Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ankyrin repeat and SOCS box protein 7

Gene

ASB7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 7
Short name:
ASB-7
Gene namesi
Name:ASB7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:17182. ASB7.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25035.

Polymorphism and mutation databases

BioMutaiASB7.
DMDMi38372887.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Ankyrin repeat and SOCS box protein 7PRO_0000066935Add
BLAST

Proteomic databases

MaxQBiQ9H672.
PaxDbiQ9H672.
PRIDEiQ9H672.

PTM databases

PhosphoSiteiQ9H672.

Expressioni

Gene expression databases

BgeeiQ9H672.
CleanExiHS_ASB7.
ExpressionAtlasiQ9H672. baseline and differential.
GenevestigatoriQ9H672.

Organism-specific databases

HPAiHPA003300.

Interactioni

Subunit structurei

Interacts with CUL5 and RNF7.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC136Q96JN2-23EBI-3916346,EBI-10171416
HMBOX1Q6NT763EBI-3916346,EBI-2549423

Protein-protein interaction databases

BioGridi126613. 42 interactions.
IntActiQ9H672. 5 interactions.
MINTiMINT-1500354.
STRINGi9606.ENSP00000328327.

Structurei

3D structure databases

ProteinModelPortaliQ9H672.
SMRiQ9H672. Positions 18-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati13 – 4230ANK 1Add
BLAST
Repeati46 – 7530ANK 2Add
BLAST
Repeati80 – 10930ANK 3Add
BLAST
Repeati116 – 14530ANK 4Add
BLAST
Repeati149 – 17830ANK 5Add
BLAST
Repeati180 – 20829ANK 6Add
BLAST
Repeati213 – 24230ANK 7Add
BLAST
Domaini265 – 31854SOCS boxPROSITE-ProRule annotationAdd
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated
Contains 7 ANK repeats.PROSITE-ProRule annotation
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00780000121910.
HOGENOMiHOG000013024.
HOVERGENiHBG037171.
InParanoidiQ9H672.
KOiK10329.
OMAiDHSANID.
OrthoDBiEOG790G10.
PhylomeDBiQ9H672.
TreeFamiTF331695.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_C.
[Graphical view]
PfamiPF12796. Ank_2. 3 hits.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 7 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H672-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLHHHCRRNP ELQEELQIQA AVAAGDVHTV RKMLEQGYSP NGRDANGWTL
60 70 80 90 100
LHFSAARGKE RCVRVFLEHG ADPTVKDLIG GFTALHYAAM HGRARIARLM
110 120 130 140 150
LESEYRSDII NAKSNDGWTP LHVAAHYGRD SFVRLLLEFK AEVDPLSDKG
160 170 180 190 200
TTPLQLAIIR ERSSCVKILL DHNANIDIQN GFLLRYAVIK SNHSYCRMFL
210 220 230 240 250
QRGADTNLGR LEDGQTPLHL SALRDDVLCA RMLYNYGADT NTRNYEGQTP
260 270 280 290 300
LAVSISISGS SRPCLDFLQE VTRQPRNLQD LCRIKIRQCI GLQNLKLLDE
310
LPIAKVMKDY LKHKFDDI
Length:318
Mass (Da):36,011
Last modified:November 14, 2003 - v2
Checksum:iF6FE48D0970DF83E
GO
Isoform 2 (identifier: Q9H672-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     273-274: RQ → SM
     275-318: Missing.

Show »
Length:274
Mass (Da):30,713
Checksum:i8E5B5AD312006AC2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti162 – 1621R → K in BAB15392 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei273 – 2742RQ → SM in isoform 2. 2 PublicationsVSP_008919
Alternative sequencei275 – 31844Missing in isoform 2. 2 PublicationsVSP_008920Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF451994 mRNA. Translation: AAP97683.1.
AK026204 mRNA. Translation: BAB15392.1.
AK289860 mRNA. Translation: BAF82549.1.
CH471101 Genomic DNA. Translation: EAX02274.1.
CH471101 Genomic DNA. Translation: EAX02276.1.
BC063581 mRNA. Translation: AAH63581.1.
CCDSiCCDS10387.1. [Q9H672-1]
CCDS10388.1. [Q9H672-2]
RefSeqiNP_078984.2. NM_024708.3. [Q9H672-2]
NP_937886.1. NM_198243.2. [Q9H672-1]
UniGeneiHs.31845.
Hs.709044.

Genome annotation databases

EnsembliENST00000332783; ENSP00000328327; ENSG00000183475. [Q9H672-1]
ENST00000343276; ENSP00000339819; ENSG00000183475. [Q9H672-2]
GeneIDi140460.
KEGGihsa:140460.
UCSCiuc002bwj.3. human. [Q9H672-2]
uc002bwk.3. human. [Q9H672-1]

Polymorphism and mutation databases

BioMutaiASB7.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF451994 mRNA. Translation: AAP97683.1.
AK026204 mRNA. Translation: BAB15392.1.
AK289860 mRNA. Translation: BAF82549.1.
CH471101 Genomic DNA. Translation: EAX02274.1.
CH471101 Genomic DNA. Translation: EAX02276.1.
BC063581 mRNA. Translation: AAH63581.1.
CCDSiCCDS10387.1. [Q9H672-1]
CCDS10388.1. [Q9H672-2]
RefSeqiNP_078984.2. NM_024708.3. [Q9H672-2]
NP_937886.1. NM_198243.2. [Q9H672-1]
UniGeneiHs.31845.
Hs.709044.

3D structure databases

ProteinModelPortaliQ9H672.
SMRiQ9H672. Positions 18-313.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126613. 42 interactions.
IntActiQ9H672. 5 interactions.
MINTiMINT-1500354.
STRINGi9606.ENSP00000328327.

PTM databases

PhosphoSiteiQ9H672.

Polymorphism and mutation databases

BioMutaiASB7.
DMDMi38372887.

Proteomic databases

MaxQBiQ9H672.
PaxDbiQ9H672.
PRIDEiQ9H672.

Protocols and materials databases

DNASUi140460.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332783; ENSP00000328327; ENSG00000183475. [Q9H672-1]
ENST00000343276; ENSP00000339819; ENSG00000183475. [Q9H672-2]
GeneIDi140460.
KEGGihsa:140460.
UCSCiuc002bwj.3. human. [Q9H672-2]
uc002bwk.3. human. [Q9H672-1]

Organism-specific databases

CTDi140460.
GeneCardsiGC15P101142.
HGNCiHGNC:17182. ASB7.
HPAiHPA003300.
MIMi615052. gene.
neXtProtiNX_Q9H672.
PharmGKBiPA25035.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00780000121910.
HOGENOMiHOG000013024.
HOVERGENiHBG037171.
InParanoidiQ9H672.
KOiK10329.
OMAiDHSANID.
OrthoDBiEOG790G10.
PhylomeDBiQ9H672.
TreeFamiTF331695.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

GenomeRNAii140460.
NextBioi84115.
PROiQ9H672.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H672.
CleanExiHS_ASB7.
ExpressionAtlasiQ9H672. baseline and differential.
GenevestigatoriQ9H672.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_C.
[Graphical view]
PfamiPF12796. Ank_2. 3 hits.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 7 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Guo J.H., Zan Q., Yu L.
    Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Small intestine.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Bone.
  5. "ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes."
    Kohroki J., Nishiyama T., Nakamura T., Masuho Y.
    FEBS Lett. 579:6796-6802(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE, INTERACTION WITH CUL5 AND RNF7.

Entry informationi

Entry nameiASB7_HUMAN
AccessioniPrimary (citable) accession number: Q9H672
Secondary accession number(s): A8K1E5, Q6GSJ6, Q7Z4S3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: November 14, 2003
Last modified: April 29, 2015
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.