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Protein

Zinc finger protein 576

Gene

ZNF576

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri34 – 5724C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri71 – 9323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri112 – 13423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri143 – 16523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 576
Gene namesi
Name:ZNF576
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28357. ZNF576.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134950110.

Polymorphism and mutation databases

BioMutaiZNF576.
DMDMi74761466.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 170170Zinc finger protein 576PRO_0000047667Add
BLAST

Proteomic databases

MaxQBiQ9H609.
PaxDbiQ9H609.
PRIDEiQ9H609.

PTM databases

iPTMnetiQ9H609.
PhosphoSiteiQ9H609.

Expressioni

Gene expression databases

BgeeiQ9H609.
CleanExiHS_ZNF576.
ExpressionAtlasiQ9H609. baseline and differential.
GenevisibleiQ9H609. HS.

Organism-specific databases

HPAiHPA050064.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AESQ081173EBI-3921014,EBI-717810
AP4B1Q9Y6B73EBI-3921014,EBI-1047606
KRT15P190123EBI-3921014,EBI-739566
SH3GLB1Q9Y3713EBI-3921014,EBI-2623095

Protein-protein interaction databases

BioGridi122594. 19 interactions.
IntActiQ9H609. 7 interactions.
STRINGi9606.ENSP00000337852.

Structurei

3D structure databases

ProteinModelPortaliQ9H609.
SMRiQ9H609. Positions 35-167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri34 – 5724C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri71 – 9323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri112 – 13423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri143 – 16523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00730000111407.
HOGENOMiHOG000120113.
HOVERGENiHBG082912.
InParanoidiQ9H609.
OMAiQCTRCLI.
OrthoDBiEOG73V6MG.
PhylomeDBiQ9H609.
TreeFamiTF350821.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H609-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDPNPEENM KQQDSPKERS PQSPGGNICH LGAPKCTRCL ITFADSKFQE
60 70 80 90 100
RHMKREHPAD FVAQKLQGVL FICFTCARSF PSSKALITHQ RSHGPAAKPT
110 120 130 140 150
LPVATTTAQP TFPCPDCGKT FGQAVSLRRH RQMHEVRAPP GTFACTECGQ
160 170
DFAQEAGLHQ HYIRHARGEL
Length:170
Mass (Da):18,890
Last modified:March 1, 2001 - v1
Checksum:i4EFAA311147613C1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti81 – 811P → L.1 Publication
Corresponds to variant rs17849705 [ dbSNP | Ensembl ].
VAR_023956

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026353 mRNA. Translation: BAB15458.1.
AC006276 Genomic DNA. No translation available.
BC002981 mRNA. Translation: AAH02981.1.
CCDSiCCDS12625.1.
RefSeqiNP_001138819.1. NM_001145347.1.
NP_077303.1. NM_024327.2.
UniGeneiHs.11110.

Genome annotation databases

EnsembliENST00000336564; ENSP00000337852; ENSG00000124444.
ENST00000391965; ENSP00000375827; ENSG00000124444.
ENST00000525771; ENSP00000436182; ENSG00000124444.
ENST00000528387; ENSP00000435934; ENSG00000124444.
ENST00000529930; ENSP00000435463; ENSG00000124444.
ENST00000533118; ENSP00000435899; ENSG00000124444.
GeneIDi79177.
KEGGihsa:79177.
UCSCiuc002owy.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026353 mRNA. Translation: BAB15458.1.
AC006276 Genomic DNA. No translation available.
BC002981 mRNA. Translation: AAH02981.1.
CCDSiCCDS12625.1.
RefSeqiNP_001138819.1. NM_001145347.1.
NP_077303.1. NM_024327.2.
UniGeneiHs.11110.

3D structure databases

ProteinModelPortaliQ9H609.
SMRiQ9H609. Positions 35-167.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122594. 19 interactions.
IntActiQ9H609. 7 interactions.
STRINGi9606.ENSP00000337852.

PTM databases

iPTMnetiQ9H609.
PhosphoSiteiQ9H609.

Polymorphism and mutation databases

BioMutaiZNF576.
DMDMi74761466.

Proteomic databases

MaxQBiQ9H609.
PaxDbiQ9H609.
PRIDEiQ9H609.

Protocols and materials databases

DNASUi79177.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336564; ENSP00000337852; ENSG00000124444.
ENST00000391965; ENSP00000375827; ENSG00000124444.
ENST00000525771; ENSP00000436182; ENSG00000124444.
ENST00000528387; ENSP00000435934; ENSG00000124444.
ENST00000529930; ENSP00000435463; ENSG00000124444.
ENST00000533118; ENSP00000435899; ENSG00000124444.
GeneIDi79177.
KEGGihsa:79177.
UCSCiuc002owy.3. human.

Organism-specific databases

CTDi79177.
GeneCardsiZNF576.
HGNCiHGNC:28357. ZNF576.
HPAiHPA050064.
neXtProtiNX_Q9H609.
PharmGKBiPA134950110.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00730000111407.
HOGENOMiHOG000120113.
HOVERGENiHBG082912.
InParanoidiQ9H609.
OMAiQCTRCLI.
OrthoDBiEOG73V6MG.
PhylomeDBiQ9H609.
TreeFamiTF350821.

Miscellaneous databases

GenomeRNAii79177.
NextBioi68157.
PROiQ9H609.

Gene expression databases

BgeeiQ9H609.
CleanExiHS_ZNF576.
ExpressionAtlasiQ9H609. baseline and differential.
GenevisibleiQ9H609. HS.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Small intestine.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-81.
    Tissue: Lung.

Entry informationi

Entry nameiZN576_HUMAN
AccessioniPrimary (citable) accession number: Q9H609
Secondary accession number(s): Q9BU03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2001
Last modified: March 16, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Overlaps in opposite strand with ZNF428.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.