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Protein

Rab GTPase-binding effector protein 2

Gene

RABEP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in membrane trafficking and in homotypic early endosome fusion.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processEndocytosis, Protein transport, Transport

Enzyme and pathway databases

SignaLinkiQ9H5N1.

Names & Taxonomyi

Protein namesi
Recommended name:
Rab GTPase-binding effector protein 2
Alternative name(s):
Rabaptin-5beta
Gene namesi
Name:RABEP2
Synonyms:RABPT5B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000177548.12.
HGNCiHGNC:24817. RABEP2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi79874.
OpenTargetsiENSG00000177548.
PharmGKBiPA134952719.

Polymorphism and mutation databases

BioMutaiRABEP2.
DMDMi47606049.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001875592 – 569Rab GTPase-binding effector protein 2Add BLAST568

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei189PhosphoserineBy similarity1
Modified residuei193PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9H5N1.
MaxQBiQ9H5N1.
PaxDbiQ9H5N1.
PeptideAtlasiQ9H5N1.
PRIDEiQ9H5N1.

PTM databases

iPTMnetiQ9H5N1.
PhosphoSitePlusiQ9H5N1.

Expressioni

Gene expression databases

BgeeiENSG00000177548.
CleanExiHS_RABEP2.
ExpressionAtlasiQ9H5N1. baseline and differential.
GenevisibleiQ9H5N1. HS.

Organism-specific databases

HPAiHPA047641.

Interactioni

Subunit structurei

Heterodimer with RABGEF1. The dimer binds RAB5A that has been activated by GTP-binding.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122962. 38 interactors.
IntActiQ9H5N1. 7 interactors.
STRINGi9606.ENSP00000350934.

Structurei

3D structure databases

ProteinModelPortaliQ9H5N1.
SMRiQ9H5N1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili34 – 187Sequence analysisAdd BLAST154
Coiled coili289 – 523Sequence analysisAdd BLAST235

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi109 – 113Poly-Gln5

Sequence similaritiesi

Belongs to the rabaptin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0993. Eukaryota.
ENOG410XSZ1. LUCA.
GeneTreeiENSGT00530000063743.
HOGENOMiHOG000154063.
HOVERGENiHBG108391.
InParanoidiQ9H5N1.
KOiK20130.
OMAiEGRQLQK.
OrthoDBiEOG091G0H2C.
PhylomeDBiQ9H5N1.
TreeFamiTF329365.

Family and domain databases

InterProiView protein in InterPro
IPR003914. Rabaptin.
IPR029882. Rabaptin-5beta.
IPR018514. Rabaptin_coiled-coil.
IPR015390. Rabaptin_Rab5-bd_dom.
PANTHERiPTHR31179:SF6. PTHR31179:SF6. 1 hit.
PfamiView protein in Pfam
PF09311. Rab5-bind. 1 hit.
PF03528. Rabaptin. 1 hit.
PRINTSiPR01432. RABAPTIN.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H5N1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAPVAAD DDERRRRPGA ALEDSRSQEG ANGEAESGEL SRLRAELAGA
60 70 80 90 100
LAEMETMKAV AEVSESTKAE AVAAVQRQCQ EEVASLQAIL KDSISSYEAQ
110 120 130 140 150
ITALKQERQQ QQQDCEEKER ELGRLKQLLS RAYPLDSLEK QMEKAHEDSE
160 170 180 190 200
KLREIVLPME KEIEELKAKL LRAEELIQEI QRRPRHAPSL HGSTELLPLS
210 220 230 240 250
RDPSPPLEPL EELSGDGGPA AEAFAHNCDD SASISSFSLG GGVGSSSSLP
260 270 280 290 300
QSRQGLSPEQ EETASLVSTG TLVPEGIYLP PPGYQLVPDT QWEQLQTEGR
310 320 330 340 350
QLQKDLESVS RERDELQEGL RRSNEDCAKQ MQVLLAQVQN SEQLLRTLQG
360 370 380 390 400
TVSQAQERVQ LQMAELVTTH KCLHHEVKRL NEENQGLRAE QLPSSAPQGS
410 420 430 440 450
QQEQGEEESL PSSVPELQQL LCCTRQEARA RLQAQEHGAE RLRIEIVTLR
460 470 480 490 500
EALEEETVAR ASLEGQLRVQ REETEVLEAS LCSLRTEMER VQQEQSKAQL
510 520 530 540 550
PDLLSEQRAK VLRLQAELET SEQVQRDFVR LSQALQVRLE RIRQAETLEQ
560
VRSIMDEAPL TDVRDIKDT
Length:569
Mass (Da):63,543
Last modified:May 24, 2004 - v2
Checksum:i47451AAFA40CF23D
GO
Isoform 2 (identifier: Q9H5N1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     299-330: Missing.
     475-478: Missing.

Note: No experimental confirmation available.
Show »
Length:533
Mass (Da):59,316
Checksum:iD32A5480B6A261D3
GO

Sequence cautioni

The sequence BAB15594 differs from that shown. Reason: Frameshift at position 524.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010458299 – 330Missing in isoform 2. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_010459475 – 478Missing in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026935 mRNA. Translation: BAB15594.1. Frameshift.
BC058900 mRNA. Translation: AAH58900.1.
CCDSiCCDS42140.1. [Q9H5N1-1]
RefSeqiNP_079092.2. NM_024816.2. [Q9H5N1-1]
UniGeneiHs.555978.

Genome annotation databases

EnsembliENST00000357573; ENSP00000350186; ENSG00000177548. [Q9H5N1-2]
ENST00000358201; ENSP00000350934; ENSG00000177548. [Q9H5N1-1]
GeneIDi79874.
KEGGihsa:79874.
UCSCiuc002drq.4. human. [Q9H5N1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRABE2_HUMAN
AccessioniPrimary (citable) accession number: Q9H5N1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: October 25, 2017
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families