Q9H579 (MROH8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein MROH8

Alternative name(s):
Maestro heat-like repeat-containing protein family member 8

Gene names

Name:	MROH8
Synonyms:	C20orf131, C20orf132

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	483 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence caution

The sequence BAC04162.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAI42666.2 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI95719.2 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H579-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9H579-2)

The sequence of this isoform differs from the canonical sequence as follows:
     331-381: Missing.
     481-483: VSP → ATDALYEVFL...LQKLMGRSSA

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 483	483	Protein MROH8		PRO_0000079462
Natural variations
	Alternative sequence	331 – 381	51	Missing in isoform 2.		VSP_003821
	Alternative sequence	481 – 483	3	VSP → ATDALYEVFLGNRLRAATFR LFPQLLMTLLIQIHHSIGLT MSDVDIPSGLYTEQEVPSEV TPLCFAMQATKTLLLRTCCL QEFNIMEKNKGWALLGGKDG HLQGLFLLANALLERNQLLA QKVMYLLVPLLNRGNDKHKL TSAGSFVELLRSPVAKRLPS IYSVARFKDWLQDGNHLFRI LGLRGLYNLVGHQEMREDIK SLLPYIVDSLRETDEKIVLS AIQILLQLVRTMDFTTLAAM MRTLFSLFGDVRSDVHRFSV TLFGAAIKSVKNPDKKSIEN QVLDSLVPLLLYSQDENDAV AEESRQVLTICAQFLKWKLP QEVYSKDPWHIKPTEAGTIC RFFEKKCKGKINILEQTLMY SKNPKLPIRRSAVLFVGLLS KYMDHNELRRMGTDWIEDDL RDLLCDPEPSLCIIASQTLL LVQMARAEPKPKQRVNWLQK LMGRSSA in isoform 2.		VSP_003822
Experimental info
	Sequence conflict	354	1	T → N in BAC04162. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 1, 2003. Version 2. Checksum: 1B1F8EC547A88352	FASTA	483	54,816
	10 20 30 40 50 60 MSSKHRICSQ EEVVIPCAYD SDSESVDLEL SNLEIIKKGS SSIELTDLDI PDIPGLHCEP 70 80 90 100 110 120 LSHSPRHLTQ QDPLSEAIVE KLIQSIQKVF NGELKGELEK LKFLGDLSSL SQALPYDETA 130 140 150 160 170 180 KSFIHSHIAD IVHTLNVLVQ EERPHSLSSS MRQEVFVTIA DLSYQDVHLL LGSEDRAELF 190 200 210 220 230 240 SLTIKSIITL PSVRTLTQIQ EIMPNGTCNT ECLYRQTFQA FSEMLQSLVV KDPHLENLDT 250 260 270 280 290 300 IIKLPLRFQR LGHLVALMAL LCGDPQEKVA EEAAEGIHSL LHITLRLKYI THDKKDQQNL 310 320 330 340 350 360 KRALTKCREF LELHSSAAKC FYNCPFRIAQ VFEGFLDSNE LCQFIMTTFD TLKTLKHPCI 370 380 390 400 410 420 QRSAGELLLT LAKNTESQFE KVPEIMGVIC AQLSIISQPR VRQQIINTVS LFISRPKYTD 430 440 450 460 470 480 IVLSFLLCHP VPYNRHLAEV WRMLSVELPS TTWILWRLLR KLQKCHNEPA QEKMAYVAVA VSP
	Isoform 2 [UniParc]. Checksum: 1B0EF63288B685FD	FASTA	876	99,626
	10 20 30 40 50 60 MSSKHRICSQ EEVVIPCAYD SDSESVDLEL SNLEIIKKGS SSIELTDLDI PDIPGLHCEP 70 80 90 100 110 120 LSHSPRHLTQ QDPLSEAIVE KLIQSIQKVF NGELKGELEK LKFLGDLSSL SQALPYDETA 130 140 150 160 170 180 KSFIHSHIAD IVHTLNVLVQ EERPHSLSSS MRQEVFVTIA DLSYQDVHLL LGSEDRAELF 190 200 210 220 230 240 SLTIKSIITL PSVRTLTQIQ EIMPNGTCNT ECLYRQTFQA FSEMLQSLVV KDPHLENLDT 250 260 270 280 290 300 IIKLPLRFQR LGHLVALMAL LCGDPQEKVA EEAAEGIHSL LHITLRLKYI THDKKDQQNL 310 320 330 340 350 360 KRALTKCREF LELHSSAAKC FYNCPFRIAQ VPEIMGVICA QLSIISQPRV RQQIINTVSL 370 380 390 400 410 420 FISRPKYTDI VLSFLLCHPV PYNRHLAEVW RMLSVELPST TWILWRLLRK LQKCHNEPAQ 430 440 450 460 470 480 EKMAYVAVAA TDALYEVFLG NRLRAATFRL FPQLLMTLLI QIHHSIGLTM SDVDIPSGLY 490 500 510 520 530 540 TEQEVPSEVT PLCFAMQATK TLLLRTCCLQ EFNIMEKNKG WALLGGKDGH LQGLFLLANA 550 560 570 580 590 600 LLERNQLLAQ KVMYLLVPLL NRGNDKHKLT SAGSFVELLR SPVAKRLPSI YSVARFKDWL 610 620 630 640 650 660 QDGNHLFRIL GLRGLYNLVG HQEMREDIKS LLPYIVDSLR ETDEKIVLSA IQILLQLVRT 670 680 690 700 710 720 MDFTTLAAMM RTLFSLFGDV RSDVHRFSVT LFGAAIKSVK NPDKKSIENQ VLDSLVPLLL 730 740 750 760 770 780 YSQDENDAVA EESRQVLTIC AQFLKWKLPQ EVYSKDPWHI KPTEAGTICR FFEKKCKGKI 790 800 810 820 830 840 NILEQTLMYS KNPKLPIRRS AVLFVGLLSK YMDHNELRRM GTDWIEDDLR DLLCDPEPSL 850 860 870 CIIASQTLLL VQMARAEPKP KQRVNWLQKL MGRSSA

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 208-483 (ISOFORM 2). Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK093432 mRNA. Translation: BAC04162.1. Different initiation. AL031659, AL136172 Genomic DNA. Translation: CAI42666.2. Sequence problems. AL136172, AL031659 Genomic DNA. Translation: CAI95719.2. Sequence problems. AL833864 mRNA. Translation: CAD38722.1.
IPI	IPI00220372. IPI00477327.
RefSeq	NP_689716.4. NM_152503.4. NP_998796.1. NM_213631.1. NP_998797.1. NM_213632.1.
UniGene	Hs.349125.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000339971.
Polymorphism databases
DMDM	28201794.
Proteomic databases
PaxDb	Q9H579.
PRIDE	Q9H579.
Protocols and materials databases
DNASU	140699.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000421643; ENSP00000413544; ENSG00000101353.
GeneID	140699.
KEGG	hsa:140699.
Organism-specific databases
CTD	140699.
GeneCards	GC20M035729.
H-InvDB	HIX0015790.
HGNC	HGNC:16125. MROH8.
neXtProt	NX_Q9H579.
PharmGKB	PA25674.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG303032.
HOVERGEN	HBG051196.
Gene expression databases
ArrayExpress	Q9H579.
Bgee	Q9H579.
CleanEx	HS_C20orf132.
Genevestigator	Q9H579.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	140699.
NextBio	84259.

Entry information

Entry name

MROH8_HUMAN

Accession

Primary (citable) accession number: Q9H579
Secondary accession number(s): Q5JYQ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2003
Last sequence update:	February 1, 2003
Last modified:	April 3, 2013
This is version 81 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.