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Q9H5J8

- TAF1D_HUMAN

UniProt

Q9H5J8 - TAF1D_HUMAN

Protein

TATA box-binding protein-associated factor RNA polymerase I subunit D

Gene

TAF1D

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.2 Publications

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. protein binding Source: IntAct

    GO - Biological processi

    1. gene expression Source: Reactome
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. termination of RNA polymerase I transcription Source: Reactome
    4. transcription elongation from RNA polymerase I promoter Source: Reactome
    5. transcription from RNA polymerase I promoter Source: Reactome
    6. transcription initiation from RNA polymerase I promoter Source: Reactome

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_1074. RNA Polymerase I Transcription Termination.
    REACT_1913. RNA Polymerase I Promoter Escape.
    REACT_200827. SIRT1 negatively regulates rRNA Expression.
    REACT_200856. NoRC negatively regulates rRNA expression.
    REACT_2204. RNA Polymerase I Chain Elongation.
    REACT_953. RNA Polymerase I Transcription Initiation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    TATA box-binding protein-associated factor RNA polymerase I subunit D
    Alternative name(s):
    RNA polymerase I-specific TBP-associated factor 41 kDa
    Short name:
    TAFI41
    TATA box-binding protein-associated factor 1D
    Short name:
    TBP-associated factor 1D
    Transcription initiation factor SL1/TIF-IB subunit D
    Gene namesi
    Name:TAF1D
    Synonyms:JOSD3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:28759. TAF1D.

    Subcellular locationi

    Nucleus 2 Publications

    GO - Cellular componenti

    1. microtubule organizing center Source: HPA
    2. nucleoplasm Source: Reactome
    3. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164726421.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 278278TATA box-binding protein-associated factor RNA polymerase I subunit DPRO_0000250717Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei23 – 231Phosphoserine1 Publication
    Modified residuei138 – 1381Phosphoserine1 Publication
    Modified residuei234 – 2341Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9H5J8.
    PaxDbiQ9H5J8.
    PRIDEiQ9H5J8.

    PTM databases

    PhosphoSiteiQ9H5J8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H5J8.
    BgeeiQ9H5J8.
    CleanExiHS_TAF1D.
    GenevestigatoriQ9H5J8.

    Organism-specific databases

    HPAiHPA055935.
    HPA060385.

    Interactioni

    Subunit structurei

    Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Interacts with UBTF.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    POLBP067464EBI-716128,EBI-713836

    Protein-protein interaction databases

    BioGridi122548. 43 interactions.
    IntActiQ9H5J8. 38 interactions.
    MINTiMINT-8247602.
    STRINGi9606.ENSP00000314971.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H5J8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG26017.
    HOGENOMiHOG000154498.
    HOVERGENiHBG096071.
    InParanoidiQ9H5J8.
    KOiK15215.
    OMAiYKPTGRP.
    OrthoDBiEOG7SV0WX.
    PhylomeDBiQ9H5J8.
    TreeFamiTF335756.

    Family and domain databases

    InterProiIPR027976. TAF1D.
    [Graphical view]
    PANTHERiPTHR14562. PTHR14562. 1 hit.
    PfamiPF15333. TAF1D. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9H5J8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDKSGIDSLD HVTSDAVELA NRSDNSSDSS LFKTQCIPYS PKGEKRNPIR    50
    KFVRTPESVH ASDSSSDSSF EPIPLTIKAI FERFKNRKKR YKKKKKRRYQ 100
    PTGRPRGRPE GRRNPIYSLI DKKKQFRSRG SGFPFLESEN EKNAPWRKIL 150
    TFEQAVARGF FNYIEKLKYE HHLKESLKQM NVGEDLENED FDSRRYKFLD 200
    DDGSISPIEE STAEDEDATH LEDNECDIKL AGDSFIVSSE FPVRLSVYLE 250
    EEDITEEAAL SKKRATKAKN TGQRGLKM 278
    Length:278
    Mass (Da):32,058
    Last modified:March 1, 2001 - v1
    Checksum:i4BA37C73BB387446
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti14 – 141S → T in CAG33650. 1 PublicationCurated
    Sequence conflicti97 – 971R → G in CAG33650. 1 PublicationCurated
    Sequence conflicti278 – 2781M → I in CAG33650. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK027016 mRNA. Translation: BAB15628.1.
    CR457369 mRNA. Translation: CAG33650.1.
    BC001972 mRNA. Translation: AAH01972.1.
    CCDSiCCDS8293.1.
    RefSeqiNP_077021.1. NM_024116.3.
    UniGeneiHs.355750.

    Genome annotation databases

    EnsembliENST00000323981; ENSP00000314971; ENSG00000166012.
    ENST00000448108; ENSP00000410409; ENSG00000166012.
    ENST00000526015; ENSP00000435087; ENSG00000166012.
    GeneIDi79101.
    KEGGihsa:79101.
    UCSCiuc001ped.3. human.

    Polymorphism databases

    DMDMi74733586.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK027016 mRNA. Translation: BAB15628.1 .
    CR457369 mRNA. Translation: CAG33650.1 .
    BC001972 mRNA. Translation: AAH01972.1 .
    CCDSi CCDS8293.1.
    RefSeqi NP_077021.1. NM_024116.3.
    UniGenei Hs.355750.

    3D structure databases

    ProteinModelPortali Q9H5J8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122548. 43 interactions.
    IntActi Q9H5J8. 38 interactions.
    MINTi MINT-8247602.
    STRINGi 9606.ENSP00000314971.

    PTM databases

    PhosphoSitei Q9H5J8.

    Polymorphism databases

    DMDMi 74733586.

    Proteomic databases

    MaxQBi Q9H5J8.
    PaxDbi Q9H5J8.
    PRIDEi Q9H5J8.

    Protocols and materials databases

    DNASUi 79101.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000323981 ; ENSP00000314971 ; ENSG00000166012 .
    ENST00000448108 ; ENSP00000410409 ; ENSG00000166012 .
    ENST00000526015 ; ENSP00000435087 ; ENSG00000166012 .
    GeneIDi 79101.
    KEGGi hsa:79101.
    UCSCi uc001ped.3. human.

    Organism-specific databases

    CTDi 79101.
    GeneCardsi GC11M093545.
    HGNCi HGNC:28759. TAF1D.
    HPAi HPA055935.
    HPA060385.
    MIMi 612823. gene.
    neXtProti NX_Q9H5J8.
    PharmGKBi PA164726421.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG26017.
    HOGENOMi HOG000154498.
    HOVERGENi HBG096071.
    InParanoidi Q9H5J8.
    KOi K15215.
    OMAi YKPTGRP.
    OrthoDBi EOG7SV0WX.
    PhylomeDBi Q9H5J8.
    TreeFami TF335756.

    Enzyme and pathway databases

    Reactomei REACT_1074. RNA Polymerase I Transcription Termination.
    REACT_1913. RNA Polymerase I Promoter Escape.
    REACT_200827. SIRT1 negatively regulates rRNA Expression.
    REACT_200856. NoRC negatively regulates rRNA expression.
    REACT_2204. RNA Polymerase I Chain Elongation.
    REACT_953. RNA Polymerase I Transcription Initiation.

    Miscellaneous databases

    ChiTaRSi TAF1D. human.
    GenomeRNAii 79101.
    NextBioi 67969.
    PROi Q9H5J8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H5J8.
    Bgeei Q9H5J8.
    CleanExi HS_TAF1D.
    Genevestigatori Q9H5J8.

    Family and domain databases

    InterProi IPR027976. TAF1D.
    [Graphical view ]
    PANTHERi PTHR14562. PTHR14562. 1 hit.
    Pfami PF15333. TAF1D. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel nuclear protein, MGC5306 interacts with DNA polymerase beta and has a potential role in cellular phenotype."
      Wang L., Bhattacharyya N., Chelsea D.M., Escobar P.F., Banerjee S.
      Cancer Res. 64:7673-7677(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cervix.
    5. "TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter."
      Friedrich J.K., Panov K.I., Cabart P., Russell J., Zomerdijk J.C.B.M.
      J. Biol. Chem. 280:29551-29558(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION OF THE SL1/TIF-IB COMPLEX.
    6. "A novel TBP-associated factor of SL1 functions in RNA polymerase I transcription."
      Gorski J.J., Pathak S., Panov K., Kasciukovic T., Panova T., Russell J., Zomerdijk J.C.B.M.
      EMBO J. 26:1560-1568(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN THE SL1/TIF-IB COMPLEX, INTERACTION WITH UBTF, SUBCELLULAR LOCATION.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-234, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTAF1D_HUMAN
    AccessioniPrimary (citable) accession number: Q9H5J8
    Secondary accession number(s): Q6I9Y6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3