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Protein

TATA box-binding protein-associated factor RNA polymerase I subunit D

Gene

TAF1D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-427359. SIRT1 negatively regulates rRNA Expression.
R-HSA-427413. NoRC negatively regulates rRNA expression.
R-HSA-5250924. B-WICH complex positively regulates rRNA expression.
R-HSA-73762. RNA Polymerase I Transcription Initiation.
R-HSA-73772. RNA Polymerase I Promoter Escape.
R-HSA-73777. RNA Polymerase I Chain Elongation.
R-HSA-73863. RNA Polymerase I Transcription Termination.

Names & Taxonomyi

Protein namesi
Recommended name:
TATA box-binding protein-associated factor RNA polymerase I subunit D
Alternative name(s):
RNA polymerase I-specific TBP-associated factor 41 kDa
Short name:
TAFI41
TATA box-binding protein-associated factor 1D
Short name:
TBP-associated factor 1D
Transcription initiation factor SL1/TIF-IB subunit D
Gene namesi
Name:TAF1D
Synonyms:JOSD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000166012.14.
HGNCiHGNC:28759. TAF1D.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi79101.
OpenTargetsiENSG00000166012.
PharmGKBiPA164726421.

Polymorphism and mutation databases

BioMutaiTAF1D.
DMDMi74733586.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002507171 – 278TATA box-binding protein-associated factor RNA polymerase I subunit DAdd BLAST278

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23PhosphoserineCombined sources1
Modified residuei138PhosphoserineCombined sources1
Modified residuei234PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H5J8.
MaxQBiQ9H5J8.
PaxDbiQ9H5J8.
PeptideAtlasiQ9H5J8.
PRIDEiQ9H5J8.

PTM databases

iPTMnetiQ9H5J8.
PhosphoSitePlusiQ9H5J8.

Expressioni

Gene expression databases

BgeeiENSG00000166012.
CleanExiHS_TAF1D.
ExpressionAtlasiQ9H5J8. baseline and differential.
GenevisibleiQ9H5J8. HS.

Organism-specific databases

HPAiHPA055935.
HPA060385.

Interactioni

Subunit structurei

Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Interacts with UBTF.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi122548. 55 interactors.
IntActiQ9H5J8. 41 interactors.
MINTiMINT-8247602.
STRINGi9606.ENSP00000314971.

Structurei

3D structure databases

ProteinModelPortaliQ9H5J8.
SMRiQ9H5J8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IZI3. Eukaryota.
ENOG41124VA. LUCA.
GeneTreeiENSGT00390000009061.
HOGENOMiHOG000154498.
HOVERGENiHBG096071.
InParanoidiQ9H5J8.
KOiK15215.
OMAiNEDFDSR.
OrthoDBiEOG091G0D0N.
PhylomeDBiQ9H5J8.
TreeFamiTF335756.

Family and domain databases

InterProiView protein in InterPro
IPR027976. TAF1D.
PANTHERiPTHR14562. PTHR14562. 1 hit.
PfamiView protein in Pfam
PF15333. TAF1D. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9H5J8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKSGIDSLD HVTSDAVELA NRSDNSSDSS LFKTQCIPYS PKGEKRNPIR
60 70 80 90 100
KFVRTPESVH ASDSSSDSSF EPIPLTIKAI FERFKNRKKR YKKKKKRRYQ
110 120 130 140 150
PTGRPRGRPE GRRNPIYSLI DKKKQFRSRG SGFPFLESEN EKNAPWRKIL
160 170 180 190 200
TFEQAVARGF FNYIEKLKYE HHLKESLKQM NVGEDLENED FDSRRYKFLD
210 220 230 240 250
DDGSISPIEE STAEDEDATH LEDNECDIKL AGDSFIVSSE FPVRLSVYLE
260 270
EEDITEEAAL SKKRATKAKN TGQRGLKM
Length:278
Mass (Da):32,058
Last modified:March 1, 2001 - v1
Checksum:i4BA37C73BB387446
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14S → T in CAG33650 (Ref. 3) Curated1
Sequence conflicti97R → G in CAG33650 (Ref. 3) Curated1
Sequence conflicti278M → I in CAG33650 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027016 mRNA. Translation: BAB15628.1.
CR457369 mRNA. Translation: CAG33650.1.
BC001972 mRNA. Translation: AAH01972.1.
CCDSiCCDS8293.1.
RefSeqiNP_077021.1. NM_024116.3.
UniGeneiHs.355750.
Hs.732267.

Genome annotation databases

EnsembliENST00000323981; ENSP00000314971; ENSG00000166012.
ENST00000448108; ENSP00000410409; ENSG00000166012.
ENST00000526015; ENSP00000435087; ENSG00000166012.
GeneIDi79101.
KEGGihsa:79101.
UCSCiuc001ped.5. human.

Similar proteinsi

Entry informationi

Entry nameiTAF1D_HUMAN
AccessioniPrimary (citable) accession number: Q9H5J8
Secondary accession number(s): Q6I9Y6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2001
Last modified: September 27, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot