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Q9H5L6

- THAP9_HUMAN

UniProt

Q9H5L6 - THAP9_HUMAN

Protein

DNA transposase THAP9

Gene

THAP9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 2 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Active transposase that specifically recognizes the bipartite 5'-TXXGGGX(A/T)-3' consensus motif and mediates transposition.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri1 – 8989THAP-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. sequence-specific DNA binding Source: UniProtKB
    3. transferase activity Source: UniProtKB-KW
    4. transposase activity Source: UniProtKB

    GO - Biological processi

    1. DNA integration Source: UniProtKB
    2. DNA recombination Source: UniProtKB
    3. transposition, DNA-mediated Source: UniProtKB

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    DNA integration, DNA recombination

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA transposase THAP9 (EC:2.7.7.-)
    Alternative name(s):
    THAP domain-containing protein 9
    Short name:
    hTh9
    Gene namesi
    Name:THAP9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:23192. THAP9.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134981371.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 903903DNA transposase THAP9PRO_0000317246Add
    BLAST

    Proteomic databases

    MaxQBiQ9H5L6.
    PaxDbiQ9H5L6.
    PRIDEiQ9H5L6.

    PTM databases

    PhosphoSiteiQ9H5L6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H5L6.
    BgeeiQ9H5L6.
    CleanExiHS_THAP9.
    GenevestigatoriQ9H5L6.

    Organism-specific databases

    HPAiHPA037421.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000305533.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H5L6.
    SMRiQ9H5L6. Positions 1-88.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi123 – 1264HCFC1-binding motif (HBM)By similarity

    Sequence similaritiesi

    Contains 1 THAP-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri1 – 8989THAP-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG72787.
    HOGENOMiHOG000154567.
    HOVERGENiHBG101681.
    InParanoidiQ9H5L6.
    OMAiSLKWLYQ.
    OrthoDBiEOG7MH11X.
    PhylomeDBiQ9H5L6.
    TreeFamiTF328542.

    Family and domain databases

    InterProiIPR006612. Znf_C2CH.
    [Graphical view]
    PfamiPF05485. THAP. 1 hit.
    [Graphical view]
    SMARTiSM00692. DM3. 1 hit.
    SM00980. THAP. 1 hit.
    [Graphical view]
    PROSITEiPS50950. ZF_THAP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9H5L6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTRSCSAVGC STRDTVLSRE RGLSFHQFPT DTIQRSKWIR AVNRVDPRSK    50
    KIWIPGPGAI LCSKHFQESD FESYGIRRKL KKGAVPSVSL YKIPQGVHLK 100
    GKARQKILKQ PLPDNSQEVA TEDHNYSLKT PLTIGAEKLA EVQQMLQVSK 150
    KRLISVKNYR MIKKRKGLRL IDALVEEKLL SEETECLLRA QFSDFKWELY 200
    NWRETDEYSA EMKQFACTLY LCSSKVYDYV RKILKLPHSS ILRTWLSKCQ 250
    PSPGFNSNIF SFLQRRVENG DQLYQYCSLL IKSMPLKQQL QWDPSSHSLQ 300
    GFMDFGLGKL DADETPLASE TVLLMAVGIF GHWRTPLGYF FVNRASGYLQ 350
    AQLLRLTIGK LSDIGITVLA VTSDATAHSV QMAKALGIHI DGDDMKCTFQ 400
    HPSSSSQQIA YFFDSCHLLR LIRNAFQNFQ SIQFINGIAH WQHLVELVAL 450
    EEQELSNMER IPSTLANLKN HVLKVNSATQ LFSESVASAL EYLLSLDLPP 500
    FQNCIGTIHF LRLINNLFDI FNSRNCYGKG LKGPLLPETY SKINHVLIEA 550
    KTIFVTLSDT SNNQIIKGKQ KLGFLGFLLN AESLKWLYQN YVFPKVMPFP 600
    YLLTYKFSHD HLELFLKMLR QVLVTSSSPT CMAFQKAYYN LETRYKFQDE 650
    VFLSKVSIFD ISIARRKDLA LWTVQRQYGV SVTKTVFHEE GICQDWSHCS 700
    LSEALLDLSD HRRNLICYAG YVANKLSALL TCEDCITALY ASDLKASKIG 750
    SLLFVKKKNG LHFPSESLCR VINICERVVR THSRMAIFEL VSKQRELYLQ 800
    QKILCELSGH INLFVDVNKH LFDGEVCAIN HFVKLLKDII ICFLNIRAKN 850
    VAQNPLKHHS ERTDMKTLSR KHWSSVQDYK CSSFANTSSK FRHLLSNDGY 900
    PFK 903
    Length:903
    Mass (Da):103,411
    Last modified:February 5, 2008 - v2
    Checksum:i64DA9DADA3D80353
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti174 – 1741L → I in BAB15609. (PubMed:14702039)Curated
    Sequence conflicti491 – 4911E → G in BAB15609. (PubMed:14702039)Curated
    Sequence conflicti875 – 8751S → P in BAG52354. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti284 – 2841M → I.1 Publication
    Corresponds to variant rs1031639 [ dbSNP | Ensembl ].
    VAR_038486
    Natural varianti299 – 2991L → F.1 Publication
    Corresponds to variant rs897945 [ dbSNP | Ensembl ].
    VAR_038487
    Natural varianti812 – 8121N → D.1 Publication
    Corresponds to variant rs6535411 [ dbSNP | Ensembl ].
    VAR_038488
    Natural varianti833 – 8331V → I.
    Corresponds to variant rs35532215 [ dbSNP | Ensembl ].
    VAR_061842

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK026973 mRNA. Translation: BAB15609.1.
    AK091412 mRNA. Translation: BAG52354.1.
    AJ717666 Genomic DNA. Translation: CAG30691.1.
    CCDSiCCDS3598.1.
    RefSeqiNP_078948.3. NM_024672.4.
    UniGeneiHs.582050.

    Genome annotation databases

    EnsembliENST00000302236; ENSP00000305533; ENSG00000168152.
    GeneIDi79725.
    KEGGihsa:79725.
    UCSCiuc003hns.1. human.

    Polymorphism databases

    DMDMi166987614.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK026973 mRNA. Translation: BAB15609.1 .
    AK091412 mRNA. Translation: BAG52354.1 .
    AJ717666 Genomic DNA. Translation: CAG30691.1 .
    CCDSi CCDS3598.1.
    RefSeqi NP_078948.3. NM_024672.4.
    UniGenei Hs.582050.

    3D structure databases

    ProteinModelPortali Q9H5L6.
    SMRi Q9H5L6. Positions 1-88.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000305533.

    PTM databases

    PhosphoSitei Q9H5L6.

    Polymorphism databases

    DMDMi 166987614.

    Proteomic databases

    MaxQBi Q9H5L6.
    PaxDbi Q9H5L6.
    PRIDEi Q9H5L6.

    Protocols and materials databases

    DNASUi 79725.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000302236 ; ENSP00000305533 ; ENSG00000168152 .
    GeneIDi 79725.
    KEGGi hsa:79725.
    UCSCi uc003hns.1. human.

    Organism-specific databases

    CTDi 79725.
    GeneCardsi GC04P083821.
    H-InvDB HIX0004338.
    HGNCi HGNC:23192. THAP9.
    HPAi HPA037421.
    MIMi 612537. gene.
    neXtProti NX_Q9H5L6.
    PharmGKBi PA134981371.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG72787.
    HOGENOMi HOG000154567.
    HOVERGENi HBG101681.
    InParanoidi Q9H5L6.
    OMAi SLKWLYQ.
    OrthoDBi EOG7MH11X.
    PhylomeDBi Q9H5L6.
    TreeFami TF328542.

    Miscellaneous databases

    GenomeRNAii 79725.
    NextBioi 35469517.
    PROi Q9H5L6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H5L6.
    Bgeei Q9H5L6.
    CleanExi HS_THAP9.
    Genevestigatori Q9H5L6.

    Family and domain databases

    InterProi IPR006612. Znf_C2CH.
    [Graphical view ]
    Pfami PF05485. THAP. 1 hit.
    [Graphical view ]
    SMARTi SM00692. DM3. 1 hit.
    SM00980. THAP. 1 hit.
    [Graphical view ]
    PROSITEi PS50950. ZF_THAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-284; PHE-299 AND ASP-812.
      Tissue: Brain.
    2. "Homologs of Drosophila P transposons were mobile in zebrafish but have been domesticated in a common ancestor of chicken and human."
      Hammer S.E., Strehl S., Hagemann S.
      Mol. Biol. Evol. 22:833-844(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 351-583.
    3. "THAP proteins target specific DNA sites through bipartite recognition of adjacent major and minor grooves."
      Sabogal A., Lyubimov A.Y., Corn J.E., Berger J.M., Rio D.C.
      Nat. Struct. Mol. Biol. 17:117-123(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DNA-BINDING.
    4. "The human THAP9 gene encodes an active P-element DNA transposase."
      Majumdar S., Singh A., Rio D.C.
      Science 339:446-448(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiTHAP9_HUMAN
    AccessioniPrimary (citable) accession number: Q9H5L6
    Secondary accession number(s): B3KRE2, Q59AC9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 74 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Able to mediate mobilization of P-elements when transfected in Drosophila.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3