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Q9H5V8

- CDCP1_HUMAN

UniProt

Q9H5V8 - CDCP1_HUMAN

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Protein
CUB domain-containing protein 1
Gene
CDCP1, TRASK, UNQ2486/PRO5773
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis.6 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei368 – 3692Cleavage; by ST14/MT-SP1

Names & Taxonomyi

Protein namesi
Recommended name:
CUB domain-containing protein 1
Alternative name(s):
Membrane glycoprotein gp140
Subtractive immunization M plus HEp3-associated 135 kDa protein
Short name:
SIMA135
Transmembrane and associated with src kinases
CD_antigen: CD318
Gene namesi
Name:CDCP1
Synonyms:TRASK
ORF Names:UNQ2486/PRO5773
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:24357. CDCP1.

Subcellular locationi

Isoform 1 : Cell membrane; Single-pass membrane protein Reviewed prediction
Note: Shedding may also lead to a soluble peptide.2 Publications
Isoform 3 : Secreted 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 667638Extracellular Reviewed prediction
Add
BLAST
Transmembranei668 – 68821Helical; Reviewed prediction
Add
BLAST
Topological domaini689 – 836148Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi734 – 7341Y → F: Impaired association with SRC. 1 Publication
Mutagenesisi762 – 7621Y → F: Impaired association with protein kinase PRKCG but not with SRC. 1 Publication

Organism-specific databases

PharmGKBiPA142672140.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 29292 Publications
Add
BLAST
Chaini30 – 836807CUB domain-containing protein 1
PRO_0000226249Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi39 – 391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi122 – 1221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi180 – 1801N-linked (GlcNAc...) Reviewed prediction
Glycosylationi205 – 2051N-linked (GlcNAc...) Reviewed prediction
Glycosylationi270 – 2701N-linked (GlcNAc...) Reviewed prediction
Glycosylationi310 – 3101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi386 – 3861N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi476 ↔ 499 By similarity
Modified residuei707 – 7071Phosphotyrosine
Modified residuei734 – 7341Phosphotyrosine1 Publication

Post-translational modificationi

Phosphorylated on tyrosine by kinases of the SRC family such as SRC and YES as well as by the protein kinase C gamma/PRKCG. Dephosphorylated by phosphotyrosine phosphatases. Also phosphorylated by suramin, a heparin analog. Tyrosine phosphorylated in response to dissociation of integrin alpha-6 beta-4 from laminin-5.4 Publications
N-glycosylated.3 Publications
A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding). Another peptide of 80 kDa (p80) is present in cultured keratinocytes probably due to tryptic cleavage at an unidentified site on its N-terminal side. Converted to p80 by plasmin, a trypsin-like protease.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9H5V8.
PaxDbiQ9H5V8.
PRIDEiQ9H5V8.

PTM databases

PhosphoSiteiQ9H5V8.

Expressioni

Tissue specificityi

Highly expressed in mitotic cells with low expression during interphase. Detected at highest levels in skeletal muscle and colon with lower levels in kidney, small intestine, placenta and lung. Up-regulated in a number of human tumor cell lines, as well as in colorectal cancer, breast carcinoma and lung cancer. Also expressed in cells with phenotypes reminiscent of mesenchymal stem cells and neural stem cells.4 Publications

Gene expression databases

BgeeiQ9H5V8.
CleanExiHS_CDCP1.
GenevestigatoriQ9H5V8.

Organism-specific databases

HPAiCAB025637.
HPA010978.
HPA010979.

Interactioni

Subunit structurei

Interacts with CDH2/N-cadherin, CDH3/P-cadherin, SDC1/syndecan-1, SDC4/syndecan-4 and the serine protease ST14/MT-SP1. Also interacts with SRC and PRKCG/protein kinase C gamma.2 Publications

Protein-protein interaction databases

BioGridi122336. 2 interactions.
DIPiDIP-33861N.
IntActiQ9H5V8. 5 interactions.
MINTiMINT-1346387.
STRINGi9606.ENSP00000296129.

Structurei

3D structure databases

ProteinModelPortaliQ9H5V8.
SMRiQ9H5V8. Positions 122-213, 231-282.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini417 – 544128CUB
Add
BLAST

Sequence similaritiesi

Contains 1 CUB domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG27234.
HOVERGENiHBG081070.
InParanoidiQ9H5V8.
KOiK06732.
OMAiSIKRLCI.
OrthoDBiEOG72RMXC.
PhylomeDBiQ9H5V8.
TreeFamiTF331392.

Family and domain databases

Gene3Di2.60.120.290. 1 hit.
InterProiIPR000859. CUB_dom.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H5V8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAGLNCGVSI ALLGVLLLGA ARLPRGAEAF EIALPRESNI TVLIKLGTPT    50
LLAKPCYIVI SKRHITMLSI KSGERIVFTF SCQSPENHFV IEIQKNIDCM 100
SGPCPFGEVQ LQPSTSLLPT LNRTFIWDVK AHKSIGLELQ FSIPRLRQIG 150
PGESCPDGVT HSISGRIDAT VVRIGTFCSN GTVSRIKMQE GVKMALHLPW 200
FHPRNVSGFS IANRSSIKRL CIIESVFEGE GSATLMSANY PEGFPEDELM 250
TWQFVVPAHL RASVSFLNFN LSNCERKEER VEYYIPGSTT NPEVFKLEDK 300
QPGNMAGNFN LSLQGCDQDA QSPGILRLQF QVLVQHPQNE SNKIYVVDLS 350
NERAMSLTIE PRPVKQSRKF VPGCFVCLES RTCSSNLTLT SGSKHKISFL 400
CDDLTRLWMN VEKTISCTDH RYCQRKSYSL QVPSDILHLP VELHDFSWKL 450
LVPKDRLSLV LVPAQKLQQH THEKPCNTSF SYLVASAIPS QDLYFGSFCP 500
GGSIKQIQVK QNISVTLRTF APSFQQEASR QGLTVSFIPY FKEEGVFTVT 550
PDTKSKVYLR TPNWDRGLPS LTSVSWNISV PRDQVACLTF FKERSGVVCQ 600
TGRAFMIIQE QRTRAEEIFS LDEDVLPKPS FHHHSFWVNI SNCSPTSGKQ 650
LDLLFSVTLT PRTVDLTVIL IAAVGGGVLL LSALGLIICC VKKKKKKTNK 700
GPAVGIYNDN INTEMPRQPK KFQKGRKDND SHVYAVIEDT MVYGHLLQDS 750
SGSFLQPEVD TYRPFQGTMG VCPPSPPTIC SRAPTAKLAT EEPPPRSPPE 800
SESEPYTFSH PNNGDVSSKD TDIPLLNTQE PMEPAE 836
Length:836
Mass (Da):92,932
Last modified:January 11, 2011 - v3
Checksum:i544FFDBBDD371518
GO
Isoform 2 (identifier: Q9H5V8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-187: Missing.

Note: No experimental confirmation available.

Show »
Length:649
Mass (Da):72,723
Checksum:iCA14C5F721CDCD49
GO
Isoform 3 (identifier: Q9H5V8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     342-343: NK → SE
     344-836: Missing.

Show »
Length:343
Mass (Da):37,818
Checksum:i3E4E13379DD94D1B
GO

Sequence cautioni

The sequence BAB15388.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti525 – 5251Q → R.3 Publications
Corresponds to variant rs3749191 [ dbSNP | Ensembl ].
VAR_025498
Natural varianti673 – 6731A → V.1 Publication
Corresponds to variant rs35428731 [ dbSNP | Ensembl ].
VAR_055095
Natural varianti709 – 7091D → G.3 Publications
Corresponds to variant rs9874077 [ dbSNP | Ensembl ].
VAR_025499

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 187187Missing in isoform 2.
VSP_017432Add
BLAST
Alternative sequencei342 – 3432NK → SE in isoform 3.
VSP_017433
Alternative sequencei344 – 836493Missing in isoform 3.
VSP_017434Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti252 – 2521W → C in BAB14695. 1 Publication
Sequence conflicti284 – 2841Y → D in BAB15388. 1 Publication
Sequence conflicti434 – 4341S → G in BAB14695. 1 Publication
Sequence conflicti466 – 4661K → R in BAB15388. 1 Publication
Sequence conflicti827 – 8271N → S in AAO33397. 1 Publication
Sequence conflicti827 – 8271N → S in BAB15511. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY026461 mRNA. Translation: AAK02058.1.
AF468010 mRNA. Translation: AAO33397.1.
AY167484 mRNA. Translation: AAO34538.1.
AY358779 mRNA. Translation: AAQ89139.1.
AK023834 mRNA. Translation: BAB14695.1.
AK026187 mRNA. Translation: BAB15388.1. Different initiation.
AK026622 mRNA. Translation: BAB15511.1.
AC104165 Genomic DNA. No translation available.
AC105902 Genomic DNA. No translation available.
BC021099 mRNA. Translation: AAH21099.1.
BC069254 mRNA. Translation: AAH69254.1.
AY375452 mRNA. Translation: AAR21289.1.
CCDSiCCDS2727.1. [Q9H5V8-1]
CCDS46812.1. [Q9H5V8-3]
RefSeqiNP_073753.3. NM_022842.4. [Q9H5V8-1]
NP_835488.1. NM_178181.2. [Q9H5V8-3]
UniGeneiHs.476093.

Genome annotation databases

EnsembliENST00000296129; ENSP00000296129; ENSG00000163814. [Q9H5V8-1]
ENST00000425231; ENSP00000399342; ENSG00000163814. [Q9H5V8-3]
GeneIDi64866.
KEGGihsa:64866.
UCSCiuc003com.3. human. [Q9H5V8-1]
uc003con.3. human. [Q9H5V8-3]

Polymorphism databases

DMDMi317373455.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY026461 mRNA. Translation: AAK02058.1 .
AF468010 mRNA. Translation: AAO33397.1 .
AY167484 mRNA. Translation: AAO34538.1 .
AY358779 mRNA. Translation: AAQ89139.1 .
AK023834 mRNA. Translation: BAB14695.1 .
AK026187 mRNA. Translation: BAB15388.1 . Different initiation.
AK026622 mRNA. Translation: BAB15511.1 .
AC104165 Genomic DNA. No translation available.
AC105902 Genomic DNA. No translation available.
BC021099 mRNA. Translation: AAH21099.1 .
BC069254 mRNA. Translation: AAH69254.1 .
AY375452 mRNA. Translation: AAR21289.1 .
CCDSi CCDS2727.1. [Q9H5V8-1 ]
CCDS46812.1. [Q9H5V8-3 ]
RefSeqi NP_073753.3. NM_022842.4. [Q9H5V8-1 ]
NP_835488.1. NM_178181.2. [Q9H5V8-3 ]
UniGenei Hs.476093.

3D structure databases

ProteinModelPortali Q9H5V8.
SMRi Q9H5V8. Positions 122-213, 231-282.
ModBasei Search...

Protein-protein interaction databases

BioGridi 122336. 2 interactions.
DIPi DIP-33861N.
IntActi Q9H5V8. 5 interactions.
MINTi MINT-1346387.
STRINGi 9606.ENSP00000296129.

PTM databases

PhosphoSitei Q9H5V8.

Polymorphism databases

DMDMi 317373455.

Proteomic databases

MaxQBi Q9H5V8.
PaxDbi Q9H5V8.
PRIDEi Q9H5V8.

Protocols and materials databases

DNASUi 64866.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296129 ; ENSP00000296129 ; ENSG00000163814 . [Q9H5V8-1 ]
ENST00000425231 ; ENSP00000399342 ; ENSG00000163814 . [Q9H5V8-3 ]
GeneIDi 64866.
KEGGi hsa:64866.
UCSCi uc003com.3. human. [Q9H5V8-1 ]
uc003con.3. human. [Q9H5V8-3 ]

Organism-specific databases

CTDi 64866.
GeneCardsi GC03M045123.
H-InvDBi HIX0003238.
HGNCi HGNC:24357. CDCP1.
HPAi CAB025637.
HPA010978.
HPA010979.
MIMi 611735. gene.
neXtProti NX_Q9H5V8.
PharmGKBi PA142672140.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG27234.
HOVERGENi HBG081070.
InParanoidi Q9H5V8.
KOi K06732.
OMAi SIKRLCI.
OrthoDBi EOG72RMXC.
PhylomeDBi Q9H5V8.
TreeFami TF331392.

Miscellaneous databases

ChiTaRSi CDCP1. human.
GeneWikii CDCP1.
GenomeRNAii 64866.
NextBioi 67027.
PROi Q9H5V8.
SOURCEi Search...

Gene expression databases

Bgeei Q9H5V8.
CleanExi HS_CDCP1.
Genevestigatori Q9H5V8.

Family and domain databases

Gene3Di 2.60.120.290. 1 hit.
InterProi IPR000859. CUB_dom.
[Graphical view ]
SUPFAMi SSF49854. SSF49854. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer."
    Scherl-Mostageer M., Sommergruber W., Abseher R., Hauptmann R., Ambros P., Schweifer N.
    Oncogene 20:4402-4408(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, VARIANT GLY-709.
  2. "Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen."
    Hooper J.D., Zijlstra A., Aimes R.T., Liang H., Claassen G.F., Tarin D., Testa J.E., Quigley J.P.
    Oncogene 22:1783-1794(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 30-48; 281-293 AND 427-438, GLYCOSYLATION, PHOSPHORYLATION, SHEDDING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANTS ARG-525 AND GLY-709.
  3. "Adhesion signaling by a novel mitotic substrate of src kinases."
    Bhatt A.S., Erdjument-Bromage H., Tempst P., Craik C.S., Moasser M.M.
    Oncogene 24:5333-5343(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 30-34 AND 369-375, IDENTIFICATION BY MASS SPECTROMETRY, PHOSPHORYLATION, GLYCOSYLATION, TISSUE SPECIFICITY, INTERACTION WITH CDH2; CDH3; SDC1; SDC4 AND ST14, FUNCTION.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS ARG-525 AND GLY-709.
    Tissue: Placenta.
  6. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-697 (ISOFORM 1), VARIANT VAL-673.
    Tissue: Kidney.
  8. "Adhesion or plasmin regulates tyrosine phosphorylation of a novel membrane glycoprotein p80/gp140/CUB domain-containing protein 1 in epithelia."
    Brown T.A., Yang T.M., Zaitsevskaia T., Xia Y., Dunn C.A., Sigle R.O., Knudsen B., Carter W.G.
    J. Biol. Chem. 279:14772-14783(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-691 (ISOFORM 1), IDENTIFICATION BY MASS SPECTROMETRY, PHOSPHORYLATION AT TYR-734, GLYCOSYLATION, TRYPTIC CLEAVAGE, VARIANT ARG-525.
    Tissue: Epidermis.
  9. "Anchorage mediated by integrin alpha6beta4 to laminin 5 (epiligrin) regulates tyrosine phosphorylation of a membrane-associated 80-kD protein."
    Xia Y., Gil S.G., Carter W.G.
    J. Cell Biol. 132:727-740(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION.
    Tissue: Epidermis.
  10. Cited for: FUNCTION.
  11. "CDCP1 identifies a broad spectrum of normal and malignant stem/progenitor cell subsets of hematopoietic and nonhematopoietic origin."
    Buehring H.-J., Kuci S., Conze T., Rathke G., Bartolovic K., Gruenebach F., Scherl-Mostageer M., Bruemmendorf T.H., Schweifer N., Lammers R.
    Stem Cells 22:334-343(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  12. "The C2 domain of PKCdelta is a phosphotyrosine binding domain."
    Benes C.H., Wu N., Elia A.E.H., Dharia T., Cantley L.C., Soltoff S.P.
    Cell 121:271-280(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH SRC AND PRKCG, MUTAGENESIS OF TYR-734 AND TYR-762.
  13. "Proteomic analysis of the tetraspanin web using LC-ESI-MS/MS and MALDI-FTICR-MS."
    Andre M., Le Caer J.-P., Greco C., Planchon S., El Nemer W., Boucheix C., Rubinstein E., Chamot-Rooke J., Le Naour F.
    Proteomics 6:1437-1449(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION.
  14. "Expression of the CUB domain containing protein 1 (CDCP1) gene in colorectal tumour cells."
    Perry S.E., Robinson P., Melcher A., Quirke P., Buehring H.-J., Cook G.P., Blair G.E.
    FEBS Lett. 581:1137-1142(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCDCP1_HUMAN
AccessioniPrimary (citable) accession number: Q9H5V8
Secondary accession number(s): Q49UB4
, Q6NT71, Q6U9Y2, Q8WU91, Q96QU7, Q9H676, Q9H8C2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: January 11, 2011
Last modified: July 9, 2014
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi