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Q9H672

- ASB7_HUMAN

UniProt

Q9H672 - ASB7_HUMAN

Protein

Ankyrin repeat and SOCS box protein 7

Gene

ASB7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (14 Nov 2003)
      Previous versions | rss
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    Functioni

    Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

    Pathwayi

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro
    2. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ankyrin repeat and SOCS box protein 7
    Short name:
    ASB-7
    Gene namesi
    Name:ASB7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:17182. ASB7.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25035.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 318318Ankyrin repeat and SOCS box protein 7PRO_0000066935Add
    BLAST

    Proteomic databases

    MaxQBiQ9H672.
    PaxDbiQ9H672.
    PRIDEiQ9H672.

    PTM databases

    PhosphoSiteiQ9H672.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H672.
    BgeeiQ9H672.
    CleanExiHS_ASB7.
    GenevestigatoriQ9H672.

    Organism-specific databases

    HPAiHPA003300.

    Interactioni

    Subunit structurei

    Interacts with CUL5 and RNF7.1 Publication

    Protein-protein interaction databases

    BioGridi126613. 16 interactions.
    IntActiQ9H672. 3 interactions.
    MINTiMINT-1500354.
    STRINGi9606.ENSP00000328327.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H672.
    SMRiQ9H672. Positions 15-313.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati13 – 4230ANK 1Add
    BLAST
    Repeati46 – 7530ANK 2Add
    BLAST
    Repeati80 – 10930ANK 3Add
    BLAST
    Repeati116 – 14530ANK 4Add
    BLAST
    Repeati149 – 17830ANK 5Add
    BLAST
    Repeati180 – 20829ANK 6Add
    BLAST
    Repeati213 – 24230ANK 7Add
    BLAST
    Domaini265 – 31854SOCS boxPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

    Sequence similaritiesi

    Contains 7 ANK repeats.PROSITE-ProRule annotation
    Contains 1 SOCS box domain.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG0666.
    HOGENOMiHOG000013024.
    HOVERGENiHBG037171.
    InParanoidiQ9H672.
    KOiK10329.
    OMAiGANTNTR.
    OrthoDBiEOG790G10.
    PhylomeDBiQ9H672.
    TreeFamiTF331695.

    Family and domain databases

    Gene3Di1.25.40.20. 3 hits.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR001496. SOCS_C.
    [Graphical view]
    PfamiPF12796. Ank_2. 3 hits.
    PF07525. SOCS_box. 1 hit.
    [Graphical view]
    PRINTSiPR01415. ANKYRIN.
    SMARTiSM00248. ANK. 7 hits.
    SM00969. SOCS_box. 1 hit.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 5 hits.
    PS50225. SOCS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H672-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLHHHCRRNP ELQEELQIQA AVAAGDVHTV RKMLEQGYSP NGRDANGWTL    50
    LHFSAARGKE RCVRVFLEHG ADPTVKDLIG GFTALHYAAM HGRARIARLM 100
    LESEYRSDII NAKSNDGWTP LHVAAHYGRD SFVRLLLEFK AEVDPLSDKG 150
    TTPLQLAIIR ERSSCVKILL DHNANIDIQN GFLLRYAVIK SNHSYCRMFL 200
    QRGADTNLGR LEDGQTPLHL SALRDDVLCA RMLYNYGADT NTRNYEGQTP 250
    LAVSISISGS SRPCLDFLQE VTRQPRNLQD LCRIKIRQCI GLQNLKLLDE 300
    LPIAKVMKDY LKHKFDDI 318
    Length:318
    Mass (Da):36,011
    Last modified:November 14, 2003 - v2
    Checksum:iF6FE48D0970DF83E
    GO
    Isoform 2 (identifier: Q9H672-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         273-274: RQ → SM
         275-318: Missing.

    Show »
    Length:274
    Mass (Da):30,713
    Checksum:i8E5B5AD312006AC2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti162 – 1621R → K in BAB15392. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei273 – 2742RQ → SM in isoform 2. 2 PublicationsVSP_008919
    Alternative sequencei275 – 31844Missing in isoform 2. 2 PublicationsVSP_008920Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF451994 mRNA. Translation: AAP97683.1.
    AK026204 mRNA. Translation: BAB15392.1.
    AK289860 mRNA. Translation: BAF82549.1.
    CH471101 Genomic DNA. Translation: EAX02274.1.
    CH471101 Genomic DNA. Translation: EAX02276.1.
    BC063581 mRNA. Translation: AAH63581.1.
    CCDSiCCDS10387.1. [Q9H672-1]
    CCDS10388.1. [Q9H672-2]
    RefSeqiNP_078984.2. NM_024708.3. [Q9H672-2]
    NP_937886.1. NM_198243.2. [Q9H672-1]
    UniGeneiHs.31845.
    Hs.709044.

    Genome annotation databases

    EnsembliENST00000332783; ENSP00000328327; ENSG00000183475. [Q9H672-1]
    ENST00000343276; ENSP00000339819; ENSG00000183475. [Q9H672-2]
    GeneIDi140460.
    KEGGihsa:140460.
    UCSCiuc002bwj.3. human. [Q9H672-2]
    uc002bwk.3. human. [Q9H672-1]

    Polymorphism databases

    DMDMi38372887.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF451994 mRNA. Translation: AAP97683.1 .
    AK026204 mRNA. Translation: BAB15392.1 .
    AK289860 mRNA. Translation: BAF82549.1 .
    CH471101 Genomic DNA. Translation: EAX02274.1 .
    CH471101 Genomic DNA. Translation: EAX02276.1 .
    BC063581 mRNA. Translation: AAH63581.1 .
    CCDSi CCDS10387.1. [Q9H672-1 ]
    CCDS10388.1. [Q9H672-2 ]
    RefSeqi NP_078984.2. NM_024708.3. [Q9H672-2 ]
    NP_937886.1. NM_198243.2. [Q9H672-1 ]
    UniGenei Hs.31845.
    Hs.709044.

    3D structure databases

    ProteinModelPortali Q9H672.
    SMRi Q9H672. Positions 15-313.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126613. 16 interactions.
    IntActi Q9H672. 3 interactions.
    MINTi MINT-1500354.
    STRINGi 9606.ENSP00000328327.

    PTM databases

    PhosphoSitei Q9H672.

    Polymorphism databases

    DMDMi 38372887.

    Proteomic databases

    MaxQBi Q9H672.
    PaxDbi Q9H672.
    PRIDEi Q9H672.

    Protocols and materials databases

    DNASUi 140460.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000332783 ; ENSP00000328327 ; ENSG00000183475 . [Q9H672-1 ]
    ENST00000343276 ; ENSP00000339819 ; ENSG00000183475 . [Q9H672-2 ]
    GeneIDi 140460.
    KEGGi hsa:140460.
    UCSCi uc002bwj.3. human. [Q9H672-2 ]
    uc002bwk.3. human. [Q9H672-1 ]

    Organism-specific databases

    CTDi 140460.
    GeneCardsi GC15P101142.
    HGNCi HGNC:17182. ASB7.
    HPAi HPA003300.
    MIMi 615052. gene.
    neXtProti NX_Q9H672.
    PharmGKBi PA25035.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0666.
    HOGENOMi HOG000013024.
    HOVERGENi HBG037171.
    InParanoidi Q9H672.
    KOi K10329.
    OMAi GANTNTR.
    OrthoDBi EOG790G10.
    PhylomeDBi Q9H672.
    TreeFami TF331695.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    Reactomei REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.

    Miscellaneous databases

    GenomeRNAii 140460.
    NextBioi 84115.
    PROi Q9H672.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H672.
    Bgeei Q9H672.
    CleanExi HS_ASB7.
    Genevestigatori Q9H672.

    Family and domain databases

    Gene3Di 1.25.40.20. 3 hits.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR001496. SOCS_C.
    [Graphical view ]
    Pfami PF12796. Ank_2. 3 hits.
    PF07525. SOCS_box. 1 hit.
    [Graphical view ]
    PRINTSi PR01415. ANKYRIN.
    SMARTi SM00248. ANK. 7 hits.
    SM00969. SOCS_box. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 5 hits.
    PS50225. SOCS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Guo J.H., Zan Q., Yu L.
      Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain and Small intestine.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Bone.
    5. "ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes."
      Kohroki J., Nishiyama T., Nakamura T., Masuho Y.
      FEBS Lett. 579:6796-6802(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE, INTERACTION WITH CUL5 AND RNF7.

    Entry informationi

    Entry nameiASB7_HUMAN
    AccessioniPrimary (citable) accession number: Q9H672
    Secondary accession number(s): A8K1E5, Q6GSJ6, Q7Z4S3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 28, 2003
    Last sequence update: November 14, 2003
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3