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Q9H672 (ASB7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ankyrin repeat and SOCS box protein 7

Short name=ASB-7
Gene names
Name:ASB7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins By similarity. Ref.5

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Interacts with CUL5 and RNF7. Ref.5

Domain

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes By similarity.

Sequence similarities

Contains 7 ANK repeats.

Contains 1 SOCS box domain.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Coding sequence diversityAlternative splicing
   DomainANK repeat
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processintracellular signal transduction

Inferred from electronic annotation. Source: InterPro

protein ubiquitination

Inferred from electronic annotation. Source: UniProtKB-UniPathway

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9H672-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9H672-2)

The sequence of this isoform differs from the canonical sequence as follows:
     273-274: RQ → SM
     275-318: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 318318Ankyrin repeat and SOCS box protein 7
PRO_0000066935

Regions

Repeat13 – 4230ANK 1
Repeat46 – 7530ANK 2
Repeat80 – 10930ANK 3
Repeat116 – 14530ANK 4
Repeat149 – 17830ANK 5
Repeat180 – 20829ANK 6
Repeat213 – 24230ANK 7
Domain265 – 31854SOCS box

Natural variations

Alternative sequence273 – 2742RQ → SM in isoform 2.
VSP_008919
Alternative sequence275 – 31844Missing in isoform 2.
VSP_008920

Experimental info

Sequence conflict1621R → K in BAB15392. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 14, 2003. Version 2.
Checksum: F6FE48D0970DF83E

FASTA31836,011
        10         20         30         40         50         60 
MLHHHCRRNP ELQEELQIQA AVAAGDVHTV RKMLEQGYSP NGRDANGWTL LHFSAARGKE 

        70         80         90        100        110        120 
RCVRVFLEHG ADPTVKDLIG GFTALHYAAM HGRARIARLM LESEYRSDII NAKSNDGWTP 

       130        140        150        160        170        180 
LHVAAHYGRD SFVRLLLEFK AEVDPLSDKG TTPLQLAIIR ERSSCVKILL DHNANIDIQN 

       190        200        210        220        230        240 
GFLLRYAVIK SNHSYCRMFL QRGADTNLGR LEDGQTPLHL SALRDDVLCA RMLYNYGADT 

       250        260        270        280        290        300 
NTRNYEGQTP LAVSISISGS SRPCLDFLQE VTRQPRNLQD LCRIKIRQCI GLQNLKLLDE 

       310 
LPIAKVMKDY LKHKFDDI 

« Hide

Isoform 2 [UniParc].

Checksum: 8E5B5AD312006AC2
Show »

FASTA27430,713

References

« Hide 'large scale' references
[1]Guo J.H., Zan Q., Yu L.
Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Testis.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain and Small intestine.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Bone.
[5]"ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes."
Kohroki J., Nishiyama T., Nakamura T., Masuho Y.
FEBS Lett. 579:6796-6802(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE, INTERACTION WITH CUL5 AND RNF7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF451994 mRNA. Translation: AAP97683.1.
AK026204 mRNA. Translation: BAB15392.1.
AK289860 mRNA. Translation: BAF82549.1.
CH471101 Genomic DNA. Translation: EAX02274.1.
CH471101 Genomic DNA. Translation: EAX02276.1.
BC063581 mRNA. Translation: AAH63581.1.
RefSeqNP_078984.2. NM_024708.3.
NP_937886.1. NM_198243.2.
UniGeneHs.31845.
Hs.709044.

3D structure databases

ProteinModelPortalQ9H672.
SMRQ9H672. Positions 2-314.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126613. 6 interactions.
IntActQ9H672. 3 interactions.
MINTMINT-1500354.
STRING9606.ENSP00000328327.

PTM databases

PhosphoSiteQ9H672.

Polymorphism databases

DMDM38372887.

Proteomic databases

PaxDbQ9H672.
PRIDEQ9H672.

Protocols and materials databases

DNASU140460.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000332783; ENSP00000328327; ENSG00000183475. [Q9H672-1]
ENST00000343276; ENSP00000339819; ENSG00000183475. [Q9H672-2]
GeneID140460.
KEGGhsa:140460.
UCSCuc002bwj.3. human. [Q9H672-2]
uc002bwk.3. human. [Q9H672-1]

Organism-specific databases

CTD140460.
GeneCardsGC15P101142.
HGNCHGNC:17182. ASB7.
HPAHPA003300.
MIM615052. gene.
neXtProtNX_Q9H672.
PharmGKBPA25035.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0666.
HOGENOMHOG000013024.
HOVERGENHBG037171.
InParanoidQ9H672.
KOK10329.
OMAGANTNTR.
OrthoDBEOG790G10.
PhylomeDBQ9H672.
TreeFamTF331695.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.
UniPathwayUPA00143.

Gene expression databases

ArrayExpressQ9H672.
BgeeQ9H672.
CleanExHS_ASB7.
GenevestigatorQ9H672.

Family and domain databases

Gene3D1.25.40.20. 3 hits.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_C.
[Graphical view]
PfamPF12796. Ank_2. 3 hits.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSPR01415. ANKYRIN.
SMARTSM00248. ANK. 7 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi140460.
NextBio84115.
PROQ9H672.
SOURCESearch...

Entry information

Entry nameASB7_HUMAN
AccessionPrimary (citable) accession number: Q9H672
Secondary accession number(s): A8K1E5, Q6GSJ6, Q7Z4S3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: November 14, 2003
Last modified: March 19, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM