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Protein

Zinc finger CCHC domain-containing protein 4

Gene

ZCCHC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be a methyltransferase.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri395 – 44753DHHC-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri443 – 46018CCHC-typeAdd
BLAST

GO - Molecular functioni

  1. methyltransferase activity Source: UniProtKB-KW
  2. nucleic acid binding Source: InterPro
  3. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCHC domain-containing protein 4
Gene namesi
Name:ZCCHC4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:22917. ZCCHC4.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134950003.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513Zinc finger CCHC domain-containing protein 4PRO_0000150952Add
BLAST

Proteomic databases

MaxQBiQ9H5U6.
PaxDbiQ9H5U6.
PRIDEiQ9H5U6.

PTM databases

PhosphoSiteiQ9H5U6.

Expressioni

Gene expression databases

BgeeiQ9H5U6.
CleanExiHS_ZCCHC4.
GenevestigatoriQ9H5U6.

Organism-specific databases

HPAiHPA035575.
HPA035576.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000303468.

Structurei

3D structure databases

ProteinModelPortaliQ9H5U6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 CCHC-type zinc finger.Curated
Contains 1 DHHC-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri395 – 44753DHHC-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri443 – 46018CCHC-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG316851.
GeneTreeiENSGT00390000012556.
HOGENOMiHOG000230723.
HOVERGENiHBG056108.
InParanoidiQ9H5U6.
OMAiVNQGKEE.
OrthoDBiEOG7P02J7.
PhylomeDBiQ9H5U6.
TreeFamiTF313872.

Family and domain databases

InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR019369. N6_adenine_Mtase-rel_euk.
IPR001878. Znf_CCHC.
IPR001594. Znf_DHHC_palmitoyltrfase.
IPR010666. Znf_GRF.
[Graphical view]
PfamiPF10237. N6-adenineMlase. 1 hit.
PF06839. zf-GRF. 1 hit.
[Graphical view]
SMARTiSM00343. ZnF_C2HC. 1 hit.
[Graphical view]
PROSITEiPS00092. N6_MTASE. 1 hit.
PS50216. ZF_DHHC. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H5U6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASRNGFEA VEAEGSAGCR GSSGMEVVLP LDPAVPAPLC PHGPTLLFVK
60 70 80 90 100
VTQGKEETRR FYACSACRDR KDCNFFQWED EKLSGARLAA REAHNRRCQP
110 120 130 140 150
PLSRTQCVER YLKFIELPLT QRKFCQTCQQ LLLPDDWGQH SEHQVLGNVS
160 170 180 190 200
ITQLRRPSQL LYPLENKKTN AQYLFADRSC QFLVDLLSAL GFRRVLCVGT
210 220 230 240 250
PRLHELIKLT ASGDKKSNIK SLLLDIDFRY SQFYMEDSFC HYNMFNHHFF
260 270 280 290 300
DGKTALEVCR AFLQEDKGEG IIMVTDPPFG GLVEPLAITF KKLIAMWKEG
310 320 330 340 350
QSQDDSHKEL PIFWIFPYFF ESRICQFFPS FQMLDYQVDY DNHALYKHGK
360 370 380 390 400
TGRKQSPVRI FTNIPPNKII LPTEEGYRFC SPCQRYVSLE NQHCELCNSC
410 420 430 440 450
TSKDGRKWNH CFLCKKCVKP SWIHCSICNH CAVPDHSCEG PKHGCFICGE
460 470 480 490 500
LDHKRSTCPN IATSKRANKA VRKQKQRKSN KMKMETTKGQ SMNHTSATRR
510
KKRRERAHQY LGS
Length:513
Mass (Da):59,010
Last modified:January 23, 2006 - v3
Checksum:iD74690827DC935F4
GO
Isoform 2 (identifier: Q9H5U6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     230-513: Missing.

Note: No experimental confirmation available.

Show »
Length:229
Mass (Da):25,866
Checksum:i20D6F1827E273314
GO
Isoform 3 (identifier: Q9H5U6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     470-472: Missing.

Note: No experimental confirmation available.

Show »
Length:510
Mass (Da):58,683
Checksum:iA70B1ECBB327ED3B
GO

Sequence cautioni

The sequence AAH16914.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB15524.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti348 – 3481H → R in BAG61250 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti382 – 3821P → L.
Corresponds to variant rs3752873 [ dbSNP | Ensembl ].
VAR_053751
Natural varianti396 – 3961L → H.3 Publications
Corresponds to variant rs315675 [ dbSNP | Ensembl ].
VAR_024925

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei230 – 513284Missing in isoform 2. 1 PublicationVSP_043359Add
BLAST
Alternative sequencei470 – 4723Missing in isoform 3. 1 PublicationVSP_043360

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY629351 mRNA. Translation: AAV41218.1.
CH471069 Genomic DNA. Translation: EAW92837.1.
AK299211 mRNA. Translation: BAG61250.1.
AK026677 mRNA. Translation: BAB15524.1. Different initiation.
BC016914 mRNA. Translation: AAH16914.1. Different initiation.
BC157834 mRNA. Translation: AAI57835.1.
BC171821 mRNA. Translation: AAI71821.1.
CCDSiCCDS43218.1. [Q9H5U6-1]
RefSeqiNP_079212.2. NM_024936.2. [Q9H5U6-1]
UniGeneiHs.278945.

Genome annotation databases

EnsembliENST00000302874; ENSP00000303468; ENSG00000168228. [Q9H5U6-1]
ENST00000507760; ENSP00000422115; ENSG00000168228. [Q9H5U6-2]
GeneIDi29063.
KEGGihsa:29063.
UCSCiuc003grl.4. human. [Q9H5U6-1]

Polymorphism databases

DMDMi85700439.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY629351 mRNA. Translation: AAV41218.1.
CH471069 Genomic DNA. Translation: EAW92837.1.
AK299211 mRNA. Translation: BAG61250.1.
AK026677 mRNA. Translation: BAB15524.1. Different initiation.
BC016914 mRNA. Translation: AAH16914.1. Different initiation.
BC157834 mRNA. Translation: AAI57835.1.
BC171821 mRNA. Translation: AAI71821.1.
CCDSiCCDS43218.1. [Q9H5U6-1]
RefSeqiNP_079212.2. NM_024936.2. [Q9H5U6-1]
UniGeneiHs.278945.

3D structure databases

ProteinModelPortaliQ9H5U6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000303468.

PTM databases

PhosphoSiteiQ9H5U6.

Polymorphism databases

DMDMi85700439.

Proteomic databases

MaxQBiQ9H5U6.
PaxDbiQ9H5U6.
PRIDEiQ9H5U6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302874; ENSP00000303468; ENSG00000168228. [Q9H5U6-1]
ENST00000507760; ENSP00000422115; ENSG00000168228. [Q9H5U6-2]
GeneIDi29063.
KEGGihsa:29063.
UCSCiuc003grl.4. human. [Q9H5U6-1]

Organism-specific databases

CTDi29063.
GeneCardsiGC04P025314.
HGNCiHGNC:22917. ZCCHC4.
HPAiHPA035575.
HPA035576.
MIMi611792. gene.
neXtProtiNX_Q9H5U6.
PharmGKBiPA134950003.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG316851.
GeneTreeiENSGT00390000012556.
HOGENOMiHOG000230723.
HOVERGENiHBG056108.
InParanoidiQ9H5U6.
OMAiVNQGKEE.
OrthoDBiEOG7P02J7.
PhylomeDBiQ9H5U6.
TreeFamiTF313872.

Miscellaneous databases

ChiTaRSiZCCHC4. human.
GenomeRNAii29063.
NextBioi51996.
PROiQ9H5U6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H5U6.
CleanExiHS_ZCCHC4.
GenevestigatoriQ9H5U6.

Family and domain databases

InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR019369. N6_adenine_Mtase-rel_euk.
IPR001878. Znf_CCHC.
IPR001594. Znf_DHHC_palmitoyltrfase.
IPR010666. Znf_GRF.
[Graphical view]
PfamiPF10237. N6-adenineMlase. 1 hit.
PF06839. zf-GRF. 1 hit.
[Graphical view]
SMARTiSM00343. ZnF_C2HC. 1 hit.
[Graphical view]
PROSITEiPS00092. N6_MTASE. 1 hit.
PS50216. ZF_DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Homo sapiens zinc finger, DHHC domain containing, similar to Mus musculus 4930449I23Rik."
    Yue L., Zou X., Ci H., Li Y.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT HIS-396.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-396.
    Tissue: Lung and Teratocarcinoma.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT HIS-396.
    Tissue: Brain cortex and Kidney.
  5. "Novel Sm-like proteins with long C-terminal tails and associated methyltransferases."
    Albrecht M., Lengauer T.
    FEBS Lett. 569:18-26(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY CHARACTERIZATION.

Entry informationi

Entry nameiZCHC4_HUMAN
AccessioniPrimary (citable) accession number: Q9H5U6
Secondary accession number(s): B2RXF6
, B4DRD8, B7ZW20, Q5IW78, Q96AN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2004
Last sequence update: January 23, 2006
Last modified: March 3, 2015
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.