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Protein

Kelch-like protein 31

Gene

KLHL31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).1 Publication

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 31
Alternative name(s):
BTB and kelch domain-containing protein 6
Kelch repeat and BTB domain-containing protein 1
Kelch-like protein KLHL
Gene namesi
Name:KLHL31
Synonyms:BKLHD6, KBTBD1, KLHL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000124743.5
HGNCiHGNC:21353 KLHL31
MIMi610749 gene
neXtProtiNX_Q9H511

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000124743
PharmGKBiPA162393541

Polymorphism and mutation databases

BioMutaiKLHL31
DMDMi74752656

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002710352 – 634Kelch-like protein 31Add BLAST633

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N,N,N-trimethylalanineBy similarity1

Post-translational modificationi

N-terminus is methylated by METTL11A/NTM1.By similarity

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ9H511
PeptideAtlasiQ9H511
PRIDEiQ9H511

PTM databases

iPTMnetiQ9H511
PhosphoSitePlusiQ9H511

Expressioni

Tissue specificityi

Strongly expressed in skeletal muscle and weakly in heart. According to PubMed:15302408, not expressed in other tissues. According to PubMed:18719355, abundantly expressed in both embryonic skeletal and heart tissues.2 Publications

Gene expression databases

BgeeiENSG00000124743
CleanExiHS_KLHL31
GenevisibleiQ9H511 HS

Interactioni

Protein-protein interaction databases

IntActiQ9H511, 1 interactor
STRINGi9606.ENSP00000359942

Structurei

3D structure databases

ProteinModelPortaliQ9H511
SMRiQ9H511
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 137BTBPROSITE-ProRule annotationAdd BLAST65
Domaini172 – 273BACKAdd BLAST102
Repeati317 – 365Kelch 1Add BLAST49
Repeati366 – 419Kelch 2Add BLAST54
Repeati420 – 466Kelch 3Add BLAST47
Repeati468 – 513Kelch 4Add BLAST46
Repeati515 – 565Kelch 5Add BLAST51
Repeati567 – 614Kelch 6Add BLAST48

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441 Eukaryota
ENOG410XNX8 LUCA
GeneTreeiENSGT00760000118825
HOGENOMiHOG000231583
HOVERGENiHBG101156
InParanoidiQ9H511
KOiK10467
OMAiSVENCMY
OrthoDBiEOG091G02ZQ
PhylomeDBiQ9H511
TreeFamiTF328485

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 4 hits
PIRSFiPIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 6 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H511-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKKKIVKK NKGDINEMTI IVEDSPLNKL NALNGLLEGG NGLSCISSEL
60 70 80 90 100
TDASYGPNLL EGLSKMRQEN FLCDLVIGTK TKSFDVHKSV MASCSEYFYN
110 120 130 140 150
ILKKDPSIQR VDLNDISPLG LATVIAYAYT GKLTLSLYTI GSIISAAVYL
160 170 180 190 200
QIHTLVKMCS DFLIREMSVE NCMYVVNIAE TYSLKNAKAA AQKFIRDNFL
210 220 230 240 250
EFAESDQFMK LTFEQINELL IDDDLQLPSE IVAFQIAMKW LEFDQKRVKY
260 270 280 290 300
AADLLSNIRF GTISAQDLVN YVQSVPRMMQ DADCHRLLVD AMNYHLLPYH
310 320 330 340 350
QNTLQSRRTR IRGGCRVLVT VGGRPGLTEK SLSRDILYRD PENGWSKLTE
360 370 380 390 400
MPAKSFNQCV AVMDGFLYVA GGEDQNDARN QAKHAVSNFC RYDPRFNTWI
410 420 430 440 450
HLASMNQKRT HFSLSVFNGL VYAAGGRNAE GSLASLECYV PSTNQWQPKT
460 470 480 490 500
PLEVARCCHA SAVADGRVLV TGGYIANAYS RSVCAYDPAS DSWQELPNLS
510 520 530 540 550
TPRGWHCAVT LSDRVYVMGG SQLGPRGERV DVLTVECYSP ATGQWSYAAP
560 570 580 590 600
LQVGVSTAGV SALHGRAYLV GGWNEGEKKY KKCIQCFSPE LNEWTEDDEL
610 620 630
PEATVGVSCC TLSMPNNVTR ESRASSVSSV PVSI
Length:634
Mass (Da):70,246
Last modified:March 1, 2001 - v1
Checksum:iE9099A93864CFC02
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05005011N → S. Corresponds to variant dbSNP:rs6908377Ensembl.1
Natural variantiVAR_050051156V → I2 PublicationsCorresponds to variant dbSNP:rs3799260Ensembl.1
Natural variantiVAR_050052508A → T. Corresponds to variant dbSNP:rs3799261Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF633513 mRNA Translation: ABR23528.1
AL157773 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04428.1
BC137267 mRNA Translation: AAI37268.1
BC137269 mRNA Translation: AAI37270.1
CCDSiCCDS34478.1
RefSeqiNP_001003760.2, NM_001003760.4
XP_005249164.1, XM_005249107.4
XP_016866347.1, XM_017010858.1
UniGeneiHs.131064

Genome annotation databases

EnsembliENST00000370905; ENSP00000359942; ENSG00000124743
ENST00000407079; ENSP00000384644; ENSG00000124743
GeneIDi401265
KEGGihsa:401265
UCSCiuc003pcb.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKLH31_HUMAN
AccessioniPrimary (citable) accession number: Q9H511
Secondary accession number(s): A6N9J2, B2RP49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2001
Last modified: April 25, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health