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Q9H5L6

- THAP9_HUMAN

UniProt

Q9H5L6 - THAP9_HUMAN

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Protein
DNA transposase THAP9
Gene
THAP9
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Active transposase that specifically recognizes the bipartite 5'-TXXGGGX(A/T)-3' consensus motif and mediates transposition.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1 – 8989THAP-type
Add
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. sequence-specific DNA binding Source: UniProtKB
  3. transferase activity Source: UniProtKB-KW
  4. transposase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. DNA integration Source: UniProtKB
  2. DNA recombination Source: UniProtKB
  3. transposition, DNA-mediated Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

DNA integration, DNA recombination

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
DNA transposase THAP9 (EC:2.7.7.-)
Alternative name(s):
THAP domain-containing protein 9
Short name:
hTh9
Gene namesi
Name:THAP9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:23192. THAP9.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134981371.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 903903DNA transposase THAP9
PRO_0000317246Add
BLAST

Proteomic databases

MaxQBiQ9H5L6.
PaxDbiQ9H5L6.
PRIDEiQ9H5L6.

PTM databases

PhosphoSiteiQ9H5L6.

Expressioni

Gene expression databases

ArrayExpressiQ9H5L6.
BgeeiQ9H5L6.
CleanExiHS_THAP9.
GenevestigatoriQ9H5L6.

Organism-specific databases

HPAiHPA037421.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000305533.

Structurei

3D structure databases

ProteinModelPortaliQ9H5L6.
SMRiQ9H5L6. Positions 1-88.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi123 – 1264HCFC1-binding motif (HBM) By similarity

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG72787.
HOGENOMiHOG000154567.
HOVERGENiHBG101681.
InParanoidiQ9H5L6.
OMAiSLKWLYQ.
OrthoDBiEOG7MH11X.
PhylomeDBiQ9H5L6.
TreeFamiTF328542.

Family and domain databases

InterProiIPR006612. Znf_C2CH.
[Graphical view]
PfamiPF05485. THAP. 1 hit.
[Graphical view]
SMARTiSM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view]
PROSITEiPS50950. ZF_THAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H5L6-1 [UniParc]FASTAAdd to Basket

« Hide

MTRSCSAVGC STRDTVLSRE RGLSFHQFPT DTIQRSKWIR AVNRVDPRSK    50
KIWIPGPGAI LCSKHFQESD FESYGIRRKL KKGAVPSVSL YKIPQGVHLK 100
GKARQKILKQ PLPDNSQEVA TEDHNYSLKT PLTIGAEKLA EVQQMLQVSK 150
KRLISVKNYR MIKKRKGLRL IDALVEEKLL SEETECLLRA QFSDFKWELY 200
NWRETDEYSA EMKQFACTLY LCSSKVYDYV RKILKLPHSS ILRTWLSKCQ 250
PSPGFNSNIF SFLQRRVENG DQLYQYCSLL IKSMPLKQQL QWDPSSHSLQ 300
GFMDFGLGKL DADETPLASE TVLLMAVGIF GHWRTPLGYF FVNRASGYLQ 350
AQLLRLTIGK LSDIGITVLA VTSDATAHSV QMAKALGIHI DGDDMKCTFQ 400
HPSSSSQQIA YFFDSCHLLR LIRNAFQNFQ SIQFINGIAH WQHLVELVAL 450
EEQELSNMER IPSTLANLKN HVLKVNSATQ LFSESVASAL EYLLSLDLPP 500
FQNCIGTIHF LRLINNLFDI FNSRNCYGKG LKGPLLPETY SKINHVLIEA 550
KTIFVTLSDT SNNQIIKGKQ KLGFLGFLLN AESLKWLYQN YVFPKVMPFP 600
YLLTYKFSHD HLELFLKMLR QVLVTSSSPT CMAFQKAYYN LETRYKFQDE 650
VFLSKVSIFD ISIARRKDLA LWTVQRQYGV SVTKTVFHEE GICQDWSHCS 700
LSEALLDLSD HRRNLICYAG YVANKLSALL TCEDCITALY ASDLKASKIG 750
SLLFVKKKNG LHFPSESLCR VINICERVVR THSRMAIFEL VSKQRELYLQ 800
QKILCELSGH INLFVDVNKH LFDGEVCAIN HFVKLLKDII ICFLNIRAKN 850
VAQNPLKHHS ERTDMKTLSR KHWSSVQDYK CSSFANTSSK FRHLLSNDGY 900
PFK 903
Length:903
Mass (Da):103,411
Last modified:February 5, 2008 - v2
Checksum:i64DA9DADA3D80353
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti284 – 2841M → I.1 Publication
Corresponds to variant rs1031639 [ dbSNP | Ensembl ].
VAR_038486
Natural varianti299 – 2991L → F.1 Publication
Corresponds to variant rs897945 [ dbSNP | Ensembl ].
VAR_038487
Natural varianti812 – 8121N → D.1 Publication
Corresponds to variant rs6535411 [ dbSNP | Ensembl ].
VAR_038488
Natural varianti833 – 8331V → I.
Corresponds to variant rs35532215 [ dbSNP | Ensembl ].
VAR_061842

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti174 – 1741L → I in BAB15609. 1 Publication
Sequence conflicti491 – 4911E → G in BAB15609. 1 Publication
Sequence conflicti875 – 8751S → P in BAG52354. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK026973 mRNA. Translation: BAB15609.1.
AK091412 mRNA. Translation: BAG52354.1.
AJ717666 Genomic DNA. Translation: CAG30691.1.
CCDSiCCDS3598.1.
RefSeqiNP_078948.3. NM_024672.4.
UniGeneiHs.582050.

Genome annotation databases

EnsembliENST00000302236; ENSP00000305533; ENSG00000168152.
GeneIDi79725.
KEGGihsa:79725.
UCSCiuc003hns.1. human.

Polymorphism databases

DMDMi166987614.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK026973 mRNA. Translation: BAB15609.1 .
AK091412 mRNA. Translation: BAG52354.1 .
AJ717666 Genomic DNA. Translation: CAG30691.1 .
CCDSi CCDS3598.1.
RefSeqi NP_078948.3. NM_024672.4.
UniGenei Hs.582050.

3D structure databases

ProteinModelPortali Q9H5L6.
SMRi Q9H5L6. Positions 1-88.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000305533.

PTM databases

PhosphoSitei Q9H5L6.

Polymorphism databases

DMDMi 166987614.

Proteomic databases

MaxQBi Q9H5L6.
PaxDbi Q9H5L6.
PRIDEi Q9H5L6.

Protocols and materials databases

DNASUi 79725.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000302236 ; ENSP00000305533 ; ENSG00000168152 .
GeneIDi 79725.
KEGGi hsa:79725.
UCSCi uc003hns.1. human.

Organism-specific databases

CTDi 79725.
GeneCardsi GC04P083821.
H-InvDBi HIX0004338.
HGNCi HGNC:23192. THAP9.
HPAi HPA037421.
MIMi 612537. gene.
neXtProti NX_Q9H5L6.
PharmGKBi PA134981371.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG72787.
HOGENOMi HOG000154567.
HOVERGENi HBG101681.
InParanoidi Q9H5L6.
OMAi SLKWLYQ.
OrthoDBi EOG7MH11X.
PhylomeDBi Q9H5L6.
TreeFami TF328542.

Miscellaneous databases

GenomeRNAii 79725.
NextBioi 35469517.
PROi Q9H5L6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9H5L6.
Bgeei Q9H5L6.
CleanExi HS_THAP9.
Genevestigatori Q9H5L6.

Family and domain databases

InterProi IPR006612. Znf_C2CH.
[Graphical view ]
Pfami PF05485. THAP. 1 hit.
[Graphical view ]
SMARTi SM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view ]
PROSITEi PS50950. ZF_THAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-284; PHE-299 AND ASP-812.
    Tissue: Brain.
  2. "Homologs of Drosophila P transposons were mobile in zebrafish but have been domesticated in a common ancestor of chicken and human."
    Hammer S.E., Strehl S., Hagemann S.
    Mol. Biol. Evol. 22:833-844(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 351-583.
  3. "THAP proteins target specific DNA sites through bipartite recognition of adjacent major and minor grooves."
    Sabogal A., Lyubimov A.Y., Corn J.E., Berger J.M., Rio D.C.
    Nat. Struct. Mol. Biol. 17:117-123(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DNA-BINDING.
  4. "The human THAP9 gene encodes an active P-element DNA transposase."
    Majumdar S., Singh A., Rio D.C.
    Science 339:446-448(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiTHAP9_HUMAN
AccessioniPrimary (citable) accession number: Q9H5L6
Secondary accession number(s): B3KRE2, Q59AC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: July 9, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Able to mediate mobilization of P-elements when transfected in Drosophila (1 Publication).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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