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Protein

Zinc finger protein 768

Gene

ZNF768

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri261 – 283C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 479C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri485 – 507C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri513 – 535C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 768
Gene namesi
Name:ZNF768
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000169957.9
HGNCiHGNC:26273 ZNF768
neXtProtiNX_Q9H5H4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169957
PharmGKBiPA162410327

Polymorphism and mutation databases

BioMutaiZNF768
DMDMi158564024

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003044081 – 540Zinc finger protein 768Add BLAST540

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17PhosphoserineCombined sources1
Modified residuei23PhosphoserineBy similarity1
Modified residuei33PhosphoserineBy similarity1
Modified residuei83PhosphoserineCombined sources1
Modified residuei90PhosphoserineCombined sources1
Modified residuei97PhosphoserineCombined sources1
Modified residuei104PhosphoserineBy similarity1
Modified residuei125PhosphoserineCombined sources1
Modified residuei132PhosphoserineCombined sources1
Modified residuei139PhosphoserineCombined sources1
Modified residuei160PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H5H4
MaxQBiQ9H5H4
PaxDbiQ9H5H4
PeptideAtlasiQ9H5H4
PRIDEiQ9H5H4

PTM databases

iPTMnetiQ9H5H4
PhosphoSitePlusiQ9H5H4

Expressioni

Gene expression databases

BgeeiENSG00000169957
CleanExiHS_ZNF768
ExpressionAtlasiQ9H5H4 baseline and differential
GenevisibleiQ9H5H4 HS

Organism-specific databases

HPAiHPA024630
HPA066512

Interactioni

Protein-protein interaction databases

BioGridi122839, 28 interactors
IntActiQ9H5H4, 16 interactors
MINTiQ9H5H4
STRINGi9606.ENSP00000369777

Structurei

3D structure databases

ProteinModelPortaliQ9H5H4
SMRiQ9H5H4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi34 – 39Poly-Glu6
Compositional biasi55 – 140Pro-richAdd BLAST86

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri261 – 283C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 479C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri485 – 507C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri513 – 535C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00900000140926
HOGENOMiHOG000234617
HOVERGENiHBG105926
InParanoidiQ9H5H4
KOiK09228
OMAiPPRPNIC
OrthoDBiEOG091G02KC
PhylomeDBiQ9H5H4
TreeFamiTF350793

Family and domain databases

InterProiView protein in InterPro
IPR000684 RNA_pol_II_repeat_euk
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF05001 RNA_pol_Rpb1_R, 4 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

Sequencei

Sequence statusi: Complete.

Q9H5H4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEREALPWGL EPQDVQSSDE MRSPEGYLRG NMSENEEEEI SQQEGSGDYE
60 70 80 90 100
VEEIPFGLEP QSPGFEPQSP EFEPQSPRFE PESPGFESRS PGLVPPSPEF
110 120 130 140 150
APRSPESDSQ SPEFESQSPR YEPQSPGYEP RSPGYEPRSP GYESESSRYE
160 170 180 190 200
SQNTELKTQS PEFEAQSSKF QEGAEMLLNP EEKSPLNISV GVHPLDSFTQ
210 220 230 240 250
GFGEQPTGDL PIGPPFEMPT GALLSTPQFE MLQNPLGLTG ALRGPGRRGG
260 270 280 290 300
RARGGQGPRP NICGICGKSF GRGSTLIQHQ RIHTGEKPYK CEVCSKAFSQ
310 320 330 340 350
SSDLIKHQRT HTGERPYKCP RCGKAFADSS YLLRHQRTHS GQKPYKCPHC
360 370 380 390 400
GKAFGDSSYL LRHQRTHSHE RPYSCTECGK CYSQNSSLRS HQRVHTGQRP
410 420 430 440 450
FSCGICGKSF SQRSALIPHA RSHAREKPFK CPECGKRFGQ SSVLAIHART
460 470 480 490 500
HLPGRTYSCP DCGKTFNRSS TLIQHQRSHT GERPYRCAVC GKGFCRSSTL
510 520 530 540
LQHHRVHSGE RPYKCDDCGK AFSQSSDLIR HQRTHAAGRR
Length:540
Mass (Da):60,229
Last modified:September 11, 2007 - v2
Checksum:i7E9299F7C1BEE866
GO

Sequence cautioni

The sequence AAH13760 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH92403 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15652 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035024181E → D1 PublicationCorresponds to variant dbSNP:rs10871453Ensembl.1
Natural variantiVAR_052900488A → S. Corresponds to variant dbSNP:rs3751848Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC013760 mRNA Translation: AAH13760.1 Different initiation.
BC092403 mRNA Translation: AAH92403.2 Different initiation.
AK027089 mRNA Translation: BAB15652.1 Different initiation.
CCDSiCCDS10681.2
RefSeqiNP_078947.3, NM_024671.3
UniGeneiHs.85658

Genome annotation databases

EnsembliENST00000380412; ENSP00000369777; ENSG00000169957
GeneIDi79724
KEGGihsa:79724
UCSCiuc002dyk.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN768_HUMAN
AccessioniPrimary (citable) accession number: Q9H5H4
Secondary accession number(s): Q569L7, Q96CX4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: May 23, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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Main funding by: National Institutes of Health