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Q9H5H4

- ZN768_HUMAN

UniProt

Q9H5H4 - ZN768_HUMAN

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Protein

Zinc finger protein 768

Gene

ZNF768

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri261 – 28323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri289 – 31123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri317 – 33923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri345 – 36723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri373 – 39523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri401 – 42323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri429 – 45123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri457 – 47923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri485 – 50723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri513 – 53523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription from RNA polymerase II promoter Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 768
Gene namesi
Name:ZNF768
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:26273. ZNF768.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. DNA-directed RNA polymerase II, core complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410327.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 540540Zinc finger protein 768PRO_0000304408Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei17 – 171Phosphoserine1 Publication
Modified residuei83 – 831Phosphoserine3 Publications
Modified residuei90 – 901Phosphoserine1 Publication
Modified residuei97 – 971Phosphoserine2 Publications
Modified residuei160 – 1601Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9H5H4.
PaxDbiQ9H5H4.
PRIDEiQ9H5H4.

PTM databases

PhosphoSiteiQ9H5H4.

Expressioni

Gene expression databases

BgeeiQ9H5H4.
CleanExiHS_ZNF768.
ExpressionAtlasiQ9H5H4. baseline and differential.
GenevestigatoriQ9H5H4.

Organism-specific databases

HPAiHPA024630.

Interactioni

Protein-protein interaction databases

BioGridi122839. 11 interactions.
IntActiQ9H5H4. 7 interactions.
MINTiMINT-4940312.
STRINGi9606.ENSP00000369777.

Structurei

3D structure databases

ProteinModelPortaliQ9H5H4.
SMRiQ9H5H4. Positions 259-538.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi34 – 396Poly-Glu
Compositional biasi55 – 14086Pro-richAdd
BLAST

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri261 – 28323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri289 – 31123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri317 – 33923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri345 – 36723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri373 – 39523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri401 – 42323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri429 – 45123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri457 – 47923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri485 – 50723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri513 – 53523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00390000013640.
HOGENOMiHOG000234617.
HOVERGENiHBG105926.
InParanoidiQ9H5H4.
KOiK09228.
OMAiSRYESQN.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9H5H4.
TreeFamiTF350793.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR000684. RNA_pol_II_repeat_euk.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF05001. RNA_pol_Rpb1_R. 3 hits.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H5H4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEREALPWGL EPQDVQSSDE MRSPEGYLRG NMSENEEEEI SQQEGSGDYE
60 70 80 90 100
VEEIPFGLEP QSPGFEPQSP EFEPQSPRFE PESPGFESRS PGLVPPSPEF
110 120 130 140 150
APRSPESDSQ SPEFESQSPR YEPQSPGYEP RSPGYEPRSP GYESESSRYE
160 170 180 190 200
SQNTELKTQS PEFEAQSSKF QEGAEMLLNP EEKSPLNISV GVHPLDSFTQ
210 220 230 240 250
GFGEQPTGDL PIGPPFEMPT GALLSTPQFE MLQNPLGLTG ALRGPGRRGG
260 270 280 290 300
RARGGQGPRP NICGICGKSF GRGSTLIQHQ RIHTGEKPYK CEVCSKAFSQ
310 320 330 340 350
SSDLIKHQRT HTGERPYKCP RCGKAFADSS YLLRHQRTHS GQKPYKCPHC
360 370 380 390 400
GKAFGDSSYL LRHQRTHSHE RPYSCTECGK CYSQNSSLRS HQRVHTGQRP
410 420 430 440 450
FSCGICGKSF SQRSALIPHA RSHAREKPFK CPECGKRFGQ SSVLAIHART
460 470 480 490 500
HLPGRTYSCP DCGKTFNRSS TLIQHQRSHT GERPYRCAVC GKGFCRSSTL
510 520 530 540
LQHHRVHSGE RPYKCDDCGK AFSQSSDLIR HQRTHAAGRR
Length:540
Mass (Da):60,229
Last modified:September 11, 2007 - v2
Checksum:i7E9299F7C1BEE866
GO

Sequence cautioni

The sequence AAH13760.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH92403.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB15652.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti181 – 1811E → D.1 Publication
Corresponds to variant rs10871453 [ dbSNP | Ensembl ].
VAR_035024
Natural varianti488 – 4881A → S.
Corresponds to variant rs3751848 [ dbSNP | Ensembl ].
VAR_052900

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC013760 mRNA. Translation: AAH13760.1. Different initiation.
BC092403 mRNA. Translation: AAH92403.2. Different initiation.
AK027089 mRNA. Translation: BAB15652.1. Different initiation.
CCDSiCCDS10681.2.
RefSeqiNP_078947.3. NM_024671.3.
UniGeneiHs.85658.

Genome annotation databases

EnsembliENST00000380412; ENSP00000369777; ENSG00000169957.
GeneIDi79724.
KEGGihsa:79724.
UCSCiuc002dyk.4. human.

Polymorphism databases

DMDMi158564024.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC013760 mRNA. Translation: AAH13760.1 . Different initiation.
BC092403 mRNA. Translation: AAH92403.2 . Different initiation.
AK027089 mRNA. Translation: BAB15652.1 . Different initiation.
CCDSi CCDS10681.2.
RefSeqi NP_078947.3. NM_024671.3.
UniGenei Hs.85658.

3D structure databases

ProteinModelPortali Q9H5H4.
SMRi Q9H5H4. Positions 259-538.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122839. 11 interactions.
IntActi Q9H5H4. 7 interactions.
MINTi MINT-4940312.
STRINGi 9606.ENSP00000369777.

PTM databases

PhosphoSitei Q9H5H4.

Polymorphism databases

DMDMi 158564024.

Proteomic databases

MaxQBi Q9H5H4.
PaxDbi Q9H5H4.
PRIDEi Q9H5H4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000380412 ; ENSP00000369777 ; ENSG00000169957 .
GeneIDi 79724.
KEGGi hsa:79724.
UCSCi uc002dyk.4. human.

Organism-specific databases

CTDi 79724.
GeneCardsi GC16M030535.
HGNCi HGNC:26273. ZNF768.
HPAi HPA024630.
neXtProti NX_Q9H5H4.
PharmGKBi PA162410327.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00390000013640.
HOGENOMi HOG000234617.
HOVERGENi HBG105926.
InParanoidi Q9H5H4.
KOi K09228.
OMAi SRYESQN.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q9H5H4.
TreeFami TF350793.

Miscellaneous databases

GenomeRNAii 79724.
NextBioi 69086.
PROi Q9H5H4.

Gene expression databases

Bgeei Q9H5H4.
CleanExi HS_ZNF768.
ExpressionAtlasi Q9H5H4. baseline and differential.
Genevestigatori Q9H5H4.

Family and domain databases

Gene3Di 3.30.160.60. 10 hits.
InterProi IPR000684. RNA_pol_II_repeat_euk.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF05001. RNA_pol_Rpb1_R. 3 hits.
PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 10 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-181.
    Tissue: Ovary and PNS.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 19-540.
    Tissue: Epithelium.
  3. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83 AND SER-160, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  4. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-97, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17 AND SER-83, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83; SER-90 AND SER-97, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZN768_HUMAN
AccessioniPrimary (citable) accession number: Q9H5H4
Secondary accession number(s): Q569L7, Q96CX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: October 29, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3