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Protein

Zinc finger protein Pegasus

Gene

IKZF5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA-binding protein that binds to the 5'GNNTGTNG-3' core sequence. Transcriptional repressor.1 Publication

Miscellaneous

'Pegasus' was the winged horse in Greek mythology.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri82 – 104C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri110 – 132C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri138 – 161C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri364 – 386C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 416C2H2-type 5PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • protein domain specific binding Source: CAFA
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
  • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB
  • zinc ion binding Source: CAFA

GO - Biological processi

  • negative regulation of transcription by RNA polymerase II Source: NTNU_SB
  • protein heterooligomerization Source: CAFA
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ9H5V7

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein Pegasus
Alternative name(s):
Ikaros family zinc finger protein 5
Gene namesi
Name:IKZF5
Synonyms:ZNFN1A5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000095574.11
HGNCiHGNC:14283 IKZF5
MIMi606238 gene
neXtProtiNX_Q9H5V7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi64376
OpenTargetsiENSG00000095574
PharmGKBiPA162391969

Polymorphism and mutation databases

DMDMi74761459

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002994711 – 419Zinc finger protein PegasusAdd BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki5Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki185Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9H5V7
MaxQBiQ9H5V7
PaxDbiQ9H5V7
PeptideAtlasiQ9H5V7
PRIDEiQ9H5V7
ProteomicsDBi80932

PTM databases

iPTMnetiQ9H5V7
PhosphoSitePlusiQ9H5V7

Miscellaneous databases

PMAP-CutDBiQ9H5V7

Expressioni

Tissue specificityi

Expressed in brain, heart, skeletal muscle, kidney, and liver. Expressed in the hematopoietic cell lines MOLT-4, NALM-6 and K-562. Highly expressed in THP-1 and M-07e cell lines, which have characteristics of myeloid and early megakaryocytic cells respectively.1 Publication

Gene expression databases

BgeeiENSG00000095574
CleanExiHS_IKZF5
GenevisibleiQ9H5V7 HS

Organism-specific databases

HPAiHPA015297
HPA051574

Interactioni

Subunit structurei

Self-associates. Interacts with other family members; IKZF1, IKZF2, IKZF3 AND IKZF4.1 Publication

GO - Molecular functioni

  • protein domain specific binding Source: CAFA

Protein-protein interaction databases

BioGridi122147, 57 interactors
IntActiQ9H5V7, 5 interactors
STRINGi9606.ENSP00000357881

Structurei

3D structure databases

ProteinModelPortaliQ9H5V7
SMRiQ9H5V7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations with other family members.
C-terminal zinc fingers mediate homodimerization.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri82 – 104C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri110 – 132C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri138 – 161C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri364 – 386C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 416C2H2-type 5PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00550000074392
HOGENOMiHOG000095162
HOVERGENiHBG108001
InParanoidiQ9H5V7
KOiK09220
OMAiEKPFMMQ
OrthoDBiEOG091G07B0
PhylomeDBiQ9H5V7
TreeFamiTF331860

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequencei

Sequence statusi: Complete.

Q9H5V7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEKKPEPLD FVKDFQEYLT QQTHHVNMIS GSVSGDKEAE ALQGAGTDGD
60 70 80 90 100
QNGLDHPSVE VSLDENSGML VDGFERTFDG KLKCRYCNYA SKGTARLIEH
110 120 130 140 150
IRIHTGEKPH RCHLCPFASA YERHLEAHMR SHTGEKPYKC ELCSFRCSDR
160 170 180 190 200
SNLSHHRRRK HKMVPIKGTR SSLSSKKMWG VLQKKTSNLG YSRRALINLS
210 220 230 240 250
PPSMVVQKPD YLNDFTHEIP NIQTDSYESM AKTTPTGGLP RDPQELMVDN
260 270 280 290 300
PLNQLSTLAG QLSSLPPENQ NPASPDVVPC PDEKPFMIQQ PSTQAVVSAV
310 320 330 340 350
SASIPQSSSP TSPEPRPSHS QRNYSPVAGP SSEPSAHTST PSIGNSQPST
360 370 380 390 400
PAPALPVQDP QLLHHCQHCD MYFADNILYT IHMGCHGYEN PFQCNICGCK
410
CKNKYDFACH FARGQHNQH
Length:419
Mass (Da):46,510
Last modified:March 1, 2001 - v1
Checksum:i71845E9DE10BB2E8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti209P → L in AAG39220 (PubMed:10978333).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230808 mRNA Translation: AAG39220.1
AK026626 mRNA Translation: BAB15512.1
AK122899 mRNA Translation: BAG53789.1
CR749800 mRNA Translation: CAH18660.1
BX647958 mRNA Translation: CAH56199.1
CH471066 Genomic DNA Translation: EAW49292.1
CH471066 Genomic DNA Translation: EAW49293.1
CH471066 Genomic DNA Translation: EAW49294.1
CCDSiCCDS41574.1
RefSeqiNP_001258769.1, NM_001271840.1
XP_006718010.1, XM_006717947.3
XP_016872039.1, XM_017016550.1
XP_016872040.1, XM_017016551.1
XP_016872041.1, XM_017016552.1
UniGeneiHs.501289

Genome annotation databases

EnsembliENST00000368886; ENSP00000357881; ENSG00000095574
ENST00000617859; ENSP00000478056; ENSG00000095574
GeneIDi64376
KEGGihsa:64376
UCSCiuc001lha.4 human

Similar proteinsi

Entry informationi

Entry nameiIKZF5_HUMAN
AccessioniPrimary (citable) accession number: Q9H5V7
Secondary accession number(s): B3KVH7, D3DRE7, Q9H2T0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2001
Last modified: June 20, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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