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Protein

TATA box-binding protein-associated factor RNA polymerase I subunit D

Gene

TAF1D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.2 Publications

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. chromatin silencing at rDNA Source: Reactome
  2. gene expression Source: Reactome
  3. negative regulation of gene expression, epigenetic Source: Reactome
  4. regulation of gene expression, epigenetic Source: Reactome
  5. termination of RNA polymerase I transcription Source: Reactome
  6. transcription elongation from RNA polymerase I promoter Source: Reactome
  7. transcription from RNA polymerase I promoter Source: Reactome
  8. transcription initiation from RNA polymerase I promoter Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_1074. RNA Polymerase I Transcription Termination.
REACT_1913. RNA Polymerase I Promoter Escape.
REACT_2204. RNA Polymerase I Chain Elongation.
REACT_263965. NoRC negatively regulates rRNA expression.
REACT_264541. SIRT1 negatively regulates rRNA Expression.
REACT_953. RNA Polymerase I Transcription Initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
TATA box-binding protein-associated factor RNA polymerase I subunit D
Alternative name(s):
RNA polymerase I-specific TBP-associated factor 41 kDa
Short name:
TAFI41
TATA box-binding protein-associated factor 1D
Short name:
TBP-associated factor 1D
Transcription initiation factor SL1/TIF-IB subunit D
Gene namesi
Name:TAF1D
Synonyms:JOSD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:28759. TAF1D.

Subcellular locationi

Nucleus 2 Publications

GO - Cellular componenti

  1. microtubule organizing center Source: HPA
  2. nucleoplasm Source: HPA
  3. RNA polymerase transcription factor SL1 complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164726421.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278TATA box-binding protein-associated factor RNA polymerase I subunit DPRO_0000250717Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231Phosphoserine1 Publication
Modified residuei138 – 1381Phosphoserine1 Publication
Modified residuei234 – 2341Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9H5J8.
PaxDbiQ9H5J8.
PRIDEiQ9H5J8.

PTM databases

PhosphoSiteiQ9H5J8.

Expressioni

Gene expression databases

BgeeiQ9H5J8.
CleanExiHS_TAF1D.
ExpressionAtlasiQ9H5J8. baseline and differential.
GenevestigatoriQ9H5J8.

Organism-specific databases

HPAiHPA055935.
HPA060385.

Interactioni

Subunit structurei

Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Interacts with UBTF.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
POLBP067464EBI-716128,EBI-713836

Protein-protein interaction databases

BioGridi122548. 46 interactions.
IntActiQ9H5J8. 38 interactions.
MINTiMINT-8247602.
STRINGi9606.ENSP00000314971.

Structurei

3D structure databases

ProteinModelPortaliQ9H5J8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG26017.
GeneTreeiENSGT00390000009061.
HOGENOMiHOG000154498.
HOVERGENiHBG096071.
InParanoidiQ9H5J8.
KOiK15215.
OMAiYKPTGRP.
OrthoDBiEOG7SV0WX.
PhylomeDBiQ9H5J8.
TreeFamiTF335756.

Family and domain databases

InterProiIPR027976. TAF1D.
[Graphical view]
PANTHERiPTHR14562. PTHR14562. 1 hit.
PfamiPF15333. TAF1D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H5J8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKSGIDSLD HVTSDAVELA NRSDNSSDSS LFKTQCIPYS PKGEKRNPIR
60 70 80 90 100
KFVRTPESVH ASDSSSDSSF EPIPLTIKAI FERFKNRKKR YKKKKKRRYQ
110 120 130 140 150
PTGRPRGRPE GRRNPIYSLI DKKKQFRSRG SGFPFLESEN EKNAPWRKIL
160 170 180 190 200
TFEQAVARGF FNYIEKLKYE HHLKESLKQM NVGEDLENED FDSRRYKFLD
210 220 230 240 250
DDGSISPIEE STAEDEDATH LEDNECDIKL AGDSFIVSSE FPVRLSVYLE
260 270
EEDITEEAAL SKKRATKAKN TGQRGLKM
Length:278
Mass (Da):32,058
Last modified:February 28, 2001 - v1
Checksum:i4BA37C73BB387446
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141S → T in CAG33650 (Ref. 3) Curated
Sequence conflicti97 – 971R → G in CAG33650 (Ref. 3) Curated
Sequence conflicti278 – 2781M → I in CAG33650 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027016 mRNA. Translation: BAB15628.1.
CR457369 mRNA. Translation: CAG33650.1.
BC001972 mRNA. Translation: AAH01972.1.
CCDSiCCDS8293.1.
RefSeqiNP_077021.1. NM_024116.3.
UniGeneiHs.355750.

Genome annotation databases

EnsembliENST00000323981; ENSP00000314971; ENSG00000166012.
ENST00000448108; ENSP00000410409; ENSG00000166012.
ENST00000526015; ENSP00000435087; ENSG00000166012.
GeneIDi79101.
KEGGihsa:79101.
UCSCiuc001ped.3. human.

Polymorphism databases

DMDMi74733586.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027016 mRNA. Translation: BAB15628.1.
CR457369 mRNA. Translation: CAG33650.1.
BC001972 mRNA. Translation: AAH01972.1.
CCDSiCCDS8293.1.
RefSeqiNP_077021.1. NM_024116.3.
UniGeneiHs.355750.

3D structure databases

ProteinModelPortaliQ9H5J8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122548. 46 interactions.
IntActiQ9H5J8. 38 interactions.
MINTiMINT-8247602.
STRINGi9606.ENSP00000314971.

PTM databases

PhosphoSiteiQ9H5J8.

Polymorphism databases

DMDMi74733586.

Proteomic databases

MaxQBiQ9H5J8.
PaxDbiQ9H5J8.
PRIDEiQ9H5J8.

Protocols and materials databases

DNASUi79101.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323981; ENSP00000314971; ENSG00000166012.
ENST00000448108; ENSP00000410409; ENSG00000166012.
ENST00000526015; ENSP00000435087; ENSG00000166012.
GeneIDi79101.
KEGGihsa:79101.
UCSCiuc001ped.3. human.

Organism-specific databases

CTDi79101.
GeneCardsiGC11M093568.
HGNCiHGNC:28759. TAF1D.
HPAiHPA055935.
HPA060385.
MIMi612823. gene.
neXtProtiNX_Q9H5J8.
PharmGKBiPA164726421.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG26017.
GeneTreeiENSGT00390000009061.
HOGENOMiHOG000154498.
HOVERGENiHBG096071.
InParanoidiQ9H5J8.
KOiK15215.
OMAiYKPTGRP.
OrthoDBiEOG7SV0WX.
PhylomeDBiQ9H5J8.
TreeFamiTF335756.

Enzyme and pathway databases

ReactomeiREACT_1074. RNA Polymerase I Transcription Termination.
REACT_1913. RNA Polymerase I Promoter Escape.
REACT_2204. RNA Polymerase I Chain Elongation.
REACT_263965. NoRC negatively regulates rRNA expression.
REACT_264541. SIRT1 negatively regulates rRNA Expression.
REACT_953. RNA Polymerase I Transcription Initiation.

Miscellaneous databases

ChiTaRSiTAF1D. human.
GenomeRNAii79101.
NextBioi67969.
PROiQ9H5J8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H5J8.
CleanExiHS_TAF1D.
ExpressionAtlasiQ9H5J8. baseline and differential.
GenevestigatoriQ9H5J8.

Family and domain databases

InterProiIPR027976. TAF1D.
[Graphical view]
PANTHERiPTHR14562. PTHR14562. 1 hit.
PfamiPF15333. TAF1D. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel nuclear protein, MGC5306 interacts with DNA polymerase beta and has a potential role in cellular phenotype."
    Wang L., Bhattacharyya N., Chelsea D.M., Escobar P.F., Banerjee S.
    Cancer Res. 64:7673-7677(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.
  5. "TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter."
    Friedrich J.K., Panov K.I., Cabart P., Russell J., Zomerdijk J.C.B.M.
    J. Biol. Chem. 280:29551-29558(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE SL1/TIF-IB COMPLEX.
  6. "A novel TBP-associated factor of SL1 functions in RNA polymerase I transcription."
    Gorski J.J., Pathak S., Panov K., Kasciukovic T., Panova T., Russell J., Zomerdijk J.C.B.M.
    EMBO J. 26:1560-1568(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE SL1/TIF-IB COMPLEX, INTERACTION WITH UBTF, SUBCELLULAR LOCATION.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-234, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTAF1D_HUMAN
AccessioniPrimary (citable) accession number: Q9H5J8
Secondary accession number(s): Q6I9Y6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2006
Last sequence update: February 28, 2001
Last modified: March 31, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.