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Protein

DNA transposase THAP9

Gene

THAP9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Active transposase that specifically recognizes the bipartite 5'-TXXGGGX(A/T)-3' consensus motif and mediates transposition.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1 – 8989THAP-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. sequence-specific DNA binding Source: UniProtKB
  3. transferase activity Source: UniProtKB-KW
  4. transposase activity Source: UniProtKB

GO - Biological processi

  1. DNA integration Source: UniProtKB
  2. DNA recombination Source: UniProtKB
  3. transposition, DNA-mediated Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

DNA integration, DNA recombination

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
DNA transposase THAP9 (EC:2.7.7.-)
Alternative name(s):
THAP domain-containing protein 9
Short name:
hTh9
Gene namesi
Name:THAP9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:23192. THAP9.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134981371.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 903903DNA transposase THAP9PRO_0000317246Add
BLAST

Proteomic databases

MaxQBiQ9H5L6.
PaxDbiQ9H5L6.
PRIDEiQ9H5L6.

PTM databases

PhosphoSiteiQ9H5L6.

Expressioni

Gene expression databases

BgeeiQ9H5L6.
CleanExiHS_THAP9.
ExpressionAtlasiQ9H5L6. baseline and differential.
GenevestigatoriQ9H5L6.

Organism-specific databases

HPAiHPA037421.

Interactioni

Protein-protein interaction databases

BioGridi122840. 1 interaction.
STRINGi9606.ENSP00000305533.

Structurei

3D structure databases

ProteinModelPortaliQ9H5L6.
SMRiQ9H5L6. Positions 1-88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi123 – 1264HCFC1-binding motif (HBM)By similarity

Sequence similaritiesi

Contains 1 THAP-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1 – 8989THAP-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG72787.
GeneTreeiENSGT00530000063390.
HOGENOMiHOG000154567.
HOVERGENiHBG101681.
InParanoidiQ9H5L6.
OMAiSLKWLYQ.
OrthoDBiEOG7MH11X.
PhylomeDBiQ9H5L6.
TreeFamiTF328542.

Family and domain databases

InterProiIPR006612. Znf_C2CH.
[Graphical view]
PfamiPF05485. THAP. 1 hit.
[Graphical view]
SMARTiSM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view]
PROSITEiPS50950. ZF_THAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H5L6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTRSCSAVGC STRDTVLSRE RGLSFHQFPT DTIQRSKWIR AVNRVDPRSK
60 70 80 90 100
KIWIPGPGAI LCSKHFQESD FESYGIRRKL KKGAVPSVSL YKIPQGVHLK
110 120 130 140 150
GKARQKILKQ PLPDNSQEVA TEDHNYSLKT PLTIGAEKLA EVQQMLQVSK
160 170 180 190 200
KRLISVKNYR MIKKRKGLRL IDALVEEKLL SEETECLLRA QFSDFKWELY
210 220 230 240 250
NWRETDEYSA EMKQFACTLY LCSSKVYDYV RKILKLPHSS ILRTWLSKCQ
260 270 280 290 300
PSPGFNSNIF SFLQRRVENG DQLYQYCSLL IKSMPLKQQL QWDPSSHSLQ
310 320 330 340 350
GFMDFGLGKL DADETPLASE TVLLMAVGIF GHWRTPLGYF FVNRASGYLQ
360 370 380 390 400
AQLLRLTIGK LSDIGITVLA VTSDATAHSV QMAKALGIHI DGDDMKCTFQ
410 420 430 440 450
HPSSSSQQIA YFFDSCHLLR LIRNAFQNFQ SIQFINGIAH WQHLVELVAL
460 470 480 490 500
EEQELSNMER IPSTLANLKN HVLKVNSATQ LFSESVASAL EYLLSLDLPP
510 520 530 540 550
FQNCIGTIHF LRLINNLFDI FNSRNCYGKG LKGPLLPETY SKINHVLIEA
560 570 580 590 600
KTIFVTLSDT SNNQIIKGKQ KLGFLGFLLN AESLKWLYQN YVFPKVMPFP
610 620 630 640 650
YLLTYKFSHD HLELFLKMLR QVLVTSSSPT CMAFQKAYYN LETRYKFQDE
660 670 680 690 700
VFLSKVSIFD ISIARRKDLA LWTVQRQYGV SVTKTVFHEE GICQDWSHCS
710 720 730 740 750
LSEALLDLSD HRRNLICYAG YVANKLSALL TCEDCITALY ASDLKASKIG
760 770 780 790 800
SLLFVKKKNG LHFPSESLCR VINICERVVR THSRMAIFEL VSKQRELYLQ
810 820 830 840 850
QKILCELSGH INLFVDVNKH LFDGEVCAIN HFVKLLKDII ICFLNIRAKN
860 870 880 890 900
VAQNPLKHHS ERTDMKTLSR KHWSSVQDYK CSSFANTSSK FRHLLSNDGY

PFK
Length:903
Mass (Da):103,411
Last modified:February 5, 2008 - v2
Checksum:i64DA9DADA3D80353
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti174 – 1741L → I in BAB15609. (PubMed:14702039)Curated
Sequence conflicti491 – 4911E → G in BAB15609. (PubMed:14702039)Curated
Sequence conflicti875 – 8751S → P in BAG52354. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti284 – 2841M → I.1 Publication
Corresponds to variant rs1031639 [ dbSNP | Ensembl ].
VAR_038486
Natural varianti299 – 2991L → F.1 Publication
Corresponds to variant rs897945 [ dbSNP | Ensembl ].
VAR_038487
Natural varianti812 – 8121N → D.1 Publication
Corresponds to variant rs6535411 [ dbSNP | Ensembl ].
VAR_038488
Natural varianti833 – 8331V → I.
Corresponds to variant rs35532215 [ dbSNP | Ensembl ].
VAR_061842

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026973 mRNA. Translation: BAB15609.1.
AK091412 mRNA. Translation: BAG52354.1.
AJ717666 Genomic DNA. Translation: CAG30691.1.
CCDSiCCDS3598.1.
RefSeqiNP_078948.3. NM_024672.4.
UniGeneiHs.582050.

Genome annotation databases

EnsembliENST00000302236; ENSP00000305533; ENSG00000168152.
GeneIDi79725.
KEGGihsa:79725.
UCSCiuc003hns.1. human.

Polymorphism databases

DMDMi166987614.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026973 mRNA. Translation: BAB15609.1.
AK091412 mRNA. Translation: BAG52354.1.
AJ717666 Genomic DNA. Translation: CAG30691.1.
CCDSiCCDS3598.1.
RefSeqiNP_078948.3. NM_024672.4.
UniGeneiHs.582050.

3D structure databases

ProteinModelPortaliQ9H5L6.
SMRiQ9H5L6. Positions 1-88.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122840. 1 interaction.
STRINGi9606.ENSP00000305533.

PTM databases

PhosphoSiteiQ9H5L6.

Polymorphism databases

DMDMi166987614.

Proteomic databases

MaxQBiQ9H5L6.
PaxDbiQ9H5L6.
PRIDEiQ9H5L6.

Protocols and materials databases

DNASUi79725.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302236; ENSP00000305533; ENSG00000168152.
GeneIDi79725.
KEGGihsa:79725.
UCSCiuc003hns.1. human.

Organism-specific databases

CTDi79725.
GeneCardsiGC04P083821.
H-InvDBHIX0004338.
HGNCiHGNC:23192. THAP9.
HPAiHPA037421.
MIMi612537. gene.
neXtProtiNX_Q9H5L6.
PharmGKBiPA134981371.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG72787.
GeneTreeiENSGT00530000063390.
HOGENOMiHOG000154567.
HOVERGENiHBG101681.
InParanoidiQ9H5L6.
OMAiSLKWLYQ.
OrthoDBiEOG7MH11X.
PhylomeDBiQ9H5L6.
TreeFamiTF328542.

Miscellaneous databases

GenomeRNAii79725.
NextBioi35469517.
PROiQ9H5L6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H5L6.
CleanExiHS_THAP9.
ExpressionAtlasiQ9H5L6. baseline and differential.
GenevestigatoriQ9H5L6.

Family and domain databases

InterProiIPR006612. Znf_C2CH.
[Graphical view]
PfamiPF05485. THAP. 1 hit.
[Graphical view]
SMARTiSM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view]
PROSITEiPS50950. ZF_THAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-284; PHE-299 AND ASP-812.
    Tissue: Brain.
  2. "Homologs of Drosophila P transposons were mobile in zebrafish but have been domesticated in a common ancestor of chicken and human."
    Hammer S.E., Strehl S., Hagemann S.
    Mol. Biol. Evol. 22:833-844(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 351-583.
  3. "THAP proteins target specific DNA sites through bipartite recognition of adjacent major and minor grooves."
    Sabogal A., Lyubimov A.Y., Corn J.E., Berger J.M., Rio D.C.
    Nat. Struct. Mol. Biol. 17:117-123(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DNA-BINDING.
  4. "The human THAP9 gene encodes an active P-element DNA transposase."
    Majumdar S., Singh A., Rio D.C.
    Science 339:446-448(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiTHAP9_HUMAN
AccessioniPrimary (citable) accession number: Q9H5L6
Secondary accession number(s): B3KRE2, Q59AC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: January 7, 2015
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Able to mediate mobilization of P-elements when transfected in Drosophila.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.