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Protein

Zinc finger protein Pegasus

Gene

IKZF5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

DNA-binding protein that binds to the 5'GNNTGTNG-3' core sequence. Transcriptional repressor.1 Publication

Miscellaneous

'Pegasus' was the winged horse in Greek mythology.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri82 – 104C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri110 – 132C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri138 – 161C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri364 – 386C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 416C2H2-type 5PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • protein domain specific binding Source: CAFA
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
  • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding Source: NTNU_SB
  • zinc ion binding Source: CAFA

GO - Biological processi

  • negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • protein heterooligomerization Source: CAFA
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein Pegasus
Alternative name(s):
Ikaros family zinc finger protein 5
Gene namesi
Name:IKZF5
Synonyms:ZNFN1A5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:14283. IKZF5.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB-SubCell
  • protein complex Source: CAFA

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000095574.
PharmGKBiPA162391969.

Polymorphism and mutation databases

DMDMi74761459.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002994711 – 419Zinc finger protein PegasusAdd BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki5Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9H5V7.
MaxQBiQ9H5V7.
PaxDbiQ9H5V7.
PeptideAtlasiQ9H5V7.
PRIDEiQ9H5V7.

PTM databases

iPTMnetiQ9H5V7.
PhosphoSitePlusiQ9H5V7.

Miscellaneous databases

PMAP-CutDBiQ9H5V7.

Expressioni

Tissue specificityi

Expressed in brain, heart, skeletal muscle, kidney, and liver. Expressed in the hematopoietic cell lines MOLT-4, NALM-6 and K-562. Highly expressed in THP-1 and M-07e cell lines, which have characteristics of myeloid and early megakaryocytic cells respectively.1 Publication

Gene expression databases

BgeeiENSG00000095574.
CleanExiHS_IKZF5.
GenevisibleiQ9H5V7. HS.

Organism-specific databases

HPAiHPA015297.
HPA051574.

Interactioni

Subunit structurei

Self-associates. Interacts with other family members; IKZF1, IKZF2, IKZF3 AND IKZF4.1 Publication

GO - Molecular functioni

  • protein domain specific binding Source: CAFA

Protein-protein interaction databases

BioGridi122147. 54 interactors.
IntActiQ9H5V7. 5 interactors.
STRINGi9606.ENSP00000357881.

Structurei

3D structure databases

ProteinModelPortaliQ9H5V7.
SMRiQ9H5V7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations with other family members.
C-terminal zinc fingers mediate homodimerization.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri82 – 104C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri110 – 132C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri138 – 161C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri364 – 386C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 416C2H2-type 5PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00550000074392.
HOGENOMiHOG000095162.
HOVERGENiHBG108001.
InParanoidiQ9H5V7.
KOiK09220.
OMAiLPMKGAR.
OrthoDBiEOG091G07B0.
PhylomeDBiQ9H5V7.
TreeFamiTF331860.

Family and domain databases

InterProiView protein in InterPro
IPR013087. Znf_C2H2_type.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 5 hits.
SUPFAMiSSF57667. SSF57667. 3 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.

Sequencei

Sequence statusi: Complete.

Q9H5V7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEKKPEPLD FVKDFQEYLT QQTHHVNMIS GSVSGDKEAE ALQGAGTDGD
60 70 80 90 100
QNGLDHPSVE VSLDENSGML VDGFERTFDG KLKCRYCNYA SKGTARLIEH
110 120 130 140 150
IRIHTGEKPH RCHLCPFASA YERHLEAHMR SHTGEKPYKC ELCSFRCSDR
160 170 180 190 200
SNLSHHRRRK HKMVPIKGTR SSLSSKKMWG VLQKKTSNLG YSRRALINLS
210 220 230 240 250
PPSMVVQKPD YLNDFTHEIP NIQTDSYESM AKTTPTGGLP RDPQELMVDN
260 270 280 290 300
PLNQLSTLAG QLSSLPPENQ NPASPDVVPC PDEKPFMIQQ PSTQAVVSAV
310 320 330 340 350
SASIPQSSSP TSPEPRPSHS QRNYSPVAGP SSEPSAHTST PSIGNSQPST
360 370 380 390 400
PAPALPVQDP QLLHHCQHCD MYFADNILYT IHMGCHGYEN PFQCNICGCK
410
CKNKYDFACH FARGQHNQH
Length:419
Mass (Da):46,510
Last modified:March 1, 2001 - v1
Checksum:i71845E9DE10BB2E8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti209P → L in AAG39220 (PubMed:10978333).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230808 mRNA. Translation: AAG39220.1.
AK026626 mRNA. Translation: BAB15512.1.
AK122899 mRNA. Translation: BAG53789.1.
CR749800 mRNA. Translation: CAH18660.1.
BX647958 mRNA. Translation: CAH56199.1.
CH471066 Genomic DNA. Translation: EAW49292.1.
CH471066 Genomic DNA. Translation: EAW49293.1.
CH471066 Genomic DNA. Translation: EAW49294.1.
CCDSiCCDS41574.1.
RefSeqiNP_001258769.1. NM_001271840.1.
XP_006718010.1. XM_006717947.3.
XP_016872039.1. XM_017016550.1.
XP_016872040.1. XM_017016551.1.
XP_016872041.1. XM_017016552.1.
UniGeneiHs.501289.

Genome annotation databases

EnsembliENST00000368886; ENSP00000357881; ENSG00000095574.
ENST00000617859; ENSP00000478056; ENSG00000095574.
GeneIDi64376.
KEGGihsa:64376.
UCSCiuc001lha.4. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiIKZF5_HUMAN
AccessioniPrimary (citable) accession number: Q9H5V7
Secondary accession number(s): B3KVH7, D3DRE7, Q9H2T0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2001
Last modified: June 7, 2017
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families