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Protein

Kelch-like protein 31

Gene

KLHL31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124743-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 31
Alternative name(s):
BTB and kelch domain-containing protein 6
Kelch repeat and BTB domain-containing protein 1
Kelch-like protein KLHL
Gene namesi
Name:KLHL31
Synonyms:BKLHD6, KBTBD1, KLHL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21353. KLHL31.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000124743.
PharmGKBiPA162393541.

Polymorphism and mutation databases

BioMutaiKLHL31.
DMDMi74752656.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002710352 – 634Kelch-like protein 31Add BLAST633

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N,N,N-trimethylalanineBy similarity1

Post-translational modificationi

N-terminus is methylated by METTL11A/NTM1.By similarity

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ9H511.
PeptideAtlasiQ9H511.
PRIDEiQ9H511.

PTM databases

iPTMnetiQ9H511.
PhosphoSitePlusiQ9H511.

Expressioni

Tissue specificityi

Strongly expressed in skeletal muscle and weakly in heart. According to PubMed:15302408, not expressed in other tissues. According to PubMed:18719355, abundantly expressed in both embryonic skeletal and heart tissues.2 Publications

Gene expression databases

BgeeiENSG00000124743.
CleanExiHS_KLHL31.
GenevisibleiQ9H511. HS.

Organism-specific databases

HPAiCAB009800.

Interactioni

Protein-protein interaction databases

IntActiQ9H511. 1 interactor.
STRINGi9606.ENSP00000359942.

Structurei

3D structure databases

ProteinModelPortaliQ9H511.
SMRiQ9H511.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 137BTBPROSITE-ProRule annotationAdd BLAST65
Domaini172 – 273BACKAdd BLAST102
Repeati317 – 365Kelch 1Add BLAST49
Repeati366 – 419Kelch 2Add BLAST54
Repeati420 – 466Kelch 3Add BLAST47
Repeati468 – 513Kelch 4Add BLAST46
Repeati515 – 565Kelch 5Add BLAST51
Repeati567 – 614Kelch 6Add BLAST48

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00760000118825.
HOGENOMiHOG000231583.
HOVERGENiHBG101156.
InParanoidiQ9H511.
KOiK10467.
OMAiMNQKRTH.
OrthoDBiEOG091G02ZQ.
PhylomeDBiQ9H511.
TreeFamiTF328485.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR030604. KLHL31.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF247. PTHR24412:SF247. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 4 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H511-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKKKIVKK NKGDINEMTI IVEDSPLNKL NALNGLLEGG NGLSCISSEL
60 70 80 90 100
TDASYGPNLL EGLSKMRQEN FLCDLVIGTK TKSFDVHKSV MASCSEYFYN
110 120 130 140 150
ILKKDPSIQR VDLNDISPLG LATVIAYAYT GKLTLSLYTI GSIISAAVYL
160 170 180 190 200
QIHTLVKMCS DFLIREMSVE NCMYVVNIAE TYSLKNAKAA AQKFIRDNFL
210 220 230 240 250
EFAESDQFMK LTFEQINELL IDDDLQLPSE IVAFQIAMKW LEFDQKRVKY
260 270 280 290 300
AADLLSNIRF GTISAQDLVN YVQSVPRMMQ DADCHRLLVD AMNYHLLPYH
310 320 330 340 350
QNTLQSRRTR IRGGCRVLVT VGGRPGLTEK SLSRDILYRD PENGWSKLTE
360 370 380 390 400
MPAKSFNQCV AVMDGFLYVA GGEDQNDARN QAKHAVSNFC RYDPRFNTWI
410 420 430 440 450
HLASMNQKRT HFSLSVFNGL VYAAGGRNAE GSLASLECYV PSTNQWQPKT
460 470 480 490 500
PLEVARCCHA SAVADGRVLV TGGYIANAYS RSVCAYDPAS DSWQELPNLS
510 520 530 540 550
TPRGWHCAVT LSDRVYVMGG SQLGPRGERV DVLTVECYSP ATGQWSYAAP
560 570 580 590 600
LQVGVSTAGV SALHGRAYLV GGWNEGEKKY KKCIQCFSPE LNEWTEDDEL
610 620 630
PEATVGVSCC TLSMPNNVTR ESRASSVSSV PVSI
Length:634
Mass (Da):70,246
Last modified:March 1, 2001 - v1
Checksum:iE9099A93864CFC02
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05005011N → S.Corresponds to variant rs6908377dbSNPEnsembl.1
Natural variantiVAR_050051156V → I.2 PublicationsCorresponds to variant rs3799260dbSNPEnsembl.1
Natural variantiVAR_050052508A → T.Corresponds to variant rs3799261dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF633513 mRNA. Translation: ABR23528.1.
AL157773 Genomic DNA. Translation: CAC16284.1.
CH471081 Genomic DNA. Translation: EAX04428.1.
BC137267 mRNA. Translation: AAI37268.1.
BC137269 mRNA. Translation: AAI37270.1.
CCDSiCCDS34478.1.
RefSeqiNP_001003760.2. NM_001003760.4.
XP_005249164.1. XM_005249107.4.
XP_016866347.1. XM_017010858.1.
UniGeneiHs.131064.

Genome annotation databases

EnsembliENST00000370905; ENSP00000359942; ENSG00000124743.
ENST00000407079; ENSP00000384644; ENSG00000124743.
GeneIDi401265.
KEGGihsa:401265.
UCSCiuc003pcb.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF633513 mRNA. Translation: ABR23528.1.
AL157773 Genomic DNA. Translation: CAC16284.1.
CH471081 Genomic DNA. Translation: EAX04428.1.
BC137267 mRNA. Translation: AAI37268.1.
BC137269 mRNA. Translation: AAI37270.1.
CCDSiCCDS34478.1.
RefSeqiNP_001003760.2. NM_001003760.4.
XP_005249164.1. XM_005249107.4.
XP_016866347.1. XM_017010858.1.
UniGeneiHs.131064.

3D structure databases

ProteinModelPortaliQ9H511.
SMRiQ9H511.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9H511. 1 interactor.
STRINGi9606.ENSP00000359942.

PTM databases

iPTMnetiQ9H511.
PhosphoSitePlusiQ9H511.

Polymorphism and mutation databases

BioMutaiKLHL31.
DMDMi74752656.

Proteomic databases

PaxDbiQ9H511.
PeptideAtlasiQ9H511.
PRIDEiQ9H511.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370905; ENSP00000359942; ENSG00000124743.
ENST00000407079; ENSP00000384644; ENSG00000124743.
GeneIDi401265.
KEGGihsa:401265.
UCSCiuc003pcb.4. human.

Organism-specific databases

CTDi401265.
GeneCardsiKLHL31.
H-InvDBHIX0005966.
HGNCiHGNC:21353. KLHL31.
HPAiCAB009800.
MIMi610749. gene.
neXtProtiNX_Q9H511.
OpenTargetsiENSG00000124743.
PharmGKBiPA162393541.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00760000118825.
HOGENOMiHOG000231583.
HOVERGENiHBG101156.
InParanoidiQ9H511.
KOiK10467.
OMAiMNQKRTH.
OrthoDBiEOG091G02ZQ.
PhylomeDBiQ9H511.
TreeFamiTF328485.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124743-MONOMER.

Miscellaneous databases

GenomeRNAii401265.
PROiQ9H511.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124743.
CleanExiHS_KLHL31.
GenevisibleiQ9H511. HS.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR030604. KLHL31.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF247. PTHR24412:SF247. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 4 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLH31_HUMAN
AccessioniPrimary (citable) accession number: Q9H511
Secondary accession number(s): A6N9J2, B2RP49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.