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Protein

Zinc finger protein 576

Gene

ZNF576

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri34 – 57C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri71 – 93C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri112 – 134C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri143 – 165C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 576
Gene namesi
Name:ZNF576
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28357. ZNF576.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000124444.
PharmGKBiPA134950110.

Polymorphism and mutation databases

BioMutaiZNF576.
DMDMi74761466.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476671 – 170Zinc finger protein 576Add BLAST170

Proteomic databases

EPDiQ9H609.
MaxQBiQ9H609.
PaxDbiQ9H609.
PeptideAtlasiQ9H609.
PRIDEiQ9H609.

PTM databases

iPTMnetiQ9H609.
PhosphoSitePlusiQ9H609.

Expressioni

Gene expression databases

BgeeiENSG00000124444.
CleanExiHS_ZNF576.
ExpressionAtlasiQ9H609. baseline and differential.
GenevisibleiQ9H609. HS.

Organism-specific databases

HPAiHPA050064.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi122594. 19 interactors.
IntActiQ9H609. 9 interactors.
STRINGi9606.ENSP00000337852.

Structurei

3D structure databases

ProteinModelPortaliQ9H609.
SMRiQ9H609.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri34 – 57C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri71 – 93C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri112 – 134C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri143 – 165C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00730000111407.
HOGENOMiHOG000120113.
HOVERGENiHBG082912.
InParanoidiQ9H609.
OMAiQCTRCLI.
OrthoDBiEOG091G0PJM.
PhylomeDBiQ9H609.
TreeFamiTF350821.

Family and domain databases

InterProiView protein in InterPro
IPR013087. Znf_C2H2_type.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 4 hits.
SUPFAMiSSF57667. SSF57667. 1 hit.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.

Sequencei

Sequence statusi: Complete.

Q9H609-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDPNPEENM KQQDSPKERS PQSPGGNICH LGAPKCTRCL ITFADSKFQE
60 70 80 90 100
RHMKREHPAD FVAQKLQGVL FICFTCARSF PSSKALITHQ RSHGPAAKPT
110 120 130 140 150
LPVATTTAQP TFPCPDCGKT FGQAVSLRRH RQMHEVRAPP GTFACTECGQ
160 170
DFAQEAGLHQ HYIRHARGEL
Length:170
Mass (Da):18,890
Last modified:March 1, 2001 - v1
Checksum:i4EFAA311147613C1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02395681P → L1 PublicationCorresponds to variant dbSNP:rs17849705Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026353 mRNA. Translation: BAB15458.1.
AC006276 Genomic DNA. No translation available.
BC002981 mRNA. Translation: AAH02981.1.
CCDSiCCDS12625.1.
RefSeqiNP_001138819.1. NM_001145347.1.
NP_077303.1. NM_024327.2.
UniGeneiHs.11110.

Genome annotation databases

EnsembliENST00000336564; ENSP00000337852; ENSG00000124444.
ENST00000391965; ENSP00000375827; ENSG00000124444.
ENST00000525771; ENSP00000436182; ENSG00000124444.
ENST00000528387; ENSP00000435934; ENSG00000124444.
ENST00000529930; ENSP00000435463; ENSG00000124444.
ENST00000533118; ENSP00000435899; ENSG00000124444.
GeneIDi79177.
KEGGihsa:79177.
UCSCiuc002owy.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiZN576_HUMAN
AccessioniPrimary (citable) accession number: Q9H609
Secondary accession number(s): Q9BU03
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2001
Last modified: May 10, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Overlaps in opposite strand with ZNF428.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families