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Protein

Putative methyltransferase NSUN3

Gene

NSUN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May have S-adenosyl-L-methionine-dependent methyl-transferase activity.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei162S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei193S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei211S-adenosyl-L-methioninePROSITE-ProRule annotation1
Active sitei265NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciZFISH:ENSG00000178694-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative methyltransferase NSUN3 (EC:2.1.1.-)
Alternative name(s):
NOL1/NOP2/Sun domain family member 3
Gene namesi
Name:NSUN3
ORF Names:MSTP077, UG0651E06
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:26208. NSUN3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi63899.
OpenTargetsiENSG00000178694.
PharmGKBiPA134961151.

Polymorphism and mutation databases

BioMutaiNSUN3.
DMDMi74733593.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002892301 – 340Putative methyltransferase NSUN3Add BLAST340

Proteomic databases

EPDiQ9H649.
MaxQBiQ9H649.
PaxDbiQ9H649.
PeptideAtlasiQ9H649.
PRIDEiQ9H649.

PTM databases

iPTMnetiQ9H649.
PhosphoSitePlusiQ9H649.

Expressioni

Gene expression databases

BgeeiENSG00000178694.
CleanExiHS_NSUN3.
ExpressionAtlasiQ9H649. baseline and differential.
GenevisibleiQ9H649. HS.

Organism-specific databases

HPAiHPA036181.
HPA057979.

Interactioni

Protein-protein interaction databases

BioGridi121978. 6 interactors.
STRINGi9606.ENSP00000318986.

Structurei

3D structure databases

ProteinModelPortaliQ9H649.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni139 – 145S-adenosyl-L-methionine bindingPROSITE-ProRule annotation7

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2198. Eukaryota.
COG0144. LUCA.
GeneTreeiENSGT00660000095341.
HOGENOMiHOG000017426.
HOVERGENiHBG106892.
InParanoidiQ9H649.
OMAiMYVAKLK.
OrthoDBiEOG091G07PM.
PhylomeDBiQ9H649.
TreeFamiTF321304.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR001678. MeTrfase_RsmB/NOP2.
IPR023267. RCMT.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01189. Methyltr_RsmB-F. 1 hit.
[Graphical view]
PRINTSiPR02008. RCMTFAMILY.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51686. SAM_MT_RSMB_NOP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H649-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTQLKAKSE GKLAKQICKV VLDHFEKQYS KELGDAWNTV REILTSPSCW
60 70 80 90 100
QYAVLLNRFN YPFELEKDLH LKGYHTLSQG SLPNYPKSVK CYLSRTPGRI
110 120 130 140 150
PSERHQIGNL KKYYLLNAAS LLPVLALELR DGEKVLDLCA APGGKSIALL
160 170 180 190 200
QCACPGYLHC NEYDSLRLRW LRQTLESFIP QPLINVIKVS ELDGRKMGDA
210 220 230 240 250
QPEMFDKVLV DAPCSNDRSW LFSSDSQKAS CRISQRRNLP LLQIELLRSA
260 270 280 290 300
IKALRPGGIL VYSTCTLSKA ENQDVISEIL NSHGNIMPMD IKGIARTCSH
310 320 330 340
DFTFAPTGQE CGLLVIPDKG KAWGPMYVAK LKKSWSTGKW
Length:340
Mass (Da):38,244
Last modified:March 1, 2001 - v1
Checksum:i7E09AF2E477EB6F3
GO

Sequence cautioni

The sequence AAN76512 differs from that shown. Chimera.Curated
The sequence AAQ13600 differs from that shown. Reason: Frameshift at position 98.Curated
The sequence BAB15234 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032605295A → V.1 PublicationCorresponds to variant rs17854922dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025762 mRNA. Translation: BAB15234.1. Different initiation.
AK026262 mRNA. Translation: BAB15417.1.
AF169972 mRNA. Translation: AAQ13600.1. Frameshift.
BC020602 mRNA. Translation: AAH20602.1.
BC057238 mRNA. Translation: AAH57238.1.
AF351612 mRNA. Translation: AAN76512.1. Sequence problems.
CCDSiCCDS2927.1.
RefSeqiNP_071355.1. NM_022072.3.
UniGeneiHs.448003.

Genome annotation databases

EnsembliENST00000314622; ENSP00000318986; ENSG00000178694.
GeneIDi63899.
KEGGihsa:63899.
UCSCiuc003drl.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025762 mRNA. Translation: BAB15234.1. Different initiation.
AK026262 mRNA. Translation: BAB15417.1.
AF169972 mRNA. Translation: AAQ13600.1. Frameshift.
BC020602 mRNA. Translation: AAH20602.1.
BC057238 mRNA. Translation: AAH57238.1.
AF351612 mRNA. Translation: AAN76512.1. Sequence problems.
CCDSiCCDS2927.1.
RefSeqiNP_071355.1. NM_022072.3.
UniGeneiHs.448003.

3D structure databases

ProteinModelPortaliQ9H649.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121978. 6 interactors.
STRINGi9606.ENSP00000318986.

PTM databases

iPTMnetiQ9H649.
PhosphoSitePlusiQ9H649.

Polymorphism and mutation databases

BioMutaiNSUN3.
DMDMi74733593.

Proteomic databases

EPDiQ9H649.
MaxQBiQ9H649.
PaxDbiQ9H649.
PeptideAtlasiQ9H649.
PRIDEiQ9H649.

Protocols and materials databases

DNASUi63899.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314622; ENSP00000318986; ENSG00000178694.
GeneIDi63899.
KEGGihsa:63899.
UCSCiuc003drl.2. human.

Organism-specific databases

CTDi63899.
DisGeNETi63899.
GeneCardsiNSUN3.
HGNCiHGNC:26208. NSUN3.
HPAiHPA036181.
HPA057979.
neXtProtiNX_Q9H649.
OpenTargetsiENSG00000178694.
PharmGKBiPA134961151.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2198. Eukaryota.
COG0144. LUCA.
GeneTreeiENSGT00660000095341.
HOGENOMiHOG000017426.
HOVERGENiHBG106892.
InParanoidiQ9H649.
OMAiMYVAKLK.
OrthoDBiEOG091G07PM.
PhylomeDBiQ9H649.
TreeFamiTF321304.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000178694-MONOMER.

Miscellaneous databases

ChiTaRSiNSUN3. human.
GenomeRNAii63899.
PROiQ9H649.

Gene expression databases

BgeeiENSG00000178694.
CleanExiHS_NSUN3.
ExpressionAtlasiQ9H649. baseline and differential.
GenevisibleiQ9H649. HS.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR001678. MeTrfase_RsmB/NOP2.
IPR023267. RCMT.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01189. Methyltr_RsmB-F. 1 hit.
[Graphical view]
PRINTSiPR02008. RCMTFAMILY.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51686. SAM_MT_RSMB_NOP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNSUN3_HUMAN
AccessioniPrimary (citable) accession number: Q9H649
Secondary accession number(s): Q6PG41, Q8IXG9, Q9H6M2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.