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Q9H598

- VIAAT_HUMAN

UniProt

Q9H598 - VIAAT_HUMAN

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Protein
Vesicular inhibitory amino acid transporter
Gene
SLC32A1, VGAT, VIAAT
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the uptake of GABA and glycine into the synaptic vesicles.

GO - Molecular functioni

  1. gamma-aminobutyric acid:proton symporter activity Source: Ensembl
  2. glycine transmembrane transporter activity Source: Ensembl

GO - Biological processi

  1. aging Source: Ensembl
  2. ion transport Source: Reactome
  3. neurotransmitter secretion Source: Reactome
  4. synaptic transmission Source: Reactome
  5. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Transport

Enzyme and pathway databases

ReactomeiREACT_19397. Transport of inorganic cations/anions and amino acids/oligopeptides.
REACT_23947. GABA synthesis, release, reuptake and degradation.

Protein family/group databases

TCDBi2.A.18.5.4. the amino acid/auxin permease (aaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicular inhibitory amino acid transporter
Alternative name(s):
GABA and glycine transporter
Solute carrier family 32 member 1
Vesicular GABA transporter
Short name:
hVIAAT
Gene namesi
Name:SLC32A1
Synonyms:VGAT, VIAAT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:11018. SLC32A1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 133133Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei134 – 15421Helical; Reviewed prediction
Add
BLAST
Topological domaini155 – 20450Lumenal, vesicle Reviewed prediction
Add
BLAST
Transmembranei205 – 22521Helical; Reviewed prediction
Add
BLAST
Topological domaini226 – 24217Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei243 – 26321Helical; Reviewed prediction
Add
BLAST
Topological domaini264 – 2652Lumenal, vesicle Reviewed prediction
Transmembranei266 – 28621Helical; Reviewed prediction
Add
BLAST
Topological domaini287 – 30519Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei306 – 32621Helical; Reviewed prediction
Add
BLAST
Topological domaini327 – 34115Lumenal, vesicle Reviewed prediction
Add
BLAST
Transmembranei342 – 36221Helical; Reviewed prediction
Add
BLAST
Topological domaini363 – 38321Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei384 – 40421Helical; Reviewed prediction
Add
BLAST
Topological domaini405 – 43834Lumenal, vesicle Reviewed prediction
Add
BLAST
Transmembranei439 – 45921Helical; Reviewed prediction
Add
BLAST
Topological domaini460 – 4612Cytoplasmic Reviewed prediction
Transmembranei462 – 48221Helical; Reviewed prediction
Add
BLAST
Topological domaini483 – 4897Lumenal, vesicle Reviewed prediction
Transmembranei490 – 51021Helical; Reviewed prediction
Add
BLAST
Topological domaini511 – 52515Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell tip Source: Ensembl
  2. clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane Source: Reactome
  3. cone cell pedicle Source: Ensembl
  4. dendrite Source: MGI
  5. dendrite terminus Source: Ensembl
  6. inhibitory synapse Source: Ensembl
  7. integral component of membrane Source: UniProtKB-KW
  8. neuron projection Source: MGI
  9. neuron projection terminus Source: MGI
  10. plasma membrane Source: Reactome
  11. synaptic vesicle membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA401.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 525525Vesicular inhibitory amino acid transporter
PRO_0000093820Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei186 – 1861Nitrated tyrosine By similarity
Glycosylationi341 – 3411N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein, Nitration

Proteomic databases

PaxDbiQ9H598.
PeptideAtlasiQ9H598.
PRIDEiQ9H598.

PTM databases

PhosphoSiteiQ9H598.

Expressioni

Tissue specificityi

Retina. Expressed throughout the horizontal cells or more specifically at the terminals.1 Publication

Gene expression databases

BgeeiQ9H598.
CleanExiHS_SLC32A1.
GenevestigatoriQ9H598.

Organism-specific databases

HPAiCAB037156.
HPA058859.
HPA059985.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000217420.

Structurei

3D structure databases

ProteinModelPortaliQ9H598.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG294245.
HOGENOMiHOG000220837.
HOVERGENiHBG061364.
InParanoidiQ9H598.
KOiK15015.
OMAiMYNSFPN.
OrthoDBiEOG7SR4M2.
PhylomeDBiQ9H598.
TreeFamiTF312818.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H598-1 [UniParc]FASTAAdd to Basket

« Hide

MATLLRSKLS NVATSVSNKS QAKMSGMFAR MGFQAATDEE AVGFAHCDDL    50
DFEHRQGLQM DILKAEGEPC GDEGAEAPVE GDIHYQRGSG APLPPSGSKD 100
QVGGGGEFGG HDKPKITAWE AGWNVTNAIQ GMFVLGLPYA ILHGGYLGLF 150
LIIFAAVVCC YTGKILIACL YEENEDGEVV RVRDSYVAIA NACCAPRFPT 200
LGGRVVNVAQ IIELVMTCIL YVVVSGNLMY NSFPGLPVSQ KSWSIIATAV 250
LLPCAFLKNL KAVSKFSLLC TLAHFVINIL VIAYCLSRAR DWAWEKVKFY 300
IDVKKFPISI GIIVFSYTSQ IFLPSLEGNM QQPSEFHCMM NWTHIAACVL 350
KGLFALVAYL TWADETKEVI TDNLPGSIRA VVNIFLVAKA LLSYPLPFFA 400
AVEVLEKSLF QEGSRAFFPA CYSGDGRLKS WGLTLRCALV VFTLLMAIYV 450
PHFALLMGLT GSLTGAGLCF LLPSLFHLRL LWRKLLWHQV FFDVAIFVIG 500
GICSVSGFVH SLEGLIEAYR TNAED 525
Length:525
Mass (Da):57,415
Last modified:June 1, 2001 - v2
Checksum:iC3C4B0786B8DE745
GO

Sequence cautioni

The sequence AAH36458.2 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti423 – 4231S → G.
Corresponds to variant rs34517228 [ dbSNP | Ensembl ].
VAR_048121

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti261 – 2611K → R in AAH36458. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY044836 mRNA. Translation: AAK98782.1.
AK055051 mRNA. Translation: BAB70846.1.
AL133519 Genomic DNA. Translation: CAC15529.2.
BC036458 mRNA. Translation: AAH36458.2. Different initiation.
BC053582 mRNA. Translation: AAH53582.1.
CCDSiCCDS13307.1.
RefSeqiNP_542119.1. NM_080552.2.
UniGeneiHs.179080.

Genome annotation databases

EnsembliENST00000217420; ENSP00000217420; ENSG00000101438.
GeneIDi140679.
KEGGihsa:140679.
UCSCiuc002xjc.3. human.

Polymorphism databases

DMDMi29428257.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY044836 mRNA. Translation: AAK98782.1 .
AK055051 mRNA. Translation: BAB70846.1 .
AL133519 Genomic DNA. Translation: CAC15529.2 .
BC036458 mRNA. Translation: AAH36458.2 . Different initiation.
BC053582 mRNA. Translation: AAH53582.1 .
CCDSi CCDS13307.1.
RefSeqi NP_542119.1. NM_080552.2.
UniGenei Hs.179080.

3D structure databases

ProteinModelPortali Q9H598.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000217420.

Chemistry

DrugBanki DB00145. Glycine.
GuidetoPHARMACOLOGYi 1133.

Protein family/group databases

TCDBi 2.A.18.5.4. the amino acid/auxin permease (aaap) family.

PTM databases

PhosphoSitei Q9H598.

Polymorphism databases

DMDMi 29428257.

Proteomic databases

PaxDbi Q9H598.
PeptideAtlasi Q9H598.
PRIDEi Q9H598.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000217420 ; ENSP00000217420 ; ENSG00000101438 .
GeneIDi 140679.
KEGGi hsa:140679.
UCSCi uc002xjc.3. human.

Organism-specific databases

CTDi 140679.
GeneCardsi GC20P037353.
HGNCi HGNC:11018. SLC32A1.
HPAi CAB037156.
HPA058859.
HPA059985.
neXtProti NX_Q9H598.
PharmGKBi PA401.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG294245.
HOGENOMi HOG000220837.
HOVERGENi HBG061364.
InParanoidi Q9H598.
KOi K15015.
OMAi MYNSFPN.
OrthoDBi EOG7SR4M2.
PhylomeDBi Q9H598.
TreeFami TF312818.

Enzyme and pathway databases

Reactomei REACT_19397. Transport of inorganic cations/anions and amino acids/oligopeptides.
REACT_23947. GABA synthesis, release, reuptake and degradation.

Miscellaneous databases

GeneWikii SLC32A1.
GenomeRNAii 140679.
NextBioi 84209.
PROi Q9H598.

Gene expression databases

Bgeei Q9H598.
CleanExi HS_SLC32A1.
Genevestigatori Q9H598.

Family and domain databases

InterProi IPR013057. AA_transpt_TM.
[Graphical view ]
Pfami PF01490. Aa_trans. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of the vesicular inhibitory amino acid transporter in pancreatic islet cells: distribution of the transporter within rat islets."
    Chessler S.D., Simonson W.T., Sweet I.R., Hammerle L.P.
    Diabetes 51:1763-1771(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Cellular localization of the vesicular inhibitory amino acid transporter in the mouse and human retina."
    Jellali A., Stussi-Garaud C., Gasnier B., Rendon A., Sahel J.-A., Dreyfus H., Picaud S.
    J. Comp. Neurol. 449:76-87(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiVIAAT_HUMAN
AccessioniPrimary (citable) accession number: Q9H598
Secondary accession number(s): Q8N489
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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