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Q9H5H4

- ZN768_HUMAN

UniProt

Q9H5H4 - ZN768_HUMAN

Protein

Zinc finger protein 768

Gene

ZNF768

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri261 – 28323C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri289 – 31123C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri317 – 33923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri345 – 36723C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri373 – 39523C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri401 – 42323C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri429 – 45123C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri457 – 47923C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri485 – 50723C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri513 – 53523C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. poly(A) RNA binding Source: UniProtKB

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription from RNA polymerase II promoter Source: InterPro

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 768
    Gene namesi
    Name:ZNF768
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:26273. ZNF768.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. DNA-directed RNA polymerase II, core complex Source: InterPro

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162410327.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 540540Zinc finger protein 768PRO_0000304408Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei17 – 171Phosphoserine1 Publication
    Modified residuei83 – 831Phosphoserine3 Publications
    Modified residuei90 – 901Phosphoserine1 Publication
    Modified residuei97 – 971Phosphoserine2 Publications
    Modified residuei160 – 1601Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9H5H4.
    PaxDbiQ9H5H4.
    PRIDEiQ9H5H4.

    PTM databases

    PhosphoSiteiQ9H5H4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H5H4.
    BgeeiQ9H5H4.
    CleanExiHS_ZNF768.
    GenevestigatoriQ9H5H4.

    Organism-specific databases

    HPAiHPA024630.

    Interactioni

    Protein-protein interaction databases

    BioGridi122839. 8 interactions.
    IntActiQ9H5H4. 7 interactions.
    MINTiMINT-4940312.
    STRINGi9606.ENSP00000369777.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H5H4.
    SMRiQ9H5H4. Positions 233-538.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi34 – 396Poly-Glu
    Compositional biasi55 – 14086Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri261 – 28323C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri289 – 31123C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri317 – 33923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri345 – 36723C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri373 – 39523C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri401 – 42323C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri429 – 45123C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri457 – 47923C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri485 – 50723C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri513 – 53523C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG105926.
    InParanoidiQ9H5H4.
    KOiK09228.
    OMAiSRYESQN.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ9H5H4.
    TreeFamiTF350793.

    Family and domain databases

    Gene3Di3.30.160.60. 10 hits.
    InterProiIPR000684. RNA_pol_II_repeat_euk.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF05001. RNA_pol_Rpb1_R. 3 hits.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 10 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 10 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9H5H4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEREALPWGL EPQDVQSSDE MRSPEGYLRG NMSENEEEEI SQQEGSGDYE    50
    VEEIPFGLEP QSPGFEPQSP EFEPQSPRFE PESPGFESRS PGLVPPSPEF 100
    APRSPESDSQ SPEFESQSPR YEPQSPGYEP RSPGYEPRSP GYESESSRYE 150
    SQNTELKTQS PEFEAQSSKF QEGAEMLLNP EEKSPLNISV GVHPLDSFTQ 200
    GFGEQPTGDL PIGPPFEMPT GALLSTPQFE MLQNPLGLTG ALRGPGRRGG 250
    RARGGQGPRP NICGICGKSF GRGSTLIQHQ RIHTGEKPYK CEVCSKAFSQ 300
    SSDLIKHQRT HTGERPYKCP RCGKAFADSS YLLRHQRTHS GQKPYKCPHC 350
    GKAFGDSSYL LRHQRTHSHE RPYSCTECGK CYSQNSSLRS HQRVHTGQRP 400
    FSCGICGKSF SQRSALIPHA RSHAREKPFK CPECGKRFGQ SSVLAIHART 450
    HLPGRTYSCP DCGKTFNRSS TLIQHQRSHT GERPYRCAVC GKGFCRSSTL 500
    LQHHRVHSGE RPYKCDDCGK AFSQSSDLIR HQRTHAAGRR 540
    Length:540
    Mass (Da):60,229
    Last modified:September 11, 2007 - v2
    Checksum:i7E9299F7C1BEE866
    GO

    Sequence cautioni

    The sequence AAH13760.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH92403.2 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB15652.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti181 – 1811E → D.1 Publication
    Corresponds to variant rs10871453 [ dbSNP | Ensembl ].
    VAR_035024
    Natural varianti488 – 4881A → S.
    Corresponds to variant rs3751848 [ dbSNP | Ensembl ].
    VAR_052900

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC013760 mRNA. Translation: AAH13760.1. Different initiation.
    BC092403 mRNA. Translation: AAH92403.2. Different initiation.
    AK027089 mRNA. Translation: BAB15652.1. Different initiation.
    CCDSiCCDS10681.2.
    RefSeqiNP_078947.3. NM_024671.3.
    UniGeneiHs.85658.

    Genome annotation databases

    EnsembliENST00000380412; ENSP00000369777; ENSG00000169957.
    GeneIDi79724.
    KEGGihsa:79724.
    UCSCiuc002dyk.4. human.

    Polymorphism databases

    DMDMi158564024.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC013760 mRNA. Translation: AAH13760.1 . Different initiation.
    BC092403 mRNA. Translation: AAH92403.2 . Different initiation.
    AK027089 mRNA. Translation: BAB15652.1 . Different initiation.
    CCDSi CCDS10681.2.
    RefSeqi NP_078947.3. NM_024671.3.
    UniGenei Hs.85658.

    3D structure databases

    ProteinModelPortali Q9H5H4.
    SMRi Q9H5H4. Positions 233-538.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122839. 8 interactions.
    IntActi Q9H5H4. 7 interactions.
    MINTi MINT-4940312.
    STRINGi 9606.ENSP00000369777.

    PTM databases

    PhosphoSitei Q9H5H4.

    Polymorphism databases

    DMDMi 158564024.

    Proteomic databases

    MaxQBi Q9H5H4.
    PaxDbi Q9H5H4.
    PRIDEi Q9H5H4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000380412 ; ENSP00000369777 ; ENSG00000169957 .
    GeneIDi 79724.
    KEGGi hsa:79724.
    UCSCi uc002dyk.4. human.

    Organism-specific databases

    CTDi 79724.
    GeneCardsi GC16M030535.
    HGNCi HGNC:26273. ZNF768.
    HPAi HPA024630.
    neXtProti NX_Q9H5H4.
    PharmGKBi PA162410327.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG105926.
    InParanoidi Q9H5H4.
    KOi K09228.
    OMAi SRYESQN.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q9H5H4.
    TreeFami TF350793.

    Miscellaneous databases

    GenomeRNAii 79724.
    NextBioi 69086.
    PROi Q9H5H4.

    Gene expression databases

    ArrayExpressi Q9H5H4.
    Bgeei Q9H5H4.
    CleanExi HS_ZNF768.
    Genevestigatori Q9H5H4.

    Family and domain databases

    Gene3Di 3.30.160.60. 10 hits.
    InterProi IPR000684. RNA_pol_II_repeat_euk.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF05001. RNA_pol_Rpb1_R. 3 hits.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 10 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 10 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-181.
      Tissue: Ovary and PNS.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 19-540.
      Tissue: Epithelium.
    3. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83 AND SER-160, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    4. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-97, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17 AND SER-83, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83; SER-90 AND SER-97, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiZN768_HUMAN
    AccessioniPrimary (citable) accession number: Q9H5H4
    Secondary accession number(s): Q569L7, Q96CX4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3