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Protein

Pecanex-like protein 3

Gene

PCNX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Pecanex-like protein 3
Alternative name(s):
Pecanex homolog protein 3Imported
Gene namesi
Name:PCNX3Imported
Synonyms:PCNXL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:18760. PCNX3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei33 – 5321HelicalSequence analysisAdd
BLAST
Transmembranei54 – 7421HelicalSequence analysisAdd
BLAST
Transmembranei790 – 81223HelicalSequence analysisAdd
BLAST
Transmembranei819 – 83618HelicalSequence analysisAdd
BLAST
Transmembranei852 – 87221HelicalSequence analysisAdd
BLAST
Transmembranei880 – 90021HelicalSequence analysisAdd
BLAST
Transmembranei903 – 92321HelicalSequence analysisAdd
BLAST
Transmembranei946 – 96823HelicalSequence analysisAdd
BLAST
Transmembranei980 – 100021HelicalSequence analysisAdd
BLAST
Transmembranei1053 – 107321HelicalSequence analysisAdd
BLAST
Transmembranei1078 – 109821HelicalSequence analysisAdd
BLAST
Transmembranei1244 – 126421HelicalSequence analysisAdd
BLAST
Transmembranei1280 – 130021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38680.

Polymorphism and mutation databases

BioMutaiPCNXL3.
DMDMi187471100.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20342034Pecanex-like protein 3PRO_0000331529Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei127 – 1271PhosphoserineBy similarity
Modified residuei129 – 1291PhosphothreonineCombined sources
Glycosylationi319 – 3191N-linked (GlcNAc...)Sequence analysis
Modified residuei370 – 3701PhosphothreonineCombined sources
Modified residuei392 – 3921PhosphoserineCombined sources
Modified residuei431 – 4311PhosphoserineBy similarity
Modified residuei505 – 5051PhosphoserineCombined sources
Modified residuei1025 – 10251PhosphoserineCombined sources
Modified residuei1697 – 16971PhosphoserineCombined sources
Glycosylationi1770 – 17701N-linked (GlcNAc...)Sequence analysis
Modified residuei1909 – 19091PhosphoserineCombined sources
Modified residuei1955 – 19551PhosphoserineCombined sources

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9H6A9.
MaxQBiQ9H6A9.
PaxDbiQ9H6A9.
PeptideAtlasiQ9H6A9.
PRIDEiQ9H6A9.

PTM databases

iPTMnetiQ9H6A9.
PhosphoSiteiQ9H6A9.
SwissPalmiQ9H6A9.

Expressioni

Gene expression databases

BgeeiQ9H6A9.
CleanExiHS_PCNXL3.
GenevisibleiQ9H6A9. HS.

Organism-specific databases

HPAiHPA018084.

Interactioni

Protein-protein interaction databases

BioGridi134447. 24 interactions.
IntActiQ9H6A9. 6 interactions.
STRINGi9606.ENSP00000347931.

Structurei

3D structure databases

ProteinModelPortaliQ9H6A9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi425 – 45834Ser-richAdd
BLAST
Compositional biasi809 – 8124Poly-Leu
Compositional biasi1427 – 14304Poly-Cys
Compositional biasi1824 – 1959136Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the pecanex family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3604. Eukaryota.
ENOG410XPRI. LUCA.
GeneTreeiENSGT00390000013164.
HOGENOMiHOG000007773.
HOVERGENiHBG045627.
InParanoidiQ9H6A9.
OMAiVMCVVIA.
OrthoDBiEOG72VH54.
PhylomeDBiQ9H6A9.
TreeFamiTF313570.

Family and domain databases

InterProiIPR007735. Pecanex.
[Graphical view]
PfamiPF05041. Pecanex_C. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H6A9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSQVLQILR QGVWASLTGG WFFDPHQSTF SNCFHLYVWI FLLIFPFLLY
60 70 80 90 100
MVLPPSLMVA GVYCLVVAVI FATIKTVNYR LHAMFDQGEI VEKRSSTMGE
110 120 130 140 150
LEEEPAQGDS NPPRDPGVEM TVFRKVSSTP PVRCSSQHSV FGFNQVSELL
160 170 180 190 200
PRMEDSGPLR DIKELVREQG SNNVIVTSAD REMLKLSSQE KLIGDLPQTP
210 220 230 240 250
PGAVPDPSLA STDSSEPSPL AGDGAPWSGS SMADTPMSPL LKGSLSQELS
260 270 280 290 300
KSFLTLTQPD RALVRTSSRR EQRRGAGGYQ PLDRRGSGEP TPQKAGSSDS
310 320 330 340 350
CFSGTDRETL SSFKSEKTNS THLDSPPGGP APEGSDTDPP SEAELPASPD
360 370 380 390 400
AGVPSDDTLR SFDTVIGAGT PPGLAEPLLV VRPKDLALLR PSKRQPPLRR
410 420 430 440 450
HSPPGRAPRR PLLEGGGFFE DEDTSEGSEL SPASSLRSQR RYSTDSSSST
460 470 480 490 500
SCYSPESSRG AAGGPRKRRA PHGAEEGTAV PPKRPYGTQR TPSTASAKTH
510 520 530 540 550
ARVLSMDGAG GDVLRPPLAG CKAELEAQVG VEQAASEPVV LPAEARRGPA
560 570 580 590 600
ANQPGWRGEL QEEGAVGGAA EETGRRDRSS SVRRTQAIRR RHNAGSNPTP
610 620 630 640 650
PASVMGSPPS SLQEAQRGRA ASHSRALTLP SALHFASSLL LTRAGANVHE
660 670 680 690 700
ACTFDDTSEG AVHYFYDESG VRRSYTFGLA GGGYENPVGQ QGEQTANGAW
710 720 730 740 750
DRHSHSSSFH SADVPEATGG LNLLQPRPVV LQGMQVRRVP LEIPEEQTLM
760 770 780 790 800
EEAPPRAQHS YKYWLLPGRW TSVRYERLAL LALLDRTRGV LENIFGVGLS
810 820 830 840 850
SLVAFLGYLL LLKGFFTDIW VFQFCLVIAS CQYSLLKSVQ PDAASPMHGH
860 870 880 890 900
NWVIAYSRPV YFCICCLLIW LLDALGSAQP FPPVSLYGLT LFSASFFFCA
910 920 930 940 950
RDVATVFTLC FPFVFLLGLL PQVNTCLMYL LEQIDMHGFG GTAATSPLTA
960 970 980 990 1000
VFSLSRSLLA AALLYGFCLG AIKTPWPEQH VPVLFSVFCG LLVALSYHLS
1010 1020 1030 1040 1050
RQSSDPTVLW SLIRSKLFPE LEERSLETAR AEPPDPLPDK MRQSVREVLH
1060 1070 1080 1090 1100
SDLVMCVVIA VLTFAISAST VFIALKSVLG FVLYALAGAV GFFTHYLLPQ
1110 1120 1130 1140 1150
LRKQLPWFCL SQPVLKPLEY SQYEVRGAAQ VMWFEKLYAG LQCVEKYLIY
1160 1170 1180 1190 1200
PAVVLNALTV DAHTVVSHPD KYCFYCRALL MTVAGLKLLR SAFCCPPQQY
1210 1220 1230 1240 1250
LTLAFTVLLF HFDYPRLSQG FLLDYFLMSL LCSKLWDLLY KLRFVLTYIA
1260 1270 1280 1290 1300
PWQITWGSAF HAFAQPFAVP HSAMLFVQAL LSGLFSTPLN PLLGSAVFIM
1310 1320 1330 1340 1350
SYARPLKFWE RDYNTKRVDH SNTRLVTQLD RNPGADDNNL NSIFYEHLTR
1360 1370 1380 1390 1400
SLQHTLCGDL VLGRWGNYGP GDCFVLASDY LNALVHLIEV GNGLVTFQLR
1410 1420 1430 1440 1450
GLEFRGTYCQ QREVEAITEG VEEDEGCCCC EPGHLPRVLS FNAAFGQRWL
1460 1470 1480 1490 1500
AWEVTASKYV LEGYSISDNN AASMLQVFDL RKILITYYVK SIIYYVSRSP
1510 1520 1530 1540 1550
KLEVWLSHEG ITAALRPVRV PGYADSDPTF SLSVDEDYDL RLSGLSLPSF
1560 1570 1580 1590 1600
CAVHLEWIQY CASRRSQPVD QDWNSPLVTL CFGLCVLGRR ALGTASHSMS
1610 1620 1630 1640 1650
ASLEPFLYGL HALFKGDFRI TSPRDEWVFA DMDLLHRVVA PGVRMALKLH
1660 1670 1680 1690 1700
QDHFTSPDEY EEPAALYDAI AANEERLVIS HEGDPAWRSA ILSNTPSLLA
1710 1720 1730 1740 1750
LRHVLDDASD EYKIIMLNRR HLSFRVIKVN RECVRGLWAG QQQELVFLRN
1760 1770 1780 1790 1800
RNPERGSIQN AKQALRNMIN SSCDQPLGYP IYVSPLTTSL AGSHPQLRAL
1810 1820 1830 1840 1850
WGGPISLGAI AHWLLRTWER LHKGCGAGCN SGGNVDDSDC SGGGGLTSLS
1860 1870 1880 1890 1900
NNPPVAHPTP ENTAGNGDQP LPPGPGWGPR SSLSGSGDGR PPPLLQWPPP
1910 1920 1930 1940 1950
RLPGPPPASP IPTEGPRTSR PPGPGLLSSE GPSGKWSLGG RKGLGGSDGE
1960 1970 1980 1990 2000
PASGSPKGGT PKSQAPLDLS LSLSLSLSPD VSTEASPPRA SQDIPCLDSS
2010 2020 2030
APESGTPMGA LGDWPAPIEE RESPAAQPLL EHQY
Length:2,034
Mass (Da):222,039
Last modified:April 29, 2008 - v2
Checksum:iC11C93DDFB2DA270
GO
Isoform 2 (identifier: Q9H6A9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     927-982: LMYLLEQIDM...KTPWPEQHVP → PRPRSPPEAL...SKPLSGISLC
     983-2034: Missing.

Note: No experimental confirmation available.
Show »
Length:982
Mass (Da):106,000
Checksum:i2AE05D4E2DDD0F70
GO
Isoform 3 (identifier: Q9H6A9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1113: Missing.
     1114-1126: VLKPLEYSQYEVR → MWKPGAESWPLHT

Note: No experimental confirmation available.
Show »
Length:921
Mass (Da):101,308
Checksum:i60258D869E371D86
GO

Sequence cautioni

The sequence BAB15353.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti258 – 2581Q → R.1 Publication
Corresponds to variant rs1151489 [ dbSNP | Ensembl ].
VAR_042889
Natural varianti458 – 4581S → C.
Corresponds to variant rs1193851 [ dbSNP | Ensembl ].
VAR_042890
Natural varianti564 – 5641G → S.
Corresponds to variant rs56232198 [ dbSNP | Ensembl ].
VAR_061500
Natural varianti813 – 8131K → N.
Corresponds to variant rs1144790 [ dbSNP | Ensembl ].
VAR_042891
Natural varianti1822 – 18221H → Q.
Corresponds to variant rs7114037 [ dbSNP | Ensembl ].
VAR_061501

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11131113Missing in isoform 3. 1 PublicationVSP_033244Add
BLAST
Alternative sequencei927 – 98256LMYLL…EQHVP → PRPRSPPEALPCLHICFALT QFGNSNCPAEVHSPDPFPTL VRVAGFSKPLSGISLC in isoform 2. 1 PublicationVSP_033242Add
BLAST
Alternative sequencei983 – 20341052Missing in isoform 2. 1 PublicationVSP_033243Add
BLAST
Alternative sequencei1114 – 112613VLKPL…QYEVR → MWKPGAESWPLHT in isoform 3. 1 PublicationVSP_033245Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640978 mRNA. Translation: CAE45990.2.
AP001362 Genomic DNA. No translation available.
AK026080 mRNA. Translation: BAB15353.1. Different initiation.
CCDSiCCDS44650.1. [Q9H6A9-1]
RefSeqiNP_115599.2. NM_032223.3. [Q9H6A9-1]
UniGeneiHs.380801.

Genome annotation databases

EnsembliENST00000355703; ENSP00000347931; ENSG00000197136. [Q9H6A9-1]
GeneIDi399909.
KEGGihsa:399909.
UCSCiuc001oey.3. human. [Q9H6A9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640978 mRNA. Translation: CAE45990.2.
AP001362 Genomic DNA. No translation available.
AK026080 mRNA. Translation: BAB15353.1. Different initiation.
CCDSiCCDS44650.1. [Q9H6A9-1]
RefSeqiNP_115599.2. NM_032223.3. [Q9H6A9-1]
UniGeneiHs.380801.

3D structure databases

ProteinModelPortaliQ9H6A9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi134447. 24 interactions.
IntActiQ9H6A9. 6 interactions.
STRINGi9606.ENSP00000347931.

PTM databases

iPTMnetiQ9H6A9.
PhosphoSiteiQ9H6A9.
SwissPalmiQ9H6A9.

Polymorphism and mutation databases

BioMutaiPCNXL3.
DMDMi187471100.

Proteomic databases

EPDiQ9H6A9.
MaxQBiQ9H6A9.
PaxDbiQ9H6A9.
PeptideAtlasiQ9H6A9.
PRIDEiQ9H6A9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355703; ENSP00000347931; ENSG00000197136. [Q9H6A9-1]
GeneIDi399909.
KEGGihsa:399909.
UCSCiuc001oey.3. human. [Q9H6A9-1]

Organism-specific databases

CTDi399909.
GeneCardsiPCNXL3.
H-InvDBHIX0201686.
HGNCiHGNC:18760. PCNX3.
HPAiHPA018084.
neXtProtiNX_Q9H6A9.
PharmGKBiPA38680.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3604. Eukaryota.
ENOG410XPRI. LUCA.
GeneTreeiENSGT00390000013164.
HOGENOMiHOG000007773.
HOVERGENiHBG045627.
InParanoidiQ9H6A9.
OMAiVMCVVIA.
OrthoDBiEOG72VH54.
PhylomeDBiQ9H6A9.
TreeFamiTF313570.

Miscellaneous databases

ChiTaRSiPCNXL3. human.
GenomeRNAii399909.
PROiQ9H6A9.

Gene expression databases

BgeeiQ9H6A9.
CleanExiHS_PCNXL3.
GenevisibleiQ9H6A9. HS.

Family and domain databases

InterProiIPR007735. Pecanex.
[Graphical view]
PfamiPF05041. Pecanex_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Esophageal carcinoma.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 107-2034 (ISOFORM 2), VARIANT ARG-258.
  4. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-370, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-129; THR-370; SER-392; SER-505; SER-1025; SER-1697; SER-1909 AND SER-1955, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.

Entry informationi

Entry nameiPCX3_HUMAN
AccessioniPrimary (citable) accession number: Q9H6A9
Secondary accession number(s): Q6MZN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: July 6, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.