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Q9H633 (RPP21_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease P protein subunit p21

Short name=RNaseP protein p21
EC=3.1.26.5
Alternative name(s):
Ribonuclease P/MRP 21 kDa subunit
Ribonucleoprotein V
Gene names
Name:RPP21
Synonyms:C6orf135, CAT60
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length154 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

Catalytic activity

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

Subunit structure

RNase P consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP21, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40.

Subcellular location

Nucleusnucleolus Ref.1.

Sequence similarities

Belongs to the eukaryotic/archaeal RNase P protein component 4 family.

Sequence caution

The sequence BI598757 differs from that shown. Reason: Erroneous termination at position 155. Translated as stop.

Ontologies

Keywords
   Biological processtRNA processing
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   Molecular functionHydrolase
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processresponse to drug

Inferred from expression pattern PubMed 18291362. Source: UniProtKB

tRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleolus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionribonuclease P activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9H633-1)

Also known as: CAT60-V1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9H633-2)

Also known as: CAT60-V3;

The sequence of this isoform differs from the canonical sequence as follows:
     19-19: Q → QVSLRQGPHGDGARRPRVTAPLPQ
Isoform 3 (identifier: Q9H633-3)

Also known as: CAT60-V4;

The sequence of this isoform differs from the canonical sequence as follows:
     123-154: DSKPLQPLPNTAHSISDRLPEEKMQTQGSSNQ → GERFQTTTTLAKHSPLHFRPPS
Isoform 4 (identifier: Q9H633-4)

The sequence of this isoform differs from the canonical sequence as follows:
     52-52: R → RRPLSSSAP
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.7
Chain2 – 154153Ribonuclease P protein subunit p21
PRO_0000153845

Amino acid modifications

Modified residue21N-acetylalanine Ref.7

Natural variations

Alternative sequence191Q → QVSLRQGPHGDGARRPRVTA PLPQ in isoform 2.
VSP_010695
Alternative sequence521R → RRPLSSSAP in isoform 4.
VSP_044901
Alternative sequence123 – 15432DSKPL…GSSNQ → GERFQTTTTLAKHSPLHFRP PS in isoform 3.
VSP_010696
Natural variant771Q → H. Ref.2 Ref.4 Ref.6
Corresponds to variant rs6986 [ dbSNP | Ensembl ].
VAR_019116
Natural variant1491Q → K. Ref.4
Corresponds to variant rs974963 [ dbSNP | Ensembl ].
VAR_045986

Experimental info

Sequence conflict91E → K in BI598757. Ref.6
Sequence conflict1131R → Q in CAD44290. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (CAT60-V1) [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: F8BD15AA20AE695F

FASTA15417,570
        10         20         30         40         50         60 
MAGPVKDREA FQRLNFLYQA AHCVLAQDPE NQALARFYCY TERTIAKRLV LRRDPSVKRT 

        70         80         90        100        110        120 
LCRGCSSLLV PGLTCTQRQR RCRGQRWTVQ TCLTCQRSQR FLNDPGHLLW GDRPEAQLGS 

       130        140        150 
QADSKPLQPL PNTAHSISDR LPEEKMQTQG SSNQ 

« Hide

Isoform 2 (CAT60-V3) [UniParc].

Checksum: 0FE5E6F3296602FB
Show »

FASTA17720,018
Isoform 3 (CAT60-V4) [UniParc].

Checksum: B037193A307F6F77
Show »

FASTA14416,544
Isoform 4 [UniParc].

Checksum: E2CA143586B0B751
Show »

FASTA16218,366

References

« Hide 'large scale' references
[1]"Function and subnuclear distribution of Rpp21, a protein subunit of the human ribonucleoprotein ribonuclease P."
Jarrous N., Reiner R., Wesolowski D., Mann H., Guerrier-Takada C., Altman S.
RNA 7:1153-1164(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
[2]"Genes from major histocompatibility complex (MHC) class I region from HLA-C to HLA-A."
Raha-Chowdhury R., Andrews S.R., Gruen J.R., Weissman S.M.
Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), VARIANT HIS-77.
Tissue: Spleen.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Small intestine.
[4]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS HIS-77 AND LYS-149.
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), VARIANT HIS-77.
Tissue: Hypothalamus and Skin.
[7]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF212152 mRNA. Translation: AAK39955.2.
AJ504713 mRNA. Translation: CAD44289.1.
AJ504714 mRNA. Translation: CAD44290.1.
AJ504715 mRNA. Translation: CAD44291.1.
AJ504716 mRNA. Translation: CAD44292.1.
AK026291 mRNA. Translation: BAB15433.1.
AL662832 Genomic DNA. Translation: CAI17503.2.
AL662832 Genomic DNA. Translation: CAI17506.2.
AL662832 Genomic DNA. Translation: CAI17507.2.
AL662795 Genomic DNA. Translation: CAI18254.1.
AL662795 Genomic DNA. Translation: CAI18255.2.
AL773535 Genomic DNA. Translation: CAI41822.1.
AL773535 Genomic DNA. Translation: CAI41824.2.
AL662795 Genomic DNA. Translation: CAM25559.1.
BX294158 Genomic DNA. Translation: CAM25886.1.
BX294158 Genomic DNA. Translation: CAM25887.1.
BX294158 Genomic DNA. Translation: CAM25888.1.
BX294158 Genomic DNA. Translation: CAM25889.1.
CR759928 Genomic DNA. Translation: CAQ08317.1.
CR759928 Genomic DNA. Translation: CAQ08318.1.
BX927214 Genomic DNA. Translation: CAQ08386.1.
BX927214 Genomic DNA. Translation: CAQ08387.1.
BX927214 Genomic DNA. Translation: CAQ08388.1.
CR759281 Genomic DNA. Translation: CAQ09024.1.
CR759281 Genomic DNA. Translation: CAQ09025.1.
CH471081 Genomic DNA. Translation: EAX03287.1.
CH471081 Genomic DNA. Translation: EAX03288.1.
CH471081 Genomic DNA. Translation: EAX03289.1.
BC011730 mRNA. Translation: AAH11730.1.
BI598757 mRNA. No translation available.
RefSeqNP_001186049.1. NM_001199120.1.
NP_001186050.1. NM_001199121.1.
NP_079115.1. NM_024839.2.
UniGeneHs.183232.

3D structure databases

ProteinModelPortalQ9H633.
SMRQ9H633. Positions 4-103.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122981. 2 interactions.
IntActQ9H633. 1 interaction.

PTM databases

PhosphoSiteQ9H633.

Polymorphism databases

DMDM52001252.

Proteomic databases

PaxDbQ9H633.
PRIDEQ9H633.

Protocols and materials databases

DNASU79897.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000376642; ENSP00000365829; ENSG00000239927. [Q9H633-1]
ENST00000411784; ENSP00000412619; ENSG00000241863. [Q9H633-2]
ENST00000414187; ENSP00000398396; ENSG00000243009.
ENST00000415583; ENSP00000403747; ENSG00000239927. [Q9H633-3]
ENST00000416977; ENSP00000404312; ENSG00000241779.
ENST00000424616; ENSP00000399295; ENSG00000241863. [Q9H633-1]
ENST00000425575; ENSP00000405834; ENSG00000239927. [Q9H633-4]
ENST00000428040; ENSP00000394320; ENSG00000241370. [Q9H633-2]
ENST00000430900; ENSP00000415046; ENSG00000239927. [Q9H633-2]
ENST00000433076; ENSP00000409799; ENSG00000241370. [Q9H633-4]
ENST00000434282; ENSP00000414284; ENSG00000242726.
ENST00000435318; ENSP00000411003; ENSG00000239865. [Q9H633-3]
ENST00000436442; ENSP00000397778; ENSG00000241370. [Q9H633-3]
ENST00000437470; ENSP00000408610; ENSG00000241863. [Q9H633-3]
ENST00000442966; ENSP00000403833; ENSG00000241370. [Q9H633-1]
ENST00000455025; ENSP00000409193; ENSG00000241863. [Q9H633-4]
GeneID79897.
KEGGhsa:79897.
UCSCuc003nqd.2. human. [Q9H633-2]
uc003nqe.2. human. [Q9H633-1]
uc003nqf.2. human. [Q9H633-3]
uc021yuc.1. human.

Organism-specific databases

CTD79897.
GeneCardsGC06P030312.
GC06Pi30321.
GC06Pj30302.
GC06Pk30303.
GC06Pl30357.
GC06Pn30302.
GC06Po30302.
H-InvDBHIX0207610.
HIX0207675.
HIX0207761.
HGNCHGNC:21300. RPP21.
HPAHPA048369.
HPA049389.
MIM612524. gene.
neXtProtNX_Q9H633.
PharmGKBPA134960979.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG285045.
HOVERGENHBG055987.
KOK03540.
OMANYLYQAA.
OrthoDBEOG75MVZT.
PhylomeDBQ9H633.

Gene expression databases

BgeeQ9H633.
CleanExHS_RPP21.
GenevestigatorQ9H633.

Family and domain databases

InterProIPR007175. Rpr2.
[Graphical view]
PANTHERPTHR14742. PTHR14742. 1 hit.
PfamPF04032. Rpr2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi79897.
NextBio69734.
PROQ9H633.
SOURCESearch...

Entry information

Entry nameRPP21_HUMAN
AccessionPrimary (citable) accession number: Q9H633
Secondary accession number(s): A2AAZ8 expand/collapse secondary AC list , B0S834, B0S835, Q5JPL9, Q5JPM1, Q5STF8, Q5STF9, Q5STG2, Q5SU41, Q5SU42, Q86Y49, Q86Y50, Q86Y51, Q96F16
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM