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Protein

Actin-like protein 8

Gene

ACTL8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • epithelial cell differentiation Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000117148-MONOMER.
SignaLinkiQ9H568.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-like protein 8
Alternative name(s):
Cancer/testis antigen 57
Short name:
CT57
Gene namesi
Name:ACTL8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24018. ACTL8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi81569.
OpenTargetsiENSG00000117148.
PharmGKBiPA142672644.

Polymorphism and mutation databases

BioMutaiACTL8.
DMDMi74752665.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002861711 – 366Actin-like protein 8Add BLAST366

Proteomic databases

EPDiQ9H568.
MaxQBiQ9H568.
PaxDbiQ9H568.
PeptideAtlasiQ9H568.
PRIDEiQ9H568.

PTM databases

iPTMnetiQ9H568.
PhosphoSitePlusiQ9H568.

Expressioni

Tissue specificityi

Strongly expressed in testis and pancreas. Weak expression in placenta.1 Publication

Gene expression databases

BgeeiENSG00000117148.
CleanExiHS_ACTL8.
GenevisibleiQ9H568. HS.

Organism-specific databases

HPAiHPA027176.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
COL4A3BPQ9Y5P43EBI-10306917,EBI-739994

Protein-protein interaction databases

BioGridi123530. 22 interactors.
IntActiQ9H568. 22 interactors.
MINTiMINT-5001993.
STRINGi9606.ENSP00000364555.

Structurei

3D structure databases

ProteinModelPortaliQ9H568.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00840000129754.
HOGENOMiHOG000233340.
HOVERGENiHBG094566.
InParanoidiQ9H568.
OMAiVSHVMAC.
OrthoDBiEOG091G08US.
PhylomeDBiQ9H568.
TreeFamiTF340354.

Family and domain databases

InterProiIPR004000. Actin.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H568-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARTVIIDH GSGFLKAGTA GWNEPQMVFP NIVNYLPCKE NPGPSYARRR
60 70 80 90 100
VSLGIDICHP DTFSYPIERG RILNWEGVQY LWSFVLENHR REQEVPPVII
110 120 130 140 150
TETPLREPAD RKKMLEILFE LLHVPSVLLA DQLQMSLYAS GLLTGVVVDS
160 170 180 190 200
GYGLTRVQPF HQGRPLPASG KTLEFAGQDL SAYLLKSLFK EDCDRRCLFQ
210 220 230 240 250
LETVAVTQMN KCYVPQNLGE ALDFRERQQS ALDESNTYQL PDGSRVELTP
260 270 280 290 300
MQRVAPEMFF SPQVFEQPGP SIPRAIVESV ESCEISLRPL LVSHVMACGG
310 320 330 340 350
NTLYPGFTKR LFRELMGDHV SSTKATVWEG SNRNFSVWLG ASVVAHLSTY
360
QSEWMSREEY GEHMRM
Length:366
Mass (Da):41,360
Last modified:March 1, 2001 - v1
Checksum:iBCCFC1E5CDC1C8FB
GO

Sequence cautioni

The sequence AAA62476 differs from that shown. Reason: Frameshift at positions 30, 49, 110, 127, 141, 344, 347 and 354.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0320793A → S.2 PublicationsCorresponds to variant rs694214dbSNPEnsembl.1
Natural variantiVAR_032080245R → C.Corresponds to variant rs3795322dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20582 mRNA. Translation: AAA62476.1. Frameshift.
AK057339 mRNA. Translation: BAB71434.1.
AL136529 Genomic DNA. Translation: CAC15940.1.
BC028909 mRNA. Translation: AAH28909.1.
CCDSiCCDS183.1.
RefSeqiNP_110439.2. NM_030812.2.
XP_011540514.1. XM_011542212.2.
UniGeneiHs.2149.

Genome annotation databases

EnsembliENST00000375406; ENSP00000364555; ENSG00000117148.
ENST00000617065; ENSP00000481590; ENSG00000117148.
GeneIDi81569.
KEGGihsa:81569.
UCSCiuc001bat.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20582 mRNA. Translation: AAA62476.1. Frameshift.
AK057339 mRNA. Translation: BAB71434.1.
AL136529 Genomic DNA. Translation: CAC15940.1.
BC028909 mRNA. Translation: AAH28909.1.
CCDSiCCDS183.1.
RefSeqiNP_110439.2. NM_030812.2.
XP_011540514.1. XM_011542212.2.
UniGeneiHs.2149.

3D structure databases

ProteinModelPortaliQ9H568.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123530. 22 interactors.
IntActiQ9H568. 22 interactors.
MINTiMINT-5001993.
STRINGi9606.ENSP00000364555.

PTM databases

iPTMnetiQ9H568.
PhosphoSitePlusiQ9H568.

Polymorphism and mutation databases

BioMutaiACTL8.
DMDMi74752665.

Proteomic databases

EPDiQ9H568.
MaxQBiQ9H568.
PaxDbiQ9H568.
PeptideAtlasiQ9H568.
PRIDEiQ9H568.

Protocols and materials databases

DNASUi81569.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375406; ENSP00000364555; ENSG00000117148.
ENST00000617065; ENSP00000481590; ENSG00000117148.
GeneIDi81569.
KEGGihsa:81569.
UCSCiuc001bat.3. human.

Organism-specific databases

CTDi81569.
DisGeNETi81569.
GeneCardsiACTL8.
H-InvDBHIX0000184.
HGNCiHGNC:24018. ACTL8.
HPAiHPA027176.
neXtProtiNX_Q9H568.
OpenTargetsiENSG00000117148.
PharmGKBiPA142672644.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00840000129754.
HOGENOMiHOG000233340.
HOVERGENiHBG094566.
InParanoidiQ9H568.
OMAiVSHVMAC.
OrthoDBiEOG091G08US.
PhylomeDBiQ9H568.
TreeFamiTF340354.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000117148-MONOMER.
SignaLinkiQ9H568.

Miscellaneous databases

ChiTaRSiACTL8. human.
GeneWikiiACTL8.
GenomeRNAii81569.
PROiQ9H568.

Gene expression databases

BgeeiENSG00000117148.
CleanExiHS_ACTL8.
GenevisibleiQ9H568. HS.

Family and domain databases

InterProiIPR004000. Actin.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACTL8_HUMAN
AccessioniPrimary (citable) accession number: Q9H568
Secondary accession number(s): Q13104, Q96M75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.