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Protein

Zinc finger and BTB domain-containing protein 3

Gene

ZBTB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri472 – 494C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri500 – 523C2H2-type 2PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-32602-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 3
Gene namesi
Name:ZBTB3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:22918. ZBTB3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000185670.
PharmGKBiPA134950004.

Polymorphism and mutation databases

BioMutaiZBTB3.
DMDMi33517138.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477101 – 574Zinc finger and BTB domain-containing protein 3Add BLAST574

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei362PhosphoserineCombined sources1
Modified residuei549PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H5J0.
MaxQBiQ9H5J0.
PaxDbiQ9H5J0.
PeptideAtlasiQ9H5J0.
PRIDEiQ9H5J0.

PTM databases

iPTMnetiQ9H5J0.
PhosphoSitePlusiQ9H5J0.

Expressioni

Gene expression databases

BgeeiENSG00000185670.
CleanExiHS_ZBTB3.
ExpressionAtlasiQ9H5J0. baseline and differential.
GenevisibleiQ9H5J0. HS.

Organism-specific databases

HPAiHPA035321.
HPA035322.

Interactioni

Protein-protein interaction databases

BioGridi122933. 24 interactors.
IntActiQ9H5J0. 2 interactors.
MINTiMINT-1197980.
STRINGi9606.ENSP00000378286.

Structurei

3D structure databases

ProteinModelPortaliQ9H5J0.
SMRiQ9H5J0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 142BTBPROSITE-ProRule annotationAdd BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi227 – 346Pro-richAdd BLAST120

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri472 – 494C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri500 – 523C2H2-type 2PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132251.
HOGENOMiHOG000234147.
HOVERGENiHBG059113.
InParanoidiQ9H5J0.
KOiK10490.
OMAiGQYHRGL.
OrthoDBiEOG091G075N.
PhylomeDBiQ9H5J0.
TreeFamiTF330979.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 2 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H5J0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLREFSKWGV EASPGKAWER KRSLLRGAVG RYRGATGGDL FWAPFPSWGT
60 70 80 90 100
MEFPEHSQQL LQSLREQRSQ GFLCDCTVMV GSTQFLAHRA VLASCSPFFQ
110 120 130 140 150
LFYKERELDK RDLVCIHNEI VTAPAFGLLL DFMYAGQLTL RGDTPVEDVL
160 170 180 190 200
AAASYLHMND IVKVCKRRLQ ARALAEADST KKEEETNSQL PSLEFLSSTS
210 220 230 240 250
RGTQPSLASA ETSGHWGKGE WKGSAAPSPT VRPPDEPPMS SGADTTQPGM
260 270 280 290 300
EVDAPHLRAP HPPVADVSLA SPSSSTETIP TNYFSSGISA VSLEPLPSLD
310 320 330 340 350
VGPESLRVVE PKDPGGPLQG FYPPASAPTS APAPVSAPVP SQAPAPAEAE
360 370 380 390 400
LVQVKVEAIV ISDEETDVSD EQPQGPERAF PSGGAVYGAQ PSQPEAFEDP
410 420 430 440 450
GAAGLEEVGP SDHFLPTDPH LPYHLLPGAG QYHRGLVTSP LPAPASLHEP
460 470 480 490 500
LYLSSEYEAA PGSFGVFTED VPTCKTCGKT FSCSYTLRRH ATVHTRERPY
510 520 530 540 550
ECRYCLRSYT QSGDLYRHIR KAHNEDLAKR SKPDPEVGPL LGVQPLPGSP
560 570
TADRQSSSGG GPPKDFVLAP KTNI
Length:574
Mass (Da):61,827
Last modified:March 1, 2001 - v1
Checksum:i28C2FF4DB6C44036
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035600424H → L in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_035601455S → F in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_018382574I → M.Corresponds to variant rs544641dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027045 mRNA. Translation: BAB15636.1.
BC025249 mRNA. Translation: AAH25249.1.
CCDSiCCDS8034.1.
RefSeqiNP_079060.1. NM_024784.3.
UniGeneiHs.147554.

Genome annotation databases

EnsembliENST00000394807; ENSP00000378286; ENSG00000185670.
GeneIDi79842.
KEGGihsa:79842.
UCSCiuc001nuz.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027045 mRNA. Translation: BAB15636.1.
BC025249 mRNA. Translation: AAH25249.1.
CCDSiCCDS8034.1.
RefSeqiNP_079060.1. NM_024784.3.
UniGeneiHs.147554.

3D structure databases

ProteinModelPortaliQ9H5J0.
SMRiQ9H5J0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122933. 24 interactors.
IntActiQ9H5J0. 2 interactors.
MINTiMINT-1197980.
STRINGi9606.ENSP00000378286.

PTM databases

iPTMnetiQ9H5J0.
PhosphoSitePlusiQ9H5J0.

Polymorphism and mutation databases

BioMutaiZBTB3.
DMDMi33517138.

Proteomic databases

EPDiQ9H5J0.
MaxQBiQ9H5J0.
PaxDbiQ9H5J0.
PeptideAtlasiQ9H5J0.
PRIDEiQ9H5J0.

Protocols and materials databases

DNASUi79842.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394807; ENSP00000378286; ENSG00000185670.
GeneIDi79842.
KEGGihsa:79842.
UCSCiuc001nuz.4. human.

Organism-specific databases

CTDi79842.
GeneCardsiZBTB3.
HGNCiHGNC:22918. ZBTB3.
HPAiHPA035321.
HPA035322.
neXtProtiNX_Q9H5J0.
OpenTargetsiENSG00000185670.
PharmGKBiPA134950004.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132251.
HOGENOMiHOG000234147.
HOVERGENiHBG059113.
InParanoidiQ9H5J0.
KOiK10490.
OMAiGQYHRGL.
OrthoDBiEOG091G075N.
PhylomeDBiQ9H5J0.
TreeFamiTF330979.

Enzyme and pathway databases

BioCyciZFISH:G66-32602-MONOMER.

Miscellaneous databases

GenomeRNAii79842.
PROiQ9H5J0.

Gene expression databases

BgeeiENSG00000185670.
CleanExiHS_ZBTB3.
ExpressionAtlasiQ9H5J0. baseline and differential.
GenevisibleiQ9H5J0. HS.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 2 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZBTB3_HUMAN
AccessioniPrimary (citable) accession number: Q9H5J0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.