Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 768

Gene

ZNF768

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri261 – 283C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 479C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri485 – 507C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri513 – 535C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 768
Gene namesi
Name:ZNF768
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:26273. ZNF768.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169957.
PharmGKBiPA162410327.

Polymorphism and mutation databases

BioMutaiZNF768.
DMDMi158564024.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003044081 – 540Zinc finger protein 768Add BLAST540

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17PhosphoserineCombined sources1
Modified residuei23PhosphoserineBy similarity1
Modified residuei33PhosphoserineBy similarity1
Modified residuei83PhosphoserineCombined sources1
Modified residuei90PhosphoserineCombined sources1
Modified residuei97PhosphoserineCombined sources1
Modified residuei104PhosphoserineBy similarity1
Modified residuei125PhosphoserineCombined sources1
Modified residuei132PhosphoserineCombined sources1
Modified residuei139PhosphoserineCombined sources1
Modified residuei160PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H5H4.
MaxQBiQ9H5H4.
PaxDbiQ9H5H4.
PeptideAtlasiQ9H5H4.
PRIDEiQ9H5H4.

PTM databases

iPTMnetiQ9H5H4.
PhosphoSitePlusiQ9H5H4.

Expressioni

Gene expression databases

BgeeiENSG00000169957.
CleanExiHS_ZNF768.
ExpressionAtlasiQ9H5H4. baseline and differential.
GenevisibleiQ9H5H4. HS.

Organism-specific databases

HPAiHPA024630.
HPA066512.

Interactioni

Protein-protein interaction databases

BioGridi122839. 23 interactors.
IntActiQ9H5H4. 9 interactors.
MINTiMINT-4940312.
STRINGi9606.ENSP00000369777.

Structurei

3D structure databases

ProteinModelPortaliQ9H5H4.
SMRiQ9H5H4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi34 – 39Poly-Glu6
Compositional biasi55 – 140Pro-richAdd BLAST86

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri261 – 283C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 479C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri485 – 507C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri513 – 535C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133765.
HOGENOMiHOG000234617.
HOVERGENiHBG105926.
InParanoidiQ9H5H4.
KOiK09228.
OMAiSRYESQN.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9H5H4.
TreeFamiTF350793.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR000684. RNA_pol_II_repeat_euk.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF05001. RNA_pol_Rpb1_R. 4 hits.
PF00096. zf-C2H2. 6 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H5H4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEREALPWGL EPQDVQSSDE MRSPEGYLRG NMSENEEEEI SQQEGSGDYE
60 70 80 90 100
VEEIPFGLEP QSPGFEPQSP EFEPQSPRFE PESPGFESRS PGLVPPSPEF
110 120 130 140 150
APRSPESDSQ SPEFESQSPR YEPQSPGYEP RSPGYEPRSP GYESESSRYE
160 170 180 190 200
SQNTELKTQS PEFEAQSSKF QEGAEMLLNP EEKSPLNISV GVHPLDSFTQ
210 220 230 240 250
GFGEQPTGDL PIGPPFEMPT GALLSTPQFE MLQNPLGLTG ALRGPGRRGG
260 270 280 290 300
RARGGQGPRP NICGICGKSF GRGSTLIQHQ RIHTGEKPYK CEVCSKAFSQ
310 320 330 340 350
SSDLIKHQRT HTGERPYKCP RCGKAFADSS YLLRHQRTHS GQKPYKCPHC
360 370 380 390 400
GKAFGDSSYL LRHQRTHSHE RPYSCTECGK CYSQNSSLRS HQRVHTGQRP
410 420 430 440 450
FSCGICGKSF SQRSALIPHA RSHAREKPFK CPECGKRFGQ SSVLAIHART
460 470 480 490 500
HLPGRTYSCP DCGKTFNRSS TLIQHQRSHT GERPYRCAVC GKGFCRSSTL
510 520 530 540
LQHHRVHSGE RPYKCDDCGK AFSQSSDLIR HQRTHAAGRR
Length:540
Mass (Da):60,229
Last modified:September 11, 2007 - v2
Checksum:i7E9299F7C1BEE866
GO

Sequence cautioni

The sequence AAH13760 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH92403 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15652 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035024181E → D.1 PublicationCorresponds to variant rs10871453dbSNPEnsembl.1
Natural variantiVAR_052900488A → S.Corresponds to variant rs3751848dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC013760 mRNA. Translation: AAH13760.1. Different initiation.
BC092403 mRNA. Translation: AAH92403.2. Different initiation.
AK027089 mRNA. Translation: BAB15652.1. Different initiation.
CCDSiCCDS10681.2.
RefSeqiNP_078947.3. NM_024671.3.
UniGeneiHs.85658.

Genome annotation databases

EnsembliENST00000380412; ENSP00000369777; ENSG00000169957.
GeneIDi79724.
KEGGihsa:79724.
UCSCiuc002dyk.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC013760 mRNA. Translation: AAH13760.1. Different initiation.
BC092403 mRNA. Translation: AAH92403.2. Different initiation.
AK027089 mRNA. Translation: BAB15652.1. Different initiation.
CCDSiCCDS10681.2.
RefSeqiNP_078947.3. NM_024671.3.
UniGeneiHs.85658.

3D structure databases

ProteinModelPortaliQ9H5H4.
SMRiQ9H5H4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122839. 23 interactors.
IntActiQ9H5H4. 9 interactors.
MINTiMINT-4940312.
STRINGi9606.ENSP00000369777.

PTM databases

iPTMnetiQ9H5H4.
PhosphoSitePlusiQ9H5H4.

Polymorphism and mutation databases

BioMutaiZNF768.
DMDMi158564024.

Proteomic databases

EPDiQ9H5H4.
MaxQBiQ9H5H4.
PaxDbiQ9H5H4.
PeptideAtlasiQ9H5H4.
PRIDEiQ9H5H4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380412; ENSP00000369777; ENSG00000169957.
GeneIDi79724.
KEGGihsa:79724.
UCSCiuc002dyk.4. human.

Organism-specific databases

CTDi79724.
GeneCardsiZNF768.
HGNCiHGNC:26273. ZNF768.
HPAiHPA024630.
HPA066512.
neXtProtiNX_Q9H5H4.
OpenTargetsiENSG00000169957.
PharmGKBiPA162410327.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133765.
HOGENOMiHOG000234617.
HOVERGENiHBG105926.
InParanoidiQ9H5H4.
KOiK09228.
OMAiSRYESQN.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9H5H4.
TreeFamiTF350793.

Miscellaneous databases

GenomeRNAii79724.
PROiQ9H5H4.

Gene expression databases

BgeeiENSG00000169957.
CleanExiHS_ZNF768.
ExpressionAtlasiQ9H5H4. baseline and differential.
GenevisibleiQ9H5H4. HS.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR000684. RNA_pol_II_repeat_euk.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF05001. RNA_pol_Rpb1_R. 4 hits.
PF00096. zf-C2H2. 6 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN768_HUMAN
AccessioniPrimary (citable) accession number: Q9H5H4
Secondary accession number(s): Q569L7, Q96CX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: November 30, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.