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Protein

Ras-related and estrogen-regulated growth inhibitor-like protein

Gene

RERGL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds GDP/GTP and may possess intrinsic GTPase activity.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 18GTPBy similarity8
Nucleotide bindingi58 – 64GTPBy similarity7
Nucleotide bindingi123 – 126GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related and estrogen-regulated growth inhibitor-like protein
Alternative name(s):
RERG/Ras-like protein
Gene namesi
Name:RERGL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111404.6
HGNCiHGNC:26213 RERGL
neXtProtiNX_Q9H628

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi79785
OpenTargetsiENSG00000111404
PharmGKBiPA162401119

Polymorphism and mutation databases

BioMutaiRERGL
DMDMi74752686

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003205631 – 205Ras-related and estrogen-regulated growth inhibitor-like proteinAdd BLAST205

Proteomic databases

PaxDbiQ9H628
PRIDEiQ9H628

PTM databases

iPTMnetiQ9H628
PhosphoSitePlusiQ9H628

Expressioni

Gene expression databases

BgeeiENSG00000111404
CleanExiHS_RERGL
ExpressionAtlasiQ9H628 baseline and differential
GenevisibleiQ9H628 HS

Organism-specific databases

HPAiHPA041740

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000229002

Structurei

3D structure databases

ProteinModelPortaliQ9H628
SMRiQ9H628
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 205Small GTPase-likeAdd BLAST205

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133696
HOGENOMiHOG000233973
HOVERGENiHBG009351
InParanoidiQ9H628
KOiK17198
OMAiSHCKRAV
OrthoDBiEOG091G0M6D
PhylomeDBiQ9H628
TreeFamiTF318030

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H628-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNFLHLKYN EKSVSVTKAL TVRFLTKRFI GEYASNFESI YKKHLCLERK
60 70 80 90 100
QLNLEIYDPC SQTQKAKFSL TSELHWADGF VIVYDISDRS SFAFAKALIY
110 120 130 140 150
RIREPQTSHC KRAVESAVFL VGNKRDLCHV REVGWEEGQK LALENRCQFC
160 170 180 190 200
ELSAAEQSLE VEMMFIRIIK DILINFKLKE KRRPSGSKSM AKLINNVFGK

RRKSV
Length:205
Mass (Da):23,855
Last modified:March 1, 2001 - v1
Checksum:iE8FDF8DEA09EC44A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039208163M → V. Corresponds to variant dbSNP:rs941048Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026308 mRNA Translation: BAB15439.1
CH471094 Genomic DNA Translation: EAW96385.1
BC042888 mRNA Translation: AAH42888.1
CCDSiCCDS8679.1
RefSeqiNP_001273130.1, NM_001286201.1
NP_079006.1, NM_024730.3
UniGeneiHs.732831

Genome annotation databases

EnsembliENST00000229002; ENSP00000229002; ENSG00000111404
GeneIDi79785
KEGGihsa:79785
UCSCiuc001rdq.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRERGL_HUMAN
AccessioniPrimary (citable) accession number: Q9H628
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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