250.
GeneID	79827.
KEGG	hsa:79827.
UCSC	uc001pyt.1. human.
Organism-specific databases
CTD	79827.
GeneCards	GC11M122943.
H-InvDB	HIX0010214.
HGNC	HGNC:24039. CLMP.
HPA	HPA002385.
MIM	611693. gene.
neXtProt	NX_Q9H6B4.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG10690.
GeneTree	ENSGT00600000084393.
HOGENOM	HBG715825.
HOVERGEN	HBG060225.
InParanoid	Q9H6B4.
OrthoDB	EOG42NJ16.
Gene expression databases
ArrayExpress	Q9H6B4.
Bgee	Q9H6B4.
Genevestigator	Q9H6B4.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003599. Ig_sub. IPR003598. Ig_sub2. IPR013106. Ig_V-set. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 2 hits.
KO	K06789.
Pfam	PF07679. I-set. 1 hit. PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00409. IG. 1 hit. SM00408. IGc2. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	69458.
SOURCE	Search...

Entry information

Entry name

CLMP_HUMAN

Accession

Primary (citable) accession number: Q9H6B4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	March 1, 2001
Last modified:	January 25, 2012
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.