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Protein

TATA box-binding protein-associated factor RNA polymerase I subunit D

Gene

TAF1D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-427359 SIRT1 negatively regulates rRNA expression
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-5250924 B-WICH complex positively regulates rRNA expression
R-HSA-73762 RNA Polymerase I Transcription Initiation
R-HSA-73772 RNA Polymerase I Promoter Escape
R-HSA-73777 RNA Polymerase I Chain Elongation
R-HSA-73863 RNA Polymerase I Transcription Termination

Names & Taxonomyi

Protein namesi
Recommended name:
TATA box-binding protein-associated factor RNA polymerase I subunit D
Alternative name(s):
RNA polymerase I-specific TBP-associated factor 41 kDa
Short name:
TAFI41
TATA box-binding protein-associated factor 1D
Short name:
TBP-associated factor 1D
Transcription initiation factor SL1/TIF-IB subunit D
Gene namesi
Name:TAF1D
Synonyms:JOSD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000166012.14
HGNCiHGNC:28759 TAF1D
MIMi612823 gene
neXtProtiNX_Q9H5J8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi79101
OpenTargetsiENSG00000166012
PharmGKBiPA164726421

Polymorphism and mutation databases

BioMutaiTAF1D
DMDMi74733586

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002507171 – 278TATA box-binding protein-associated factor RNA polymerase I subunit DAdd BLAST278

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23PhosphoserineCombined sources1
Modified residuei138PhosphoserineCombined sources1
Modified residuei234PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H5J8
MaxQBiQ9H5J8
PaxDbiQ9H5J8
PeptideAtlasiQ9H5J8
PRIDEiQ9H5J8

PTM databases

iPTMnetiQ9H5J8
PhosphoSitePlusiQ9H5J8

Expressioni

Gene expression databases

BgeeiENSG00000166012
CleanExiHS_TAF1D
ExpressionAtlasiQ9H5J8 baseline and differential
GenevisibleiQ9H5J8 HS

Organism-specific databases

HPAiHPA055935
HPA060385

Interactioni

Subunit structurei

Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Interacts with UBTF.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi122548, 56 interactors
IntActiQ9H5J8, 41 interactors
MINTiQ9H5J8
STRINGi9606.ENSP00000314971

Structurei

3D structure databases

ProteinModelPortaliQ9H5J8
SMRiQ9H5J8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IZI3 Eukaryota
ENOG41124VA LUCA
GeneTreeiENSGT00390000009061
HOGENOMiHOG000154498
HOVERGENiHBG096071
InParanoidiQ9H5J8
KOiK15215
OMAiNEDFDSR
OrthoDBiEOG091G0D0N
PhylomeDBiQ9H5J8
TreeFamiTF335756

Family and domain databases

InterProiView protein in InterPro
IPR027976 TAF1D
PANTHERiPTHR14562 PTHR14562, 1 hit
PfamiView protein in Pfam
PF15333 TAF1D, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H5J8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKSGIDSLD HVTSDAVELA NRSDNSSDSS LFKTQCIPYS PKGEKRNPIR
60 70 80 90 100
KFVRTPESVH ASDSSSDSSF EPIPLTIKAI FERFKNRKKR YKKKKKRRYQ
110 120 130 140 150
PTGRPRGRPE GRRNPIYSLI DKKKQFRSRG SGFPFLESEN EKNAPWRKIL
160 170 180 190 200
TFEQAVARGF FNYIEKLKYE HHLKESLKQM NVGEDLENED FDSRRYKFLD
210 220 230 240 250
DDGSISPIEE STAEDEDATH LEDNECDIKL AGDSFIVSSE FPVRLSVYLE
260 270
EEDITEEAAL SKKRATKAKN TGQRGLKM
Length:278
Mass (Da):32,058
Last modified:March 1, 2001 - v1
Checksum:i4BA37C73BB387446
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14S → T in CAG33650 (Ref. 3) Curated1
Sequence conflicti97R → G in CAG33650 (Ref. 3) Curated1
Sequence conflicti278M → I in CAG33650 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027016 mRNA Translation: BAB15628.1
CR457369 mRNA Translation: CAG33650.1
BC001972 mRNA Translation: AAH01972.1
CCDSiCCDS8293.1
RefSeqiNP_077021.1, NM_024116.3
UniGeneiHs.355750
Hs.732267

Genome annotation databases

EnsembliENST00000323981; ENSP00000314971; ENSG00000166012
ENST00000448108; ENSP00000410409; ENSG00000166012
ENST00000526015; ENSP00000435087; ENSG00000166012
GeneIDi79101
KEGGihsa:79101
UCSCiuc001ped.5 human

Similar proteinsi

Entry informationi

Entry nameiTAF1D_HUMAN
AccessioniPrimary (citable) accession number: Q9H5J8
Secondary accession number(s): Q6I9Y6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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