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Protein

CXADR-like membrane protein

Gene

CLMP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development.3 Publications

GO - Biological processi

  • digestive tract development Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
CXADR-like membrane protein
Alternative name(s):
Adipocyte adhesion molecule
Coxsackie- and adenovirus receptor-like membrane protein
Short name:
CAR-like membrane protein
Gene namesi
Name:CLMP
Synonyms:ACAM, ASAM
ORF Names:UNQ318/PRO363
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:24039. CLMP.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 235217ExtracellularSequence analysisAdd
BLAST
Transmembranei236 – 25621HelicalSequence analysisAdd
BLAST
Topological domaini257 – 373117CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • bicellular tight junction Source: UniProtKB
  • cell surface Source: UniProtKB
  • cytoplasmic microtubule Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Involvement in diseasei

Congenital short bowel syndrome (CSBS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by a shortened small intestine, intestinal malrotation, and malabsorption. The mean length of the small intestine in CSBS patients is approximately 50 cm, compared with a normal length at birth of 190-280 cm. Patients with CSBS may develop severe malnutrition as a result of the hugely reduced absorptive surface of the small intestine. Infants require parenteral nutrition for survival. However, parenteral nutrition itself causes life-threatening complications such as sepsis and liver failure which are associated with a high rate of mortality early in life.
See also OMIM:615237
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti124 – 1241V → D in CSBS; affects subcellular location; the mutant protein is localized in the cytoplasm. 1 Publication
Corresponds to variant rs587776967 [ dbSNP | Ensembl ].
VAR_069713

Keywords - Diseasei

Disease mutation

Organism-specific databases

MalaCardsiCLMP.
MIMi615237. phenotype.
Orphaneti2301. Congenital short bowel syndrome.

Polymorphism and mutation databases

BioMutaiCLMP.
DMDMi74761472.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 373355CXADR-like membrane proteinPRO_0000293026Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi35 ↔ 111PROSITE-ProRule annotation
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence analysis
Disulfide bondi153 ↔ 208PROSITE-ProRule annotation
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9H6B4.
MaxQBiQ9H6B4.
PaxDbiQ9H6B4.
PeptideAtlasiQ9H6B4.
PRIDEiQ9H6B4.

PTM databases

iPTMnetiQ9H6B4.
PhosphoSiteiQ9H6B4.

Expressioni

Tissue specificityi

Predominantly expressed in epithelial cells within different tissues and in the white adipose tissue. Expressed at high levels in small intestine and placenta, at intermediate levels in the heart, skeletal muscle, colon, spleen, kidney and lung and at low levels in the liver and peripheral blood leukocytes. Highly abundant in the intestine during embryo and fetal development (at protein level).3 Publications

Developmental stagei

At 7 and 8 weeks of development, it is highly abundant in the rapidly dividing cells of the central and peripheral nervous systems, the mesenchyme of the frontonasal and mandibular processes and the dermamyotome, and it is expressed in the endodermal derivatives of the foregut, midgut, and hindgut, as well as in the liver, lung, esophagus, and trachea. During midterm fetal stages, 18 and 23 weeks of development, increased expression is observed in the intestinal crypts. Midterm liver and kidney tissues strongly express CLMP in the parenchyma of the lobules and cortex, respectively.1 Publication

Inductioni

Up-regulated in mature adipocytes and adipocyte tissue of obese individuals.1 Publication

Gene expression databases

BgeeiENSG00000166250.
GenevisibleiQ9H6B4. HS.

Organism-specific databases

HPAiHPA002385.

Interactioni

Protein-protein interaction databases

BioGridi122919. 7 interactions.
STRINGi9606.ENSP00000405577.

Structurei

3D structure databases

ProteinModelPortaliQ9H6B4.
SMRiQ9H6B4. Positions 23-225.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 127109Ig-like C2-type 1Add
BLAST
Domaini135 – 22490Ig-like C2-type 2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi265 – 2684Poly-Glu
Compositional biasi288 – 31427Ser-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEC5. Eukaryota.
ENOG4111I1J. LUCA.
GeneTreeiENSGT00760000119145.
HOVERGENiHBG060225.
InParanoidiQ9H6B4.
KOiK06789.
OMAiITYSSHH.
OrthoDBiEOG091G05PI.
PhylomeDBiQ9H6B4.
TreeFamiTF330875.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H6B4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLLLLLLV SYYVGTLGTH TEIKRVAEEK VTLPCHHQLG LPEKDTLDIE
60 70 80 90 100
WLLTDNEGNQ KVVITYSSRH VYNNLTEEQK GRVAFASNFL AGDASLQIEP
110 120 130 140 150
LKPSDEGRYT CKVKNSGRYV WSHVILKVLV RPSKPKCELE GELTEGSDLT
160 170 180 190 200
LQCESSSGTE PIVYYWQRIR EKEGEDERLP PKSRIDYNHP GRVLLQNLTM
210 220 230 240 250
SYSGLYQCTA GNEAGKESCV VRVTVQYVQS IGMVAGAVTG IVAGALLIFL
260 270 280 290 300
LVWLLIRRKD KERYEEEERP NEIREDAEAP KARLVKPSSS SSGSRSSRSG
310 320 330 340 350
SSSTRSTANS ASRSQRTLST DAAPQPGLAT QAYSLVGPEV RGSEPKKVHH
360 370
ANLTKAETTP SMIPSQSRAF QTV
Length:373
Mass (Da):41,281
Last modified:March 1, 2001 - v1
Checksum:iFDA215EB3B3C4335
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti69 – 691R → H.
Corresponds to variant rs2276348 [ dbSNP | Ensembl ].
VAR_049824
Natural varianti124 – 1241V → D in CSBS; affects subcellular location; the mutant protein is localized in the cytoplasm. 1 Publication
Corresponds to variant rs587776967 [ dbSNP | Ensembl ].
VAR_069713

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY326422 mRNA. Translation: AAP88386.1.
AY358340 mRNA. Translation: AAQ88706.1.
AK026068 mRNA. Translation: BAB15347.1.
BC009371 mRNA. Translation: AAH09371.1.
BK001245 mRNA. Translation: DAA01139.1.
CCDSiCCDS8441.1.
RefSeqiNP_079045.1. NM_024769.3.
UniGeneiHs.591949.

Genome annotation databases

EnsembliENST00000448775; ENSP00000405577; ENSG00000166250.
GeneIDi79827.
KEGGihsa:79827.
UCSCiuc001pyt.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY326422 mRNA. Translation: AAP88386.1.
AY358340 mRNA. Translation: AAQ88706.1.
AK026068 mRNA. Translation: BAB15347.1.
BC009371 mRNA. Translation: AAH09371.1.
BK001245 mRNA. Translation: DAA01139.1.
CCDSiCCDS8441.1.
RefSeqiNP_079045.1. NM_024769.3.
UniGeneiHs.591949.

3D structure databases

ProteinModelPortaliQ9H6B4.
SMRiQ9H6B4. Positions 23-225.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122919. 7 interactions.
STRINGi9606.ENSP00000405577.

PTM databases

iPTMnetiQ9H6B4.
PhosphoSiteiQ9H6B4.

Polymorphism and mutation databases

BioMutaiCLMP.
DMDMi74761472.

Proteomic databases

EPDiQ9H6B4.
MaxQBiQ9H6B4.
PaxDbiQ9H6B4.
PeptideAtlasiQ9H6B4.
PRIDEiQ9H6B4.

Protocols and materials databases

DNASUi79827.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000448775; ENSP00000405577; ENSG00000166250.
GeneIDi79827.
KEGGihsa:79827.
UCSCiuc001pyt.4. human.

Organism-specific databases

CTDi79827.
GeneCardsiCLMP.
HGNCiHGNC:24039. CLMP.
HPAiHPA002385.
MalaCardsiCLMP.
MIMi611693. gene.
615237. phenotype.
neXtProtiNX_Q9H6B4.
Orphaneti2301. Congenital short bowel syndrome.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEC5. Eukaryota.
ENOG4111I1J. LUCA.
GeneTreeiENSGT00760000119145.
HOVERGENiHBG060225.
InParanoidiQ9H6B4.
KOiK06789.
OMAiITYSSHH.
OrthoDBiEOG091G05PI.
PhylomeDBiQ9H6B4.
TreeFamiTF330875.

Miscellaneous databases

ChiTaRSiCLMP. human.
GenomeRNAii79827.
PROiQ9H6B4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166250.
GenevisibleiQ9H6B4. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLMP_HUMAN
AccessioniPrimary (citable) accession number: Q9H6B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.