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Protein

Dual specificity protein phosphatase 21

Gene

DUSP21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei106Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • peptidyl-tyrosine dephosphorylation Source: UniProtKB

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 21 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
Low molecular weight dual specificity phosphatase 21
Short name:
LMW-DSP21
Gene namesi
Name:DUSP21
Synonyms:LMWDSP21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:20476. DUSP21.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extrinsic component of mitochondrial inner membrane Source: Ensembl
  • mitochondrial matrix Source: Ensembl
  • nucleus Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion inner membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi63904.
OpenTargetsiENSG00000189037.
PharmGKBiPA134967875.

Polymorphism and mutation databases

BioMutaiDUSP21.
DMDMi50400652.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000948341 – 190Dual specificity protein phosphatase 21Add BLAST190

Proteomic databases

PaxDbiQ9H596.
PeptideAtlasiQ9H596.
PRIDEiQ9H596.

PTM databases

DEPODiQ9H596.
iPTMnetiQ9H596.
PhosphoSitePlusiQ9H596.

Expressioni

Tissue specificityi

Expressed in testis.1 Publication

Gene expression databases

BgeeiENSG00000189037.
CleanExiHS_DUSP21.
GenevisibleiQ9H596. HS.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi121980. 41 interactors.
IntActiQ9H596. 20 interactors.
MINTiMINT-3068077.
STRINGi9606.ENSP00000343244.

Structurei

3D structure databases

ProteinModelPortaliQ9H596.
SMRiQ9H596.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 161Tyrosine-protein phosphataseAdd BLAST141

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni43 – 128Sufficient for mitochondrial localizationBy similarityAdd BLAST86

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1718. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00760000118853.
HOGENOMiHOG000233766.
HOVERGENiHBG051422.
InParanoidiQ9H596.
KOiK14165.
OMAiRMINSPV.
OrthoDBiEOG091G0249.
PhylomeDBiQ9H596.
TreeFamiTF316009.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.90.190.10. 1 hit.
InterProiView protein in InterPro
IPR020417. Atypical_DUSP.
IPR020420. Atypical_DUSP_famB.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiView protein in Pfam
PF00782. DSPc. 1 hit.
PRINTSiPR01908. ADSPHPHTASE.
PR01910. ADSPHPHTASEB.
SMARTiView protein in SMART
SM00195. DSPc. 1 hit.
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiView protein in PROSITE
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9H596-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTASASSFSS SQGVQQPSIY SFSQITRSLF LSNGVAANDK LLLSSNRITA
60 70 80 90 100
IVNASVEVVN VFFEGIQYIK VPVTDARDSR LYDFFDPIAD LIHTIDMRQG
110 120 130 140 150
RTLLHCMAGV SRSASLCLAY LMKYHSMSLL DAHTWTKSRR PIIRPNNGFW
160 170 180 190
EQLINYEFKL FNNNTVRMIN SPVGNIPDIY EKDLRMMISM
Length:190
Mass (Da):21,529
Last modified:March 1, 2001 - v1
Checksum:i3E52BA31A4944EE3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti190M → I in CAG33440 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035644167R → C in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_019423186M → T2 PublicationsCorresponds to variant dbSNP:rs1045031Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF533018 mRNA. Translation: AAN59788.1.
AY156515 mRNA. Translation: AAO17295.1.
CR457159 mRNA. Translation: CAG33440.1.
AL133545 Genomic DNA. No translation available.
BC119755 mRNA. Translation: AAI19756.1.
BC119756 mRNA. Translation: AAI19757.1.
CCDSiCCDS14264.1.
RefSeqiNP_071359.3. NM_022076.3.
UniGeneiHs.534478.

Genome annotation databases

EnsembliENST00000339042; ENSP00000343244; ENSG00000189037.
GeneIDi63904.
KEGGihsa:63904.
UCSCiuc004dgd.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDUS21_HUMAN
AccessioniPrimary (citable) accession number: Q9H596
Secondary accession number(s): Q0VDA6, Q6IAJ6, Q6YDQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2001
Last modified: August 30, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families