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Q9H5V9

- CX056_HUMAN

UniProt

Q9H5V9 - CX056_HUMAN

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Protein

UPF0428 protein CXorf56

Gene

CXorf56

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0428 protein CXorf56
Gene namesi
Name:CXorf56
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:26239. CXorf56.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485444.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222UPF0428 protein CXorf56PRO_0000287609Add
BLAST

Proteomic databases

MaxQBiQ9H5V9.
PaxDbiQ9H5V9.
PRIDEiQ9H5V9.

PTM databases

PhosphoSiteiQ9H5V9.

Expressioni

Gene expression databases

BgeeiQ9H5V9.
CleanExiHS_CXorf56.
GenevestigatoriQ9H5V9.

Organism-specific databases

HPAiHPA038245.
HPA038617.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NFKBIL1Q9UBC11EBI-1053419,EBI-1043728

Protein-protein interaction databases

BioGridi122000. 10 interactions.
IntActiQ9H5V9. 2 interactions.
MINTiMINT-3068281.
STRINGi9606.ENSP00000360652.

Structurei

3D structure databases

ProteinModelPortaliQ9H5V9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili170 – 22051Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the UPF0428 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG271379.
GeneTreeiENSGT00390000002197.
HOGENOMiHOG000007597.
HOVERGENiHBG067022.
InParanoidiQ9H5V9.
OMAiPKKVRVM.
OrthoDBiEOG7TTQ8V.
PhylomeDBiQ9H5V9.
TreeFamiTF300272.

Family and domain databases

InterProiIPR029704. UPF0428.
[Graphical view]
PANTHERiPTHR13420:SF2. PTHR13420:SF2. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H5V9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPKVVSRSVV CSDTRDREEY DDGEKPLHVY YCLCGQMVLV LDCQLEKLPM
60 70 80 90 100
RPRDRSRVID AAKHAHKFCN TEDEETMYLR RPEGIERQYR KKCAKCGLPL
110 120 130 140 150
FYQSQPKNAP VTFIVDGAVV KFGQGFGKTN IYTQKQEPPK KVMMTKRTKD
160 170 180 190 200
MGKFSSVTVS TIDEEEEEIE AREVADSYAQ NAKVIEKQLE RKGMSKRRLQ
210 220
ELAELEAKKA KMKGTLIDNQ FK
Length:222
Mass (Da):25,625
Last modified:March 1, 2001 - v1
Checksum:i586CD0CE472989DF
GO
Isoform 2 (identifier: Q9H5V9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: Missing.

Show »
Length:173
Mass (Da):19,981
Checksum:iD540E84E6E7F16EC
GO
Isoform 3 (identifier: Q9H5V9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     82-95: Missing.

Show »
Length:208
Mass (Da):23,937
Checksum:i421BBEFED1D67123
GO

Sequence cautioni

The sequence AAB96348.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti194 – 1941M → V in BAG60994. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4949Missing in isoform 2. 1 PublicationVSP_044273Add
BLAST
Alternative sequencei82 – 9514Missing in isoform 3. 1 PublicationVSP_044274Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026618 mRNA. Translation: BAB15510.1.
AK298877 mRNA. Translation: BAG60994.1.
AK096297 mRNA. Translation: BAG53251.1.
AC004000 Genomic DNA. Translation: AAB96348.1. Sequence problems.
AC004913 Genomic DNA. No translation available.
AC005190 Genomic DNA. No translation available.
CH471161 Genomic DNA. Translation: EAW89864.1.
CH471161 Genomic DNA. Translation: EAW89865.1.
CH471161 Genomic DNA. Translation: EAW89866.1.
CH471161 Genomic DNA. Translation: EAW89867.1.
BC023506 mRNA. No translation available.
CCDSiCCDS55484.1. [Q9H5V9-2]
CCDS55485.1. [Q9H5V9-3]
RefSeqiNP_001164040.1. NM_001170569.1. [Q9H5V9-2]
NP_001164041.1. NM_001170570.1. [Q9H5V9-3]
NP_071384.1. NM_022101.3. [Q9H5V9-1]
UniGeneiHs.248572.

Genome annotation databases

EnsembliENST00000320339; ENSP00000320345; ENSG00000018610. [Q9H5V9-2]
ENST00000536133; ENSP00000441786; ENSG00000018610. [Q9H5V9-3]
GeneIDi63932.
KEGGihsa:63932.
UCSCiuc004erj.2. human. [Q9H5V9-1]
uc011mtu.2. human. [Q9H5V9-3]

Polymorphism databases

DMDMi74733589.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026618 mRNA. Translation: BAB15510.1 .
AK298877 mRNA. Translation: BAG60994.1 .
AK096297 mRNA. Translation: BAG53251.1 .
AC004000 Genomic DNA. Translation: AAB96348.1 . Sequence problems.
AC004913 Genomic DNA. No translation available.
AC005190 Genomic DNA. No translation available.
CH471161 Genomic DNA. Translation: EAW89864.1 .
CH471161 Genomic DNA. Translation: EAW89865.1 .
CH471161 Genomic DNA. Translation: EAW89866.1 .
CH471161 Genomic DNA. Translation: EAW89867.1 .
BC023506 mRNA. No translation available.
CCDSi CCDS55484.1. [Q9H5V9-2 ]
CCDS55485.1. [Q9H5V9-3 ]
RefSeqi NP_001164040.1. NM_001170569.1. [Q9H5V9-2 ]
NP_001164041.1. NM_001170570.1. [Q9H5V9-3 ]
NP_071384.1. NM_022101.3. [Q9H5V9-1 ]
UniGenei Hs.248572.

3D structure databases

ProteinModelPortali Q9H5V9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122000. 10 interactions.
IntActi Q9H5V9. 2 interactions.
MINTi MINT-3068281.
STRINGi 9606.ENSP00000360652.

PTM databases

PhosphoSitei Q9H5V9.

Polymorphism databases

DMDMi 74733589.

Proteomic databases

MaxQBi Q9H5V9.
PaxDbi Q9H5V9.
PRIDEi Q9H5V9.

Protocols and materials databases

DNASUi 63932.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000320339 ; ENSP00000320345 ; ENSG00000018610 . [Q9H5V9-2 ]
ENST00000536133 ; ENSP00000441786 ; ENSG00000018610 . [Q9H5V9-3 ]
GeneIDi 63932.
KEGGi hsa:63932.
UCSCi uc004erj.2. human. [Q9H5V9-1 ]
uc011mtu.2. human. [Q9H5V9-3 ]

Organism-specific databases

CTDi 63932.
GeneCardsi GC0XM118672.
H-InvDB HIX0020763.
HGNCi HGNC:26239. CXorf56.
HPAi HPA038245.
HPA038617.
neXtProti NX_Q9H5V9.
PharmGKBi PA143485444.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG271379.
GeneTreei ENSGT00390000002197.
HOGENOMi HOG000007597.
HOVERGENi HBG067022.
InParanoidi Q9H5V9.
OMAi PKKVRVM.
OrthoDBi EOG7TTQ8V.
PhylomeDBi Q9H5V9.
TreeFami TF300272.

Miscellaneous databases

GenomeRNAii 63932.
NextBioi 65686.

Gene expression databases

Bgeei Q9H5V9.
CleanExi HS_CXorf56.
Genevestigatori Q9H5V9.

Family and domain databases

InterProi IPR029704. UPF0428.
[Graphical view ]
PANTHERi PTHR13420:SF2. PTHR13420:SF2. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skin.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCX056_HUMAN
AccessioniPrimary (citable) accession number: Q9H5V9
Secondary accession number(s): A8MPX7
, B4DQN2, D3DWH9, F5GWL7, O43351
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

May be duplicated on chromosome 8, within an intron of the ERLIN2 gene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3