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Q9H6B1

- Z385D_HUMAN

UniProt

Q9H6B1 - Z385D_HUMAN

Protein

Zinc finger protein 385D

Gene

ZNF385D

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri80 – 11031Matrin-type 1Add
    BLAST
    Zinc fingeri204 – 23431Matrin-type 2Add
    BLAST
    Zinc fingeri267 – 29731Matrin-type 3Add
    BLAST

    GO - Molecular functioni

    1. nucleic acid binding Source: InterPro
    2. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 385D
    Alternative name(s):
    Zinc finger protein 659
    Gene namesi
    Name:ZNF385D
    Synonyms:ZNF659
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:26191. ZNF385D.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162410152.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 395395Zinc finger protein 385DPRO_0000191819Add
    BLAST

    Proteomic databases

    PaxDbiQ9H6B1.
    PRIDEiQ9H6B1.

    PTM databases

    PhosphoSiteiQ9H6B1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H6B1.
    BgeeiQ9H6B1.
    CleanExiHS_ZNF385D.
    GenevestigatoriQ9H6B1.

    Organism-specific databases

    HPAiHPA036190.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000281523.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H6B1.
    SMRiQ9H6B1. Positions 81-108, 204-233.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi129 – 19567Thr-richAdd
    BLAST
    Compositional biasi341 – 35010Poly-Ala

    Sequence similaritiesi

    Contains 3 matrin-type zinc fingers.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri80 – 11031Matrin-type 1Add
    BLAST
    Zinc fingeri204 – 23431Matrin-type 2Add
    BLAST
    Zinc fingeri267 – 29731Matrin-type 3Add
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG41467.
    HOGENOMiHOG000231865.
    HOVERGENiHBG054524.
    InParanoidiQ9H6B1.
    OMAiRNIMYFX.
    OrthoDBiEOG7XPZ67.
    PhylomeDBiQ9H6B1.
    TreeFamiTF326622.

    Family and domain databases

    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR003604. Znf_U1.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 3 hits.
    SM00451. ZnF_U1. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9H6B1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRNIMYFGGT CQSPALPALV RPPAPPLQPS LDIKPFLPFP LDTAAAVNLF    50
    PNFNAMDPIQ KAVINHTFGV PLPHRRKQII SCNICQLRFN SDSQAAAHYK 100
    GTKHAKKLKA LEAMKNKQKS VTAKDSAKTT FTSITTNTIN TSSDKTDGTA 150
    GTPAISTTTT VEIRKSSVMT TEITSKVEKS PTTATGNSSC PSTETEEEKA 200
    KRLLYCSLCK VAVNSASQLE AHNSGTKHKT MLEARNGSGT IKAFPRAGVK 250
    GKGPVNKGNT GLQNKTFHCE ICDVHVNSET QLKQHISSRR HKDRAAGKPP 300
    KPKYSPYNKL QKTAHPLGVK LVFSKEPSKP LAPRILPNPL AAAAAAAAVA 350
    VSSPFSLRTA PAATLFQTSA LPPALLRPAP GPIRTAHTPV LFAPY 395
    Length:395
    Mass (Da):42,296
    Last modified:March 1, 2001 - v1
    Checksum:iD16D251A935776AA
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti386 – 3861A → T in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036058
    Natural varianti387 – 3871H → Q in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036059

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK026072 mRNA. Translation: BAB15350.1.
    BC007212 mRNA. Translation: AAH07212.1.
    CCDSiCCDS2636.1.
    RefSeqiNP_078973.1. NM_024697.2.
    UniGeneiHs.21026.

    Genome annotation databases

    EnsembliENST00000281523; ENSP00000281523; ENSG00000151789.
    GeneIDi79750.
    KEGGihsa:79750.
    UCSCiuc003cce.3. human.

    Polymorphism databases

    DMDMi74733598.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK026072 mRNA. Translation: BAB15350.1 .
    BC007212 mRNA. Translation: AAH07212.1 .
    CCDSi CCDS2636.1.
    RefSeqi NP_078973.1. NM_024697.2.
    UniGenei Hs.21026.

    3D structure databases

    ProteinModelPortali Q9H6B1.
    SMRi Q9H6B1. Positions 81-108, 204-233.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000281523.

    PTM databases

    PhosphoSitei Q9H6B1.

    Polymorphism databases

    DMDMi 74733598.

    Proteomic databases

    PaxDbi Q9H6B1.
    PRIDEi Q9H6B1.

    Protocols and materials databases

    DNASUi 79750.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000281523 ; ENSP00000281523 ; ENSG00000151789 .
    GeneIDi 79750.
    KEGGi hsa:79750.
    UCSCi uc003cce.3. human.

    Organism-specific databases

    CTDi 79750.
    GeneCardsi GC03M021459.
    HGNCi HGNC:26191. ZNF385D.
    HPAi HPA036190.
    neXtProti NX_Q9H6B1.
    PharmGKBi PA162410152.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41467.
    HOGENOMi HOG000231865.
    HOVERGENi HBG054524.
    InParanoidi Q9H6B1.
    OMAi RNIMYFX.
    OrthoDBi EOG7XPZ67.
    PhylomeDBi Q9H6B1.
    TreeFami TF326622.

    Miscellaneous databases

    GenomeRNAii 79750.
    NextBioi 69191.
    PROi Q9H6B1.

    Gene expression databases

    ArrayExpressi Q9H6B1.
    Bgeei Q9H6B1.
    CleanExi HS_ZNF385D.
    Genevestigatori Q9H6B1.

    Family and domain databases

    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR003604. Znf_U1.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 3 hits.
    SM00451. ZnF_U1. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney epithelium.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    3. Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-386 AND GLN-387.

    Entry informationi

    Entry nameiZ385D_HUMAN
    AccessioniPrimary (citable) accession number: Q9H6B1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2005
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3