ID   Z385D_HUMAN             Reviewed;         395 AA.
AC   Q9H6B1;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   24-JAN-2024, entry version 151.
DE   RecName: Full=Zinc finger protein 385D;
DE   AltName: Full=Zinc finger protein 659;
GN   Name=ZNF385D; Synonyms=ZNF659;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney epithelium;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   VARIANTS [LARGE SCALE ANALYSIS] THR-386 AND GLN-387.
RX   PubMed=16959974; DOI=10.1126/science.1133427;
RA   Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA   Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA   Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA   Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA   Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA   Velculescu V.E.;
RT   "The consensus coding sequences of human breast and colorectal cancers.";
RL   Science 314:268-274(2006).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; AK026072; BAB15350.1; -; mRNA.
DR   EMBL; BC007212; AAH07212.1; -; mRNA.
DR   CCDS; CCDS2636.1; -.
DR   RefSeq; NP_078973.1; NM_024697.2.
DR   AlphaFoldDB; Q9H6B1; -.
DR   BioGRID; 122861; 1.
DR   IntAct; Q9H6B1; 1.
DR   STRING; 9606.ENSP00000281523; -.
DR   GlyCosmos; Q9H6B1; 1 site, 1 glycan.
DR   GlyGen; Q9H6B1; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q9H6B1; -.
DR   PhosphoSitePlus; Q9H6B1; -.
DR   BioMuta; ZNF385D; -.
DR   DMDM; 74733598; -.
DR   EPD; Q9H6B1; -.
DR   MassIVE; Q9H6B1; -.
DR   PaxDb; 9606-ENSP00000281523; -.
DR   PeptideAtlas; Q9H6B1; -.
DR   ProteomicsDB; 80972; -.
DR   Antibodypedia; 27129; 87 antibodies from 21 providers.
DR   DNASU; 79750; -.
DR   Ensembl; ENST00000281523.8; ENSP00000281523.2; ENSG00000151789.13.
DR   GeneID; 79750; -.
DR   KEGG; hsa:79750; -.
DR   MANE-Select; ENST00000281523.8; ENSP00000281523.2; NM_024697.3; NP_078973.1.
DR   UCSC; uc003cce.4; human.
DR   AGR; HGNC:26191; -.
DR   CTD; 79750; -.
DR   DisGeNET; 79750; -.
DR   GeneCards; ZNF385D; -.
DR   HGNC; HGNC:26191; ZNF385D.
DR   HPA; ENSG00000151789; Tissue enhanced (brain, retina).
DR   neXtProt; NX_Q9H6B1; -.
DR   OpenTargets; ENSG00000151789; -.
DR   PharmGKB; PA162410152; -.
DR   VEuPathDB; HostDB:ENSG00000151789; -.
DR   eggNOG; ENOG502QY40; Eukaryota.
DR   GeneTree; ENSGT00940000160242; -.
DR   HOGENOM; CLU_027876_1_0_1; -.
DR   InParanoid; Q9H6B1; -.
DR   OMA; RNIMYFX; -.
DR   OrthoDB; 3177542at2759; -.
DR   PhylomeDB; Q9H6B1; -.
DR   TreeFam; TF326622; -.
DR   PathwayCommons; Q9H6B1; -.
DR   SignaLink; Q9H6B1; -.
DR   BioGRID-ORCS; 79750; 8 hits in 1150 CRISPR screens.
DR   ChiTaRS; ZNF385D; human.
DR   GenomeRNAi; 79750; -.
DR   Pharos; Q9H6B1; Tdark.
DR   PRO; PR:Q9H6B1; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; Q9H6B1; Protein.
DR   Bgee; ENSG00000151789; Expressed in descending thoracic aorta and 144 other cell types or tissues.
DR   ExpressionAtlas; Q9H6B1; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 3.
DR   InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR23067; DOUBLE-STRANDED RNA-BINDING ZINC FINGER PROTEIN; 1.
DR   PANTHER; PTHR23067:SF12; ZINC FINGER PROTEIN 385D; 1.
DR   Pfam; PF12874; zf-met; 3.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SMART; SM00451; ZnF_U1; 3.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 3.
DR   Genevisible; Q9H6B1; HS.
PE   2: Evidence at transcript level;
KW   Metal-binding; Nucleus; Reference proteome; Repeat; Zinc; Zinc-finger.
FT   CHAIN           1..395
FT                   /note="Zinc finger protein 385D"
FT                   /id="PRO_0000191819"
FT   ZN_FING         80..110
FT                   /note="Matrin-type 1"
FT   ZN_FING         204..234
FT                   /note="Matrin-type 2"
FT   ZN_FING         267..297
FT                   /note="Matrin-type 3"
FT   REGION          169..194
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          282..309
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        169..193
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         386
FT                   /note="A -> T (in a colorectal cancer sample; somatic
FT                   mutation; dbSNP:rs757067821)"
FT                   /evidence="ECO:0000269|PubMed:16959974"
FT                   /id="VAR_036058"
FT   VARIANT         387
FT                   /note="H -> Q (in a colorectal cancer sample; somatic
FT                   mutation)"
FT                   /evidence="ECO:0000269|PubMed:16959974"
FT                   /id="VAR_036059"
SQ   SEQUENCE   395 AA;  42296 MW;  D16D251A935776AA CRC64;
     MRNIMYFGGT CQSPALPALV RPPAPPLQPS LDIKPFLPFP LDTAAAVNLF PNFNAMDPIQ
     KAVINHTFGV PLPHRRKQII SCNICQLRFN SDSQAAAHYK GTKHAKKLKA LEAMKNKQKS
     VTAKDSAKTT FTSITTNTIN TSSDKTDGTA GTPAISTTTT VEIRKSSVMT TEITSKVEKS
     PTTATGNSSC PSTETEEEKA KRLLYCSLCK VAVNSASQLE AHNSGTKHKT MLEARNGSGT
     IKAFPRAGVK GKGPVNKGNT GLQNKTFHCE ICDVHVNSET QLKQHISSRR HKDRAAGKPP
     KPKYSPYNKL QKTAHPLGVK LVFSKEPSKP LAPRILPNPL AAAAAAAAVA VSSPFSLRTA
     PAATLFQTSA LPPALLRPAP GPIRTAHTPV LFAPY
//