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Q9H672

- ASB7_HUMAN

UniProt

Q9H672 - ASB7_HUMAN

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Protein

Ankyrin repeat and SOCS box protein 7

Gene

ASB7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 7
Short name:
ASB-7
Gene namesi
Name:ASB7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:17182. ASB7.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25035.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Ankyrin repeat and SOCS box protein 7PRO_0000066935Add
BLAST

Proteomic databases

MaxQBiQ9H672.
PaxDbiQ9H672.
PRIDEiQ9H672.

PTM databases

PhosphoSiteiQ9H672.

Expressioni

Gene expression databases

BgeeiQ9H672.
CleanExiHS_ASB7.
ExpressionAtlasiQ9H672. baseline and differential.
GenevestigatoriQ9H672.

Organism-specific databases

HPAiHPA003300.

Interactioni

Subunit structurei

Interacts with CUL5 and RNF7.1 Publication

Protein-protein interaction databases

BioGridi126613. 21 interactions.
IntActiQ9H672. 3 interactions.
MINTiMINT-1500354.
STRINGi9606.ENSP00000328327.

Structurei

3D structure databases

ProteinModelPortaliQ9H672.
SMRiQ9H672. Positions 18-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati13 – 4230ANK 1Add
BLAST
Repeati46 – 7530ANK 2Add
BLAST
Repeati80 – 10930ANK 3Add
BLAST
Repeati116 – 14530ANK 4Add
BLAST
Repeati149 – 17830ANK 5Add
BLAST
Repeati180 – 20829ANK 6Add
BLAST
Repeati213 – 24230ANK 7Add
BLAST
Domaini265 – 31854SOCS boxPROSITE-ProRule annotationAdd
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Contains 7 ANK repeats.PROSITE-ProRule annotation
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00750000117346.
HOGENOMiHOG000013024.
HOVERGENiHBG037171.
InParanoidiQ9H672.
KOiK10329.
OMAiGANTNTR.
OrthoDBiEOG790G10.
PhylomeDBiQ9H672.
TreeFamiTF331695.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_C.
[Graphical view]
PfamiPF12796. Ank_2. 3 hits.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 7 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H672-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLHHHCRRNP ELQEELQIQA AVAAGDVHTV RKMLEQGYSP NGRDANGWTL
60 70 80 90 100
LHFSAARGKE RCVRVFLEHG ADPTVKDLIG GFTALHYAAM HGRARIARLM
110 120 130 140 150
LESEYRSDII NAKSNDGWTP LHVAAHYGRD SFVRLLLEFK AEVDPLSDKG
160 170 180 190 200
TTPLQLAIIR ERSSCVKILL DHNANIDIQN GFLLRYAVIK SNHSYCRMFL
210 220 230 240 250
QRGADTNLGR LEDGQTPLHL SALRDDVLCA RMLYNYGADT NTRNYEGQTP
260 270 280 290 300
LAVSISISGS SRPCLDFLQE VTRQPRNLQD LCRIKIRQCI GLQNLKLLDE
310
LPIAKVMKDY LKHKFDDI
Length:318
Mass (Da):36,011
Last modified:November 14, 2003 - v2
Checksum:iF6FE48D0970DF83E
GO
Isoform 2 (identifier: Q9H672-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     273-274: RQ → SM
     275-318: Missing.

Show »
Length:274
Mass (Da):30,713
Checksum:i8E5B5AD312006AC2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti162 – 1621R → K in BAB15392. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei273 – 2742RQ → SM in isoform 2. 2 PublicationsVSP_008919
Alternative sequencei275 – 31844Missing in isoform 2. 2 PublicationsVSP_008920Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF451994 mRNA. Translation: AAP97683.1.
AK026204 mRNA. Translation: BAB15392.1.
AK289860 mRNA. Translation: BAF82549.1.
CH471101 Genomic DNA. Translation: EAX02274.1.
CH471101 Genomic DNA. Translation: EAX02276.1.
BC063581 mRNA. Translation: AAH63581.1.
CCDSiCCDS10387.1. [Q9H672-1]
CCDS10388.1. [Q9H672-2]
RefSeqiNP_078984.2. NM_024708.3. [Q9H672-2]
NP_937886.1. NM_198243.2. [Q9H672-1]
UniGeneiHs.31845.
Hs.709044.

Genome annotation databases

EnsembliENST00000332783; ENSP00000328327; ENSG00000183475. [Q9H672-1]
ENST00000343276; ENSP00000339819; ENSG00000183475. [Q9H672-2]
GeneIDi140460.
KEGGihsa:140460.
UCSCiuc002bwj.3. human. [Q9H672-2]
uc002bwk.3. human. [Q9H672-1]

Polymorphism databases

DMDMi38372887.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF451994 mRNA. Translation: AAP97683.1 .
AK026204 mRNA. Translation: BAB15392.1 .
AK289860 mRNA. Translation: BAF82549.1 .
CH471101 Genomic DNA. Translation: EAX02274.1 .
CH471101 Genomic DNA. Translation: EAX02276.1 .
BC063581 mRNA. Translation: AAH63581.1 .
CCDSi CCDS10387.1. [Q9H672-1 ]
CCDS10388.1. [Q9H672-2 ]
RefSeqi NP_078984.2. NM_024708.3. [Q9H672-2 ]
NP_937886.1. NM_198243.2. [Q9H672-1 ]
UniGenei Hs.31845.
Hs.709044.

3D structure databases

ProteinModelPortali Q9H672.
SMRi Q9H672. Positions 18-313.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126613. 21 interactions.
IntActi Q9H672. 3 interactions.
MINTi MINT-1500354.
STRINGi 9606.ENSP00000328327.

PTM databases

PhosphoSitei Q9H672.

Polymorphism databases

DMDMi 38372887.

Proteomic databases

MaxQBi Q9H672.
PaxDbi Q9H672.
PRIDEi Q9H672.

Protocols and materials databases

DNASUi 140460.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000332783 ; ENSP00000328327 ; ENSG00000183475 . [Q9H672-1 ]
ENST00000343276 ; ENSP00000339819 ; ENSG00000183475 . [Q9H672-2 ]
GeneIDi 140460.
KEGGi hsa:140460.
UCSCi uc002bwj.3. human. [Q9H672-2 ]
uc002bwk.3. human. [Q9H672-1 ]

Organism-specific databases

CTDi 140460.
GeneCardsi GC15P101142.
HGNCi HGNC:17182. ASB7.
HPAi HPA003300.
MIMi 615052. gene.
neXtProti NX_Q9H672.
PharmGKBi PA25035.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0666.
GeneTreei ENSGT00750000117346.
HOGENOMi HOG000013024.
HOVERGENi HBG037171.
InParanoidi Q9H672.
KOi K10329.
OMAi GANTNTR.
OrthoDBi EOG790G10.
PhylomeDBi Q9H672.
TreeFami TF331695.

Enzyme and pathway databases

UniPathwayi UPA00143 .
Reactomei REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

GenomeRNAii 140460.
NextBioi 84115.
PROi Q9H672.
SOURCEi Search...

Gene expression databases

Bgeei Q9H672.
CleanExi HS_ASB7.
ExpressionAtlasi Q9H672. baseline and differential.
Genevestigatori Q9H672.

Family and domain databases

Gene3Di 1.25.40.20. 3 hits.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_C.
[Graphical view ]
Pfami PF12796. Ank_2. 3 hits.
PF07525. SOCS_box. 1 hit.
[Graphical view ]
PRINTSi PR01415. ANKYRIN.
SMARTi SM00248. ANK. 7 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS50225. SOCS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Guo J.H., Zan Q., Yu L.
    Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Small intestine.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Bone.
  5. "ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes."
    Kohroki J., Nishiyama T., Nakamura T., Masuho Y.
    FEBS Lett. 579:6796-6802(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE, INTERACTION WITH CUL5 AND RNF7.

Entry informationi

Entry nameiASB7_HUMAN
AccessioniPrimary (citable) accession number: Q9H672
Secondary accession number(s): A8K1E5, Q6GSJ6, Q7Z4S3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: November 14, 2003
Last modified: November 26, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3