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Q9H5V9

- CX056_HUMAN

UniProt

Q9H5V9 - CX056_HUMAN

Protein

UPF0428 protein CXorf56

Gene

CXorf56

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UPF0428 protein CXorf56
    Gene namesi
    Name:CXorf56
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:26239. CXorf56.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485444.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 222222UPF0428 protein CXorf56PRO_0000287609Add
    BLAST

    Proteomic databases

    MaxQBiQ9H5V9.
    PaxDbiQ9H5V9.
    PRIDEiQ9H5V9.

    PTM databases

    PhosphoSiteiQ9H5V9.

    Expressioni

    Gene expression databases

    BgeeiQ9H5V9.
    CleanExiHS_CXorf56.
    GenevestigatoriQ9H5V9.

    Organism-specific databases

    HPAiHPA038245.
    HPA038617.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NFKBIL1Q9UBC11EBI-1053419,EBI-1043728

    Protein-protein interaction databases

    BioGridi122000. 7 interactions.
    IntActiQ9H5V9. 2 interactions.
    MINTiMINT-3068281.
    STRINGi9606.ENSP00000360652.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H5V9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili170 – 22051Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the UPF0428 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG271379.
    HOGENOMiHOG000007597.
    HOVERGENiHBG067022.
    InParanoidiQ9H5V9.
    OMAiPKKVRVM.
    OrthoDBiEOG7TTQ8V.
    PhylomeDBiQ9H5V9.
    TreeFamiTF300272.

    Family and domain databases

    InterProiIPR029704. UPF0428.
    [Graphical view]
    PANTHERiPTHR13420:SF2. PTHR13420:SF2. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H5V9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPKVVSRSVV CSDTRDREEY DDGEKPLHVY YCLCGQMVLV LDCQLEKLPM    50
    RPRDRSRVID AAKHAHKFCN TEDEETMYLR RPEGIERQYR KKCAKCGLPL 100
    FYQSQPKNAP VTFIVDGAVV KFGQGFGKTN IYTQKQEPPK KVMMTKRTKD 150
    MGKFSSVTVS TIDEEEEEIE AREVADSYAQ NAKVIEKQLE RKGMSKRRLQ 200
    ELAELEAKKA KMKGTLIDNQ FK 222
    Length:222
    Mass (Da):25,625
    Last modified:March 1, 2001 - v1
    Checksum:i586CD0CE472989DF
    GO
    Isoform 2 (identifier: Q9H5V9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-49: Missing.

    Show »
    Length:173
    Mass (Da):19,981
    Checksum:iD540E84E6E7F16EC
    GO
    Isoform 3 (identifier: Q9H5V9-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         82-95: Missing.

    Show »
    Length:208
    Mass (Da):23,937
    Checksum:i421BBEFED1D67123
    GO

    Sequence cautioni

    The sequence AAB96348.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti194 – 1941M → V in BAG60994. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4949Missing in isoform 2. 1 PublicationVSP_044273Add
    BLAST
    Alternative sequencei82 – 9514Missing in isoform 3. 1 PublicationVSP_044274Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK026618 mRNA. Translation: BAB15510.1.
    AK298877 mRNA. Translation: BAG60994.1.
    AK096297 mRNA. Translation: BAG53251.1.
    AC004000 Genomic DNA. Translation: AAB96348.1. Sequence problems.
    AC004913 Genomic DNA. No translation available.
    AC005190 Genomic DNA. No translation available.
    CH471161 Genomic DNA. Translation: EAW89864.1.
    CH471161 Genomic DNA. Translation: EAW89865.1.
    CH471161 Genomic DNA. Translation: EAW89866.1.
    CH471161 Genomic DNA. Translation: EAW89867.1.
    BC023506 mRNA. No translation available.
    CCDSiCCDS14579.1. [Q9H5V9-1]
    CCDS55484.1. [Q9H5V9-2]
    CCDS55485.1. [Q9H5V9-3]
    RefSeqiNP_001164040.1. NM_001170569.1. [Q9H5V9-2]
    NP_001164041.1. NM_001170570.1. [Q9H5V9-3]
    NP_071384.1. NM_022101.3. [Q9H5V9-1]
    UniGeneiHs.248572.

    Genome annotation databases

    EnsembliENST00000320339; ENSP00000320345; ENSG00000018610. [Q9H5V9-2]
    ENST00000536133; ENSP00000441786; ENSG00000018610. [Q9H5V9-3]
    GeneIDi63932.
    KEGGihsa:63932.
    UCSCiuc004erj.2. human. [Q9H5V9-1]
    uc011mtu.2. human. [Q9H5V9-3]

    Polymorphism databases

    DMDMi74733589.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK026618 mRNA. Translation: BAB15510.1 .
    AK298877 mRNA. Translation: BAG60994.1 .
    AK096297 mRNA. Translation: BAG53251.1 .
    AC004000 Genomic DNA. Translation: AAB96348.1 . Sequence problems.
    AC004913 Genomic DNA. No translation available.
    AC005190 Genomic DNA. No translation available.
    CH471161 Genomic DNA. Translation: EAW89864.1 .
    CH471161 Genomic DNA. Translation: EAW89865.1 .
    CH471161 Genomic DNA. Translation: EAW89866.1 .
    CH471161 Genomic DNA. Translation: EAW89867.1 .
    BC023506 mRNA. No translation available.
    CCDSi CCDS14579.1. [Q9H5V9-1 ]
    CCDS55484.1. [Q9H5V9-2 ]
    CCDS55485.1. [Q9H5V9-3 ]
    RefSeqi NP_001164040.1. NM_001170569.1. [Q9H5V9-2 ]
    NP_001164041.1. NM_001170570.1. [Q9H5V9-3 ]
    NP_071384.1. NM_022101.3. [Q9H5V9-1 ]
    UniGenei Hs.248572.

    3D structure databases

    ProteinModelPortali Q9H5V9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122000. 7 interactions.
    IntActi Q9H5V9. 2 interactions.
    MINTi MINT-3068281.
    STRINGi 9606.ENSP00000360652.

    PTM databases

    PhosphoSitei Q9H5V9.

    Polymorphism databases

    DMDMi 74733589.

    Proteomic databases

    MaxQBi Q9H5V9.
    PaxDbi Q9H5V9.
    PRIDEi Q9H5V9.

    Protocols and materials databases

    DNASUi 63932.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000320339 ; ENSP00000320345 ; ENSG00000018610 . [Q9H5V9-2 ]
    ENST00000536133 ; ENSP00000441786 ; ENSG00000018610 . [Q9H5V9-3 ]
    GeneIDi 63932.
    KEGGi hsa:63932.
    UCSCi uc004erj.2. human. [Q9H5V9-1 ]
    uc011mtu.2. human. [Q9H5V9-3 ]

    Organism-specific databases

    CTDi 63932.
    GeneCardsi GC0XM118672.
    H-InvDB HIX0020763.
    HGNCi HGNC:26239. CXorf56.
    HPAi HPA038245.
    HPA038617.
    neXtProti NX_Q9H5V9.
    PharmGKBi PA143485444.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG271379.
    HOGENOMi HOG000007597.
    HOVERGENi HBG067022.
    InParanoidi Q9H5V9.
    OMAi PKKVRVM.
    OrthoDBi EOG7TTQ8V.
    PhylomeDBi Q9H5V9.
    TreeFami TF300272.

    Miscellaneous databases

    GenomeRNAii 63932.
    NextBioi 65686.

    Gene expression databases

    Bgeei Q9H5V9.
    CleanExi HS_CXorf56.
    Genevestigatori Q9H5V9.

    Family and domain databases

    InterProi IPR029704. UPF0428.
    [Graphical view ]
    PANTHERi PTHR13420:SF2. PTHR13420:SF2. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    2. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skin.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCX056_HUMAN
    AccessioniPrimary (citable) accession number: Q9H5V9
    Secondary accession number(s): A8MPX7
    , B4DQN2, D3DWH9, F5GWL7, O43351
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    May be duplicated on chromosome 8, within an intron of the ERLIN2 gene.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families
    3. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3