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Q9H583

- HEAT1_HUMAN

UniProt

Q9H583 - HEAT1_HUMAN

Protein

HEAT repeat-containing protein 1

Gene

HEATR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 3 (19 Jul 2005)
      Previous versions | rss
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    Functioni

    Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis By similarity.By similarity

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. protein binding Source: IntAct

    GO - Biological processi

    1. rRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Biological processi

    Ribosome biogenesis, rRNA processing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HEAT repeat-containing protein 1
    Alternative name(s):
    Protein BAP28
    Cleaved into the following chain:
    Gene namesi
    Name:HEATR1
    Synonyms:BAP28
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:25517. HEATR1.

    Subcellular locationi

    Nucleusnucleolus 1 Publication

    GO - Cellular componenti

    1. membrane Source: UniProtKB
    2. mitochondrion Source: HPA
    3. nucleolus Source: HPA
    4. nucleus Source: HPA
    5. ribonucleoprotein complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671697.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 21442144HEAT repeat-containing protein 1PRO_0000424485Add
    BLAST
    Initiator methioninei1 – 11Removed; alternate1 Publication
    Chaini2 – 21442143HEAT repeat-containing protein 1, N-terminally processedPRO_0000186201Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Modified residuei2 – 21N-acetylthreonine; in HEAT repeat-containing protein 1, N-terminally processed2 Publications
    Modified residuei1190 – 11901Phosphoserine2 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9H583.
    PaxDbiQ9H583.
    PRIDEiQ9H583.

    2D gel databases

    SWISS-2DPAGEQ9H583.

    PTM databases

    PhosphoSiteiQ9H583.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H583.
    BgeeiQ9H583.
    CleanExiHS_HEATR1.
    GenevestigatoriQ9H583.

    Organism-specific databases

    HPAiHPA046917.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Q763533EBI-1048716,EBI-6248077From a different organism.

    Protein-protein interaction databases

    BioGridi120433. 22 interactions.
    IntActiQ9H583. 8 interactions.
    MINTiMINT-2817924.
    STRINGi9606.ENSP00000355541.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H583.
    SMRiQ9H583. Positions 1666-1738.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati2106 – 214237HEATAdd
    BLAST

    Sequence similaritiesi

    Belongs to the HEATR1/UTP10 family.Curated
    Contains 1 HEAT repeat.Curated

    Phylogenomic databases

    eggNOGiNOG116525.
    HOGENOMiHOG000007886.
    HOVERGENiHBG050660.
    InParanoidiQ9H583.
    KOiK14550.
    OMAiTMEDTFV.
    OrthoDBiEOG75B84D.
    PhylomeDBiQ9H583.
    TreeFamiTF314593.

    Family and domain databases

    Gene3Di1.25.10.10. 7 hits.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR012954. BP28_C_dom.
    IPR022125. U3snoRNP10.
    [Graphical view]
    PfamiPF08146. BP28CT. 1 hit.
    PF12397. U3snoRNP10. 1 hit.
    [Graphical view]
    SMARTiSM01036. BP28CT. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 8 hits.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9H583-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSLAQQLQR LALPQSDASL LSRDEVASLL FDPKEAATID RDTAFAIGCT     50
    GLEELLGIDP SFEQFEAPLF SQLAKTLERS VQTKAVNKQL DENISLFLIH 100
    LSPYFLLKPA QKCLEWLIHR FHIHLYNQDS LIACVLPYHE TRIFVRVIQL 150
    LKINNSKHRW FWLLPVKQSG VPLAKGTLIT HCYKDLGFMD FICSLVTKSV 200
    KVFAEYPGSS AQLRVLLAFY ASTIVSALVA AEDVSDNIIA KLFPYIQKGL 250
    KSSLPDYRAA TYMIICQISV KVTMENTFVN SLASQIIKTL TKIPSLIKDG 300
    LSCLIVLLQR QKPESLGKKP FPHLCNVPDL ITILHGISET YDVSPLLHYM 350
    LPHLVVSIIH HVTGEETEGM DGQIYKRHLE AILTKISLKN NLDHLLASLL 400
    FEEYISYSSQ EEMDSNKVSL LNEQFLPLIR LLESKYPRTL DVVLEEHLKE 450
    IADLKKQELF HQFVSLSTSG GKYQFLADSD TSLMLSLNHP LAPVRILAMN 500
    HLKKIMKTSK EGVDESFIKE AVLARLGDDN IDVVLSAISA FEIFKEHFSS 550
    EVTISNLLNL FQRAELSKNG EWYEVLKIAA DILIKEEILS ENDQLSNQVV 600
    VCLLPFMVIN NDDTESAEMK IAIYLSKSGI CSLHPLLRGW EEALENVIKS 650
    TKPGKLIGVA NQKMIELLAD NINLGDPSSM LKMVEDLISV GEEESFNLKQ 700
    KVTFHVILSV LVSCCSSLKE THFPFAIRVF SLLQKKIKKL ESVITAVEIP 750
    SEWHIELMLD RGIPVELWAH YVEELNSTQR VAVEDSVFLV FSLKKFIYAL 800
    KAPKSFPKGD IWWNPEQLKE DSRDYLHLLI GLFEMMLNGA DAVHFRVLMK 850
    LFIKVHLEDV FQLFKFCSVL WTYGSSLSNP LNCSVKTVLQ TQALYVGCAM 900
    LSSQKTQCKH QLASISSPVV TSLLINLGSP VKEVRRAAIQ CLQALSGVAS 950
    PFYLIIDHLI SKAEEITSDA AYVIQDLATL FEELQREKKL KSHQKLSETL 1000
    KNLLSCVYSC PSYIAKDLMK VLQGVNGEMV LSQLLPMAEQ LLEKIQKEPT 1050
    AVLKDEAMVL HLTLGKYNEF SVSLLNEDPK SLDIFIKAVH TTKELYAGMP 1100
    TIQITALEKI TKPFFAAISD EKVQQKLLRM LFDLLVNCKN SHCAQTVSSV 1150
    FKGISVNAEQ VRIELEPPDK AKPLGTVQQK RRQKMQQKKS QDLESVQEVG 1200
    GSYWQRVTLI LELLQHKKKL RSPQILVPTL FNLLSRCLEP LPQEQGNMEY 1250
    TKQLILSCLL NICQKLSPDG GKIPKDILDE EKFNVELIVQ CIRLSEMPQT 1300
    HHHALLLLGT VAGIFPDKVL HNIMSIFTFM GANVMRLDDT YSFQVINKTV 1350
    KMVIPALIQS DSGDSIEVSR NVEEIVVKII SVFVDALPHV PEHRRLPILV 1400
    QLVDTLGAEK FLWILLILLF EQYVTKTVLA AAYGEKDAIL EADTEFWFSV 1450
    CCEFSVQHQI QSLMNILQYL LKLPEEKEET IPKAVSFNKS ESQEEMLQVF 1500
    NVETHTSKQL RHFKFLSVSF MSQLLSSNNF LKKVVESGGP EILKGLEERL 1550
    LETVLGYISA VAQSMERNAD KLTVKFWRAL LSKAYDLLDK VNALLPTETF 1600
    IPVIRGLVGN PLPSVRRKAL DLLNNKLQQN ISWKKTIVTR FLKLVPDLLA 1650
    IVQRKKKEGE EEQAINRQTA LYTLKLLCKN FGAENPDPFV PVLNTAVKLI 1700
    APERKEEKNV LGSALLCIAE VTSTLEALAI PQLPSLMPSL LTTMKNTSEL 1750
    VSSEVYLLSA LAALQKVVET LPHFISPYLE GILSQVIHLE KITSEMGSAS 1800
    QANIRLTSLK KTLATTLAPR VLLPAIKKTY KQIEKNWKNH MGPFMSILQE 1850
    HIGVMKKEEL TSHQSQLTAF FLEALDFRAQ HSENDLEEVG KTENCIIDCL 1900
    VAMVVKLSEV TFRPLFFKLF DWAKTEDAPK DRLLTFYNLA DCIAEKLKGL 1950
    FTLFAGHLVK PFADTLNQVN ISKTDEAFFD SENDPEKCCL LLQFILNCLY 2000
    KIFLFDTQHF ISKERAEALM MPLVDQLENR LGGEEKFQER VTKHLIPCIA 2050
    QFSVAMADDS LWKPLNYQIL LKTRDSSPKV RFAALITVLA LAEKLKENYI 2100
    VLLPESIPFL AELMEDECEE VEHQCQKTIQ QLETVLGEPL QSYF 2144
    Length:2,144
    Mass (Da):242,370
    Last modified:July 19, 2005 - v3
    Checksum:i7590EEA17A5FF39D
    GO

    Sequence cautioni

    The sequence BAA91564.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti348 – 3481H → R.1 Publication
    Corresponds to variant rs2794751 [ dbSNP | Ensembl ].
    VAR_049329
    Natural varianti607 – 6071M → V.1 Publication
    Corresponds to variant rs2794763 [ dbSNP | Ensembl ].
    VAR_049330
    Natural varianti957 – 9571D → G.
    Corresponds to variant rs16833953 [ dbSNP | Ensembl ].
    VAR_049331
    Natural varianti1433 – 14331Y → C.
    Corresponds to variant rs653737 [ dbSNP | Ensembl ].
    VAR_049332
    Natural varianti1559 – 15591S → N.
    Corresponds to variant rs6661946 [ dbSNP | Ensembl ].
    VAR_049333
    Natural varianti1654 – 16541R → H.
    Corresponds to variant rs16833884 [ dbSNP | Ensembl ].
    VAR_049334
    Natural varianti1694 – 16941N → S.2 Publications
    Corresponds to variant rs2275689 [ dbSNP | Ensembl ].
    VAR_010939
    Natural varianti1854 – 18541V → A.2 Publications
    Corresponds to variant rs1885533 [ dbSNP | Ensembl ].
    VAR_010940
    Natural varianti1967 – 19671N → D.2 Publications
    Corresponds to variant rs1126627 [ dbSNP | Ensembl ].
    VAR_010941
    Natural varianti2017 – 20171E → G Polymorphism confirmed at protein level. 3 Publications
    Corresponds to variant rs2275687 [ dbSNP | Ensembl ].
    VAR_010942
    Natural varianti2077 – 20771S → L.
    Corresponds to variant rs6664730 [ dbSNP | Ensembl ].
    VAR_049335

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AX067150 mRNA. Translation: CAC26776.1.
    AL359921 Genomic DNA. Translation: CAI13775.1.
    BC065205 mRNA. Translation: AAH65205.1.
    AK001221 mRNA. Translation: BAA91564.1. Different initiation.
    CCDSiCCDS31066.1.
    RefSeqiNP_060542.4. NM_018072.5.
    UniGeneiHs.708114.

    Genome annotation databases

    EnsembliENST00000366582; ENSP00000355541; ENSG00000119285.
    GeneIDi55127.
    KEGGihsa:55127.
    UCSCiuc001hyd.2. human.

    Polymorphism databases

    DMDMi71153494.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AX067150 mRNA. Translation: CAC26776.1 .
    AL359921 Genomic DNA. Translation: CAI13775.1 .
    BC065205 mRNA. Translation: AAH65205.1 .
    AK001221 mRNA. Translation: BAA91564.1 . Different initiation.
    CCDSi CCDS31066.1.
    RefSeqi NP_060542.4. NM_018072.5.
    UniGenei Hs.708114.

    3D structure databases

    ProteinModelPortali Q9H583.
    SMRi Q9H583. Positions 1666-1738.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120433. 22 interactions.
    IntActi Q9H583. 8 interactions.
    MINTi MINT-2817924.
    STRINGi 9606.ENSP00000355541.

    PTM databases

    PhosphoSitei Q9H583.

    Polymorphism databases

    DMDMi 71153494.

    2D gel databases

    SWISS-2DPAGE Q9H583.

    Proteomic databases

    MaxQBi Q9H583.
    PaxDbi Q9H583.
    PRIDEi Q9H583.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000366582 ; ENSP00000355541 ; ENSG00000119285 .
    GeneIDi 55127.
    KEGGi hsa:55127.
    UCSCi uc001hyd.2. human.

    Organism-specific databases

    CTDi 55127.
    GeneCardsi GC01M236712.
    H-InvDB HIX0001726.
    HGNCi HGNC:25517. HEATR1.
    HPAi HPA046917.
    neXtProti NX_Q9H583.
    PharmGKBi PA142671697.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG116525.
    HOGENOMi HOG000007886.
    HOVERGENi HBG050660.
    InParanoidi Q9H583.
    KOi K14550.
    OMAi TMEDTFV.
    OrthoDBi EOG75B84D.
    PhylomeDBi Q9H583.
    TreeFami TF314593.

    Miscellaneous databases

    ChiTaRSi HEATR1. human.
    GeneWikii HEATR1.
    GenomeRNAii 55127.
    NextBioi 58786.
    PROi Q9H583.

    Gene expression databases

    ArrayExpressi Q9H583.
    Bgeei Q9H583.
    CleanExi HS_HEATR1.
    Genevestigatori Q9H583.

    Family and domain databases

    Gene3Di 1.25.10.10. 7 hits.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR012954. BP28_C_dom.
    IPR022125. U3snoRNP10.
    [Graphical view ]
    Pfami PF08146. BP28CT. 1 hit.
    PF12397. U3snoRNP10. 1 hit.
    [Graphical view ]
    SMARTi SM01036. BP28CT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 8 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ARG-348; VAL-607; SER-1694; ALA-1854; ASP-1967 AND GLY-2017.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1039-2144, VARIANTS SER-1694; ALA-1854; ASP-1967 AND GLY-2017.
      Tissue: Lymph.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1777-2144.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1190, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1190, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    11. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 AND THR-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Detection and validation of non-synonymous coding SNPs from orthogonal analysis of shotgun proteomics data."
      Bunger M.K., Cargile B.J., Sevinsky J.R., Deyanova E., Yates N.A., Hendrickson R.C., Stephenson J.L. Jr.
      J. Proteome Res. 6:2331-2340(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT GLY-2017, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiHEAT1_HUMAN
    AccessioniPrimary (citable) accession number: Q9H583
    Secondary accession number(s): Q5T3Q8, Q6P197, Q9NW23
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 123 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3