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Protein

Ribonuclease P protein subunit p21

Gene

RPP21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi62ZincBy similarity1
Metal bindingi65ZincBy similarity1
Metal bindingi92ZincBy similarity1
Metal bindingi95ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

  • response to drug Source: UniProtKB
  • rRNA processing Source: Reactome
  • tRNA 5'-leader removal Source: Reactome
  • tRNA processing Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:HS13674-MONOMER.
ReactomeiR-HSA-6784531. tRNA processing in the nucleus.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit p21 (EC:3.1.26.5)
Short name:
RNaseP protein p21
Alternative name(s):
Ribonuclease P/MRP 21 kDa subunit
Ribonucleoprotein V
Gene namesi
Name:RPP21
Synonyms:C6orf135, CAT60
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21300. RPP21.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi79897.
OpenTargetsiENSG00000239865.
ENSG00000239927.
ENSG00000241370.
ENSG00000241863.
PharmGKBiPA134960979.

Polymorphism and mutation databases

BioMutaiRPP21.
DMDMi52001252.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001538452 – 154Ribonuclease P protein subunit p21Add BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9H633.
MaxQBiQ9H633.
PaxDbiQ9H633.
PeptideAtlasiQ9H633.
PRIDEiQ9H633.

PTM databases

iPTMnetiQ9H633.
PhosphoSitePlusiQ9H633.

Expressioni

Gene expression databases

BgeeiENSG00000239865.
CleanExiHS_RPP21.
GenevisibleiQ9H633. HS.

Interactioni

Subunit structurei

RNase P consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP21, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40.

Protein-protein interaction databases

BioGridi122981. 11 interactors.
IntActiQ9H633. 1 interactor.
STRINGi9606.ENSP00000409799.

Structurei

3D structure databases

ProteinModelPortaliQ9H633.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4394. Eukaryota.
COG2023. LUCA.
GeneTreeiENSGT00390000003020.
HOGENOMiHOG000231207.
HOVERGENiHBG055987.
InParanoidiQ9H633.
KOiK03540.
OMAiDPKHLLW.
OrthoDBiEOG091G12P3.
PhylomeDBiQ9H633.

Family and domain databases

InterProiIPR007175. Rpr2.
[Graphical view]
PANTHERiPTHR14742. PTHR14742. 1 hit.
PfamiPF04032. Rpr2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H633-1) [UniParc]FASTAAdd to basket
Also known as: CAT60-V1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGPVKDREA FQRLNFLYQA AHCVLAQDPE NQALARFYCY TERTIAKRLV
60 70 80 90 100
LRRDPSVKRT LCRGCSSLLV PGLTCTQRQR RCRGQRWTVQ TCLTCQRSQR
110 120 130 140 150
FLNDPGHLLW GDRPEAQLGS QADSKPLQPL PNTAHSISDR LPEEKMQTQG

SSNQ
Length:154
Mass (Da):17,570
Last modified:March 1, 2001 - v1
Checksum:iF8BD15AA20AE695F
GO
Isoform 2 (identifier: Q9H633-2) [UniParc]FASTAAdd to basket
Also known as: CAT60-V3

The sequence of this isoform differs from the canonical sequence as follows:
     19-19: Q → QVSLRQGPHGDGARRPRVTAPLPQ

Show »
Length:177
Mass (Da):20,018
Checksum:i0FE5E6F3296602FB
GO
Isoform 3 (identifier: Q9H633-3) [UniParc]FASTAAdd to basket
Also known as: CAT60-V4

The sequence of this isoform differs from the canonical sequence as follows:
     123-154: DSKPLQPLPNTAHSISDRLPEEKMQTQGSSNQ → GERFQTTTTLAKHSPLHFRPPS

Show »
Length:144
Mass (Da):16,544
Checksum:iB037193A307F6F77
GO
Isoform 4 (identifier: Q9H633-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-52: R → RRPLSSSAP

Note: No experimental confirmation available.
Show »
Length:162
Mass (Da):18,366
Checksum:iE2CA143586B0B751
GO

Sequence cautioni

The sequence BI598757 differs from that shown. Reason: Erroneous termination at position 155. Translated as stop.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9E → K in BI598757 (PubMed:15489334).Curated1
Sequence conflicti113R → Q in CAD44290 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01911677Q → H.3 PublicationsCorresponds to variant rs6986dbSNPEnsembl.1
Natural variantiVAR_045986149Q → K.1 PublicationCorresponds to variant rs974963dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01069519Q → QVSLRQGPHGDGARRPRVTA PLPQ in isoform 2. 1 Publication1
Alternative sequenceiVSP_04490152R → RRPLSSSAP in isoform 4. 1 Publication1
Alternative sequenceiVSP_010696123 – 154DSKPL…GSSNQ → GERFQTTTTLAKHSPLHFRP PS in isoform 3. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212152 mRNA. Translation: AAK39955.2.
AJ504713 mRNA. Translation: CAD44289.1.
AJ504714 mRNA. Translation: CAD44290.1.
AJ504715 mRNA. Translation: CAD44291.1.
AJ504716 mRNA. Translation: CAD44292.1.
AK026291 mRNA. Translation: BAB15433.1.
AL662832 Genomic DNA. Translation: CAI17503.2.
AL662832 Genomic DNA. Translation: CAI17506.2.
AL662832 Genomic DNA. Translation: CAI17507.2.
AL662795 Genomic DNA. Translation: CAI18254.1.
AL662795 Genomic DNA. Translation: CAI18255.2.
AL773535 Genomic DNA. Translation: CAI41822.1.
AL773535 Genomic DNA. Translation: CAI41824.2.
AL662795 Genomic DNA. Translation: CAM25559.1.
BX294158 Genomic DNA. Translation: CAM25886.1.
BX294158 Genomic DNA. Translation: CAM25887.1.
BX294158 Genomic DNA. Translation: CAM25888.1.
BX294158 Genomic DNA. Translation: CAM25889.1.
CR759928 Genomic DNA. Translation: CAQ08317.1.
CR759928 Genomic DNA. Translation: CAQ08318.1.
BX927214 Genomic DNA. Translation: CAQ08386.1.
BX927214 Genomic DNA. Translation: CAQ08387.1.
BX927214 Genomic DNA. Translation: CAQ08388.1.
CR759281 Genomic DNA. Translation: CAQ09024.1.
CR759281 Genomic DNA. Translation: CAQ09025.1.
CH471081 Genomic DNA. Translation: EAX03287.1.
CH471081 Genomic DNA. Translation: EAX03288.1.
CH471081 Genomic DNA. Translation: EAX03289.1.
BC011730 mRNA. Translation: AAH11730.1.
BI598757 mRNA. No translation available.
CCDSiCCDS4679.1. [Q9H633-1]
CCDS56409.1. [Q9H633-4]
CCDS56410.1. [Q9H633-3]
RefSeqiNP_001186049.1. NM_001199120.1. [Q9H633-4]
NP_001186050.1. NM_001199121.1. [Q9H633-3]
NP_079115.1. NM_024839.2. [Q9H633-1]
UniGeneiHs.183232.

Genome annotation databases

EnsembliENST00000376642; ENSP00000365829; ENSG00000239927. [Q9H633-1]
ENST00000411784; ENSP00000412619; ENSG00000241863. [Q9H633-2]
ENST00000414187; ENSP00000398396; ENSG00000243009.
ENST00000415583; ENSP00000403747; ENSG00000239927. [Q9H633-3]
ENST00000416977; ENSP00000404312; ENSG00000241779.
ENST00000424616; ENSP00000399295; ENSG00000241863. [Q9H633-1]
ENST00000425575; ENSP00000405834; ENSG00000239927. [Q9H633-4]
ENST00000428040; ENSP00000394320; ENSG00000241370. [Q9H633-2]
ENST00000430900; ENSP00000415046; ENSG00000239927. [Q9H633-2]
ENST00000433076; ENSP00000409799; ENSG00000241370. [Q9H633-4]
ENST00000434282; ENSP00000414284; ENSG00000242726.
ENST00000435318; ENSP00000411003; ENSG00000239865. [Q9H633-3]
ENST00000436442; ENSP00000397778; ENSG00000241370. [Q9H633-3]
ENST00000437470; ENSP00000408610; ENSG00000241863. [Q9H633-3]
ENST00000442966; ENSP00000403833; ENSG00000241370. [Q9H633-1]
ENST00000455025; ENSP00000409193; ENSG00000241863. [Q9H633-4]
GeneIDi79897.
KEGGihsa:79897.
UCSCiuc003nqd.3. human. [Q9H633-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212152 mRNA. Translation: AAK39955.2.
AJ504713 mRNA. Translation: CAD44289.1.
AJ504714 mRNA. Translation: CAD44290.1.
AJ504715 mRNA. Translation: CAD44291.1.
AJ504716 mRNA. Translation: CAD44292.1.
AK026291 mRNA. Translation: BAB15433.1.
AL662832 Genomic DNA. Translation: CAI17503.2.
AL662832 Genomic DNA. Translation: CAI17506.2.
AL662832 Genomic DNA. Translation: CAI17507.2.
AL662795 Genomic DNA. Translation: CAI18254.1.
AL662795 Genomic DNA. Translation: CAI18255.2.
AL773535 Genomic DNA. Translation: CAI41822.1.
AL773535 Genomic DNA. Translation: CAI41824.2.
AL662795 Genomic DNA. Translation: CAM25559.1.
BX294158 Genomic DNA. Translation: CAM25886.1.
BX294158 Genomic DNA. Translation: CAM25887.1.
BX294158 Genomic DNA. Translation: CAM25888.1.
BX294158 Genomic DNA. Translation: CAM25889.1.
CR759928 Genomic DNA. Translation: CAQ08317.1.
CR759928 Genomic DNA. Translation: CAQ08318.1.
BX927214 Genomic DNA. Translation: CAQ08386.1.
BX927214 Genomic DNA. Translation: CAQ08387.1.
BX927214 Genomic DNA. Translation: CAQ08388.1.
CR759281 Genomic DNA. Translation: CAQ09024.1.
CR759281 Genomic DNA. Translation: CAQ09025.1.
CH471081 Genomic DNA. Translation: EAX03287.1.
CH471081 Genomic DNA. Translation: EAX03288.1.
CH471081 Genomic DNA. Translation: EAX03289.1.
BC011730 mRNA. Translation: AAH11730.1.
BI598757 mRNA. No translation available.
CCDSiCCDS4679.1. [Q9H633-1]
CCDS56409.1. [Q9H633-4]
CCDS56410.1. [Q9H633-3]
RefSeqiNP_001186049.1. NM_001199120.1. [Q9H633-4]
NP_001186050.1. NM_001199121.1. [Q9H633-3]
NP_079115.1. NM_024839.2. [Q9H633-1]
UniGeneiHs.183232.

3D structure databases

ProteinModelPortaliQ9H633.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122981. 11 interactors.
IntActiQ9H633. 1 interactor.
STRINGi9606.ENSP00000409799.

PTM databases

iPTMnetiQ9H633.
PhosphoSitePlusiQ9H633.

Polymorphism and mutation databases

BioMutaiRPP21.
DMDMi52001252.

Proteomic databases

EPDiQ9H633.
MaxQBiQ9H633.
PaxDbiQ9H633.
PeptideAtlasiQ9H633.
PRIDEiQ9H633.

Protocols and materials databases

DNASUi79897.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376642; ENSP00000365829; ENSG00000239927. [Q9H633-1]
ENST00000411784; ENSP00000412619; ENSG00000241863. [Q9H633-2]
ENST00000414187; ENSP00000398396; ENSG00000243009.
ENST00000415583; ENSP00000403747; ENSG00000239927. [Q9H633-3]
ENST00000416977; ENSP00000404312; ENSG00000241779.
ENST00000424616; ENSP00000399295; ENSG00000241863. [Q9H633-1]
ENST00000425575; ENSP00000405834; ENSG00000239927. [Q9H633-4]
ENST00000428040; ENSP00000394320; ENSG00000241370. [Q9H633-2]
ENST00000430900; ENSP00000415046; ENSG00000239927. [Q9H633-2]
ENST00000433076; ENSP00000409799; ENSG00000241370. [Q9H633-4]
ENST00000434282; ENSP00000414284; ENSG00000242726.
ENST00000435318; ENSP00000411003; ENSG00000239865. [Q9H633-3]
ENST00000436442; ENSP00000397778; ENSG00000241370. [Q9H633-3]
ENST00000437470; ENSP00000408610; ENSG00000241863. [Q9H633-3]
ENST00000442966; ENSP00000403833; ENSG00000241370. [Q9H633-1]
ENST00000455025; ENSP00000409193; ENSG00000241863. [Q9H633-4]
GeneIDi79897.
KEGGihsa:79897.
UCSCiuc003nqd.3. human. [Q9H633-1]

Organism-specific databases

CTDi79897.
DisGeNETi79897.
GeneCardsiRPP21.
H-InvDBHIX0207610.
HIX0207675.
HIX0207761.
HGNCiHGNC:21300. RPP21.
MIMi612524. gene.
neXtProtiNX_Q9H633.
OpenTargetsiENSG00000239865.
ENSG00000239927.
ENSG00000241370.
ENSG00000241863.
PharmGKBiPA134960979.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4394. Eukaryota.
COG2023. LUCA.
GeneTreeiENSGT00390000003020.
HOGENOMiHOG000231207.
HOVERGENiHBG055987.
InParanoidiQ9H633.
KOiK03540.
OMAiDPKHLLW.
OrthoDBiEOG091G12P3.
PhylomeDBiQ9H633.

Enzyme and pathway databases

BioCyciZFISH:HS13674-MONOMER.
ReactomeiR-HSA-6784531. tRNA processing in the nucleus.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Miscellaneous databases

GenomeRNAii79897.
PROiQ9H633.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000239865.
CleanExiHS_RPP21.
GenevisibleiQ9H633. HS.

Family and domain databases

InterProiIPR007175. Rpr2.
[Graphical view]
PANTHERiPTHR14742. PTHR14742. 1 hit.
PfamiPF04032. Rpr2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRPP21_HUMAN
AccessioniPrimary (citable) accession number: Q9H633
Secondary accession number(s): A2AAZ8
, B0S834, B0S835, Q5JPL9, Q5JPM1, Q5STF8, Q5STF9, Q5STG2, Q5SU41, Q5SU42, Q86Y49, Q86Y50, Q86Y51, Q96F16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.