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Q9H633

- RPP21_HUMAN

UniProt

Q9H633 - RPP21_HUMAN

Protein

Ribonuclease P protein subunit p21

Gene

RPP21

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

    Catalytic activityi

    Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi62 – 621ZincBy similarity
    Metal bindingi65 – 651ZincBy similarity
    Metal bindingi92 – 921ZincBy similarity
    Metal bindingi95 – 951ZincBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonuclease P activity Source: UniProtKB-EC

    GO - Biological processi

    1. response to drug Source: UniProtKB
    2. tRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease P protein subunit p21 (EC:3.1.26.5)
    Short name:
    RNaseP protein p21
    Alternative name(s):
    Ribonuclease P/MRP 21 kDa subunit
    Ribonucleoprotein V
    Gene namesi
    Name:RPP21
    Synonyms:C6orf135, CAT60
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:21300. RPP21.

    Subcellular locationi

    Nucleusnucleolus 1 Publication

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134960979.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 154153Ribonuclease P protein subunit p21PRO_0000153845Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9H633.
    PaxDbiQ9H633.
    PRIDEiQ9H633.

    PTM databases

    PhosphoSiteiQ9H633.

    Expressioni

    Gene expression databases

    BgeeiQ9H633.
    CleanExiHS_RPP21.
    GenevestigatoriQ9H633.

    Organism-specific databases

    HPAiHPA048369.
    HPA049389.

    Interactioni

    Subunit structurei

    RNase P consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP21, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40.

    Protein-protein interaction databases

    BioGridi122981. 2 interactions.
    IntActiQ9H633. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H633.
    SMRiQ9H633. Positions 4-103.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG285045.
    HOVERGENiHBG055987.
    KOiK03540.
    OMAiNYLYQAA.
    OrthoDBiEOG75MVZT.
    PhylomeDBiQ9H633.

    Family and domain databases

    InterProiIPR007175. Rpr2.
    [Graphical view]
    PANTHERiPTHR14742. PTHR14742. 1 hit.
    PfamiPF04032. Rpr2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H633-1) [UniParc]FASTAAdd to Basket

    Also known as: CAT60-V1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGPVKDREA FQRLNFLYQA AHCVLAQDPE NQALARFYCY TERTIAKRLV    50
    LRRDPSVKRT LCRGCSSLLV PGLTCTQRQR RCRGQRWTVQ TCLTCQRSQR 100
    FLNDPGHLLW GDRPEAQLGS QADSKPLQPL PNTAHSISDR LPEEKMQTQG 150
    SSNQ 154
    Length:154
    Mass (Da):17,570
    Last modified:March 1, 2001 - v1
    Checksum:iF8BD15AA20AE695F
    GO
    Isoform 2 (identifier: Q9H633-2) [UniParc]FASTAAdd to Basket

    Also known as: CAT60-V3

    The sequence of this isoform differs from the canonical sequence as follows:
         19-19: Q → QVSLRQGPHGDGARRPRVTAPLPQ

    Show »
    Length:177
    Mass (Da):20,018
    Checksum:i0FE5E6F3296602FB
    GO
    Isoform 3 (identifier: Q9H633-3) [UniParc]FASTAAdd to Basket

    Also known as: CAT60-V4

    The sequence of this isoform differs from the canonical sequence as follows:
         123-154: DSKPLQPLPNTAHSISDRLPEEKMQTQGSSNQ → GERFQTTTTLAKHSPLHFRPPS

    Show »
    Length:144
    Mass (Da):16,544
    Checksum:iB037193A307F6F77
    GO
    Isoform 4 (identifier: Q9H633-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         52-52: R → RRPLSSSAP

    Note: No experimental confirmation available.

    Show »
    Length:162
    Mass (Da):18,366
    Checksum:iE2CA143586B0B751
    GO

    Sequence cautioni

    The sequence BI598757 differs from that shown. Reason: Erroneous termination at position 155. Translated as stop.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti9 – 91E → K in BI598757. (PubMed:15489334)Curated
    Sequence conflicti113 – 1131R → Q in CAD44290. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti77 – 771Q → H.3 Publications
    Corresponds to variant rs6986 [ dbSNP | Ensembl ].
    VAR_019116
    Natural varianti149 – 1491Q → K.1 Publication
    Corresponds to variant rs974963 [ dbSNP | Ensembl ].
    VAR_045986

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei19 – 191Q → QVSLRQGPHGDGARRPRVTA PLPQ in isoform 2. 1 PublicationVSP_010695
    Alternative sequencei52 – 521R → RRPLSSSAP in isoform 4. 1 PublicationVSP_044901
    Alternative sequencei123 – 15432DSKPL…GSSNQ → GERFQTTTTLAKHSPLHFRP PS in isoform 3. 1 PublicationVSP_010696Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF212152 mRNA. Translation: AAK39955.2.
    AJ504713 mRNA. Translation: CAD44289.1.
    AJ504714 mRNA. Translation: CAD44290.1.
    AJ504715 mRNA. Translation: CAD44291.1.
    AJ504716 mRNA. Translation: CAD44292.1.
    AK026291 mRNA. Translation: BAB15433.1.
    AL662832 Genomic DNA. Translation: CAI17503.2.
    AL662832 Genomic DNA. Translation: CAI17506.2.
    AL662832 Genomic DNA. Translation: CAI17507.2.
    AL662795 Genomic DNA. Translation: CAI18254.1.
    AL662795 Genomic DNA. Translation: CAI18255.2.
    AL773535 Genomic DNA. Translation: CAI41822.1.
    AL773535 Genomic DNA. Translation: CAI41824.2.
    AL662795 Genomic DNA. Translation: CAM25559.1.
    BX294158 Genomic DNA. Translation: CAM25886.1.
    BX294158 Genomic DNA. Translation: CAM25887.1.
    BX294158 Genomic DNA. Translation: CAM25888.1.
    BX294158 Genomic DNA. Translation: CAM25889.1.
    CR759928 Genomic DNA. Translation: CAQ08317.1.
    CR759928 Genomic DNA. Translation: CAQ08318.1.
    BX927214 Genomic DNA. Translation: CAQ08386.1.
    BX927214 Genomic DNA. Translation: CAQ08387.1.
    BX927214 Genomic DNA. Translation: CAQ08388.1.
    CR759281 Genomic DNA. Translation: CAQ09024.1.
    CR759281 Genomic DNA. Translation: CAQ09025.1.
    CH471081 Genomic DNA. Translation: EAX03287.1.
    CH471081 Genomic DNA. Translation: EAX03288.1.
    CH471081 Genomic DNA. Translation: EAX03289.1.
    BC011730 mRNA. Translation: AAH11730.1.
    BI598757 mRNA. No translation available.
    CCDSiCCDS4679.1. [Q9H633-1]
    CCDS56409.1. [Q9H633-4]
    CCDS56410.1. [Q9H633-3]
    RefSeqiNP_001186049.1. NM_001199120.1. [Q9H633-4]
    NP_001186050.1. NM_001199121.1. [Q9H633-3]
    NP_079115.1. NM_024839.2. [Q9H633-1]
    UniGeneiHs.183232.

    Genome annotation databases

    EnsembliENST00000376642; ENSP00000365829; ENSG00000239927. [Q9H633-1]
    ENST00000411784; ENSP00000412619; ENSG00000241863. [Q9H633-2]
    ENST00000414187; ENSP00000398396; ENSG00000243009.
    ENST00000415583; ENSP00000403747; ENSG00000239927. [Q9H633-3]
    ENST00000416977; ENSP00000404312; ENSG00000241779.
    ENST00000424616; ENSP00000399295; ENSG00000241863. [Q9H633-1]
    ENST00000425575; ENSP00000405834; ENSG00000239927. [Q9H633-4]
    ENST00000428040; ENSP00000394320; ENSG00000241370. [Q9H633-2]
    ENST00000430900; ENSP00000415046; ENSG00000239927. [Q9H633-2]
    ENST00000433076; ENSP00000409799; ENSG00000241370. [Q9H633-4]
    ENST00000434282; ENSP00000414284; ENSG00000242726.
    ENST00000435318; ENSP00000411003; ENSG00000239865. [Q9H633-3]
    ENST00000436442; ENSP00000397778; ENSG00000241370. [Q9H633-3]
    ENST00000437470; ENSP00000408610; ENSG00000241863. [Q9H633-3]
    ENST00000442966; ENSP00000403833; ENSG00000241370. [Q9H633-1]
    ENST00000455025; ENSP00000409193; ENSG00000241863. [Q9H633-4]
    GeneIDi79897.
    KEGGihsa:79897.
    UCSCiuc003nqd.2. human. [Q9H633-2]
    uc003nqe.2. human. [Q9H633-1]
    uc003nqf.2. human. [Q9H633-3]
    uc021yuc.1. human.

    Polymorphism databases

    DMDMi52001252.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF212152 mRNA. Translation: AAK39955.2 .
    AJ504713 mRNA. Translation: CAD44289.1 .
    AJ504714 mRNA. Translation: CAD44290.1 .
    AJ504715 mRNA. Translation: CAD44291.1 .
    AJ504716 mRNA. Translation: CAD44292.1 .
    AK026291 mRNA. Translation: BAB15433.1 .
    AL662832 Genomic DNA. Translation: CAI17503.2 .
    AL662832 Genomic DNA. Translation: CAI17506.2 .
    AL662832 Genomic DNA. Translation: CAI17507.2 .
    AL662795 Genomic DNA. Translation: CAI18254.1 .
    AL662795 Genomic DNA. Translation: CAI18255.2 .
    AL773535 Genomic DNA. Translation: CAI41822.1 .
    AL773535 Genomic DNA. Translation: CAI41824.2 .
    AL662795 Genomic DNA. Translation: CAM25559.1 .
    BX294158 Genomic DNA. Translation: CAM25886.1 .
    BX294158 Genomic DNA. Translation: CAM25887.1 .
    BX294158 Genomic DNA. Translation: CAM25888.1 .
    BX294158 Genomic DNA. Translation: CAM25889.1 .
    CR759928 Genomic DNA. Translation: CAQ08317.1 .
    CR759928 Genomic DNA. Translation: CAQ08318.1 .
    BX927214 Genomic DNA. Translation: CAQ08386.1 .
    BX927214 Genomic DNA. Translation: CAQ08387.1 .
    BX927214 Genomic DNA. Translation: CAQ08388.1 .
    CR759281 Genomic DNA. Translation: CAQ09024.1 .
    CR759281 Genomic DNA. Translation: CAQ09025.1 .
    CH471081 Genomic DNA. Translation: EAX03287.1 .
    CH471081 Genomic DNA. Translation: EAX03288.1 .
    CH471081 Genomic DNA. Translation: EAX03289.1 .
    BC011730 mRNA. Translation: AAH11730.1 .
    BI598757 mRNA. No translation available.
    CCDSi CCDS4679.1. [Q9H633-1 ]
    CCDS56409.1. [Q9H633-4 ]
    CCDS56410.1. [Q9H633-3 ]
    RefSeqi NP_001186049.1. NM_001199120.1. [Q9H633-4 ]
    NP_001186050.1. NM_001199121.1. [Q9H633-3 ]
    NP_079115.1. NM_024839.2. [Q9H633-1 ]
    UniGenei Hs.183232.

    3D structure databases

    ProteinModelPortali Q9H633.
    SMRi Q9H633. Positions 4-103.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122981. 2 interactions.
    IntActi Q9H633. 1 interaction.

    PTM databases

    PhosphoSitei Q9H633.

    Polymorphism databases

    DMDMi 52001252.

    Proteomic databases

    MaxQBi Q9H633.
    PaxDbi Q9H633.
    PRIDEi Q9H633.

    Protocols and materials databases

    DNASUi 79897.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000376642 ; ENSP00000365829 ; ENSG00000239927 . [Q9H633-1 ]
    ENST00000411784 ; ENSP00000412619 ; ENSG00000241863 . [Q9H633-2 ]
    ENST00000414187 ; ENSP00000398396 ; ENSG00000243009 .
    ENST00000415583 ; ENSP00000403747 ; ENSG00000239927 . [Q9H633-3 ]
    ENST00000416977 ; ENSP00000404312 ; ENSG00000241779 .
    ENST00000424616 ; ENSP00000399295 ; ENSG00000241863 . [Q9H633-1 ]
    ENST00000425575 ; ENSP00000405834 ; ENSG00000239927 . [Q9H633-4 ]
    ENST00000428040 ; ENSP00000394320 ; ENSG00000241370 . [Q9H633-2 ]
    ENST00000430900 ; ENSP00000415046 ; ENSG00000239927 . [Q9H633-2 ]
    ENST00000433076 ; ENSP00000409799 ; ENSG00000241370 . [Q9H633-4 ]
    ENST00000434282 ; ENSP00000414284 ; ENSG00000242726 .
    ENST00000435318 ; ENSP00000411003 ; ENSG00000239865 . [Q9H633-3 ]
    ENST00000436442 ; ENSP00000397778 ; ENSG00000241370 . [Q9H633-3 ]
    ENST00000437470 ; ENSP00000408610 ; ENSG00000241863 . [Q9H633-3 ]
    ENST00000442966 ; ENSP00000403833 ; ENSG00000241370 . [Q9H633-1 ]
    ENST00000455025 ; ENSP00000409193 ; ENSG00000241863 . [Q9H633-4 ]
    GeneIDi 79897.
    KEGGi hsa:79897.
    UCSCi uc003nqd.2. human. [Q9H633-2 ]
    uc003nqe.2. human. [Q9H633-1 ]
    uc003nqf.2. human. [Q9H633-3 ]
    uc021yuc.1. human.

    Organism-specific databases

    CTDi 79897.
    GeneCardsi GC06P030312.
    GC06Pi30321.
    GC06Pj30302.
    GC06Pk30303.
    GC06Pl30357.
    GC06Pn30302.
    GC06Po30302.
    H-InvDB HIX0207610.
    HIX0207675.
    HIX0207761.
    HGNCi HGNC:21300. RPP21.
    HPAi HPA048369.
    HPA049389.
    MIMi 612524. gene.
    neXtProti NX_Q9H633.
    PharmGKBi PA134960979.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG285045.
    HOVERGENi HBG055987.
    KOi K03540.
    OMAi NYLYQAA.
    OrthoDBi EOG75MVZT.
    PhylomeDBi Q9H633.

    Miscellaneous databases

    GenomeRNAii 79897.
    NextBioi 69734.
    PROi Q9H633.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9H633.
    CleanExi HS_RPP21.
    Genevestigatori Q9H633.

    Family and domain databases

    InterProi IPR007175. Rpr2.
    [Graphical view ]
    PANTHERi PTHR14742. PTHR14742. 1 hit.
    Pfami PF04032. Rpr2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Function and subnuclear distribution of Rpp21, a protein subunit of the human ribonucleoprotein ribonuclease P."
      Jarrous N., Reiner R., Wesolowski D., Mann H., Guerrier-Takada C., Altman S.
      RNA 7:1153-1164(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
    2. "Genes from major histocompatibility complex (MHC) class I region from HLA-C to HLA-A."
      Raha-Chowdhury R., Andrews S.R., Gruen J.R., Weissman S.M.
      Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), VARIANT HIS-77.
      Tissue: Spleen.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Small intestine.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS HIS-77 AND LYS-149.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), VARIANT HIS-77.
      Tissue: Hypothalamus and Skin.
    7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRPP21_HUMAN
    AccessioniPrimary (citable) accession number: Q9H633
    Secondary accession number(s): A2AAZ8
    , B0S834, B0S835, Q5JPL9, Q5JPM1, Q5STF8, Q5STF9, Q5STG2, Q5SU41, Q5SU42, Q86Y49, Q86Y50, Q86Y51, Q96F16
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2004
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3