Q9H5U6 (ZCHC4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger CCHC domain-containing protein 4

Gene names

Name:

ZCCHC4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	513 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be a methyltransferase.
Sequence similarities	Contains 1 CCHC-type zinc finger. Contains 1 DHHC-type zinc finger.
Sequence caution	The sequence AAH16914.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB15524.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	methyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW nucleic acid binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H5U6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9H5U6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     230-513: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9H5U6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     470-472: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 513	513	Zinc finger CCHC domain-containing protein 4		PRO_0000150952
Regions
	Zinc finger	395 – 447	53	DHHC-type
	Zinc finger	443 – 460	18	CCHC-type
Natural variations
	Alternative sequence	230 – 513	284	Missing in isoform 2.		VSP_043359
	Alternative sequence	470 – 472	3	Missing in isoform 3.		VSP_043360
	Natural variant	382	1	P → L. Corresponds to variant rs3752873 [ dbSNP | Ensembl ].		VAR_053751
	Natural variant	396	1	L → H. Ref.2 Ref.3 Ref.4 Corresponds to variant rs315675 [ dbSNP | Ensembl ].		VAR_024925
Experimental info
	Sequence conflict	348	1	H → R in BAG61250. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 24, 2006. Version 3. Checksum: D74690827DC935F4	FASTA	513	59,010
	10 20 30 40 50 60 MAASRNGFEA VEAEGSAGCR GSSGMEVVLP LDPAVPAPLC PHGPTLLFVK VTQGKEETRR 70 80 90 100 110 120 FYACSACRDR KDCNFFQWED EKLSGARLAA REAHNRRCQP PLSRTQCVER YLKFIELPLT 130 140 150 160 170 180 QRKFCQTCQQ LLLPDDWGQH SEHQVLGNVS ITQLRRPSQL LYPLENKKTN AQYLFADRSC 190 200 210 220 230 240 QFLVDLLSAL GFRRVLCVGT PRLHELIKLT ASGDKKSNIK SLLLDIDFRY SQFYMEDSFC 250 260 270 280 290 300 HYNMFNHHFF DGKTALEVCR AFLQEDKGEG IIMVTDPPFG GLVEPLAITF KKLIAMWKEG 310 320 330 340 350 360 QSQDDSHKEL PIFWIFPYFF ESRICQFFPS FQMLDYQVDY DNHALYKHGK TGRKQSPVRI 370 380 390 400 410 420 FTNIPPNKII LPTEEGYRFC SPCQRYVSLE NQHCELCNSC TSKDGRKWNH CFLCKKCVKP 430 440 450 460 470 480 SWIHCSICNH CAVPDHSCEG PKHGCFICGE LDHKRSTCPN IATSKRANKA VRKQKQRKSN 490 500 510 KMKMETTKGQ SMNHTSATRR KKRRERAHQY LGS
	Isoform 2 [UniParc]. Checksum: 20D6F1827E273314	FASTA	229	25,866
	10 20 30 40 50 60 MAASRNGFEA VEAEGSAGCR GSSGMEVVLP LDPAVPAPLC PHGPTLLFVK VTQGKEETRR 70 80 90 100 110 120 FYACSACRDR KDCNFFQWED EKLSGARLAA REAHNRRCQP PLSRTQCVER YLKFIELPLT 130 140 150 160 170 180 QRKFCQTCQQ LLLPDDWGQH SEHQVLGNVS ITQLRRPSQL LYPLENKKTN AQYLFADRSC 190 200 210 220 QFLVDLLSAL GFRRVLCVGT PRLHELIKLT ASGDKKSNIK SLLLDIDFR
	Isoform 3 [UniParc]. Checksum: A70B1ECBB327ED3B	FASTA	510	58,683
	10 20 30 40 50 60 MAASRNGFEA VEAEGSAGCR GSSGMEVVLP LDPAVPAPLC PHGPTLLFVK VTQGKEETRR 70 80 90 100 110 120 FYACSACRDR KDCNFFQWED EKLSGARLAA REAHNRRCQP PLSRTQCVER YLKFIELPLT 130 140 150 160 170 180 QRKFCQTCQQ LLLPDDWGQH SEHQVLGNVS ITQLRRPSQL LYPLENKKTN AQYLFADRSC 190 200 210 220 230 240 QFLVDLLSAL GFRRVLCVGT PRLHELIKLT ASGDKKSNIK SLLLDIDFRY SQFYMEDSFC 250 260 270 280 290 300 HYNMFNHHFF DGKTALEVCR AFLQEDKGEG IIMVTDPPFG GLVEPLAITF KKLIAMWKEG 310 320 330 340 350 360 QSQDDSHKEL PIFWIFPYFF ESRICQFFPS FQMLDYQVDY DNHALYKHGK TGRKQSPVRI 370 380 390 400 410 420 FTNIPPNKII LPTEEGYRFC SPCQRYVSLE NQHCELCNSC TSKDGRKWNH CFLCKKCVKP 430 440 450 460 470 480 SWIHCSICNH CAVPDHSCEG PKHGCFICGE LDHKRSTCPN IATSKRANKK QKQRKSNKMK 490 500 510 METTKGQSMN HTSATRRKKR RERAHQYLGS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Homo sapiens zinc finger, DHHC domain containing, similar to Mus musculus 4930449I23Rik." Yue L., Zou X., Ci H., Li Y. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Testis.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT HIS-396.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-396. Tissue: Lung and Teratocarcinoma.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT HIS-396. Tissue: Brain cortex and Kidney.
[5]	"Novel Sm-like proteins with long C-terminal tails and associated methyltransferases." Albrecht M., Lengauer T. FEBS Lett. 569:18-26(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PRELIMINARY CHARACTERIZATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY629351 mRNA. Translation: AAV41218.1. CH471069 Genomic DNA. Translation: EAW92837.1. AK299211 mRNA. Translation: BAG61250.1. AK026677 mRNA. Translation: BAB15524.1. Different initiation. BC016914 mRNA. Translation: AAH16914.1. Different initiation. BC157834 mRNA. Translation: AAI57835.1. BC171821 mRNA. Translation: AAI71821.1.
IPI	IPI00401051.
RefSeq	NP_079212.2. NM_024936.2.
UniGene	Hs.278945.
3D structure databases
ProteinModelPortal	Q9H5U6.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000303468.
PTM databases
PhosphoSite	Q9H5U6.
Polymorphism databases
DMDM	85700439.
Proteomic databases
PaxDb	Q9H5U6.
PRIDE	Q9H5U6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000302874; ENSP00000303468; ENSG00000168228. ENST00000507760; ENSP00000422115; ENSG00000168228.
GeneID	29063.
KEGG	hsa:29063.
UCSC	uc003grl.4. human.
Organism-specific databases
CTD	29063.
GeneCards	GC04P025314.
HGNC	HGNC:22917. ZCCHC4.
HPA	HPA035576.
MIM	611792. gene.
neXtProt	NX_Q9H5U6.
PharmGKB	PA134950003.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG316851.
HOGENOM	HOG000230723.
HOVERGEN	HBG056108.
InParanoid	Q9H5U6.
OMA	FADRSCQ.
OrthoDB	EOG4TTGHJ.
Gene expression databases
Bgee	Q9H5U6.
CleanEx	HS_ZCCHC4.
Genevestigator	Q9H5U6.
GermOnline	ENSG00000168228. Homo sapiens.
Family and domain databases
InterPro	IPR002052. DNA_methylase_N6_adenine_CS. IPR019369. N6_adenine_Mtase-rel_euk. IPR001878. Znf_CCHC. IPR001594. Znf_DHHC_palmitoyltrfase. IPR010666. Znf_GRF. [Graphical view]
Pfam	PF10237. N6-adenineMlase. 1 hit. PF06839. zf-GRF. 1 hit. [Graphical view]
SMART	SM00343. ZnF_C2HC. 1 hit. [Graphical view]
PROSITE	PS00092. N6_MTASE. 1 hit. PS50158. ZF_CCHC. False negative. PS50216. ZF_DHHC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ZCCHC4. human.
GenomeRNAi	29063.
NextBio	51996.
SOURCE	Search...

Entry information

Entry name

ZCHC4_HUMAN

Accession

Primary (citable) accession number: Q9H5U6
Secondary accession number(s): B2RXF6 , B4DRD8, B7ZW20, Q5IW78, Q96AN7

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	January 24, 2006
Last modified:	April 3, 2013
This is version 92 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.