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Q9H5J8 (TAF1D_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
TATA box-binding protein-associated factor RNA polymerase I subunit D
Alternative name(s):
RNA polymerase I-specific TBP-associated factor 41 kDa
Short name=TAFI41
TATA box-binding protein-associated factor 1D
Short name=TBP-associated factor 1D
Transcription initiation factor SL1/TIF-IB subunit D
Gene names
Name:TAF1D
Synonyms:JOSD3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length278 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Ref.5 Ref.6

Subunit structure

Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Interacts with UBTF. Ref.6

Subcellular location

Nucleus Ref.1 Ref.6.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

POLBP067464EBI-716128,EBI-713836

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 278278TATA box-binding protein-associated factor RNA polymerase I subunit D
PRO_0000250717

Amino acid modifications

Modified residue231Phosphoserine Ref.10
Modified residue1381Phosphoserine Ref.7
Modified residue2341Phosphoserine Ref.9

Experimental info

Sequence conflict141S → T in CAG33650. Ref.3
Sequence conflict971R → G in CAG33650. Ref.3
Sequence conflict2781M → I in CAG33650. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9H5J8 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 4BA37C73BB387446

FASTA27832,058
        10         20         30         40         50         60 
MDKSGIDSLD HVTSDAVELA NRSDNSSDSS LFKTQCIPYS PKGEKRNPIR KFVRTPESVH 

        70         80         90        100        110        120 
ASDSSSDSSF EPIPLTIKAI FERFKNRKKR YKKKKKRRYQ PTGRPRGRPE GRRNPIYSLI 

       130        140        150        160        170        180 
DKKKQFRSRG SGFPFLESEN EKNAPWRKIL TFEQAVARGF FNYIEKLKYE HHLKESLKQM 

       190        200        210        220        230        240 
NVGEDLENED FDSRRYKFLD DDGSISPIEE STAEDEDATH LEDNECDIKL AGDSFIVSSE 

       250        260        270 
FPVRLSVYLE EEDITEEAAL SKKRATKAKN TGQRGLKM 

« Hide

References

« Hide 'large scale' references
[1]"A novel nuclear protein, MGC5306 interacts with DNA polymerase beta and has a potential role in cellular phenotype."
Wang L., Bhattacharyya N., Chelsea D.M., Escobar P.F., Banerjee S.
Cancer Res. 64:7673-7677(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Cervix.
[5]"TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter."
Friedrich J.K., Panov K.I., Cabart P., Russell J., Zomerdijk J.C.B.M.
J. Biol. Chem. 280:29551-29558(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION OF THE SL1/TIF-IB COMPLEX.
[6]"A novel TBP-associated factor of SL1 functions in RNA polymerase I transcription."
Gorski J.J., Pathak S., Panov K., Kasciukovic T., Panova T., Russell J., Zomerdijk J.C.B.M.
EMBO J. 26:1560-1568(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, IDENTIFICATION IN THE SL1/TIF-IB COMPLEX, INTERACTION WITH UBTF, SUBCELLULAR LOCATION.
[7]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-234, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[10]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK027016 mRNA. Translation: BAB15628.1.
CR457369 mRNA. Translation: CAG33650.1.
BC001972 mRNA. Translation: AAH01972.1.
CCDSCCDS8293.1.
RefSeqNP_077021.1. NM_024116.3.
UniGeneHs.355750.

3D structure databases

ProteinModelPortalQ9H5J8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122548. 43 interactions.
IntActQ9H5J8. 38 interactions.
MINTMINT-8247602.
STRING9606.ENSP00000314971.

PTM databases

PhosphoSiteQ9H5J8.

Polymorphism databases

DMDM74733586.

Proteomic databases

MaxQBQ9H5J8.
PaxDbQ9H5J8.
PRIDEQ9H5J8.

Protocols and materials databases

DNASU79101.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000323981; ENSP00000314971; ENSG00000166012.
ENST00000448108; ENSP00000410409; ENSG00000166012.
ENST00000526015; ENSP00000435087; ENSG00000166012.
GeneID79101.
KEGGhsa:79101.
UCSCuc001ped.3. human.

Organism-specific databases

CTD79101.
GeneCardsGC11M093545.
HGNCHGNC:28759. TAF1D.
HPAHPA055935.
HPA060385.
MIM612823. gene.
neXtProtNX_Q9H5J8.
PharmGKBPA164726421.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG26017.
HOGENOMHOG000154498.
HOVERGENHBG096071.
InParanoidQ9H5J8.
KOK15215.
OMAYKPTGRP.
OrthoDBEOG7SV0WX.
PhylomeDBQ9H5J8.
TreeFamTF335756.

Enzyme and pathway databases

ReactomeREACT_1788. Transcription.
REACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ9H5J8.
BgeeQ9H5J8.
CleanExHS_TAF1D.
GenevestigatorQ9H5J8.

Family and domain databases

InterProIPR027976. TAF1D.
[Graphical view]
PANTHERPTHR14562. PTHR14562. 1 hit.
PfamPF15333. TAF1D. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTAF1D. human.
GenomeRNAi79101.
NextBio67969.
PROQ9H5J8.
SOURCESearch...

Entry information

Entry nameTAF1D_HUMAN
AccessionPrimary (citable) accession number: Q9H5J8
Secondary accession number(s): Q6I9Y6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM