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Q9H5U6 (ZCHC4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger CCHC domain-containing protein 4
Gene names
Name:ZCCHC4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length513 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be a methyltransferase.

Sequence similarities

Contains 1 CCHC-type zinc finger.

Contains 1 DHHC-type zinc finger.

Sequence caution

The sequence AAH16914.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAB15524.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9H5U6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9H5U6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     230-513: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q9H5U6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     470-472: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 513513Zinc finger CCHC domain-containing protein 4
PRO_0000150952

Regions

Zinc finger395 – 44753DHHC-type
Zinc finger443 – 46018CCHC-type

Natural variations

Alternative sequence230 – 513284Missing in isoform 2.
VSP_043359
Alternative sequence470 – 4723Missing in isoform 3.
VSP_043360
Natural variant3821P → L.
Corresponds to variant rs3752873 [ dbSNP | Ensembl ].
VAR_053751
Natural variant3961L → H. Ref.2 Ref.3 Ref.4
Corresponds to variant rs315675 [ dbSNP | Ensembl ].
VAR_024925

Experimental info

Sequence conflict3481H → R in BAG61250. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 24, 2006. Version 3.
Checksum: D74690827DC935F4

FASTA51359,010
        10         20         30         40         50         60 
MAASRNGFEA VEAEGSAGCR GSSGMEVVLP LDPAVPAPLC PHGPTLLFVK VTQGKEETRR 

        70         80         90        100        110        120 
FYACSACRDR KDCNFFQWED EKLSGARLAA REAHNRRCQP PLSRTQCVER YLKFIELPLT 

       130        140        150        160        170        180 
QRKFCQTCQQ LLLPDDWGQH SEHQVLGNVS ITQLRRPSQL LYPLENKKTN AQYLFADRSC 

       190        200        210        220        230        240 
QFLVDLLSAL GFRRVLCVGT PRLHELIKLT ASGDKKSNIK SLLLDIDFRY SQFYMEDSFC 

       250        260        270        280        290        300 
HYNMFNHHFF DGKTALEVCR AFLQEDKGEG IIMVTDPPFG GLVEPLAITF KKLIAMWKEG 

       310        320        330        340        350        360 
QSQDDSHKEL PIFWIFPYFF ESRICQFFPS FQMLDYQVDY DNHALYKHGK TGRKQSPVRI 

       370        380        390        400        410        420 
FTNIPPNKII LPTEEGYRFC SPCQRYVSLE NQHCELCNSC TSKDGRKWNH CFLCKKCVKP 

       430        440        450        460        470        480 
SWIHCSICNH CAVPDHSCEG PKHGCFICGE LDHKRSTCPN IATSKRANKA VRKQKQRKSN 

       490        500        510 
KMKMETTKGQ SMNHTSATRR KKRRERAHQY LGS 

« Hide

Isoform 2 [UniParc].

Checksum: 20D6F1827E273314
Show »

FASTA22925,866
Isoform 3 [UniParc].

Checksum: A70B1ECBB327ED3B
Show »

FASTA51058,683

References

« Hide 'large scale' references
[1]"Homo sapiens zinc finger, DHHC domain containing, similar to Mus musculus 4930449I23Rik."
Yue L., Zou X., Ci H., Li Y.
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Testis.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT HIS-396.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-396.
Tissue: Lung and Teratocarcinoma.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT HIS-396.
Tissue: Brain cortex and Kidney.
[5]"Novel Sm-like proteins with long C-terminal tails and associated methyltransferases."
Albrecht M., Lengauer T.
FEBS Lett. 569:18-26(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PRELIMINARY CHARACTERIZATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY629351 mRNA. Translation: AAV41218.1.
CH471069 Genomic DNA. Translation: EAW92837.1.
AK299211 mRNA. Translation: BAG61250.1.
AK026677 mRNA. Translation: BAB15524.1. Different initiation.
BC016914 mRNA. Translation: AAH16914.1. Different initiation.
BC157834 mRNA. Translation: AAI57835.1.
BC171821 mRNA. Translation: AAI71821.1.
RefSeqNP_079212.2. NM_024936.2.
UniGeneHs.278945.

3D structure databases

ProteinModelPortalQ9H5U6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000303468.

PTM databases

PhosphoSiteQ9H5U6.

Polymorphism databases

DMDM85700439.

Proteomic databases

PaxDbQ9H5U6.
PRIDEQ9H5U6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000302874; ENSP00000303468; ENSG00000168228. [Q9H5U6-1]
ENST00000507760; ENSP00000422115; ENSG00000168228. [Q9H5U6-2]
GeneID29063.
KEGGhsa:29063.
UCSCuc003grl.4. human. [Q9H5U6-1]

Organism-specific databases

CTD29063.
GeneCardsGC04P025314.
HGNCHGNC:22917. ZCCHC4.
HPAHPA035576.
MIM611792. gene.
neXtProtNX_Q9H5U6.
PharmGKBPA134950003.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG316851.
HOGENOMHOG000230723.
HOVERGENHBG056108.
InParanoidQ9H5U6.
OMAVNQGKEE.
OrthoDBEOG7P02J7.
PhylomeDBQ9H5U6.
TreeFamTF313872.

Gene expression databases

BgeeQ9H5U6.
CleanExHS_ZCCHC4.
GenevestigatorQ9H5U6.

Family and domain databases

InterProIPR002052. DNA_methylase_N6_adenine_CS.
IPR019369. N6_adenine_Mtase-rel_euk.
IPR001878. Znf_CCHC.
IPR001594. Znf_DHHC_palmitoyltrfase.
IPR010666. Znf_GRF.
[Graphical view]
PfamPF10237. N6-adenineMlase. 1 hit.
PF06839. zf-GRF. 1 hit.
[Graphical view]
SMARTSM00343. ZnF_C2HC. 1 hit.
[Graphical view]
PROSITEPS00092. N6_MTASE. 1 hit.
PS50216. ZF_DHHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZCCHC4. human.
GenomeRNAi29063.
NextBio51996.
PROQ9H5U6.
SOURCESearch...

Entry information

Entry nameZCHC4_HUMAN
AccessionPrimary (citable) accession number: Q9H5U6
Secondary accession number(s): B2RXF6 expand/collapse secondary AC list , B4DRD8, B7ZW20, Q5IW78, Q96AN7
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: January 24, 2006
Last modified: April 16, 2014
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM