Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein MROH8

Gene

MROH8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MROH8
Alternative name(s):
Maestro heat-like repeat-containing protein family member 8
Gene namesi
Name:MROH8
Synonyms:C20orf131, C20orf132
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16125. MROH8.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25674.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 483483Protein MROH8PRO_0000079462Add
BLAST

Proteomic databases

PaxDbiQ9H579.
PRIDEiQ9H579.

Expressioni

Gene expression databases

BgeeiQ9H579.
CleanExiHS_C20orf132.
ExpressionAtlasiQ9H579. baseline and differential.
GenevestigatoriQ9H579.

Organism-specific databases

HPAiHPA060298.

Interactioni

Protein-protein interaction databases

BioGridi126660. 1 interaction.
MINTiMINT-5009781.
STRINGi9606.ENSP00000339971.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG303032.
HOVERGENiHBG051196.
InParanoidiQ9H579.
PhylomeDBiQ9H579.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H579-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSKHRICSQ EEVVIPCAYD SDSESVDLEL SNLEIIKKGS SSIELTDLDI
60 70 80 90 100
PDIPGLHCEP LSHSPRHLTQ QDPLSEAIVE KLIQSIQKVF NGELKGELEK
110 120 130 140 150
LKFLGDLSSL SQALPYDETA KSFIHSHIAD IVHTLNVLVQ EERPHSLSSS
160 170 180 190 200
MRQEVFVTIA DLSYQDVHLL LGSEDRAELF SLTIKSIITL PSVRTLTQIQ
210 220 230 240 250
EIMPNGTCNT ECLYRQTFQA FSEMLQSLVV KDPHLENLDT IIKLPLRFQR
260 270 280 290 300
LGHLVALMAL LCGDPQEKVA EEAAEGIHSL LHITLRLKYI THDKKDQQNL
310 320 330 340 350
KRALTKCREF LELHSSAAKC FYNCPFRIAQ VFEGFLDSNE LCQFIMTTFD
360 370 380 390 400
TLKTLKHPCI QRSAGELLLT LAKNTESQFE KVPEIMGVIC AQLSIISQPR
410 420 430 440 450
VRQQIINTVS LFISRPKYTD IVLSFLLCHP VPYNRHLAEV WRMLSVELPS
460 470 480
TTWILWRLLR KLQKCHNEPA QEKMAYVAVA VSP
Length:483
Mass (Da):54,816
Last modified:January 31, 2003 - v2
Checksum:i1B1F8EC547A88352
GO
Isoform 2 (identifier: Q9H579-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     331-381: Missing.
     481-483: VSP → ATDALYEVFL...LQKLMGRSSA

Note: No experimental confirmation available.

Show »
Length:876
Mass (Da):99,626
Checksum:i1B0EF63288B685FD
GO

Sequence cautioni

The sequence BAC04162.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAI42666.2 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI95719.2 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti354 – 3541T → N in BAC04162 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei331 – 38151Missing in isoform 2. 1 PublicationVSP_003821Add
BLAST
Alternative sequencei481 – 4833VSP → ATDALYEVFLGNRLRAATFR LFPQLLMTLLIQIHHSIGLT MSDVDIPSGLYTEQEVPSEV TPLCFAMQATKTLLLRTCCL QEFNIMEKNKGWALLGGKDG HLQGLFLLANALLERNQLLA QKVMYLLVPLLNRGNDKHKL TSAGSFVELLRSPVAKRLPS IYSVARFKDWLQDGNHLFRI LGLRGLYNLVGHQEMREDIK SLLPYIVDSLRETDEKIVLS AIQILLQLVRTMDFTTLAAM MRTLFSLFGDVRSDVHRFSV TLFGAAIKSVKNPDKKSIEN QVLDSLVPLLLYSQDENDAV AEESRQVLTICAQFLKWKLP QEVYSKDPWHIKPTEAGTIC RFFEKKCKGKINILEQTLMY SKNPKLPIRRSAVLFVGLLS KYMDHNELRRMGTDWIEDDL RDLLCDPEPSLCIIASQTLL LVQMARAEPKPKQRVNWLQK LMGRSSA in isoform 2. 1 PublicationVSP_003822

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093432 mRNA. Translation: BAC04162.1. Different initiation.
AL031659, AL136172 Genomic DNA. Translation: CAI42666.2. Sequence problems.
AL136172, AL031659 Genomic DNA. Translation: CAI95719.2. Sequence problems.
AL833864 mRNA. Translation: CAD38722.1.
RefSeqiNP_689716.4. NM_152503.5.
NP_998796.1. NM_213631.2.
NP_998797.2. NM_213632.2.
UniGeneiHs.349125.

Genome annotation databases

EnsembliENST00000421643; ENSP00000413544; ENSG00000101353.
GeneIDi140699.
KEGGihsa:140699.

Polymorphism databases

DMDMi28201794.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093432 mRNA. Translation: BAC04162.1. Different initiation.
AL031659, AL136172 Genomic DNA. Translation: CAI42666.2. Sequence problems.
AL136172, AL031659 Genomic DNA. Translation: CAI95719.2. Sequence problems.
AL833864 mRNA. Translation: CAD38722.1.
RefSeqiNP_689716.4. NM_152503.5.
NP_998796.1. NM_213631.2.
NP_998797.2. NM_213632.2.
UniGeneiHs.349125.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126660. 1 interaction.
MINTiMINT-5009781.
STRINGi9606.ENSP00000339971.

Polymorphism databases

DMDMi28201794.

Proteomic databases

PaxDbiQ9H579.
PRIDEiQ9H579.

Protocols and materials databases

DNASUi140699.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000421643; ENSP00000413544; ENSG00000101353.
GeneIDi140699.
KEGGihsa:140699.

Organism-specific databases

CTDi140699.
GeneCardsiGC20M035730.
H-InvDBHIX0015790.
HGNCiHGNC:16125. MROH8.
HPAiHPA060298.
neXtProtiNX_Q9H579.
PharmGKBiPA25674.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG303032.
HOVERGENiHBG051196.
InParanoidiQ9H579.
PhylomeDBiQ9H579.

Miscellaneous databases

GeneWikiiC20orf132.
GenomeRNAii140699.
NextBioi84259.

Gene expression databases

BgeeiQ9H579.
CleanExiHS_C20orf132.
ExpressionAtlasiQ9H579. baseline and differential.
GenevestigatoriQ9H579.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 208-483 (ISOFORM 2).
    Tissue: Testis.

Entry informationi

Entry nameiMROH8_HUMAN
AccessioniPrimary (citable) accession number: Q9H579
Secondary accession number(s): Q5JYQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2003
Last sequence update: January 31, 2003
Last modified: January 6, 2015
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.