Q9H5I5 (PIEZ2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Piezo-type mechanosensitive ion channel component 2

Alternative name(s):
Protein FAM38B

Gene names

Name:	PIEZO2
Synonyms:	C18orf30, C18orf58, FAM38B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2752 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Component of mechanosensitive channel required for rapidly adaptating mechanically activated (MA) currents in DRG neurons By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Miscellaneous	Piezo comes from the Greek 'piesi' meaning pressure.
Sequence similarities	Belongs to the PIEZO family.
Sequence caution	The sequence BAB15556.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB15556.1 differs from that shown. Reason: Erroneous termination at position 2718. Translated as Arg. The sequence BAB15641.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAC03832.1 differs from that shown. Reason: Unlikely isoform. Aberrant splice sites. The sequence BAC05412.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAC05412.1 differs from that shown. Reason: Contaminating sequence at the 3'end. Probable cloning artifact.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Transmembrane Transmembrane helix
Molecular function	Ion channel
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cation transport Inferred from sequence or structural similarity. Source: UniProtKB regulation of membrane potential Inferred from electronic annotation. Source: Compara sensory perception of mechanical stimulus Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	cation channel activity Inferred from electronic annotation. Source: Compara mechanically-gated ion channel activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H5I5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9H5I5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2387-2449: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9H5I5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-2043: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q9H5I5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     831-831: R → SHAKVNGRVYLIINSIKKKLPIHQNE

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2752	2752	Piezo-type mechanosensitive ion channel component 2		PRO_0000186818
Regions
	Transmembrane	5 – 25	21	Helical; Potential
	Transmembrane	27 – 47	21	Helical; Potential
	Transmembrane	62 – 82	21	Helical; Potential
	Transmembrane	119 – 139	21	Helical; Potential
	Transmembrane	214 – 234	21	Helical; Potential
	Transmembrane	237 – 257	21	Helical; Potential
	Transmembrane	266 – 286	21	Helical; Potential
	Transmembrane	336 – 356	21	Helical; Potential
	Transmembrane	505 – 525	21	Helical; Potential
	Transmembrane	541 – 561	21	Helical; Potential
	Transmembrane	581 – 598	18	Helical; Potential
	Transmembrane	678 – 698	21	Helical; Potential
	Transmembrane	704 – 724	21	Helical; Potential
	Transmembrane	732 – 752	21	Helical; Potential
	Transmembrane	782 – 802	21	Helical; Potential
	Transmembrane	932 – 952	21	Helical; Potential
	Transmembrane	958 – 978	21	Helical; Potential
	Transmembrane	985 – 1005	21	Helical; Potential
	Transmembrane	1053 – 1073	21	Helical; Potential
	Transmembrane	1134 – 1154	21	Helical; Potential
	Transmembrane	1170 – 1190	21	Helical; Potential
	Transmembrane	1217 – 1237	21	Helical; Potential
	Transmembrane	1291 – 1311	21	Helical; Potential
	Transmembrane	1315 – 1335	21	Helical; Potential
	Transmembrane	1349 – 1371	23	Helical; Potential
	Transmembrane	1404 – 1424	21	Helical; Potential
	Transmembrane	1900 – 1920	21	Helical; Potential
	Transmembrane	1935 – 1955	21	Helical; Potential
	Transmembrane	1967 – 1987	21	Helical; Potential
	Transmembrane	2191 – 2211	21	Helical; Potential
	Transmembrane	2232 – 2252	21	Helical; Potential
	Transmembrane	2260 – 2280	21	Helical; Potential
	Transmembrane	2290 – 2310	21	Helical; Potential
	Transmembrane	2327 – 2344	18	Helical; Potential
	Transmembrane	2358 – 2378	21	Helical; Potential
	Transmembrane	2406 – 2426	21	Helical; Potential
	Transmembrane	2662 – 2682	21	Helical; Potential
	Coiled coil	1458 – 1529	72	Potential
	Compositional bias	453 – 480	28	Glu-rich
	Compositional bias	609 – 668	60	Glu-rich
	Compositional bias	852 – 901	50	Glu-rich
	Compositional bias	2099 – 2135	37	Ser-rich
Amino acid modifications
	Glycosylation	95	1	N-linked (GlcNAc...) Potential
	Glycosylation	1013	1	N-linked (GlcNAc...) Potential
	Glycosylation	1085	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 2043	2043	Missing in isoform 3.		VSP_040471
	Alternative sequence	831	1	R → SHAKVNGRVYLIINSIKKKL PIHQNE in isoform 4.		VSP_040630
	Alternative sequence	2387 – 2449	63	Missing in isoform 2.		VSP_040472
	Natural variant	2463	1	V → I. Corresponds to variant rs3748428 [ dbSNP | Ensembl ].		VAR_033925
Experimental info
	Sequence conflict	455	1	S → F in BAC03832. Ref.1
	Sequence conflict	758	1	N → D in BAC05412. Ref.1
	Sequence conflict	999	1	L → S in BAC05412. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 11, 2011. Version 2. Checksum: AD11A1FCEB6D0079	FASTA	2,752	318,064
	10 20 30 40 50 60 MASEVVCGLI FRLLLPICLA VACAFRYNGL SFVYLIYLLL IPLFSEPTKT TMQGHTGRLL 70 80 90 100 110 120 KSLCFISLSF LLLHIIFHIT LVSLEAQHRI APGYNCSTWE KTFRQIGFES LKGADAGNGI 130 140 150 160 170 180 RVFVPDIGMF IASLTIWLLC RNIVQKPVTD EAAQSNPEFE NEELAEGEKI DSEEALIYEE 190 200 210 220 230 240 DFNGGDGVEG ELEESTKLKM FRRLASVASK LKEFIGNMIT TAGKVVVTIL LGSSGMMLPS 250 260 270 280 290 300 LTSSVYFFVF LGLCTWWSWC RTFDPLLFSC LCVLLAIFTA GHLIGLYLYQ FQFFQEAVPP 310 320 330 340 350 360 NDYYARLFGI KSVIQTDCSS TWKIIVNPDL SWYHHANPIL LLVMYYTLAT LIRIWLQEPL 370 380 390 400 410 420 VQDEGTKEED KALACSPIQI TAGRRRSLWY ATHYPTDERK LLSMTQDDYK PSDGLLVTVN 430 440 450 460 470 480 GNPVDYHTIH PSLPMENGPG KADLYSTPQY RWEPSDESSE KREEEEEEKE EFEEERSREE 490 500 510 520 530 540 KRSIKVHAMV SVFQFIMKQS YICALIAMMA WSITYHSWLT FVLLIWSCTL WMIRNRRKYA 550 560 570 580 590 600 MISSPFMVVY GNLLLILQYI WSFELPEIKK VPGFLEKKEP GELASKILFT ITFWLLLRQH 610 620 630 640 650 660 LTEQKALQEK EALLSEVKIG SQENEEKDEE LQDIQVEGEP KEEEEEEAKE EKQERKKVEQ 670 680 690 700 710 720 EEAEEEDEQD IMKVLGNLVV AMFIKYWIYV CGGMFFFVSF EGKIVMYKII YMVLFLFCVA 730 740 750 760 770 780 LYQVHYEWWR KILKYFWMSV VIYTMLVLIF IYTYQFENFP GLWQNMTGLK KEKLEDLGLK 790 800 810 820 830 840 QFTVAELFTR IFIPTSFLLV CILHLHYFHD RFLELTDLKS IPSKEDNTIY RLAHPEGSLP 850 860 870 880 890 900 DLTMMHLTAS LEKPEVRKLA EPGEEKLEGY SEKAQKGDLG KDSEESEEDG EEEEESEEEE 910 920 930 940 950 960 ETSDLRNKWH LVIDRLTVLF LKFLEYFHKL QVFMWWILEL HIIKIVSSYI IWVSVKEVSL 970 980 990 1000 1010 1020 FNYVFLISWA FALPYAKLRR LASSVCTVWT CVIIVCKMLY QLQTIKPENF SVNCSLPNEN 1030 1040 1050 1060 1070 1080 QTNIPFNELN KSLLYSAPID PTEWVGLRKS SPLLVYLRNN LLMLAILAFE VTIYRHQEYY 1090 1100 1110 1120 1130 1140 RGRNNLTAPV SRTIFHDITR LHLDDGLINC AKYFINYFFY KFGLETCFLM SVNVIGQRMD 1150 1160 1170 1180 1190 1200 FYAMIHACWL IAVLYRRRRK AIAEIWPKYC CFLACIITFQ YFICIGIPPA PCRDYPWRFK 1210 1220 1230 1240 1250 1260 GASFNDNIIK WLYFPDFIVR PNPVFLVYDF MLLLCASLQR QIFEDENKAA VRIMAGDNVE 1270 1280 1290 1300 1310 1320 ICMNLDAASF SQHNPVPDFI HCRSYLDMSK VIIFSYLFWF VLTIIFITGT TRISIFCMGY 1330 1340 1350 1360 1370 1380 LVACFYFLLF GGDLLLKPIK SILRYWDWLI AYNVFVITMK NILSIGACGY IGTLVHNSCW 1390 1400 1410 1420 1430 1440 LIQAFSLACT VKGYQMPAAN SPCTLPSGEA GIIWDSICFA FLLLQRRVFM SYYFLHVVAD 1450 1460 1470 1480 1490 1500 IKASQILASR GAELFQATIV KAVKARIEEE KKSMDQLKRQ MDRIKARQQK YKKGKERMLS 1510 1520 1530 1540 1550 1560 LTQEPGEGQD MQKLSEEDDE READKQKAKG KKKQWWRPWV DHASMVRSGD YYLFETDSEE 1570 1580 1590 1600 1610 1620 EEEEELKKED EEPPRRSAFQ FVYQAWITDP KTALRQRHKE KKRSAREERK RRRKGSKEGP 1630 1640 1650 1660 1670 1680 VEWEDREDEP IKKKSDGPDN IIKRIFNILK FTWVLFLATV DSFTTWLNSI SREHIDISTV 1690 1700 1710 1720 1730 1740 LRIERCMLTR EIKKGNVPTR ESIHMYYQNH IMNLSRESGL DTIDEHPGAA SGAQTAHRMD 1750 1760 1770 1780 1790 1800 SLDSHDSISS EPTQCTMLYS RQGTTETIEE VEAEQEEEAG STAPEPREAK EYEATGYDVG 1810 1820 1830 1840 1850 1860 AMGAEEASLT PEEELTQFST LDGDVEAPPS YSKAVSFEHL SFGSQDDSAG KNRMAVSPDD 1870 1880 1890 1900 1910 1920 SRTDKLGSSI LPPLTHELTA SELLLKKMFH DDELEESEKF YVGQPRFLLL FYAMYNTLVA 1930 1940 1950 1960 1970 1980 RSEMVCYFVI ILNHMVSASM ITLLLPILIF LWAMLSVPRP SRRFWMMAIV YTEVAIVVKY 1990 2000 2010 2020 2030 2040 FFQFGFFPWN KNVEVNKDKP YHPPNIIGVE KKEGYVLYDL IQLLALFFHR SILKCHGLWD 2050 2060 2070 2080 2090 2100 EDDMTESGMA REESDDELSL GHGRRDSSDS LKSINLAASV ESVHVTFPEQ QTAVRRKRSG 2110 2120 2130 2140 2150 2160 SSSEPSQRSS FSSNRSQRGS TSTRNSSQKG SSVLSIKQKG KRELYMEKLQ EHLIKAKAFT 2170 2180 2190 2200 2210 2220 IKKTLEIYVP IKQFFYNLIH PEYSAVTDVY VLMFLADTVD FIIIVFGFWA FGKHSAAADI 2230 2240 2250 2260 2270 2280 TSSLSEDQVP GPFLVMVLIQ FGTMVVDRAL YLRKTVLGKV IFQVILVFGI HFWMFFILPG 2290 2300 2310 2320 2330 2340 VTERKFSQNL VAQLWYFVKC VYFGLSAYQI RCGYPTRVLG NFLTKSYNYV NLFLFQGFRL 2350 2360 2370 2380 2390 2400 VPFLTELRAV MDWVWTDTTL SLSSWICVED IYAHIFILKC WRESEKRYPQ PRGQKKKKVV 2410 2420 2430 2440 2450 2460 KYGMGGMIIV LLICIVWFPL LFMSLIKSVA GVINQPLDVS VTITLGGYQP IFTMSAQQSQ 2470 2480 2490 2500 2510 2520 LKVMDQQSFN KFIQAFSRDT GAMQFLENYE KEDITVAELE GNSNSLWTIS PPSKQKMIHE 2530 2540 2550 2560 2570 2580 LLDPNSSFSV VFSWSIQRNL SLGAKSEIAT DKLSFPLKNI TRKNIAKMIA GNSTESSKTP 2590 2600 2610 2620 2630 2640 VTIEKIYPYY VKAPSDSNSK PIKQLLSENN FMDITIILSR DNTTKYNSEW WVLNLTGNRI 2650 2660 2670 2680 2690 2700 YNPNSQALEL VVFNDKVSPP SLGFLAGYGI MGLYASVVLV IGKFVREFFS GISHSIMFEE 2710 2720 2730 2740 2750 LPNVDRILKL CTDIFLVRET GELELEEDLY AKLIFLYRSP ETMIKWTREK TN
	Isoform 2 [UniParc]. Checksum: AABB4B9D00BD9A7B	FASTA	2,689	311,074
	10 20 30 40 50 60 MASEVVCGLI FRLLLPICLA VACAFRYNGL SFVYLIYLLL IPLFSEPTKT TMQGHTGRLL 70 80 90 100 110 120 KSLCFISLSF LLLHIIFHIT LVSLEAQHRI APGYNCSTWE KTFRQIGFES LKGADAGNGI 130 140 150 160 170 180 RVFVPDIGMF IASLTIWLLC RNIVQKPVTD EAAQSNPEFE NEELAEGEKI DSEEALIYEE 190 200 210 220 230 240 DFNGGDGVEG ELEESTKLKM FRRLASVASK LKEFIGNMIT TAGKVVVTIL LGSSGMMLPS 250 260 270 280 290 300 LTSSVYFFVF LGLCTWWSWC RTFDPLLFSC LCVLLAIFTA GHLIGLYLYQ FQFFQEAVPP 310 320 330 340 350 360 NDYYARLFGI KSVIQTDCSS TWKIIVNPDL SWYHHANPIL LLVMYYTLAT LIRIWLQEPL 370 380 390 400 410 420 VQDEGTKEED KALACSPIQI TAGRRRSLWY ATHYPTDERK LLSMTQDDYK PSDGLLVTVN 430 440 450 460 470 480 GNPVDYHTIH PSLPMENGPG KADLYSTPQY RWEPSDESSE KREEEEEEKE EFEEERSREE 490 500 510 520 530 540 KRSIKVHAMV SVFQFIMKQS YICALIAMMA WSITYHSWLT FVLLIWSCTL WMIRNRRKYA 550 560 570 580 590 600 MISSPFMVVY GNLLLILQYI WSFELPEIKK VPGFLEKKEP GELASKILFT ITFWLLLRQH 610 620 630 640 650 660 LTEQKALQEK EALLSEVKIG SQENEEKDEE LQDIQVEGEP KEEEEEEAKE EKQERKKVEQ 670 680 690 700 710 720 EEAEEEDEQD IMKVLGNLVV AMFIKYWIYV CGGMFFFVSF EGKIVMYKII YMVLFLFCVA 730 740 750 760 770 780 LYQVHYEWWR KILKYFWMSV VIYTMLVLIF IYTYQFENFP GLWQNMTGLK KEKLEDLGLK 790 800 810 820 830 840 QFTVAELFTR IFIPTSFLLV CILHLHYFHD RFLELTDLKS IPSKEDNTIY RLAHPEGSLP 850 860 870 880 890 900 DLTMMHLTAS LEKPEVRKLA EPGEEKLEGY SEKAQKGDLG KDSEESEEDG EEEEESEEEE 910 920 930 940 950 960 ETSDLRNKWH LVIDRLTVLF LKFLEYFHKL QVFMWWILEL HIIKIVSSYI IWVSVKEVSL 970 980 990 1000 1010 1020 FNYVFLISWA FALPYAKLRR LASSVCTVWT CVIIVCKMLY QLQTIKPENF SVNCSLPNEN 1030 1040 1050 1060 1070 1080 QTNIPFNELN KSLLYSAPID PTEWVGLRKS SPLLVYLRNN LLMLAILAFE VTIYRHQEYY 1090 1100 1110 1120 1130 1140 RGRNNLTAPV SRTIFHDITR LHLDDGLINC AKYFINYFFY KFGLETCFLM SVNVIGQRMD 1150 1160 1170 1180 1190 1200 FYAMIHACWL IAVLYRRRRK AIAEIWPKYC CFLACIITFQ YFICIGIPPA PCRDYPWRFK 1210 1220 1230 1240 1250 1260 GASFNDNIIK WLYFPDFIVR PNPVFLVYDF MLLLCASLQR QIFEDENKAA VRIMAGDNVE 1270 1280 1290 1300 1310 1320 ICMNLDAASF SQHNPVPDFI HCRSYLDMSK VIIFSYLFWF VLTIIFITGT TRISIFCMGY 1330 1340 1350 1360 1370 1380 LVACFYFLLF GGDLLLKPIK SILRYWDWLI AYNVFVITMK NILSIGACGY IGTLVHNSCW 1390 1400 1410 1420 1430 1440 LIQAFSLACT VKGYQMPAAN SPCTLPSGEA GIIWDSICFA FLLLQRRVFM SYYFLHVVAD 1450 1460 1470 1480 1490 1500 IKASQILASR GAELFQATIV KAVKARIEEE KKSMDQLKRQ MDRIKARQQK YKKGKERMLS 1510 1520 1530 1540 1550 1560 LTQEPGEGQD MQKLSEEDDE READKQKAKG KKKQWWRPWV DHASMVRSGD YYLFETDSEE 1570 1580 1590 1600 1610 1620 EEEEELKKED EEPPRRSAFQ FVYQAWITDP KTALRQRHKE KKRSAREERK RRRKGSKEGP 1630 1640 1650 1660 1670 1680 VEWEDREDEP IKKKSDGPDN IIKRIFNILK FTWVLFLATV DSFTTWLNSI SREHIDISTV 1690 1700 1710 1720 1730 1740 LRIERCMLTR EIKKGNVPTR ESIHMYYQNH IMNLSRESGL DTIDEHPGAA SGAQTAHRMD 1750 1760 1770 1780 1790 1800 SLDSHDSISS EPTQCTMLYS RQGTTETIEE VEAEQEEEAG STAPEPREAK EYEATGYDVG 1810 1820 1830 1840 1850 1860 AMGAEEASLT PEEELTQFST LDGDVEAPPS YSKAVSFEHL SFGSQDDSAG KNRMAVSPDD 1870 1880 1890 1900 1910 1920 SRTDKLGSSI LPPLTHELTA SELLLKKMFH DDELEESEKF YVGQPRFLLL FYAMYNTLVA 1930 1940 1950 1960 1970 1980 RSEMVCYFVI ILNHMVSASM ITLLLPILIF LWAMLSVPRP SRRFWMMAIV YTEVAIVVKY 1990 2000 2010 2020 2030 2040 FFQFGFFPWN KNVEVNKDKP YHPPNIIGVE KKEGYVLYDL IQLLALFFHR SILKCHGLWD 2050 2060 2070 2080 2090 2100 EDDMTESGMA REESDDELSL GHGRRDSSDS LKSINLAASV ESVHVTFPEQ QTAVRRKRSG 2110 2120 2130 2140 2150 2160 SSSEPSQRSS FSSNRSQRGS TSTRNSSQKG SSVLSIKQKG KRELYMEKLQ EHLIKAKAFT 2170 2180 2190 2200 2210 2220 IKKTLEIYVP IKQFFYNLIH PEYSAVTDVY VLMFLADTVD FIIIVFGFWA FGKHSAAADI 2230 2240 2250 2260 2270 2280 TSSLSEDQVP GPFLVMVLIQ FGTMVVDRAL YLRKTVLGKV IFQVILVFGI HFWMFFILPG 2290 2300 2310 2320 2330 2340 VTERKFSQNL VAQLWYFVKC VYFGLSAYQI RCGYPTRVLG NFLTKSYNYV NLFLFQGFRL 2350 2360 2370 2380 2390 2400 VPFLTELRAV MDWVWTDTTL SLSSWICVED IYAHIFILKC WRESEKPIFT MSAQQSQLKV 2410 2420 2430 2440 2450 2460 MDQQSFNKFI QAFSRDTGAM QFLENYEKED ITVAELEGNS NSLWTISPPS KQKMIHELLD 2470 2480 2490 2500 2510 2520 PNSSFSVVFS WSIQRNLSLG AKSEIATDKL SFPLKNITRK NIAKMIAGNS TESSKTPVTI 2530 2540 2550 2560 2570 2580 EKIYPYYVKA PSDSNSKPIK QLLSENNFMD ITIILSRDNT TKYNSEWWVL NLTGNRIYNP 2590 2600 2610 2620 2630 2640 NSQALELVVF NDKVSPPSLG FLAGYGIMGL YASVVLVIGK FVREFFSGIS HSIMFEELPN 2650 2660 2670 2680 VDRILKLCTD IFLVRETGEL ELEEDLYAKL IFLYRSPETM IKWTREKTN
	Isoform 3 [UniParc]. Checksum: DBD498DC75245E19	FASTA	709	80,795
	10 20 30 40 50 60 MTESGMAREE SDDELSLGHG RRDSSDSLKS INLAASVESV HVTFPEQQTA VRRKRSGSSS 70 80 90 100 110 120 EPSQRSSFSS NRSQRGSTST RNSSQKGSSV LSIKQKGKRE LYMEKLQEHL IKAKAFTIKK 130 140 150 160 170 180 TLEIYVPIKQ FFYNLIHPEY SAVTDVYVLM FLADTVDFII IVFGFWAFGK HSAAADITSS 190 200 210 220 230 240 LSEDQVPGPF LVMVLIQFGT MVVDRALYLR KTVLGKVIFQ VILVFGIHFW MFFILPGVTE 250 260 270 280 290 300 RKFSQNLVAQ LWYFVKCVYF GLSAYQIRCG YPTRVLGNFL TKSYNYVNLF LFQGFRLVPF 310 320 330 340 350 360 LTELRAVMDW VWTDTTLSLS SWICVEDIYA HIFILKCWRE SEKRYPQPRG QKKKKVVKYG 370 380 390 400 410 420 MGGMIIVLLI CIVWFPLLFM SLIKSVAGVI NQPLDVSVTI TLGGYQPIFT MSAQQSQLKV 430 440 450 460 470 480 MDQQSFNKFI QAFSRDTGAM QFLENYEKED ITVAELEGNS NSLWTISPPS KQKMIHELLD 490 500 510 520 530 540 PNSSFSVVFS WSIQRNLSLG AKSEIATDKL SFPLKNITRK NIAKMIAGNS TESSKTPVTI 550 560 570 580 590 600 EKIYPYYVKA PSDSNSKPIK QLLSENNFMD ITIILSRDNT TKYNSEWWVL NLTGNRIYNP 610 620 630 640 650 660 NSQALELVVF NDKVSPPSLG FLAGYGIMGL YASVVLVIGK FVREFFSGIS HSIMFEELPN 670 680 690 700 VDRILKLCTD IFLVRETGEL ELEEDLYAKL IFLYRSPETM IKWTREKTN
	Isoform 4 [UniParc]. Checksum: 466021E614EDCFFC	FASTA	2,777	320,890
	10 20 30 40 50 60 MASEVVCGLI FRLLLPICLA VACAFRYNGL SFVYLIYLLL IPLFSEPTKT TMQGHTGRLL 70 80 90 100 110 120 KSLCFISLSF LLLHIIFHIT LVSLEAQHRI APGYNCSTWE KTFRQIGFES LKGADAGNGI 130 140 150 160 170 180 RVFVPDIGMF IASLTIWLLC RNIVQKPVTD EAAQSNPEFE NEELAEGEKI DSEEALIYEE 190 200 210 220 230 240 DFNGGDGVEG ELEESTKLKM FRRLASVASK LKEFIGNMIT TAGKVVVTIL LGSSGMMLPS 250 260 270 280 290 300 LTSSVYFFVF LGLCTWWSWC RTFDPLLFSC LCVLLAIFTA GHLIGLYLYQ FQFFQEAVPP 310 320 330 340 350 360 NDYYARLFGI KSVIQTDCSS TWKIIVNPDL SWYHHANPIL LLVMYYTLAT LIRIWLQEPL 370 380 390 400 410 420 VQDEGTKEED KALACSPIQI TAGRRRSLWY ATHYPTDERK LLSMTQDDYK PSDGLLVTVN 430 440 450 460 470 480 GNPVDYHTIH PSLPMENGPG KADLYSTPQY RWEPSDESSE KREEEEEEKE EFEEERSREE 490 500 510 520 530 540 KRSIKVHAMV SVFQFIMKQS YICALIAMMA WSITYHSWLT FVLLIWSCTL WMIRNRRKYA 550 560 570 580 590 600 MISSPFMVVY GNLLLILQYI WSFELPEIKK VPGFLEKKEP GELASKILFT ITFWLLLRQH 610 620 630 640 650 660 LTEQKALQEK EALLSEVKIG SQENEEKDEE LQDIQVEGEP KEEEEEEAKE EKQERKKVEQ 670 680 690 700 710 720 EEAEEEDEQD IMKVLGNLVV AMFIKYWIYV CGGMFFFVSF EGKIVMYKII YMVLFLFCVA 730 740 750 760 770 780 LYQVHYEWWR KILKYFWMSV VIYTMLVLIF IYTYQFENFP GLWQNMTGLK KEKLEDLGLK 790 800 810 820 830 840 QFTVAELFTR IFIPTSFLLV CILHLHYFHD RFLELTDLKS IPSKEDNTIY SHAKVNGRVY 850 860 870 880 890 900 LIINSIKKKL PIHQNELAHP EGSLPDLTMM HLTASLEKPE VRKLAEPGEE KLEGYSEKAQ 910 920 930 940 950 960 KGDLGKDSEE SEEDGEEEEE SEEEEETSDL RNKWHLVIDR LTVLFLKFLE YFHKLQVFMW 970 980 990 1000 1010 1020 WILELHIIKI VSSYIIWVSV KEVSLFNYVF LISWAFALPY AKLRRLASSV CTVWTCVIIV 1030 1040 1050 1060 1070 1080 CKMLYQLQTI KPENFSVNCS LPNENQTNIP FNELNKSLLY SAPIDPTEWV GLRKSSPLLV 1090 1100 1110 1120 1130 1140 YLRNNLLMLA ILAFEVTIYR HQEYYRGRNN LTAPVSRTIF HDITRLHLDD GLINCAKYFI 1150 1160 1170 1180 1190 1200 NYFFYKFGLE TCFLMSVNVI GQRMDFYAMI HACWLIAVLY RRRRKAIAEI WPKYCCFLAC 1210 1220 1230 1240 1250 1260 IITFQYFICI GIPPAPCRDY PWRFKGASFN DNIIKWLYFP DFIVRPNPVF LVYDFMLLLC 1270 1280 1290 1300 1310 1320 ASLQRQIFED ENKAAVRIMA GDNVEICMNL DAASFSQHNP VPDFIHCRSY LDMSKVIIFS 1330 1340 1350 1360 1370 1380 YLFWFVLTII FITGTTRISI FCMGYLVACF YFLLFGGDLL LKPIKSILRY WDWLIAYNVF 1390 1400 1410 1420 1430 1440 VITMKNILSI GACGYIGTLV HNSCWLIQAF SLACTVKGYQ MPAANSPCTL PSGEAGIIWD 1450 1460 1470 1480 1490 1500 SICFAFLLLQ RRVFMSYYFL HVVADIKASQ ILASRGAELF QATIVKAVKA RIEEEKKSMD 1510 1520 1530 1540 1550 1560 QLKRQMDRIK ARQQKYKKGK ERMLSLTQEP GEGQDMQKLS EEDDEREADK QKAKGKKKQW 1570 1580 1590 1600 1610 1620 WRPWVDHASM VRSGDYYLFE TDSEEEEEEE LKKEDEEPPR RSAFQFVYQA WITDPKTALR 1630 1640 1650 1660 1670 1680 QRHKEKKRSA REERKRRRKG SKEGPVEWED REDEPIKKKS DGPDNIIKRI FNILKFTWVL 1690 1700 1710 1720 1730 1740 FLATVDSFTT WLNSISREHI DISTVLRIER CMLTREIKKG NVPTRESIHM YYQNHIMNLS 1750 1760 1770 1780 1790 1800 RESGLDTIDE HPGAASGAQT AHRMDSLDSH DSISSEPTQC TMLYSRQGTT ETIEEVEAEQ 1810 1820 1830 1840 1850 1860 EEEAGSTAPE PREAKEYEAT GYDVGAMGAE EASLTPEEEL TQFSTLDGDV EAPPSYSKAV 1870 1880 1890 1900 1910 1920 SFEHLSFGSQ DDSAGKNRMA VSPDDSRTDK LGSSILPPLT HELTASELLL KKMFHDDELE 1930 1940 1950 1960 1970 1980 ESEKFYVGQP RFLLLFYAMY NTLVARSEMV CYFVIILNHM VSASMITLLL PILIFLWAML 1990 2000 2010 2020 2030 2040 SVPRPSRRFW MMAIVYTEVA IVVKYFFQFG FFPWNKNVEV NKDKPYHPPN IIGVEKKEGY 2050 2060 2070 2080 2090 2100 VLYDLIQLLA LFFHRSILKC HGLWDEDDMT ESGMAREESD DELSLGHGRR DSSDSLKSIN 2110 2120 2130 2140 2150 2160 LAASVESVHV TFPEQQTAVR RKRSGSSSEP SQRSSFSSNR SQRGSTSTRN SSQKGSSVLS 2170 2180 2190 2200 2210 2220 IKQKGKRELY MEKLQEHLIK AKAFTIKKTL EIYVPIKQFF YNLIHPEYSA VTDVYVLMFL 2230 2240 2250 2260 2270 2280 ADTVDFIIIV FGFWAFGKHS AAADITSSLS EDQVPGPFLV MVLIQFGTMV VDRALYLRKT 2290 2300 2310 2320 2330 2340 VLGKVIFQVI LVFGIHFWMF FILPGVTERK FSQNLVAQLW YFVKCVYFGL SAYQIRCGYP 2350 2360 2370 2380 2390 2400 TRVLGNFLTK SYNYVNLFLF QGFRLVPFLT ELRAVMDWVW TDTTLSLSSW ICVEDIYAHI 2410 2420 2430 2440 2450 2460 FILKCWRESE KRYPQPRGQK KKKVVKYGMG GMIIVLLICI VWFPLLFMSL IKSVAGVINQ 2470 2480 2490 2500 2510 2520 PLDVSVTITL GGYQPIFTMS AQQSQLKVMD QQSFNKFIQA FSRDTGAMQF LENYEKEDIT 2530 2540 2550 2560 2570 2580 VAELEGNSNS LWTISPPSKQ KMIHELLDPN SSFSVVFSWS IQRNLSLGAK SEIATDKLSF 2590 2600 2610 2620 2630 2640 PLKNITRKNI AKMIAGNSTE SSKTPVTIEK IYPYYVKAPS DSNSKPIKQL LSENNFMDIT 2650 2660 2670 2680 2690 2700 IILSRDNTTK YNSEWWVLNL TGNRIYNPNS QALELVVFND KVSPPSLGFL AGYGIMGLYA 2710 2720 2730 2740 2750 2760 SVVLVIGKFV REFFSGISHS IMFEELPNVD RILKLCTDIF LVRETGELEL EEDLYAKLIF 2770 LYRSPETMIK WTREKTN

References

[1]

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 713-1275 (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2141-2752 (ISOFORM 2). Tissue: Brain, Hepatoma, Lung, Teratocarcinoma and Testis.

[2]

"DNA sequence and analysis of human chromosome 18." Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S. Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK026797 mRNA. Translation: BAB15556.1. Sequence problems. AK027056 mRNA. Translation: BAB15641.1. Different initiation. AK092226 mRNA. Translation: BAC03832.1. Sequence problems. AK098782 mRNA. Translation: BAC05412.1. Sequence problems. AK302764 mRNA. Translation: BAH13798.1. AP001180 Genomic DNA. No translation available. AP005117 Genomic DNA. No translation available. AP005120 Genomic DNA. No translation available. AP005404 Genomic DNA. No translation available. AP005793 Genomic DNA. No translation available.
IPI	IPI00640526. IPI00642845. IPI00791071. IPI00944547. IPI00974143.
RefSeq	NP_071351.2. NM_022068.2.
UniGene	Hs.436902.
3D structure databases
ProteinModelPortal	Q9H5I5.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000285141.
PTM databases
PhosphoSite	Q9H5I5.
Polymorphism databases
DMDM	68565215.
Proteomic databases
PaxDb	Q9H5I5.
PRIDE	Q9H5I5.
Protocols and materials databases
DNASU	63895.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000285141; ENSP00000285141; ENSG00000154864. ENST00000302079; ENSP00000303316; ENSG00000154864. ENST00000503781; ENSP00000421377; ENSG00000154864. ENST00000538948; ENSP00000443129; ENSG00000154864. ENST00000580640; ENSP00000463094; ENSG00000154864.
GeneID	63895.
KEGG	hsa:63895.
UCSC	uc002kos.2. human. uc002kow.1. human.
Organism-specific databases
CTD	63895.
GeneCards	GC18M010670.
HGNC	HGNC:26270. PIEZO2.
HPA	HPA015986. HPA031974. HPA040616.
MIM	613629. gene.
neXtProt	NX_Q9H5I5.
PharmGKB	PA134930761.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG298938.
HOVERGEN	HBG060934.
InParanoid	Q8NAR6.
OMA	SDGPDNI.
OrthoDB	EOG4HDST3.
Gene expression databases
ArrayExpress	Q9H5I5.
Bgee	Q9H5I5.
CleanEx	HS_FAM38B.
Genevestigator	Q9H5I5.
GermOnline	ENSG00000154864. Homo sapiens.
Family and domain databases
InterPro	IPR027272. Piezo. [Graphical view]
PANTHER	PTHR13167. PTHR13167. 1 hit.
Pfam	PF12166. DUF3595. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PIEZO2. human.
GenomeRNAi	63895.
NextBio	65586.
SOURCE	Search...

Entry information

Entry name

PIEZ2_HUMAN

Accession

Primary (citable) accession number: Q9H5I5
Secondary accession number(s): B7Z812 , Q8N787, Q8NAR6, Q9H5R4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	January 11, 2011
Last modified:	May 1, 2013
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.