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Protein

IGF-like family receptor 1

Gene

IGFLR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2.1 Publication

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

SignaLinkiQ9H665.

Names & Taxonomyi

Protein namesi
Recommended name:
IGF-like family receptor 1
Alternative name(s):
Transmembrane protein 149
U2 small nuclear RNA auxiliary factor 1-like 4
Gene namesi
Name:IGFLR1
Synonyms:TMEM149, U2AF1L4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:23620. IGFLR1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 163ExtracellularSequence analysisAdd BLAST141
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 355CytoplasmicSequence analysisAdd BLAST171

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi79713.
OpenTargetsiENSG00000126246.
PharmGKBiPA134884390.

Chemistry databases

ChEMBLiCHEMBL2029192.

Polymorphism and mutation databases

BioMutaiIGFLR1.
DMDMi74718463.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000029035723 – 355IGF-like family receptor 1Add BLAST333

Proteomic databases

PaxDbiQ9H665.
PeptideAtlasiQ9H665.
PRIDEiQ9H665.

PTM databases

iPTMnetiQ9H665.
PhosphoSitePlusiQ9H665.

Expressioni

Inductioni

Up-regulated by the proinflammatory cytokine TNFA and in skin upon tissue inflammation.1 Publication

Gene expression databases

BgeeiENSG00000126246.
CleanExiHS_TMEM149.
HS_U2AF1L4.
ExpressionAtlasiQ9H665. baseline and differential.
GenevisibleiQ9H665. HS.

Organism-specific databases

HPAiHPA012369.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
IGFL1Q6UW325EBI-3870439,EBI-3870426

Protein-protein interaction databases

IntActiQ9H665. 3 interactors.
STRINGi9606.ENSP00000246532.

Chemistry databases

BindingDBiQ9H665.

Structurei

3D structure databases

ProteinModelPortaliQ9H665.
SMRiQ9H665.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKJZ. Eukaryota.
ENOG410YY5D. LUCA.
GeneTreeiENSGT00390000005702.
HOVERGENiHBG099100.
InParanoidiQ9H665.
OMAiWSTFAYS.
OrthoDBiEOG091G0H32.
PhylomeDBiQ9H665.
TreeFamiTF338761.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H665-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPGRCLLTA LLLLALAPPP EASQYCGRLE YWNPDNKCCS SCLQRFGPPP
60 70 80 90 100
CPDYEFRENC GLNDHGDFVT PPFRKCSSGQ CNPDGAELCS PCGGGAVTPT
110 120 130 140 150
PAAGGGRTPW RCRERPVPAK GHCPLTPGNP GAPSSQERSS PASSIAWRTP
160 170 180 190 200
EPVPQQAWPN FLPLVVLVLL LTLAVIAILL FILLWHLCWP KEKADPYPYP
210 220 230 240 250
GLVCGVPNTH TPSSSHLSSP GALETGDTWK EASLLPLLSR ELSSLASQPL
260 270 280 290 300
SRLLDELEVL EELIVLLDPE PGPGGGMAHG TTRHLAARYG LPAAWSTFAY
310 320 330 340 350
SLRPSRSPLR ALIEMVVARE PSASLGQLGT HLAQLGRADA LRVLSKLGSS

GVCWA
Length:355
Mass (Da):37,895
Last modified:March 1, 2001 - v1
Checksum:i52C41A73E673623C
GO
Isoform 2 (identifier: Q9H665-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-240: Missing.

Show »
Length:167
Mass (Da):17,816
Checksum:i14EC1AC3B47BC972
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032775189W → R.Corresponds to variant rs34562867dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02614553 – 240Missing in isoform 2. 1 PublicationAdd BLAST188

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026226 mRNA. Translation: BAB15400.1.
AD000671 Genomic DNA. No translation available.
BC031329 mRNA. Translation: AAH31329.1.
BC126481 mRNA. Translation: AAI26482.1.
BC126483 mRNA. Translation: AAI26484.1.
CCDSiCCDS12472.1. [Q9H665-1]
RefSeqiNP_078936.1. NM_024660.3. [Q9H665-1]
UniGeneiHs.352548.

Genome annotation databases

EnsembliENST00000246532; ENSP00000246532; ENSG00000126246. [Q9H665-1]
ENST00000592537; ENSP00000466181; ENSG00000126246. [Q9H665-1]
ENST00000592889; ENSP00000467750; ENSG00000126246. [Q9H665-2]
GeneIDi79713.
KEGGihsa:79713.
UCSCiuc002obb.4. human. [Q9H665-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026226 mRNA. Translation: BAB15400.1.
AD000671 Genomic DNA. No translation available.
BC031329 mRNA. Translation: AAH31329.1.
BC126481 mRNA. Translation: AAI26482.1.
BC126483 mRNA. Translation: AAI26484.1.
CCDSiCCDS12472.1. [Q9H665-1]
RefSeqiNP_078936.1. NM_024660.3. [Q9H665-1]
UniGeneiHs.352548.

3D structure databases

ProteinModelPortaliQ9H665.
SMRiQ9H665.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9H665. 3 interactors.
STRINGi9606.ENSP00000246532.

Chemistry databases

BindingDBiQ9H665.
ChEMBLiCHEMBL2029192.

PTM databases

iPTMnetiQ9H665.
PhosphoSitePlusiQ9H665.

Polymorphism and mutation databases

BioMutaiIGFLR1.
DMDMi74718463.

Proteomic databases

PaxDbiQ9H665.
PeptideAtlasiQ9H665.
PRIDEiQ9H665.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246532; ENSP00000246532; ENSG00000126246. [Q9H665-1]
ENST00000592537; ENSP00000466181; ENSG00000126246. [Q9H665-1]
ENST00000592889; ENSP00000467750; ENSG00000126246. [Q9H665-2]
GeneIDi79713.
KEGGihsa:79713.
UCSCiuc002obb.4. human. [Q9H665-1]

Organism-specific databases

CTDi79713.
DisGeNETi79713.
GeneCardsiIGFLR1.
HGNCiHGNC:23620. IGFLR1.
HPAiHPA012369.
MIMi614143. gene.
neXtProtiNX_Q9H665.
OpenTargetsiENSG00000126246.
PharmGKBiPA134884390.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKJZ. Eukaryota.
ENOG410YY5D. LUCA.
GeneTreeiENSGT00390000005702.
HOVERGENiHBG099100.
InParanoidiQ9H665.
OMAiWSTFAYS.
OrthoDBiEOG091G0H32.
PhylomeDBiQ9H665.
TreeFamiTF338761.

Enzyme and pathway databases

SignaLinkiQ9H665.

Miscellaneous databases

ChiTaRSiIGFLR1. human.
GenomeRNAii79713.
PROiQ9H665.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126246.
CleanExiHS_TMEM149.
HS_U2AF1L4.
ExpressionAtlasiQ9H665. baseline and differential.
GenevisibleiQ9H665. HS.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIGFR1_HUMAN
AccessioniPrimary (citable) accession number: Q9H665
Secondary accession number(s): Q8N5X0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.