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Q9H5H4 (ZN768_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 768
Gene names
Name:ZNF768
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length540 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 10 C2H2-type zinc fingers.

Sequence caution

The sequence AAH13760.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH92403.2 differs from that shown. Reason: Erroneous initiation.

The sequence BAB15652.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 540540Zinc finger protein 768
PRO_0000304408

Regions

Zinc finger261 – 28323C2H2-type 1
Zinc finger289 – 31123C2H2-type 2
Zinc finger317 – 33923C2H2-type 3
Zinc finger345 – 36723C2H2-type 4
Zinc finger373 – 39523C2H2-type 5
Zinc finger401 – 42323C2H2-type 6
Zinc finger429 – 45123C2H2-type 7
Zinc finger457 – 47923C2H2-type 8
Zinc finger485 – 50723C2H2-type 9
Zinc finger513 – 53523C2H2-type 10
Compositional bias34 – 396Poly-Glu
Compositional bias55 – 14086Pro-rich

Amino acid modifications

Modified residue171Phosphoserine Ref.5
Modified residue831Phosphoserine Ref.3 Ref.5 Ref.8
Modified residue901Phosphoserine Ref.8
Modified residue971Phosphoserine Ref.4 Ref.8
Modified residue1601Phosphoserine Ref.3

Natural variations

Natural variant1811E → D. Ref.1
Corresponds to variant rs10871453 [ dbSNP | Ensembl ].
VAR_035024
Natural variant4881A → S.
Corresponds to variant rs3751848 [ dbSNP | Ensembl ].
VAR_052900

Sequences

Sequence LengthMass (Da)Tools
Q9H5H4 [UniParc].

Last modified September 11, 2007. Version 2.
Checksum: 7E9299F7C1BEE866

FASTA54060,229
        10         20         30         40         50         60 
MEREALPWGL EPQDVQSSDE MRSPEGYLRG NMSENEEEEI SQQEGSGDYE VEEIPFGLEP 

        70         80         90        100        110        120 
QSPGFEPQSP EFEPQSPRFE PESPGFESRS PGLVPPSPEF APRSPESDSQ SPEFESQSPR 

       130        140        150        160        170        180 
YEPQSPGYEP RSPGYEPRSP GYESESSRYE SQNTELKTQS PEFEAQSSKF QEGAEMLLNP 

       190        200        210        220        230        240 
EEKSPLNISV GVHPLDSFTQ GFGEQPTGDL PIGPPFEMPT GALLSTPQFE MLQNPLGLTG 

       250        260        270        280        290        300 
ALRGPGRRGG RARGGQGPRP NICGICGKSF GRGSTLIQHQ RIHTGEKPYK CEVCSKAFSQ 

       310        320        330        340        350        360 
SSDLIKHQRT HTGERPYKCP RCGKAFADSS YLLRHQRTHS GQKPYKCPHC GKAFGDSSYL 

       370        380        390        400        410        420 
LRHQRTHSHE RPYSCTECGK CYSQNSSLRS HQRVHTGQRP FSCGICGKSF SQRSALIPHA 

       430        440        450        460        470        480 
RSHAREKPFK CPECGKRFGQ SSVLAIHART HLPGRTYSCP DCGKTFNRSS TLIQHQRSHT 

       490        500        510        520        530        540 
GERPYRCAVC GKGFCRSSTL LQHHRVHSGE RPYKCDDCGK AFSQSSDLIR HQRTHAAGRR 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-181.
Tissue: Ovary and PNS.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 19-540.
Tissue: Epithelium.
[3]"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83 AND SER-160, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[4]"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-97, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[5]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17 AND SER-83, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83; SER-90 AND SER-97, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC013760 mRNA. Translation: AAH13760.1. Different initiation.
BC092403 mRNA. Translation: AAH92403.2. Different initiation.
AK027089 mRNA. Translation: BAB15652.1. Different initiation.
RefSeqNP_078947.3. NM_024671.3.
UniGeneHs.85658.

3D structure databases

ProteinModelPortalQ9H5H4.
SMRQ9H5H4. Positions 233-539.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122839. 7 interactions.
IntActQ9H5H4. 7 interactions.
MINTMINT-4940312.
STRING9606.ENSP00000369777.

PTM databases

PhosphoSiteQ9H5H4.

Polymorphism databases

DMDM158564024.

Proteomic databases

PaxDbQ9H5H4.
PRIDEQ9H5H4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000380412; ENSP00000369777; ENSG00000169957.
GeneID79724.
KEGGhsa:79724.
UCSCuc002dyk.4. human.

Organism-specific databases

CTD79724.
GeneCardsGC16M030535.
HGNCHGNC:26273. ZNF768.
HPAHPA024630.
neXtProtNX_Q9H5H4.
PharmGKBPA162410327.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG105926.
InParanoidQ9H5H4.
KOK09228.
OMASRYESQN.
OrthoDBEOG7KSX7Q.
PhylomeDBQ9H5H4.
TreeFamTF350793.

Gene expression databases

ArrayExpressQ9H5H4.
BgeeQ9H5H4.
CleanExHS_ZNF768.
GenevestigatorQ9H5H4.

Family and domain databases

Gene3D3.30.160.60. 10 hits.
InterProIPR000684. RNA_pol_II_repeat_euk.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF05001. RNA_pol_Rpb1_R. 3 hits.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi79724.
NextBio69086.
PROQ9H5H4.

Entry information

Entry nameZN768_HUMAN
AccessionPrimary (citable) accession number: Q9H5H4
Secondary accession number(s): Q569L7, Q96CX4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: April 16, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM