Q9H5L6 (THAP9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA transposase THAP9
EC=2.7.7.-

Alternative name(s):
THAP domain-containing protein 9
Short name=hTh9

Gene names

Name:

THAP9

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	903 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Active transposase that specifically recognizes the bipartite 5'-TXXGGGX(A/T)-3' consensus motif and mediates transposition. Ref.3 Ref.4
Miscellaneous	Able to mediate mobilization of P-elements when transfected in Drosophila (Ref.4).
Sequence similarities	Contains 1 THAP-type zinc finger.

Ontologies

Keywords
Biological process	DNA integration DNA recombination
Coding sequence diversity	Polymorphism
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA integration Inferred from direct assay Ref.4. Source: UniProtKB transposition, DNA-mediated Inferred from direct assay Ref.4. Source: UniProtKB
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding Inferred from direct assay Ref.3. Source: UniProtKB transferase activity Inferred from electronic annotation. Source: UniProtKB-KW transposase activity Inferred from direct assay Ref.4. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 903	903	DNA transposase THAP9		PRO_0000317246
Regions
	Zinc finger	1 – 89	89	THAP-type
	Motif	123 – 126	4	HCFC1-binding motif (HBM) By similarity
Natural variations
	Natural variant	284	1	M → I. Ref.1 Corresponds to variant rs1031639 [ dbSNP | Ensembl ].		VAR_038486
	Natural variant	299	1	L → F. Ref.1 Corresponds to variant rs897945 [ dbSNP | Ensembl ].		VAR_038487
	Natural variant	812	1	N → D. Ref.1 Corresponds to variant rs6535411 [ dbSNP | Ensembl ].		VAR_038488
	Natural variant	833	1	V → I. Corresponds to variant rs35532215 [ dbSNP | Ensembl ].		VAR_061842
Experimental info
	Sequence conflict	174	1	L → I in BAB15609. Ref.1
	Sequence conflict	491	1	E → G in BAB15609. Ref.1
	Sequence conflict	875	1	S → P in BAG52354. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9H5L6 [UniParc]. Last modified February 5, 2008. Version 2. Checksum: 64DA9DADA3D80353	FASTA	903	103,411
	10 20 30 40 50 60 MTRSCSAVGC STRDTVLSRE RGLSFHQFPT DTIQRSKWIR AVNRVDPRSK KIWIPGPGAI 70 80 90 100 110 120 LCSKHFQESD FESYGIRRKL KKGAVPSVSL YKIPQGVHLK GKARQKILKQ PLPDNSQEVA 130 140 150 160 170 180 TEDHNYSLKT PLTIGAEKLA EVQQMLQVSK KRLISVKNYR MIKKRKGLRL IDALVEEKLL 190 200 210 220 230 240 SEETECLLRA QFSDFKWELY NWRETDEYSA EMKQFACTLY LCSSKVYDYV RKILKLPHSS 250 260 270 280 290 300 ILRTWLSKCQ PSPGFNSNIF SFLQRRVENG DQLYQYCSLL IKSMPLKQQL QWDPSSHSLQ 310 320 330 340 350 360 GFMDFGLGKL DADETPLASE TVLLMAVGIF GHWRTPLGYF FVNRASGYLQ AQLLRLTIGK 370 380 390 400 410 420 LSDIGITVLA VTSDATAHSV QMAKALGIHI DGDDMKCTFQ HPSSSSQQIA YFFDSCHLLR 430 440 450 460 470 480 LIRNAFQNFQ SIQFINGIAH WQHLVELVAL EEQELSNMER IPSTLANLKN HVLKVNSATQ 490 500 510 520 530 540 LFSESVASAL EYLLSLDLPP FQNCIGTIHF LRLINNLFDI FNSRNCYGKG LKGPLLPETY 550 560 570 580 590 600 SKINHVLIEA KTIFVTLSDT SNNQIIKGKQ KLGFLGFLLN AESLKWLYQN YVFPKVMPFP 610 620 630 640 650 660 YLLTYKFSHD HLELFLKMLR QVLVTSSSPT CMAFQKAYYN LETRYKFQDE VFLSKVSIFD 670 680 690 700 710 720 ISIARRKDLA LWTVQRQYGV SVTKTVFHEE GICQDWSHCS LSEALLDLSD HRRNLICYAG 730 740 750 760 770 780 YVANKLSALL TCEDCITALY ASDLKASKIG SLLFVKKKNG LHFPSESLCR VINICERVVR 790 800 810 820 830 840 THSRMAIFEL VSKQRELYLQ QKILCELSGH INLFVDVNKH LFDGEVCAIN HFVKLLKDII 850 860 870 880 890 900 ICFLNIRAKN VAQNPLKHHS ERTDMKTLSR KHWSSVQDYK CSSFANTSSK FRHLLSNDGY PFK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-284; PHE-299 AND ASP-812. Tissue: Brain.
[2]	"Homologs of Drosophila P transposons were mobile in zebrafish but have been domesticated in a common ancestor of chicken and human." Hammer S.E., Strehl S., Hagemann S. Mol. Biol. Evol. 22:833-844(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 351-583.
[3]	"THAP proteins target specific DNA sites through bipartite recognition of adjacent major and minor grooves." Sabogal A., Lyubimov A.Y., Corn J.E., Berger J.M., Rio D.C. Nat. Struct. Mol. Biol. 17:117-123(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, DNA-BINDING.
[4]	"The human THAP9 gene encodes an active P-element DNA transposase." Majumdar S., Singh A., Rio D.C. Science 339:446-448(2013) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK026973 mRNA. Translation: BAB15609.1. AK091412 mRNA. Translation: BAG52354.1. AJ717666 Genomic DNA. Translation: CAG30691.1.
IPI	IPI00885067.
RefSeq	NP_078948.3. NM_024672.4.
UniGene	Hs.582050.
3D structure databases
ProteinModelPortal	Q9H5L6.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000305533.
PTM databases
PhosphoSite	Q9H5L6.
Polymorphism databases
DMDM	166987614.
Proteomic databases
PaxDb	Q9H5L6.
PRIDE	Q9H5L6.
Protocols and materials databases
DNASU	79725.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000302236; ENSP00000305533; ENSG00000168152. ENST00000536314; ENSP00000443638; ENSG00000168152.
GeneID	79725.
KEGG	hsa:79725.
UCSC	uc003hns.1. human.
Organism-specific databases
CTD	79725.
GeneCards	GC04P083821.
H-InvDB	HIX0004338.
HGNC	HGNC:23192. THAP9.
HPA	HPA037421.
MIM	612537. gene.
neXtProt	NX_Q9H5L6.
PharmGKB	PA134981371.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG72787.
HOGENOM	HOG000154567.
HOVERGEN	HBG101681.
InParanoid	Q9H5L6.
OMA	GFLLNAE.
OrthoDB	EOG4G4GPP.
PhylomeDB	Q9H5L6.
Gene expression databases
ArrayExpress	Q9H5L6.
Bgee	Q9H5L6.
CleanEx	HS_THAP9.
Genevestigator	Q9H5L6.
Family and domain databases
InterPro	IPR006612. Znf_C2CH. [Graphical view]
Pfam	PF05485. THAP. 1 hit. [Graphical view]
SMART	SM00692. DM3. 1 hit. SM00980. THAP. 1 hit. [Graphical view]
PROSITE	PS50950. ZF_THAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	79725.
NextBio	35469517.
SOURCE	Search...

Entry information

Entry name

THAP9_HUMAN

Accession

Primary (citable) accession number: Q9H5L6
Secondary accession number(s): B3KRE2, Q59AC9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	February 5, 2008
Last modified:	May 1, 2013
This is version 65 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.