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Q9H582

- ZN644_HUMAN

UniProt

Q9H582 - ZN644_HUMAN

Protein

Zinc finger protein 644

Gene

ZNF644

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri410 – 43223C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri448 – 47023C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri496 – 51823C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri525 – 54824C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri586 – 60924C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri963 – 98725C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1038 – 106023C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 644
    Alternative name(s):
    Zinc finger motif enhancer-binding protein 2
    Short name:
    Zep-2
    Gene namesi
    Name:ZNF644
    Synonyms:KIAA1221, ZEP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:29222. ZNF644.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Myopia 21, autosomal dominant (MYP21) [MIM:614167]: A refractive error of the eye, in which parallel rays from a distant object come to focus in front of the retina, vision being better for near objects than for far.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti587 – 5871I → V in MYP21. 1 Publication
    Corresponds to variant rs146936371 [ dbSNP | Ensembl ].
    VAR_066389
    Natural varianti672 – 6721S → G in MYP21. 1 Publication
    VAR_066390
    Natural varianti680 – 6801R → G in MYP21. 1 Publication
    VAR_066391
    Natural varianti699 – 6991C → Y in MYP21. 1 Publication
    VAR_066392

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi614167. phenotype.
    PharmGKBiPA134984168.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13271327Zinc finger protein 644PRO_0000047698Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei309 – 3091Phosphoserine1 Publication
    Modified residuei1000 – 10001Phosphoserine4 Publications
    Modified residuei1189 – 11891Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9H582.
    PaxDbiQ9H582.
    PRIDEiQ9H582.

    PTM databases

    PhosphoSiteiQ9H582.

    Expressioni

    Tissue specificityi

    Expressed in liver, placenta, retina and retinal pigment epithelium.1 Publication

    Gene expression databases

    ArrayExpressiQ9H582.
    BgeeiQ9H582.
    CleanExiHS_ZNF644.
    GenevestigatoriQ9H582.

    Organism-specific databases

    HPAiHPA057795.

    Interactioni

    Protein-protein interaction databases

    BioGridi123913. 6 interactions.
    IntActiQ9H582. 2 interactions.
    MINTiMINT-4658204.
    STRINGi9606.ENSP00000337008.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H582.
    SMRiQ9H582. Positions 398-551, 574-618.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri410 – 43223C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri448 – 47023C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri496 – 51823C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri525 – 54824C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri586 – 60924C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri963 – 98725C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1038 – 106023C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG262560.
    HOVERGENiHBG058603.
    OMAiECNFMAV.
    OrthoDBiEOG747PH4.
    PhylomeDBiQ9H582.
    TreeFamiTF333705.

    Family and domain databases

    Gene3Di3.30.160.60. 1 hit.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 8 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H582-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRSFLQQDVN KTKSRLNVLN GLANNMDDLK INTDITGAKE ELLDDNNFIS     50
    DKESGVHKPK DCQTSFQKNN TLTLPEELSK DKSENALSGG QSSLFIHAGA 100
    PTVSSENFIL PKGAAVNGPV SHSSLTKTSN MNKGSVSLTT GQPVDQPTTE 150
    SCSTLKVAAD LQLSTPQKAS QHQVLFLLSD VAHAKNPTHS NKKLPTSASV 200
    GCDIQNSVGS NIKSDGTLIN QVEVGEDGED LLVKDDCVNT VTGISSGTDG 250
    FRSENDTNWD PQKEFIQFLM TNEETVDKAP PHSKIGLEKK RKRKMDVSKI 300
    TRYTEDCFSD SNCVPNKSKM QEVDFLEQNE ELQAVDSQKY ALSKVKPEST 350
    DEDLESVDAF QHLIYNPDKC GEESSPVHTS TFLSNTLKKK CEESDSESPA 400
    TFSTEEPSFY PCTKCNVNFR EKKHLHRHMM YHLDGNSHFR HLNVPRPYAC 450
    RECGRTFRDR NSLLKHMIIH QERRQKLMEE IRELKELQDE GRSARLQCPQ 500
    CVFGTNCPKT FVQHAKTHEK DKRYYCCEEC NFMAVTENEL ECHRGIAHGA 550
    VVKCPMVTSD IAQRKTQKKT FMKDSVVGSS KKSATYICKM CPFTTSAKSV 600
    LKKHTEYLHS SSCVDSFGSP LGLDKRKNDI LEEPVDSDST KTLTKQQSTT 650
    FPKNSALKQD VKRTFGSTSQ SSSFSKIHKR PHRIQKARKS IAQSGVNMCN 700
    QNSSPHKNVT IKSSVDQKPK YFHQAAKEKS NAKANSHYLY RHKYENYRMI 750
    KKSGESYPVH FKKEEASSLN SLHLFSSSSN SHNNFISDPH KPDAKRPESF 800
    KDHRRVAVKR VIKESKKESS VGGEDLDSYP DFLHKMTVVV LQKLNSAEKK 850
    DSYETEDESS WDNVELGDYT TQAIEDETYS DINQEHVNLF PLFKSKVEGQ 900
    EPGENATLSY DQNDGFYFEY YEDTGSNNFL HEIHDPQHLE TADASLSKHS 950
    SVFHWTDLSL EKKSCPYCPA TFETGVGLSN HVRGHLHRAG LSYEARHVVS 1000
    PEQIATSDKM QHFKRTGTGT PVKRVRKAIE KSETTSEHTC QLCGGWFDTK 1050
    IGLSNHVRGH LKRLGKTKWD AHKSPICVLN EMMQNEEKYE KILKALNSRR 1100
    IIPRPFVAQK LASSDDFISQ NVIPLEAYRN GLKTEALSVS ASEEEGLNFL 1150
    NEYDETKPEL PSGKKNQSLT LIELLKNKRM GEERNSAISP QKIHNQTARK 1200
    RFVQKCVLPL NEDSPLMYQP QKMDLTMHSA LDCKQKKSRS RSGSKKKMLT 1250
    LPHGADEVYI LRCRFCGLVF RGPLSVQEDW IKHLQRHIVN ANLPRTGAGM 1300
    VEVTSLLKKP ASITETSFSL LMAEAAS 1327
    Length:1,327
    Mass (Da):149,565
    Last modified:December 7, 2004 - v2
    Checksum:i53CE36BE21FC5056
    GO
    Isoform 2 (identifier: Q9H582-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1230-1232: ALD → GLI
         1233-1327: Missing.

    Show »
    Length:1,232
    Mass (Da):139,012
    Checksum:i50D719F07AF12CBA
    GO
    Isoform 3 (identifier: Q9H582-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1222: Missing.
         1223-1229: MDLTMHS → MLIRQNL

    Show »
    Length:105
    Mass (Da):11,724
    Checksum:i237D95A0CC5CAD1D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti296 – 2961D → M in BAD32777. 1 PublicationCurated
    Sequence conflicti1125 – 11251L → P in BAD32777. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti53 – 531E → Q in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035593
    Natural varianti556 – 5561M → V.
    Corresponds to variant rs17131242 [ dbSNP | Ensembl ].
    VAR_052885
    Natural varianti587 – 5871I → V in MYP21. 1 Publication
    Corresponds to variant rs146936371 [ dbSNP | Ensembl ].
    VAR_066389
    Natural varianti672 – 6721S → G in MYP21. 1 Publication
    VAR_066390
    Natural varianti680 – 6801R → G in MYP21. 1 Publication
    VAR_066391
    Natural varianti699 – 6991C → Y in MYP21. 1 Publication
    VAR_066392
    Natural varianti794 – 7941A → V.
    Corresponds to variant rs10922938 [ dbSNP | Ensembl ].
    VAR_052886

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 12221222Missing in isoform 3. 2 PublicationsVSP_015855Add
    BLAST
    Alternative sequencei1223 – 12297MDLTMHS → MLIRQNL in isoform 3. 2 PublicationsVSP_015856
    Alternative sequencei1230 – 12323ALD → GLI in isoform 2. 1 PublicationVSP_012158
    Alternative sequencei1233 – 132795Missing in isoform 2. 1 PublicationVSP_012159Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB019255 mRNA. Translation: BAD32777.1.
    AK291520 mRNA. Translation: BAF84209.1.
    AL136109 Genomic DNA. Translation: CAI23362.1.
    AL136109 Genomic DNA. Translation: CAI23363.1.
    CH471097 Genomic DNA. Translation: EAW73118.1.
    BC050656 mRNA. Translation: AAH50656.1.
    BC063683 mRNA. Translation: AAH63683.2.
    BC110841 mRNA. Translation: AAI10842.1.
    BC132776 mRNA. Translation: AAI32777.1.
    BC132778 mRNA. Translation: AAI32779.1.
    AB033047 mRNA. Translation: BAA86535.1.
    CCDSiCCDS731.1. [Q9H582-1]
    CCDS732.1. [Q9H582-3]
    RefSeqiNP_057704.2. NM_016620.3. [Q9H582-3]
    NP_115562.3. NM_032186.4. [Q9H582-3]
    NP_958357.1. NM_201269.2. [Q9H582-1]
    XP_005271318.1. XM_005271261.2. [Q9H582-1]
    XP_006711010.1. XM_006710947.1. [Q9H582-3]
    XP_006711011.1. XM_006710948.1. [Q9H582-3]
    UniGeneiHs.173001.
    Hs.745048.

    Genome annotation databases

    EnsembliENST00000337393; ENSP00000337008; ENSG00000122482. [Q9H582-1]
    ENST00000347275; ENSP00000340828; ENSG00000122482. [Q9H582-3]
    ENST00000361321; ENSP00000354659; ENSG00000122482. [Q9H582-3]
    ENST00000370440; ENSP00000359469; ENSG00000122482. [Q9H582-1]
    GeneIDi84146.
    KEGGihsa:84146.
    UCSCiuc001dnv.3. human. [Q9H582-3]
    uc001dnw.3. human. [Q9H582-1]

    Polymorphism databases

    DMDMi56404958.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB019255 mRNA. Translation: BAD32777.1 .
    AK291520 mRNA. Translation: BAF84209.1 .
    AL136109 Genomic DNA. Translation: CAI23362.1 .
    AL136109 Genomic DNA. Translation: CAI23363.1 .
    CH471097 Genomic DNA. Translation: EAW73118.1 .
    BC050656 mRNA. Translation: AAH50656.1 .
    BC063683 mRNA. Translation: AAH63683.2 .
    BC110841 mRNA. Translation: AAI10842.1 .
    BC132776 mRNA. Translation: AAI32777.1 .
    BC132778 mRNA. Translation: AAI32779.1 .
    AB033047 mRNA. Translation: BAA86535.1 .
    CCDSi CCDS731.1. [Q9H582-1 ]
    CCDS732.1. [Q9H582-3 ]
    RefSeqi NP_057704.2. NM_016620.3. [Q9H582-3 ]
    NP_115562.3. NM_032186.4. [Q9H582-3 ]
    NP_958357.1. NM_201269.2. [Q9H582-1 ]
    XP_005271318.1. XM_005271261.2. [Q9H582-1 ]
    XP_006711010.1. XM_006710947.1. [Q9H582-3 ]
    XP_006711011.1. XM_006710948.1. [Q9H582-3 ]
    UniGenei Hs.173001.
    Hs.745048.

    3D structure databases

    ProteinModelPortali Q9H582.
    SMRi Q9H582. Positions 398-551, 574-618.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123913. 6 interactions.
    IntActi Q9H582. 2 interactions.
    MINTi MINT-4658204.
    STRINGi 9606.ENSP00000337008.

    PTM databases

    PhosphoSitei Q9H582.

    Polymorphism databases

    DMDMi 56404958.

    Proteomic databases

    MaxQBi Q9H582.
    PaxDbi Q9H582.
    PRIDEi Q9H582.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000337393 ; ENSP00000337008 ; ENSG00000122482 . [Q9H582-1 ]
    ENST00000347275 ; ENSP00000340828 ; ENSG00000122482 . [Q9H582-3 ]
    ENST00000361321 ; ENSP00000354659 ; ENSG00000122482 . [Q9H582-3 ]
    ENST00000370440 ; ENSP00000359469 ; ENSG00000122482 . [Q9H582-1 ]
    GeneIDi 84146.
    KEGGi hsa:84146.
    UCSCi uc001dnv.3. human. [Q9H582-3 ]
    uc001dnw.3. human. [Q9H582-1 ]

    Organism-specific databases

    CTDi 84146.
    GeneCardsi GC01M091380.
    HGNCi HGNC:29222. ZNF644.
    HPAi HPA057795.
    MIMi 614159. gene.
    614167. phenotype.
    neXtProti NX_Q9H582.
    PharmGKBi PA134984168.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG262560.
    HOVERGENi HBG058603.
    OMAi ECNFMAV.
    OrthoDBi EOG747PH4.
    PhylomeDBi Q9H582.
    TreeFami TF333705.

    Miscellaneous databases

    ChiTaRSi ZNF644. human.
    GeneWikii ZNF644.
    GenomeRNAii 84146.
    NextBioi 73468.
    PROi Q9H582.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H582.
    Bgeei Q9H582.
    CleanExi HS_ZNF644.
    Genevestigatori Q9H582.

    Family and domain databases

    Gene3Di 3.30.160.60. 1 hit.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 8 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Zep-2: zinc finger motif enhancer binding protein-2."
      Fukamizu A.
      Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Pericardium.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Duodenum, Eye and Skin.
    6. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
      DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 46-1327 (ISOFORM 1).
      Tissue: Brain.
    7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1000, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-309 AND SER-1000, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1000, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1000 AND SER-1189, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-53.
    12. Cited for: VARIANTS MYP21 VAL-587; GLY-672; GLY-680 AND TYR-699, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiZN644_HUMAN
    AccessioniPrimary (citable) accession number: Q9H582
    Secondary accession number(s): A2RU71
    , Q2TAM0, Q5TCC0, Q6BEP7, Q6P446, Q6PI06, Q7LG67, Q9ULJ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3