Q9H568 (ACTL8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Actin-like protein 8

Alternative name(s):
Cancer/testis antigen 57
Short name=CT57

Gene names

Name:

ACTL8

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cytoplasm › cytoskeleton By similarity.
Tissue specificity	Strongly expressed in testis and pancreas. Weak expression in placenta. Ref.5
Sequence similarities	Belongs to the actin family.
Sequence caution	The sequence AAA62476.1 differs from that shown. Reason: Frameshift at positions 30, 49, 110, 127, 141, 344, 347 and 354.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from direct assay. Source: HPA cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 366	366	Actin-like protein 8		PRO_0000286171
Natural variations
	Natural variant	3	1	A → S. Ref.2 Ref.4 Corresponds to variant rs694214 [ dbSNP | Ensembl ].		VAR_032079
	Natural variant	245	1	R → C. Corresponds to variant rs3795322 [ dbSNP | Ensembl ].		VAR_032080

Sequences

	Sequence		Length	Mass (Da)
	Q9H568 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: BCCFC1E5CDC1C8FB	FASTA	366	41,360
	10 20 30 40 50 60 MAARTVIIDH GSGFLKAGTA GWNEPQMVFP NIVNYLPCKE NPGPSYARRR VSLGIDICHP 70 80 90 100 110 120 DTFSYPIERG RILNWEGVQY LWSFVLENHR REQEVPPVII TETPLREPAD RKKMLEILFE 130 140 150 160 170 180 LLHVPSVLLA DQLQMSLYAS GLLTGVVVDS GYGLTRVQPF HQGRPLPASG KTLEFAGQDL 190 200 210 220 230 240 SAYLLKSLFK EDCDRRCLFQ LETVAVTQMN KCYVPQNLGE ALDFRERQQS ALDESNTYQL 250 260 270 280 290 300 PDGSRVELTP MQRVAPEMFF SPQVFEQPGP SIPRAIVESV ESCEISLRPL LVSHVMACGG 310 320 330 340 350 360 NTLYPGFTKR LFRELMGDHV SSTKATVWEG SNRNFSVWLG ASVVAHLSTY QSEWMSREEY GEHMRM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Partial sequencing and chromosome mapping of cDNA clones from a Burkitt's lymphoma." Sanders R. Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: B-cell lymphoma.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-3. Tissue: Testis.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-3. Tissue: Brain.
[5]	"Identification of cancer/testis-antigen genes by massively parallel signature sequencing." Chen Y.-T., Scanlan M.J., Venditti C.A., Chua R., Theiler G., Stevenson B.J., Iseli C., Gure A.O., Vasicek T., Strausberg R.L., Jongeneel C.V., Old L.J., Simpson A.J.G. Proc. Natl. Acad. Sci. U.S.A. 102:7940-7945(2005) [PubMed: 15905330] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U20582 mRNA. Translation: AAA62476.1. Frameshift. AK057339 mRNA. Translation: BAB71434.1. AL136529 Genomic DNA. Translation: CAC15940.1. BC028909 mRNA. Translation: AAH28909.1.
IPI	IPI00329820.
RefSeq	NP_110439.2. NM_030812.2.
UniGene	Hs.2149.
3D structure databases
ProteinModelPortal	Q9H568.
SMR	Q9H568. Positions 2-365.
ModBase	Search...
PTM databases
PhosphoSite	Q9H568.
Polymorphism databases
DMDM	74752665.
Proteomic databases
PRIDE	Q9H568.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000235799; ENSP00000235799; ENSG00000117148. ENST00000375406; ENSP00000364555; ENSG00000117148.
GeneID	81569.
KEGG	hsa:81569.
UCSC	uc001bat.1. human.
Organism-specific databases
CTD	81569.
GeneCards	GC01P018081.
H-InvDB	HIX0000184.
HGNC	HGNC:24018. ACTL8.
HPA	HPA027176.
neXtProt	NX_Q9H568.
PharmGKB	PA142672644.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG14596.
GeneTree	ENSGT00600000084408.
HOGENOM	HBG559892.
HOVERGEN	HBG094566.
InParanoid	Q9H568.
OMA	VSHVMAC.
OrthoDB	EOG4R7V9W.
PhylomeDB	Q9H568.
Gene expression databases
ArrayExpress	Q9H568.
Bgee	Q9H568.
CleanEx	HS_ACTL8.
Genevestigator	Q9H568.
Family and domain databases
InterPro	IPR004000. Actin-like. [Graphical view]
PANTHER	PTHR11937. Actin_like. 1 hit.
Pfam	PF00022. Actin. 1 hit. [Graphical view]
PRINTS	PR00190. ACTIN.
SMART	SM00268. ACTIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	71862.

Entry information

Entry name

ACTL8_HUMAN

Accession

Primary (citable) accession number: Q9H568
Secondary accession number(s): Q13104, Q96M75

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
Last sequence update:	March 1, 2001
Last modified:	January 25, 2012
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.