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Q9H5J8

- TAF1D_HUMAN

UniProt

Q9H5J8 - TAF1D_HUMAN

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Protein

TATA box-binding protein-associated factor RNA polymerase I subunit D

Gene

TAF1D

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.2 Publications

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. gene expression Source: Reactome
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. termination of RNA polymerase I transcription Source: Reactome
  4. transcription elongation from RNA polymerase I promoter Source: Reactome
  5. transcription from RNA polymerase I promoter Source: Reactome
  6. transcription initiation from RNA polymerase I promoter Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_1074. RNA Polymerase I Transcription Termination.
REACT_1913. RNA Polymerase I Promoter Escape.
REACT_200827. SIRT1 negatively regulates rRNA Expression.
REACT_200856. NoRC negatively regulates rRNA expression.
REACT_2204. RNA Polymerase I Chain Elongation.
REACT_953. RNA Polymerase I Transcription Initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
TATA box-binding protein-associated factor RNA polymerase I subunit D
Alternative name(s):
RNA polymerase I-specific TBP-associated factor 41 kDa
Short name:
TAFI41
TATA box-binding protein-associated factor 1D
Short name:
TBP-associated factor 1D
Transcription initiation factor SL1/TIF-IB subunit D
Gene namesi
Name:TAF1D
Synonyms:JOSD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:28759. TAF1D.

Subcellular locationi

Nucleus 2 Publications

GO - Cellular componenti

  1. microtubule organizing center Source: HPA
  2. nucleoplasm Source: Reactome
  3. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164726421.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278TATA box-binding protein-associated factor RNA polymerase I subunit DPRO_0000250717Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231Phosphoserine1 Publication
Modified residuei138 – 1381Phosphoserine1 Publication
Modified residuei234 – 2341Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9H5J8.
PaxDbiQ9H5J8.
PRIDEiQ9H5J8.

PTM databases

PhosphoSiteiQ9H5J8.

Expressioni

Gene expression databases

BgeeiQ9H5J8.
CleanExiHS_TAF1D.
ExpressionAtlasiQ9H5J8. baseline and differential.
GenevestigatoriQ9H5J8.

Organism-specific databases

HPAiHPA055935.
HPA060385.

Interactioni

Subunit structurei

Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Interacts with UBTF.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
POLBP067464EBI-716128,EBI-713836

Protein-protein interaction databases

BioGridi122548. 46 interactions.
IntActiQ9H5J8. 38 interactions.
MINTiMINT-8247602.
STRINGi9606.ENSP00000314971.

Structurei

3D structure databases

ProteinModelPortaliQ9H5J8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG26017.
GeneTreeiENSGT00390000009061.
HOGENOMiHOG000154498.
HOVERGENiHBG096071.
InParanoidiQ9H5J8.
KOiK15215.
OMAiYKPTGRP.
OrthoDBiEOG7SV0WX.
PhylomeDBiQ9H5J8.
TreeFamiTF335756.

Family and domain databases

InterProiIPR027976. TAF1D.
[Graphical view]
PANTHERiPTHR14562. PTHR14562. 1 hit.
PfamiPF15333. TAF1D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H5J8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDKSGIDSLD HVTSDAVELA NRSDNSSDSS LFKTQCIPYS PKGEKRNPIR
60 70 80 90 100
KFVRTPESVH ASDSSSDSSF EPIPLTIKAI FERFKNRKKR YKKKKKRRYQ
110 120 130 140 150
PTGRPRGRPE GRRNPIYSLI DKKKQFRSRG SGFPFLESEN EKNAPWRKIL
160 170 180 190 200
TFEQAVARGF FNYIEKLKYE HHLKESLKQM NVGEDLENED FDSRRYKFLD
210 220 230 240 250
DDGSISPIEE STAEDEDATH LEDNECDIKL AGDSFIVSSE FPVRLSVYLE
260 270
EEDITEEAAL SKKRATKAKN TGQRGLKM
Length:278
Mass (Da):32,058
Last modified:March 1, 2001 - v1
Checksum:i4BA37C73BB387446
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141S → T in CAG33650. 1 PublicationCurated
Sequence conflicti97 – 971R → G in CAG33650. 1 PublicationCurated
Sequence conflicti278 – 2781M → I in CAG33650. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027016 mRNA. Translation: BAB15628.1.
CR457369 mRNA. Translation: CAG33650.1.
BC001972 mRNA. Translation: AAH01972.1.
CCDSiCCDS8293.1.
RefSeqiNP_077021.1. NM_024116.3.
UniGeneiHs.355750.

Genome annotation databases

EnsembliENST00000323981; ENSP00000314971; ENSG00000166012.
ENST00000448108; ENSP00000410409; ENSG00000166012.
ENST00000526015; ENSP00000435087; ENSG00000166012.
GeneIDi79101.
KEGGihsa:79101.
UCSCiuc001ped.3. human.

Polymorphism databases

DMDMi74733586.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027016 mRNA. Translation: BAB15628.1 .
CR457369 mRNA. Translation: CAG33650.1 .
BC001972 mRNA. Translation: AAH01972.1 .
CCDSi CCDS8293.1.
RefSeqi NP_077021.1. NM_024116.3.
UniGenei Hs.355750.

3D structure databases

ProteinModelPortali Q9H5J8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122548. 46 interactions.
IntActi Q9H5J8. 38 interactions.
MINTi MINT-8247602.
STRINGi 9606.ENSP00000314971.

PTM databases

PhosphoSitei Q9H5J8.

Polymorphism databases

DMDMi 74733586.

Proteomic databases

MaxQBi Q9H5J8.
PaxDbi Q9H5J8.
PRIDEi Q9H5J8.

Protocols and materials databases

DNASUi 79101.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000323981 ; ENSP00000314971 ; ENSG00000166012 .
ENST00000448108 ; ENSP00000410409 ; ENSG00000166012 .
ENST00000526015 ; ENSP00000435087 ; ENSG00000166012 .
GeneIDi 79101.
KEGGi hsa:79101.
UCSCi uc001ped.3. human.

Organism-specific databases

CTDi 79101.
GeneCardsi GC11M093568.
HGNCi HGNC:28759. TAF1D.
HPAi HPA055935.
HPA060385.
MIMi 612823. gene.
neXtProti NX_Q9H5J8.
PharmGKBi PA164726421.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG26017.
GeneTreei ENSGT00390000009061.
HOGENOMi HOG000154498.
HOVERGENi HBG096071.
InParanoidi Q9H5J8.
KOi K15215.
OMAi YKPTGRP.
OrthoDBi EOG7SV0WX.
PhylomeDBi Q9H5J8.
TreeFami TF335756.

Enzyme and pathway databases

Reactomei REACT_1074. RNA Polymerase I Transcription Termination.
REACT_1913. RNA Polymerase I Promoter Escape.
REACT_200827. SIRT1 negatively regulates rRNA Expression.
REACT_200856. NoRC negatively regulates rRNA expression.
REACT_2204. RNA Polymerase I Chain Elongation.
REACT_953. RNA Polymerase I Transcription Initiation.

Miscellaneous databases

ChiTaRSi TAF1D. human.
GenomeRNAii 79101.
NextBioi 67969.
PROi Q9H5J8.
SOURCEi Search...

Gene expression databases

Bgeei Q9H5J8.
CleanExi HS_TAF1D.
ExpressionAtlasi Q9H5J8. baseline and differential.
Genevestigatori Q9H5J8.

Family and domain databases

InterProi IPR027976. TAF1D.
[Graphical view ]
PANTHERi PTHR14562. PTHR14562. 1 hit.
Pfami PF15333. TAF1D. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel nuclear protein, MGC5306 interacts with DNA polymerase beta and has a potential role in cellular phenotype."
    Wang L., Bhattacharyya N., Chelsea D.M., Escobar P.F., Banerjee S.
    Cancer Res. 64:7673-7677(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.
  5. "TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter."
    Friedrich J.K., Panov K.I., Cabart P., Russell J., Zomerdijk J.C.B.M.
    J. Biol. Chem. 280:29551-29558(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE SL1/TIF-IB COMPLEX.
  6. "A novel TBP-associated factor of SL1 functions in RNA polymerase I transcription."
    Gorski J.J., Pathak S., Panov K., Kasciukovic T., Panova T., Russell J., Zomerdijk J.C.B.M.
    EMBO J. 26:1560-1568(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE SL1/TIF-IB COMPLEX, INTERACTION WITH UBTF, SUBCELLULAR LOCATION.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-234, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTAF1D_HUMAN
AccessioniPrimary (citable) accession number: Q9H5J8
Secondary accession number(s): Q6I9Y6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3