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Protein

Ribonuclease P protein subunit p21

Gene

RPP21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi62ZincBy similarity1
Metal bindingi65ZincBy similarity1
Metal bindingi92ZincBy similarity1
Metal bindingi95ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

  • response to drug Source: UniProtKB
  • tRNA 5'-leader removal Source: FlyBase
  • tRNA processing Source: GO_Central

Keywordsi

Molecular functionHydrolase
Biological processtRNA processing
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-6784531 tRNA processing in the nucleus
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit p21 (EC:3.1.26.5)
Short name:
RNaseP protein p21
Alternative name(s):
Ribonuclease P/MRP 21 kDa subunit
Ribonucleoprotein V
Gene namesi
Name:RPP21
Synonyms:C6orf135, CAT60
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000241370.5
HGNCiHGNC:21300 RPP21
MIMi612524 gene
neXtProtiNX_Q9H633

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi79897
OpenTargetsiENSG00000241370
PharmGKBiPA134960979

Polymorphism and mutation databases

BioMutaiRPP21
DMDMi52001252

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001538452 – 154Ribonuclease P protein subunit p21Add BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9H633
PaxDbiQ9H633
PeptideAtlasiQ9H633
PRIDEiQ9H633

PTM databases

iPTMnetiQ9H633
PhosphoSitePlusiQ9H633

Expressioni

Gene expression databases

BgeeiENSG00000241370
CleanExiHS_RPP21
ExpressionAtlasiQ9H633 baseline and differential
GenevisibleiQ9H633 HS

Interactioni

Subunit structurei

RNase P consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP21, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40.

Protein-protein interaction databases

BioGridi122981, 12 interactors
CORUMiQ9H633
IntActiQ9H633, 1 interactor
STRINGi9606.ENSP00000409799

Structurei

3D structure databases

ProteinModelPortaliQ9H633
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4394 Eukaryota
COG2023 LUCA
GeneTreeiENSGT00390000003020
HOGENOMiHOG000231207
HOVERGENiHBG055987
InParanoidiQ9H633
KOiK03540
OMAiERMNFLY
OrthoDBiEOG091G12P3
PhylomeDBiQ9H633

Family and domain databases

InterProiView protein in InterPro
IPR007175 Rpr2
PfamiView protein in Pfam
PF04032 Rpr2, 1 hit

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H633-1) [UniParc]FASTAAdd to basket
Also known as: CAT60-V1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGPVKDREA FQRLNFLYQA AHCVLAQDPE NQALARFYCY TERTIAKRLV
60 70 80 90 100
LRRDPSVKRT LCRGCSSLLV PGLTCTQRQR RCRGQRWTVQ TCLTCQRSQR
110 120 130 140 150
FLNDPGHLLW GDRPEAQLGS QADSKPLQPL PNTAHSISDR LPEEKMQTQG

SSNQ
Length:154
Mass (Da):17,570
Last modified:March 1, 2001 - v1
Checksum:iF8BD15AA20AE695F
GO
Isoform 2 (identifier: Q9H633-2) [UniParc]FASTAAdd to basket
Also known as: CAT60-V3

The sequence of this isoform differs from the canonical sequence as follows:
     19-19: Q → QVSLRQGPHGDGARRPRVTAPLPQ

Show »
Length:177
Mass (Da):20,018
Checksum:i0FE5E6F3296602FB
GO
Isoform 3 (identifier: Q9H633-3) [UniParc]FASTAAdd to basket
Also known as: CAT60-V4

The sequence of this isoform differs from the canonical sequence as follows:
     123-154: DSKPLQPLPNTAHSISDRLPEEKMQTQGSSNQ → GERFQTTTTLAKHSPLHFRPPS

Show »
Length:144
Mass (Da):16,544
Checksum:iB037193A307F6F77
GO
Isoform 4 (identifier: Q9H633-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-52: R → RRPLSSSAP

Note: No experimental confirmation available.
Show »
Length:162
Mass (Da):18,366
Checksum:iE2CA143586B0B751
GO

Sequence cautioni

The sequence BI598757 differs from that shown. Reason: Erroneous termination at position 155. Translated as stop.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9E → K in BI598757 (PubMed:15489334).Curated1
Sequence conflicti113R → Q in CAD44290 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01911677Q → H3 PublicationsCorresponds to variant dbSNP:rs6986Ensembl.1
Natural variantiVAR_045986149Q → K1 PublicationCorresponds to variant dbSNP:rs974963Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01069519Q → QVSLRQGPHGDGARRPRVTA PLPQ in isoform 2. 1 Publication1
Alternative sequenceiVSP_04490152R → RRPLSSSAP in isoform 4. 1 Publication1
Alternative sequenceiVSP_010696123 – 154DSKPL…GSSNQ → GERFQTTTTLAKHSPLHFRP PS in isoform 3. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212152 mRNA Translation: AAK39955.2
AJ504713 mRNA Translation: CAD44289.1
AJ504714 mRNA Translation: CAD44290.1
AJ504715 mRNA Translation: CAD44291.1
AJ504716 mRNA Translation: CAD44292.1
AK026291 mRNA Translation: BAB15433.1
AL662832 Genomic DNA No translation available.
AL662795 Genomic DNA No translation available.
AL773535 Genomic DNA No translation available.
BX294158 Genomic DNA No translation available.
CR759928 Genomic DNA No translation available.
BX927214 Genomic DNA No translation available.
CR759281 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03287.1
CH471081 Genomic DNA Translation: EAX03288.1
CH471081 Genomic DNA Translation: EAX03289.1
BC011730 mRNA Translation: AAH11730.1
BI598757 mRNA No translation available.
CCDSiCCDS4679.1 [Q9H633-1]
CCDS56409.1 [Q9H633-4]
CCDS56410.1 [Q9H633-3]
RefSeqiNP_001186049.1, NM_001199120.1 [Q9H633-4]
NP_001186050.1, NM_001199121.1 [Q9H633-3]
NP_079115.1, NM_024839.2 [Q9H633-1]
UniGeneiHs.183232

Genome annotation databases

EnsembliENST00000376642; ENSP00000365829; ENSG00000239927 [Q9H633-1]
ENST00000411784; ENSP00000412619; ENSG00000241863 [Q9H633-2]
ENST00000414187; ENSP00000398396; ENSG00000243009
ENST00000415583; ENSP00000403747; ENSG00000239927 [Q9H633-3]
ENST00000416977; ENSP00000404312; ENSG00000241779
ENST00000424616; ENSP00000399295; ENSG00000241863 [Q9H633-1]
ENST00000425575; ENSP00000405834; ENSG00000239927 [Q9H633-4]
ENST00000428040; ENSP00000394320; ENSG00000241370 [Q9H633-2]
ENST00000430900; ENSP00000415046; ENSG00000239927 [Q9H633-2]
ENST00000433076; ENSP00000409799; ENSG00000241370 [Q9H633-4]
ENST00000434282; ENSP00000414284; ENSG00000242726
ENST00000435318; ENSP00000411003; ENSG00000239865 [Q9H633-3]
ENST00000436442; ENSP00000397778; ENSG00000241370 [Q9H633-3]
ENST00000437470; ENSP00000408610; ENSG00000241863 [Q9H633-3]
ENST00000442966; ENSP00000403833; ENSG00000241370 [Q9H633-1]
ENST00000455025; ENSP00000409193; ENSG00000241863 [Q9H633-4]
GeneIDi79897
KEGGihsa:79897
UCSCiuc003nqd.3 human [Q9H633-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRPP21_HUMAN
AccessioniPrimary (citable) accession number: Q9H633
Secondary accession number(s): A2AAZ8
, B0S834, B0S835, Q5JPL9, Q5JPM1, Q5STF8, Q5STF9, Q5STG2, Q5SU41, Q5SU42, Q86Y49, Q86Y50, Q86Y51, Q96F16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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