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Protein

Protein MROH8

Gene

MROH8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MROH8
Alternative name(s):
Maestro heat-like repeat-containing protein family member 8
Gene namesi
Name:MROH8
Synonyms:C20orf131, C20orf132
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16125. MROH8.

Pathology & Biotechi

Organism-specific databases

DisGeNETi140699.
PharmGKBiPA25674.

Polymorphism and mutation databases

BioMutaiMROH8.
DMDMi28201794.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000794621 – 483Protein MROH8Add BLAST483

Proteomic databases

PeptideAtlasiQ9H579.
PRIDEiQ9H579.

Expressioni

Gene expression databases

BgeeiENSG00000101353.
CleanExiHS_C20orf132.
ExpressionAtlasiQ9H579. baseline and differential.
GenevisibleiQ9H579. HS.

Organism-specific databases

HPAiHPA060298.

Interactioni

Protein-protein interaction databases

BioGridi126660. 1 interactor.
MINTiMINT-5009781.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG051196.
InParanoidiQ9H579.
PhylomeDBiQ9H579.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H579-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSKHRICSQ EEVVIPCAYD SDSESVDLEL SNLEIIKKGS SSIELTDLDI
60 70 80 90 100
PDIPGLHCEP LSHSPRHLTQ QDPLSEAIVE KLIQSIQKVF NGELKGELEK
110 120 130 140 150
LKFLGDLSSL SQALPYDETA KSFIHSHIAD IVHTLNVLVQ EERPHSLSSS
160 170 180 190 200
MRQEVFVTIA DLSYQDVHLL LGSEDRAELF SLTIKSIITL PSVRTLTQIQ
210 220 230 240 250
EIMPNGTCNT ECLYRQTFQA FSEMLQSLVV KDPHLENLDT IIKLPLRFQR
260 270 280 290 300
LGHLVALMAL LCGDPQEKVA EEAAEGIHSL LHITLRLKYI THDKKDQQNL
310 320 330 340 350
KRALTKCREF LELHSSAAKC FYNCPFRIAQ VFEGFLDSNE LCQFIMTTFD
360 370 380 390 400
TLKTLKHPCI QRSAGELLLT LAKNTESQFE KVPEIMGVIC AQLSIISQPR
410 420 430 440 450
VRQQIINTVS LFISRPKYTD IVLSFLLCHP VPYNRHLAEV WRMLSVELPS
460 470 480
TTWILWRLLR KLQKCHNEPA QEKMAYVAVA VSP
Length:483
Mass (Da):54,816
Last modified:February 1, 2003 - v2
Checksum:i1B1F8EC547A88352
GO
Isoform 2 (identifier: Q9H579-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     331-381: Missing.
     481-483: VSP → ATDALYEVFL...LQKLMGRSSA

Note: No experimental confirmation available.
Show »
Length:876
Mass (Da):99,626
Checksum:i1B0EF63288B685FD
GO

Sequence cautioni

The sequence BAC04162 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAI42666 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI95719 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti354T → N in BAC04162 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003821331 – 381Missing in isoform 2. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_003822481 – 483VSP → ATDALYEVFLGNRLRAATFR LFPQLLMTLLIQIHHSIGLT MSDVDIPSGLYTEQEVPSEV TPLCFAMQATKTLLLRTCCL QEFNIMEKNKGWALLGGKDG HLQGLFLLANALLERNQLLA QKVMYLLVPLLNRGNDKHKL TSAGSFVELLRSPVAKRLPS IYSVARFKDWLQDGNHLFRI LGLRGLYNLVGHQEMREDIK SLLPYIVDSLRETDEKIVLS AIQILLQLVRTMDFTTLAAM MRTLFSLFGDVRSDVHRFSV TLFGAAIKSVKNPDKKSIEN QVLDSLVPLLLYSQDENDAV AEESRQVLTICAQFLKWKLP QEVYSKDPWHIKPTEAGTIC RFFEKKCKGKINILEQTLMY SKNPKLPIRRSAVLFVGLLS KYMDHNELRRMGTDWIEDDL RDLLCDPEPSLCIIASQTLL LVQMARAEPKPKQRVNWLQK LMGRSSA in isoform 2. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093432 mRNA. Translation: BAC04162.1. Different initiation.
AL031659, AL136172 Genomic DNA. Translation: CAI42666.2. Sequence problems.
AL136172, AL031659 Genomic DNA. Translation: CAI95719.2. Sequence problems.
AL833864 mRNA. Translation: CAD38722.1.
RefSeqiNP_689716.4. NM_152503.5.
NP_998796.1. NM_213631.2.
NP_998797.2. NM_213632.2.
UniGeneiHs.349125.

Genome annotation databases

EnsembliENST00000421643; ENSP00000413544; ENSG00000101353.
GeneIDi140699.
KEGGihsa:140699.
UCSCiuc061wux.1. human. [Q9H579-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMROH8_HUMAN
AccessioniPrimary (citable) accession number: Q9H579
Secondary accession number(s): Q5JYQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: February 1, 2003
Last modified: April 12, 2017
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM