Q9H672 (ASB7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ankyrin repeat and SOCS box protein 7
Short name=ASB-7

Gene names

Name:

ASB7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins By similarity. Ref.5
Pathway	Protein modification; protein ubiquitination.
Subunit structure	Interacts with CUL5 and RNF7. Ref.5
Domain	The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes By similarity.
Sequence similarities	Contains 7 ANK repeats. Contains 1 SOCS box domain.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Coding sequence diversity	Alternative splicing
Domain	ANK repeat Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular signal transduction Inferred from electronic annotation. Source: InterPro protein ubiquitination Inferred from electronic annotation. Source: UniProtKB-UniPathway
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H672-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9H672-2)

The sequence of this isoform differs from the canonical sequence as follows:
     273-274: RQ → SM
     275-318: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 318	318	Ankyrin repeat and SOCS box protein 7		PRO_0000066935
Regions
	Repeat	13 – 42	30	ANK 1
	Repeat	46 – 75	30	ANK 2
	Repeat	80 – 109	30	ANK 3
	Repeat	116 – 145	30	ANK 4
	Repeat	149 – 178	30	ANK 5
	Repeat	180 – 208	29	ANK 6
	Repeat	213 – 242	30	ANK 7
	Domain	265 – 318	54	SOCS box
Natural variations
	Alternative sequence	273 – 274	2	RQ → SM in isoform 2.		VSP_008919
	Alternative sequence	275 – 318	44	Missing in isoform 2.		VSP_008920
Experimental info
	Sequence conflict	162	1	R → K in BAB15392. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 14, 2003. Version 2. Checksum: F6FE48D0970DF83E	FASTA	318	36,011
	10 20 30 40 50 60 MLHHHCRRNP ELQEELQIQA AVAAGDVHTV RKMLEQGYSP NGRDANGWTL LHFSAARGKE 70 80 90 100 110 120 RCVRVFLEHG ADPTVKDLIG GFTALHYAAM HGRARIARLM LESEYRSDII NAKSNDGWTP 130 140 150 160 170 180 LHVAAHYGRD SFVRLLLEFK AEVDPLSDKG TTPLQLAIIR ERSSCVKILL DHNANIDIQN 190 200 210 220 230 240 GFLLRYAVIK SNHSYCRMFL QRGADTNLGR LEDGQTPLHL SALRDDVLCA RMLYNYGADT 250 260 270 280 290 300 NTRNYEGQTP LAVSISISGS SRPCLDFLQE VTRQPRNLQD LCRIKIRQCI GLQNLKLLDE 310 LPIAKVMKDY LKHKFDDI
	Isoform 2 [UniParc]. Checksum: 8E5B5AD312006AC2	FASTA	274	30,713
	10 20 30 40 50 60 MLHHHCRRNP ELQEELQIQA AVAAGDVHTV RKMLEQGYSP NGRDANGWTL LHFSAARGKE 70 80 90 100 110 120 RCVRVFLEHG ADPTVKDLIG GFTALHYAAM HGRARIARLM LESEYRSDII NAKSNDGWTP 130 140 150 160 170 180 LHVAAHYGRD SFVRLLLEFK AEVDPLSDKG TTPLQLAIIR ERSSCVKILL DHNANIDIQN 190 200 210 220 230 240 GFLLRYAVIK SNHSYCRMFL QRGADTNLGR LEDGQTPLHL SALRDDVLCA RMLYNYGADT 250 260 270 NTRNYEGQTP LAVSISISGS SRPCLDFLQE VTSM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Guo J.H., Zan Q., Yu L. Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain and Small intestine.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Bone.
[5]	"ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes." Kohroki J., Nishiyama T., Nakamura T., Masuho Y. FEBS Lett. 579:6796-6802(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE, INTERACTION WITH CUL5 AND RNF7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF451994 mRNA. Translation: AAP97683.1. AK026204 mRNA. Translation: BAB15392.1. AK289860 mRNA. Translation: BAF82549.1. CH471101 Genomic DNA. Translation: EAX02274.1. CH471101 Genomic DNA. Translation: EAX02276.1. BC063581 mRNA. Translation: AAH63581.1.
IPI	IPI00385151. IPI00395026.
RefSeq	NP_078984.2. NM_024708.3. NP_937886.1. NM_198243.2.
UniGene	Hs.31845.
3D structure databases
ProteinModelPortal	Q9H672.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H672. 1 interaction.
MINT	MINT-1500354.
STRING	9606.ENSP00000328327.
PTM databases
PhosphoSite	Q9H672.
Polymorphism databases
DMDM	38372887.
Proteomic databases
PaxDb	Q9H672.
PRIDE	Q9H672.
Protocols and materials databases
DNASU	140460.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000332783; ENSP00000328327; ENSG00000183475. ENST00000343276; ENSP00000339819; ENSG00000183475.
GeneID	140460.
KEGG	hsa:140460.
UCSC	uc002bwj.3. human. uc002bwk.3. human.
Organism-specific databases
CTD	140460.
GeneCards	GC15P101142.
HGNC	HGNC:17182. ASB7.
HPA	HPA003300.
MIM	615052. gene.
neXtProt	NX_Q9H672.
PharmGKB	PA25035.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0666.
HOGENOM	HOG000013024.
HOVERGEN	HBG037171.
InParanoid	Q9H672.
KO	K10329.
OMA	LYTYGAD.
OrthoDB	EOG4ZS93H.
PhylomeDB	Q9H672.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
UniPathway	UPA00143.
Gene expression databases
ArrayExpress	Q9H672.
Bgee	Q9H672.
CleanEx	HS_ASB7.
Genevestigator	Q9H672.
GermOnline	ENSG00000183475. Homo sapiens.
Family and domain databases
Gene3D	1.25.40.20. 3 hits.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR001496. SOCS_C. [Graphical view]
Pfam	PF00023. Ank. 1 hit. PF12796. Ank_2. 3 hits. PF07525. SOCS_box. 1 hit. [Graphical view]
PRINTS	PR01415. ANKYRIN.
SMART	SM00248. ANK. 7 hits. SM00969. SOCS_box. 1 hit. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 5 hits. PS50225. SOCS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	140460.
NextBio	84115.
SOURCE	Search...

Entry information

Entry name

ASB7_HUMAN

Accession

Primary (citable) accession number: Q9H672
Secondary accession number(s): A8K1E5, Q6GSJ6, Q7Z4S3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 28, 2003
Last sequence update:	November 14, 2003
Last modified:	May 1, 2013
This is version 103 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.