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Q9H6B1

- Z385D_HUMAN

UniProt

Q9H6B1 - Z385D_HUMAN

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Protein
Zinc finger protein 385D
Gene
ZNF385D, ZNF659
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri80 – 11031Matrin-type 1
Add
BLAST
Zinc fingeri204 – 23431Matrin-type 2
Add
BLAST
Zinc fingeri267 – 29731Matrin-type 3
Add
BLAST

GO - Molecular functioni

  1. nucleic acid binding Source: InterPro
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 385D
Alternative name(s):
Zinc finger protein 659
Gene namesi
Name:ZNF385D
Synonyms:ZNF659
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:26191. ZNF385D.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410152.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 395395Zinc finger protein 385D
PRO_0000191819Add
BLAST

Proteomic databases

PaxDbiQ9H6B1.
PRIDEiQ9H6B1.

PTM databases

PhosphoSiteiQ9H6B1.

Expressioni

Gene expression databases

ArrayExpressiQ9H6B1.
BgeeiQ9H6B1.
CleanExiHS_ZNF385D.
GenevestigatoriQ9H6B1.

Organism-specific databases

HPAiHPA036190.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000281523.

Structurei

3D structure databases

ProteinModelPortaliQ9H6B1.
SMRiQ9H6B1. Positions 81-108, 204-233.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi129 – 19567Thr-rich
Add
BLAST
Compositional biasi341 – 35010Poly-Ala

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG41467.
HOGENOMiHOG000231865.
HOVERGENiHBG054524.
InParanoidiQ9H6B1.
OMAiRNIMYFX.
OrthoDBiEOG7XPZ67.
PhylomeDBiQ9H6B1.
TreeFamiTF326622.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR003604. Znf_U1.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
SM00451. ZnF_U1. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H6B1-1 [UniParc]FASTAAdd to Basket

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MRNIMYFGGT CQSPALPALV RPPAPPLQPS LDIKPFLPFP LDTAAAVNLF    50
PNFNAMDPIQ KAVINHTFGV PLPHRRKQII SCNICQLRFN SDSQAAAHYK 100
GTKHAKKLKA LEAMKNKQKS VTAKDSAKTT FTSITTNTIN TSSDKTDGTA 150
GTPAISTTTT VEIRKSSVMT TEITSKVEKS PTTATGNSSC PSTETEEEKA 200
KRLLYCSLCK VAVNSASQLE AHNSGTKHKT MLEARNGSGT IKAFPRAGVK 250
GKGPVNKGNT GLQNKTFHCE ICDVHVNSET QLKQHISSRR HKDRAAGKPP 300
KPKYSPYNKL QKTAHPLGVK LVFSKEPSKP LAPRILPNPL AAAAAAAAVA 350
VSSPFSLRTA PAATLFQTSA LPPALLRPAP GPIRTAHTPV LFAPY 395
Length:395
Mass (Da):42,296
Last modified:March 1, 2001 - v1
Checksum:iD16D251A935776AA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti386 – 3861A → T in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036058
Natural varianti387 – 3871H → Q in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036059

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK026072 mRNA. Translation: BAB15350.1.
BC007212 mRNA. Translation: AAH07212.1.
CCDSiCCDS2636.1.
RefSeqiNP_078973.1. NM_024697.2.
UniGeneiHs.21026.

Genome annotation databases

EnsembliENST00000281523; ENSP00000281523; ENSG00000151789.
GeneIDi79750.
KEGGihsa:79750.
UCSCiuc003cce.3. human.

Polymorphism databases

DMDMi74733598.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK026072 mRNA. Translation: BAB15350.1 .
BC007212 mRNA. Translation: AAH07212.1 .
CCDSi CCDS2636.1.
RefSeqi NP_078973.1. NM_024697.2.
UniGenei Hs.21026.

3D structure databases

ProteinModelPortali Q9H6B1.
SMRi Q9H6B1. Positions 81-108, 204-233.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000281523.

PTM databases

PhosphoSitei Q9H6B1.

Polymorphism databases

DMDMi 74733598.

Proteomic databases

PaxDbi Q9H6B1.
PRIDEi Q9H6B1.

Protocols and materials databases

DNASUi 79750.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000281523 ; ENSP00000281523 ; ENSG00000151789 .
GeneIDi 79750.
KEGGi hsa:79750.
UCSCi uc003cce.3. human.

Organism-specific databases

CTDi 79750.
GeneCardsi GC03M021459.
HGNCi HGNC:26191. ZNF385D.
HPAi HPA036190.
neXtProti NX_Q9H6B1.
PharmGKBi PA162410152.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG41467.
HOGENOMi HOG000231865.
HOVERGENi HBG054524.
InParanoidi Q9H6B1.
OMAi RNIMYFX.
OrthoDBi EOG7XPZ67.
PhylomeDBi Q9H6B1.
TreeFami TF326622.

Miscellaneous databases

GenomeRNAii 79750.
NextBioi 69191.
PROi Q9H6B1.

Gene expression databases

ArrayExpressi Q9H6B1.
Bgeei Q9H6B1.
CleanExi HS_ZNF385D.
Genevestigatori Q9H6B1.

Family and domain databases

InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR003604. Znf_U1.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 3 hits.
SM00451. ZnF_U1. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney epithelium.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  3. Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-386 AND GLN-387.

Entry informationi

Entry nameiZ385D_HUMAN
AccessioniPrimary (citable) accession number: Q9H6B1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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