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Protein

Zinc finger protein 385D

Gene

ZNF385D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri80 – 110Matrin-type 1Add BLAST31
Zinc fingeri204 – 234Matrin-type 2Add BLAST31
Zinc fingeri267 – 297Matrin-type 3Add BLAST31

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 385D
Alternative name(s):
Zinc finger protein 659
Gene namesi
Name:ZNF385D
Synonyms:ZNF659
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:26191. ZNF385D.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi79750.
OpenTargetsiENSG00000151789.
PharmGKBiPA162410152.

Polymorphism and mutation databases

BioMutaiZNF385D.
DMDMi74733598.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001918191 – 395Zinc finger protein 385DAdd BLAST395

Proteomic databases

EPDiQ9H6B1.
PaxDbiQ9H6B1.
PeptideAtlasiQ9H6B1.
PRIDEiQ9H6B1.

PTM databases

iPTMnetiQ9H6B1.
PhosphoSitePlusiQ9H6B1.

Expressioni

Gene expression databases

BgeeiENSG00000151789.
CleanExiHS_ZNF385D.
ExpressionAtlasiQ9H6B1. baseline and differential.
GenevisibleiQ9H6B1. HS.

Organism-specific databases

HPAiHPA036190.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000281523.

Structurei

3D structure databases

ProteinModelPortaliQ9H6B1.
SMRiQ9H6B1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi129 – 195Thr-richAdd BLAST67
Compositional biasi341 – 350Poly-Ala10

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri80 – 110Matrin-type 1Add BLAST31
Zinc fingeri204 – 234Matrin-type 2Add BLAST31
Zinc fingeri267 – 297Matrin-type 3Add BLAST31

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IHAD. Eukaryota.
ENOG410Y1ZH. LUCA.
GeneTreeiENSGT00390000002371.
HOGENOMiHOG000231865.
HOVERGENiHBG054524.
InParanoidiQ9H6B1.
OMAiRNIMYFX.
OrthoDBiEOG091G089X.
PhylomeDBiQ9H6B1.
TreeFamiTF326622.

Family and domain databases

InterProiView protein in InterPro
IPR003604. Matrin/U1-like-C_Znf_C2H2.
IPR022755. Znf_C2H2_jaz.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF12171. zf-C2H2_jaz. 1 hit.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 3 hits.
SM00451. ZnF_U1. 3 hits.
SUPFAMiSSF57667. SSF57667. 3 hits.

Sequencei

Sequence statusi: Complete.

Q9H6B1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNIMYFGGT CQSPALPALV RPPAPPLQPS LDIKPFLPFP LDTAAAVNLF
60 70 80 90 100
PNFNAMDPIQ KAVINHTFGV PLPHRRKQII SCNICQLRFN SDSQAAAHYK
110 120 130 140 150
GTKHAKKLKA LEAMKNKQKS VTAKDSAKTT FTSITTNTIN TSSDKTDGTA
160 170 180 190 200
GTPAISTTTT VEIRKSSVMT TEITSKVEKS PTTATGNSSC PSTETEEEKA
210 220 230 240 250
KRLLYCSLCK VAVNSASQLE AHNSGTKHKT MLEARNGSGT IKAFPRAGVK
260 270 280 290 300
GKGPVNKGNT GLQNKTFHCE ICDVHVNSET QLKQHISSRR HKDRAAGKPP
310 320 330 340 350
KPKYSPYNKL QKTAHPLGVK LVFSKEPSKP LAPRILPNPL AAAAAAAAVA
360 370 380 390
VSSPFSLRTA PAATLFQTSA LPPALLRPAP GPIRTAHTPV LFAPY
Length:395
Mass (Da):42,296
Last modified:March 1, 2001 - v1
Checksum:iD16D251A935776AA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036058386A → T in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_036059387H → Q in a colorectal cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026072 mRNA. Translation: BAB15350.1.
BC007212 mRNA. Translation: AAH07212.1.
CCDSiCCDS2636.1.
RefSeqiNP_078973.1. NM_024697.2.
UniGeneiHs.21026.

Genome annotation databases

EnsembliENST00000281523; ENSP00000281523; ENSG00000151789.
GeneIDi79750.
KEGGihsa:79750.
UCSCiuc003cce.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiZ385D_HUMAN
AccessioniPrimary (citable) accession number: Q9H6B1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: March 1, 2001
Last modified: June 7, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations