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Q9H5U6

- ZCHC4_HUMAN

UniProt

Q9H5U6 - ZCHC4_HUMAN

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Protein
Zinc finger CCHC domain-containing protein 4
Gene
ZCCHC4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May be a methyltransferase.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri395 – 44753DHHC-type
Add
BLAST
Zinc fingeri443 – 46018CCHC-type
Add
BLAST

GO - Molecular functioni

  1. methyltransferase activity Source: UniProtKB-KW
  2. nucleic acid binding Source: InterPro
  3. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger CCHC domain-containing protein 4
    Gene namesi
    Name:ZCCHC4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:22917. ZCCHC4.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134950003.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 513513Zinc finger CCHC domain-containing protein 4
    PRO_0000150952Add
    BLAST

    Proteomic databases

    MaxQBiQ9H5U6.
    PaxDbiQ9H5U6.
    PRIDEiQ9H5U6.

    PTM databases

    PhosphoSiteiQ9H5U6.

    Expressioni

    Gene expression databases

    BgeeiQ9H5U6.
    CleanExiHS_ZCCHC4.
    GenevestigatoriQ9H5U6.

    Organism-specific databases

    HPAiHPA035576.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000303468.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H5U6.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG316851.
    HOGENOMiHOG000230723.
    HOVERGENiHBG056108.
    InParanoidiQ9H5U6.
    OMAiVNQGKEE.
    OrthoDBiEOG7P02J7.
    PhylomeDBiQ9H5U6.
    TreeFamiTF313872.

    Family and domain databases

    InterProiIPR002052. DNA_methylase_N6_adenine_CS.
    IPR019369. N6_adenine_Mtase-rel_euk.
    IPR001878. Znf_CCHC.
    IPR001594. Znf_DHHC_palmitoyltrfase.
    IPR010666. Znf_GRF.
    [Graphical view]
    PfamiPF10237. N6-adenineMlase. 1 hit.
    PF06839. zf-GRF. 1 hit.
    [Graphical view]
    SMARTiSM00343. ZnF_C2HC. 1 hit.
    [Graphical view]
    PROSITEiPS00092. N6_MTASE. 1 hit.
    PS50216. ZF_DHHC. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H5U6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAASRNGFEA VEAEGSAGCR GSSGMEVVLP LDPAVPAPLC PHGPTLLFVK    50
    VTQGKEETRR FYACSACRDR KDCNFFQWED EKLSGARLAA REAHNRRCQP 100
    PLSRTQCVER YLKFIELPLT QRKFCQTCQQ LLLPDDWGQH SEHQVLGNVS 150
    ITQLRRPSQL LYPLENKKTN AQYLFADRSC QFLVDLLSAL GFRRVLCVGT 200
    PRLHELIKLT ASGDKKSNIK SLLLDIDFRY SQFYMEDSFC HYNMFNHHFF 250
    DGKTALEVCR AFLQEDKGEG IIMVTDPPFG GLVEPLAITF KKLIAMWKEG 300
    QSQDDSHKEL PIFWIFPYFF ESRICQFFPS FQMLDYQVDY DNHALYKHGK 350
    TGRKQSPVRI FTNIPPNKII LPTEEGYRFC SPCQRYVSLE NQHCELCNSC 400
    TSKDGRKWNH CFLCKKCVKP SWIHCSICNH CAVPDHSCEG PKHGCFICGE 450
    LDHKRSTCPN IATSKRANKA VRKQKQRKSN KMKMETTKGQ SMNHTSATRR 500
    KKRRERAHQY LGS 513
    Length:513
    Mass (Da):59,010
    Last modified:January 24, 2006 - v3
    Checksum:iD74690827DC935F4
    GO
    Isoform 2 (identifier: Q9H5U6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         230-513: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:229
    Mass (Da):25,866
    Checksum:i20D6F1827E273314
    GO
    Isoform 3 (identifier: Q9H5U6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         470-472: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:510
    Mass (Da):58,683
    Checksum:iA70B1ECBB327ED3B
    GO

    Sequence cautioni

    The sequence AAH16914.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAB15524.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti382 – 3821P → L.
    Corresponds to variant rs3752873 [ dbSNP | Ensembl ].
    VAR_053751
    Natural varianti396 – 3961L → H.3 Publications
    Corresponds to variant rs315675 [ dbSNP | Ensembl ].
    VAR_024925

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei230 – 513284Missing in isoform 2.
    VSP_043359Add
    BLAST
    Alternative sequencei470 – 4723Missing in isoform 3.
    VSP_043360

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti348 – 3481H → R in BAG61250. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY629351 mRNA. Translation: AAV41218.1.
    CH471069 Genomic DNA. Translation: EAW92837.1.
    AK299211 mRNA. Translation: BAG61250.1.
    AK026677 mRNA. Translation: BAB15524.1. Different initiation.
    BC016914 mRNA. Translation: AAH16914.1. Different initiation.
    BC157834 mRNA. Translation: AAI57835.1.
    BC171821 mRNA. Translation: AAI71821.1.
    CCDSiCCDS43218.1. [Q9H5U6-1]
    RefSeqiNP_079212.2. NM_024936.2. [Q9H5U6-1]
    UniGeneiHs.278945.

    Genome annotation databases

    EnsembliENST00000302874; ENSP00000303468; ENSG00000168228. [Q9H5U6-1]
    ENST00000507760; ENSP00000422115; ENSG00000168228. [Q9H5U6-2]
    GeneIDi29063.
    KEGGihsa:29063.
    UCSCiuc003grl.4. human. [Q9H5U6-1]

    Polymorphism databases

    DMDMi85700439.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY629351 mRNA. Translation: AAV41218.1 .
    CH471069 Genomic DNA. Translation: EAW92837.1 .
    AK299211 mRNA. Translation: BAG61250.1 .
    AK026677 mRNA. Translation: BAB15524.1 . Different initiation.
    BC016914 mRNA. Translation: AAH16914.1 . Different initiation.
    BC157834 mRNA. Translation: AAI57835.1 .
    BC171821 mRNA. Translation: AAI71821.1 .
    CCDSi CCDS43218.1. [Q9H5U6-1 ]
    RefSeqi NP_079212.2. NM_024936.2. [Q9H5U6-1 ]
    UniGenei Hs.278945.

    3D structure databases

    ProteinModelPortali Q9H5U6.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000303468.

    PTM databases

    PhosphoSitei Q9H5U6.

    Polymorphism databases

    DMDMi 85700439.

    Proteomic databases

    MaxQBi Q9H5U6.
    PaxDbi Q9H5U6.
    PRIDEi Q9H5U6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000302874 ; ENSP00000303468 ; ENSG00000168228 . [Q9H5U6-1 ]
    ENST00000507760 ; ENSP00000422115 ; ENSG00000168228 . [Q9H5U6-2 ]
    GeneIDi 29063.
    KEGGi hsa:29063.
    UCSCi uc003grl.4. human. [Q9H5U6-1 ]

    Organism-specific databases

    CTDi 29063.
    GeneCardsi GC04P025314.
    HGNCi HGNC:22917. ZCCHC4.
    HPAi HPA035576.
    MIMi 611792. gene.
    neXtProti NX_Q9H5U6.
    PharmGKBi PA134950003.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG316851.
    HOGENOMi HOG000230723.
    HOVERGENi HBG056108.
    InParanoidi Q9H5U6.
    OMAi VNQGKEE.
    OrthoDBi EOG7P02J7.
    PhylomeDBi Q9H5U6.
    TreeFami TF313872.

    Miscellaneous databases

    ChiTaRSi ZCCHC4. human.
    GenomeRNAii 29063.
    NextBioi 51996.
    PROi Q9H5U6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9H5U6.
    CleanExi HS_ZCCHC4.
    Genevestigatori Q9H5U6.

    Family and domain databases

    InterProi IPR002052. DNA_methylase_N6_adenine_CS.
    IPR019369. N6_adenine_Mtase-rel_euk.
    IPR001878. Znf_CCHC.
    IPR001594. Znf_DHHC_palmitoyltrfase.
    IPR010666. Znf_GRF.
    [Graphical view ]
    Pfami PF10237. N6-adenineMlase. 1 hit.
    PF06839. zf-GRF. 1 hit.
    [Graphical view ]
    SMARTi SM00343. ZnF_C2HC. 1 hit.
    [Graphical view ]
    PROSITEi PS00092. N6_MTASE. 1 hit.
    PS50216. ZF_DHHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Homo sapiens zinc finger, DHHC domain containing, similar to Mus musculus 4930449I23Rik."
      Yue L., Zou X., Ci H., Li Y.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT HIS-396.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-396.
      Tissue: Lung and Teratocarcinoma.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT HIS-396.
      Tissue: Brain cortex and Kidney.
    5. "Novel Sm-like proteins with long C-terminal tails and associated methyltransferases."
      Albrecht M., Lengauer T.
      FEBS Lett. 569:18-26(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PRELIMINARY CHARACTERIZATION.

    Entry informationi

    Entry nameiZCHC4_HUMAN
    AccessioniPrimary (citable) accession number: Q9H5U6
    Secondary accession number(s): B2RXF6
    , B4DRD8, B7ZW20, Q5IW78, Q96AN7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: January 24, 2006
    Last modified: July 9, 2014
    This is version 102 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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