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Protein

Ras-related and estrogen-regulated growth inhibitor-like protein

Gene

RERGL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Binds GDP/GTP and may possess intrinsic GTPase activity.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 188GTPBy similarity
Nucleotide bindingi58 – 647GTPBy similarity
Nucleotide bindingi123 – 1264GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related and estrogen-regulated growth inhibitor-like protein
Alternative name(s):
RERG/Ras-like protein
Gene namesi
Name:RERGL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:26213. RERGL.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162401119.

Polymorphism and mutation databases

BioMutaiRERGL.
DMDMi74752686.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205Ras-related and estrogen-regulated growth inhibitor-like proteinPRO_0000320563Add
BLAST

Proteomic databases

PaxDbiQ9H628.
PRIDEiQ9H628.

PTM databases

iPTMnetiQ9H628.
PhosphoSiteiQ9H628.

Expressioni

Gene expression databases

BgeeiQ9H628.
CleanExiHS_RERGL.
ExpressionAtlasiQ9H628. baseline and differential.
GenevisibleiQ9H628. HS.

Organism-specific databases

HPAiHPA041740.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000229002.

Structurei

3D structure databases

ProteinModelPortaliQ9H628.
SMRiQ9H628. Positions 19-155.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 205205Small GTPase-likeAdd
BLAST

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121877.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ9H628.
KOiK17198.
OMAiYDPCSQP.
OrthoDBiEOG70W3F5.
PhylomeDBiQ9H628.
TreeFamiTF318030.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H628-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNFLHLKYN EKSVSVTKAL TVRFLTKRFI GEYASNFESI YKKHLCLERK
60 70 80 90 100
QLNLEIYDPC SQTQKAKFSL TSELHWADGF VIVYDISDRS SFAFAKALIY
110 120 130 140 150
RIREPQTSHC KRAVESAVFL VGNKRDLCHV REVGWEEGQK LALENRCQFC
160 170 180 190 200
ELSAAEQSLE VEMMFIRIIK DILINFKLKE KRRPSGSKSM AKLINNVFGK

RRKSV
Length:205
Mass (Da):23,855
Last modified:March 1, 2001 - v1
Checksum:iE8FDF8DEA09EC44A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti163 – 1631M → V.
Corresponds to variant rs941048 [ dbSNP | Ensembl ].
VAR_039208

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026308 mRNA. Translation: BAB15439.1.
CH471094 Genomic DNA. Translation: EAW96385.1.
BC042888 mRNA. Translation: AAH42888.1.
CCDSiCCDS8679.1.
RefSeqiNP_001273130.1. NM_001286201.1.
NP_079006.1. NM_024730.3.
UniGeneiHs.732831.

Genome annotation databases

EnsembliENST00000229002; ENSP00000229002; ENSG00000111404.
GeneIDi79785.
KEGGihsa:79785.
UCSCiuc001rdq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026308 mRNA. Translation: BAB15439.1.
CH471094 Genomic DNA. Translation: EAW96385.1.
BC042888 mRNA. Translation: AAH42888.1.
CCDSiCCDS8679.1.
RefSeqiNP_001273130.1. NM_001286201.1.
NP_079006.1. NM_024730.3.
UniGeneiHs.732831.

3D structure databases

ProteinModelPortaliQ9H628.
SMRiQ9H628. Positions 19-155.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000229002.

PTM databases

iPTMnetiQ9H628.
PhosphoSiteiQ9H628.

Polymorphism and mutation databases

BioMutaiRERGL.
DMDMi74752686.

Proteomic databases

PaxDbiQ9H628.
PRIDEiQ9H628.

Protocols and materials databases

DNASUi79785.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000229002; ENSP00000229002; ENSG00000111404.
GeneIDi79785.
KEGGihsa:79785.
UCSCiuc001rdq.4. human.

Organism-specific databases

CTDi79785.
GeneCardsiRERGL.
HGNCiHGNC:26213. RERGL.
HPAiHPA041740.
neXtProtiNX_Q9H628.
PharmGKBiPA162401119.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121877.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ9H628.
KOiK17198.
OMAiYDPCSQP.
OrthoDBiEOG70W3F5.
PhylomeDBiQ9H628.
TreeFamiTF318030.

Miscellaneous databases

ChiTaRSiRERGL. human.
GenomeRNAii79785.
PROiQ9H628.

Gene expression databases

BgeeiQ9H628.
CleanExiHS_RERGL.
ExpressionAtlasiQ9H628. baseline and differential.
GenevisibleiQ9H628. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Small intestine.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiRERGL_HUMAN
AccessioniPrimary (citable) accession number: Q9H628
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.