Q9H5J0 (ZBTB3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger and BTB domain-containing protein 3

Gene names

Name:

ZBTB3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	574 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Potential.
Sequence similarities	Contains 1 BTB (POZ) domain. Contains 2 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 574	574	Zinc finger and BTB domain-containing protein 3		PRO_0000047710
Regions
	Domain	74 – 142	69	BTB
	Zinc finger	472 – 494	23	C2H2-type 1
	Zinc finger	500 – 523	24	C2H2-type 2
	Compositional bias	227 – 346	120	Pro-rich
Amino acid modifications
	Modified residue	362	1	Phosphoserine Ref.3
Natural variations
	Natural variant	424	1	H → L in a breast cancer sample; somatic mutation. Ref.4		VAR_035600
	Natural variant	455	1	S → F in a breast cancer sample; somatic mutation. Ref.4		VAR_035601
	Natural variant	574	1	I → M. Corresponds to variant rs544641 [ dbSNP | Ensembl ].		VAR_018382

Sequences

	Sequence		Length	Mass (Da)
	Q9H5J0 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 28C2FF4DB6C44036	FASTA	574	61,827
	10 20 30 40 50 60 MLREFSKWGV EASPGKAWER KRSLLRGAVG RYRGATGGDL FWAPFPSWGT MEFPEHSQQL 70 80 90 100 110 120 LQSLREQRSQ GFLCDCTVMV GSTQFLAHRA VLASCSPFFQ LFYKERELDK RDLVCIHNEI 130 140 150 160 170 180 VTAPAFGLLL DFMYAGQLTL RGDTPVEDVL AAASYLHMND IVKVCKRRLQ ARALAEADST 190 200 210 220 230 240 KKEEETNSQL PSLEFLSSTS RGTQPSLASA ETSGHWGKGE WKGSAAPSPT VRPPDEPPMS 250 260 270 280 290 300 SGADTTQPGM EVDAPHLRAP HPPVADVSLA SPSSSTETIP TNYFSSGISA VSLEPLPSLD 310 320 330 340 350 360 VGPESLRVVE PKDPGGPLQG FYPPASAPTS APAPVSAPVP SQAPAPAEAE LVQVKVEAIV 370 380 390 400 410 420 ISDEETDVSD EQPQGPERAF PSGGAVYGAQ PSQPEAFEDP GAAGLEEVGP SDHFLPTDPH 430 440 450 460 470 480 LPYHLLPGAG QYHRGLVTSP LPAPASLHEP LYLSSEYEAA PGSFGVFTED VPTCKTCGKT 490 500 510 520 530 540 FSCSYTLRRH ATVHTRERPY ECRYCLRSYT QSGDLYRHIR KAHNEDLAKR SKPDPEVGPL 550 560 570 LGVQPLPGSP TADRQSSSGG GPPKDFVLAP KTNI

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[3]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[4]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-424 AND PHE-455.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK027045 mRNA. Translation: BAB15636.1. BC025249 mRNA. Translation: AAH25249.1.
IPI	IPI00165014.
RefSeq	NP_079060.1. NM_024784.3.
UniGene	Hs.147554.
3D structure databases
ProteinModelPortal	Q9H5J0.
SMR	Q9H5J0. Positions 49-170, 393-525.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1197980.
PTM databases
PhosphoSite	Q9H5J0.
Polymorphism databases
DMDM	33517138.
Proteomic databases
PRIDE	Q9H5J0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000394807; ENSP00000378286; ENSG00000185670.
GeneID	79842.
KEGG	hsa:79842.
UCSC	uc001nuz.1. human.
Organism-specific databases
CTD	79842.
GeneCards	GC11M062518.
H-InvDB	HIX0017278.
HGNC	HGNC:22918. ZBTB3.
HPA	HPA035322.
neXtProt	NX_Q9H5J0.
PharmGKB	PA134950004.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG10151.
GeneTree	ENSGT00600000084014.
HOGENOM	HBG717232.
HOVERGEN	HBG059113.
InParanoid	Q9H5J0.
OMA	FTEDVPT.
OrthoDB	EOG441QCJ.
PhylomeDB	Q9H5J0.
Gene expression databases
ArrayExpress	Q9H5J0.
Bgee	Q9H5J0.
CleanEx	HS_ZBTB3.
Genevestigator	Q9H5J0.
GermOnline	ENSG00000185670. Homo sapiens.
Family and domain databases
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.710.10. BTB/POZ_fold. 1 hit. G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 2 hits.
KO	K10490.
Pfam	PF00651. BTB. 1 hit. PF00096. zf-C2H2. 2 hits. [Graphical view]
SMART	SM00225. BTB. 1 hit. SM00355. ZnF_C2H2. 2 hits. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
PROSITE	PS50097. BTB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 2 hits. PS50157. ZINC_FINGER_C2H2_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	69524.

Entry information

Entry name

ZBTB3_HUMAN

Accession

Primary (citable) accession number: Q9H5J0

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 4, 2003
Last sequence update:	March 1, 2001
Last modified:	January 25, 2012
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.